TPM1_HUMAN
Evidence for PS localization
Functions
Binds to actin filaments in muscle and non-muscle cells (PubMed). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 175 | Asp | Asn | Cardiomyopathy,familialhypertrophic,3(CMH3) | - |
| 180 | Glu | Gly | Cardiomyopathy,familialhypertrophic,3(CMH3) | - |
| 63 | Ala | Val | Cardiomyopathy,familialhypertrophic,3(CMH3) | - |
| 180 | Glu | Val | Cardiomyopathy,familialhypertrophic,3(CMH3) | - |
| 40 | Glu | Lys | Cardiomyopathy,dilated,1Y(CMD1Y) | - |
| 54 | Glu | Lys | Cardiomyopathy,dilated,1Y(CMD1Y) | - |
| 192 | Glu | Lys | Leftventricularnon-compaction9(LVNC9) | - |
| 248 | Lys | Glu | Leftventricularnon-compaction9(LVNC9) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TPM1_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 41.7910 | 4 | yes |
| GO:0043168 | anion binding | 26.8657 | 4 | no |
| GO:0043169 | cation binding | 26.1194 | 4 | no |
| GO:0046872 | metal ion binding | 25.3731 | 5 | no |
| GO:0000166 | nucleotide binding | 22.3881 | 4 | no |
| GO:0019900 | kinase binding | 21.6418 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.6418 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.6418 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.8955 | 4 | no |
| GO:0045296 | cadherin binding | 20.1493 | 4 | no |
| GO:0042803 | protein homodimerization activity | 16.4179 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 2.9851 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TPM1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.5075 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.2687 | 4 | yes |
| GO:0006996 | organelle organization | 44.0299 | 4 | yes |
| GO:0022607 | cellular component assembly | 42.5373 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.5522 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.8060 | 4 | no |
| GO:0008104 | protein localization | 37.3134 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.3284 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.8358 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 31.3433 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.5970 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 29.8507 | 5 | yes |
| GO:0007015 | actin filament organization | 29.1045 | 5 | yes |
| GO:0010646 | regulation of cell communication | 29.1045 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.3582 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.6119 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.8657 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.8657 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.1194 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.1194 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.1194 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.1194 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.8806 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 23.8806 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 23.8806 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.8806 | 6 | no |
| GO:0051049 | regulation of transport | 23.1343 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.3881 | 5 | no |
| GO:0071702 | organic substance transport | 22.3881 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.3881 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.3881 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 21.6418 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 21.6418 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.6418 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.6418 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 20.8955 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 20.8955 | 4 | no |
| GO:0015031 | protein transport | 20.8955 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.8955 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.1493 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.1493 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 17.9104 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 15.6716 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 14.9254 | 4 | yes |
| GO:0030030 | cell projection organization | 14.9254 | 4 | yes |
| GO:2000145 | regulation of cell motility | 14.9254 | 4 | yes |
| GO:0030334 | regulation of cell migration | 14.1791 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 14.1791 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 13.4328 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 12.6866 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 12.6866 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 11.9403 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 11.9403 | 7 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 11.9403 | 4 | yes |
| GO:0031032 | actomyosin structure organization | 9.7015 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 8.2090 | 5 | yes |
| GO:0006936 | muscle contraction | 7.4627 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 7.4627 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 7.4627 | 5 | yes |
| GO:0044057 | regulation of system process | 5.9701 | 4 | yes |
| GO:0030336 | negative regulation of cell migration | 5.2239 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 5.2239 | 5 | yes |
| GO:0040013 | negative regulation of locomotion | 5.2239 | 4 | yes |
| GO:0045214 | sarcomere organization | 5.2239 | 5 | yes |
| GO:2000146 | negative regulation of cell motility | 5.2239 | 5 | yes |
| GO:0000302 | response to reactive oxygen species | 4.4776 | 4 | yes |
| GO:0034599 | cellular response to oxidative stress | 4.4776 | 4 | yes |
| GO:0048660 | regulation of smooth muscle cell proliferation | 4.4776 | 5 | yes |
| GO:0062197 | cellular response to chemical stress | 4.4776 | 4 | yes |
| GO:0008016 | regulation of heart contraction | 3.7313 | 6 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 3.7313 | 6 | yes |
| GO:0042060 | wound healing | 3.7313 | 4 | yes |
| GO:0051492 | regulation of stress fiber assembly | 3.7313 | 6 | yes |
| GO:0090257 | regulation of muscle system process | 3.7313 | 5 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 3.7313 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 3.7313 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 2.9851 | 6 | yes |
