Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PDLI5_HUMAN

GO
G2C
SynGO
SynaptomeDB

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PDLI5_HUMAN
GO:0046872 metal ion binding 27.7778 4 yes
GO:0017076 purine nucleotide binding 26.3889 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 23.6111 5 no
GO:0003779 actin binding 22.2222 4 yes
GO:0030695 GTPase regulator activity 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 20.8333 4 no
GO:0019900 kinase binding 19.4444 4 yes
GO:0019901 protein kinase binding 15.2778 5 yes
GO:0045296 cadherin binding 15.2778 4 yes
GO:0005080 protein kinase C binding 2.7778 6 yes
GO:0042805 actinin binding 2.7778 4 yes
GO:0051371 muscle alpha-actinin binding 2.7778 6 yes
GO:0051393 alpha-actinin binding 2.7778 5 yes
GO:0098631 cell adhesion mediator activity 2.7778 4 yes
GO:0098632 cell-cell adhesion mediator activity 2.7778 5 yes
GO:0098641 cadherin binding involved in cell-cell adhesion 2.7778 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PDLI5_HUMAN
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0010646 regulation of cell communication 48.6111 4 no
GO:0031323 regulation of cellular metabolic process 47.2222 4 no
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0006996 organelle organization 40.2778 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 40.2778 4 no
GO:0009893 positive regulation of metabolic process 36.1111 4 no
GO:0051246 regulation of protein metabolic process 36.1111 5 no
GO:1902531 regulation of intracellular signal transduction 34.7222 5 no
GO:0031325 positive regulation of cellular metabolic process 31.9444 5 no
GO:0051049 regulation of transport 31.9444 4 no
GO:0008104 protein localization 30.5556 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0051130 positive regulation of cellular component organization 27.7778 5 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0033043 regulation of organelle organization 27.7778 5 no
GO:0007010 cytoskeleton organization 26.3889 5 yes
GO:0044087 regulation of cellular component biogenesis 26.3889 4 yes
GO:0010468 regulation of gene expression 26.3889 5 no
GO:0031399 regulation of protein modification process 26.3889 6 no
GO:0045595 regulation of cell differentiation 26.3889 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.6111 5 no
GO:0030030 cell projection organization 23.6111 4 no
GO:0031326 regulation of cellular biosynthetic process 23.6111 5 no
GO:0048584 positive regulation of response to stimulus 23.6111 4 no
GO:0051094 positive regulation of developmental process 23.6111 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 yes
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0009967 positive regulation of signal transduction 20.8333 5 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0010941 regulation of cell death 20.8333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0042981 regulation of apoptotic process 20.8333 6 no
GO:0043067 regulation of programmed cell death 20.8333 5 no
GO:0048585 negative regulation of response to stimulus 20.8333 4 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:0016192 vesicle-mediated transport 20.8333 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.8333 5 no
GO:0010975 regulation of neuron projection development 16.6667 7 yes
GO:0050807 regulation of synapse organization 8.3333 5 yes
GO:0099175 regulation of postsynapse organization 5.5556 6 yes
GO:0007507 heart development 4.1667 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 4.1667 5 yes
GO:1901888 regulation of cell junction assembly 4.1667 5 yes
GO:0061049 cell growth involved in cardiac muscle cell development 2.7778 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PDLI5_HUMAN
DOID:0080000 muscular disease 4.1667 3 no
DOID:423 myopathy 4.1667 5 no
DOID:66 muscle tissue disease 4.1667 4 no
DOID:0050700 cardiomyopathy 2.7778 4 no
DOID:0060036 intrinsic cardiomyopathy 2.7778 5 no
DOID:114 heart disease 2.7778 3 no
DOID:12930 dilated cardiomyopathy 2.7778 6 no
DOID:9884 muscular dystrophy 2.7778 6 no
DOID:37 skin disease 2.7778 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACTA_HUMAN [view interactions] Low throughput no no
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TPM1_HUMAN [view entry] [view interactions] Low throughput yes no
TPM2