| GO:0006941 | striated muscle contraction | 2.9851 | 5 | yes |
| GO:0031529 | ruffle organization | 2.9851 | 6 | yes |
| GO:0034614 | cellular response to reactive oxygen species | 2.9851 | 5 | yes |
| GO:0070252 | actin-mediated cell contraction | 2.9851 | 4 | yes |
| GO:0014910 | regulation of smooth muscle cell migration | 2.2388 | 6 | yes |
| GO:0014912 | negative regulation of smooth muscle cell migration | 2.2388 | 7 | yes |
| GO:0030049 | muscle filament sliding | 2.2388 | 6 | yes |
| GO:0033275 | actin-myosin filament sliding | 2.2388 | 5 | yes |
| GO:0048662 | negative regulation of smooth muscle cell proliferation | 2.2388 | 6 | yes |
| GO:0051496 | positive regulation of stress fiber assembly | 2.2388 | 7 | yes |
| GO:0055008 | cardiac muscle tissue morphogenesis | 2.2388 | 5 | yes |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 2.2388 | 6 | yes |
| GO:0060048 | cardiac muscle contraction | 2.2388 | 6 | yes |
| GO:0060415 | muscle tissue morphogenesis | 2.2388 | 4 | yes |
| GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 2.2388 | 6 | yes |
| GO:0003062 | regulation of heart rate by chemical signal | 1.4925 | 4 | yes |
| GO:0003065 | positive regulation of heart rate by epinephrine | 1.4925 | 5 | yes |
| GO:0010460 | positive regulation of heart rate | 1.4925 | 4 | yes |
| GO:0032781 | positive regulation of ATP-dependent activity | 1.4925 | 4 | yes |
| GO:0045823 | positive regulation of heart contraction | 1.4925 | 6 | yes |
| GO:1903524 | positive regulation of blood circulation | 1.4925 | 5 | yes |
| GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation | 1.4925 | 7 | yes |
| GO:1904752 | regulation of vascular associated smooth muscle cell migration | 1.4925 | 7 | yes |
| GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | 1.4925 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYOC_HUMAN | [view interactions] | Low throughput | no | no |
| PDLI5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNNT1_HUMAN | [view interactions] | Low throughput | no | no |
| TPM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPK3_HUMAN | [view interactions] | Low throughput | no | yes |
| MT3_HUMAN | [view interactions] | Low throughput | no | yes |
| CNN1_HUMAN | [view interactions] | Low throughput | no | no |
| TNNT2_HUMAN | [view interactions] | Low throughput | no | no |
| NEBU_HUMAN | [view interactions] | Low throughput | no | no |
| TRI32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | Low throughput | no | no |
| APOH_HUMAN | [view interactions] | Low throughput | no | no |
| MYH7_HUMAN | [view interactions] | Low throughput | no | no |
| TPM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| WASH1_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| TSSC4_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
| CROCC_HUMAN | [view interactions] | High throughput | no | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| KLH21_HUMAN | [view interactions] | High throughput | no | no |
| C102A_HUMAN | [view interactions] | High throughput | no | yes |
| CNTLN_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUND_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| PEO1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHCBP_HUMAN | [view interactions] | High throughput | no | no |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| SESN2_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASML_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG2_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| KCD15_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| CYBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| RALA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| EAPP_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| HNMT_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| SIX1_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| COR2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIN4_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| TPRN_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2_HUMAN | [view interactions] | High throughput | no | no |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGH_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| BACD2_HUMAN | [view interactions] | High throughput | no | no |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| CD59_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBPM_HUMAN | [view interactions] | High throughput | no | no |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ST1A1_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| CDR2L_HUMAN | [view interactions] | High throughput | no | yes |
| THOC1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNN2_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DP13B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR16_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH2_HUMAN | [view interactions] | High throughput | no | yes |
| GLT18_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| MYH8_HUMAN | [view interactions] | High throughput | no | no |
| CC112_HUMAN | [view interactions] | High throughput | no | no |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNNI1_HUMAN | [view interactions] | High throughput | no | no |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| CD3Z_HUMAN | [view interactions] | High throughput | no | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB27A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK3_HUMAN | [view interactions] | High throughput | no | no |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRF8_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC3_HUMAN | [view interactions] | High throughput | no | no |
| ELF3_HUMAN | [view interactions] | High throughput | no | no |
| TLX1_HUMAN | [view interactions] | High throughput | no | no |
| NKX25_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| CAGE1_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| CK024_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUH_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| MAST2_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |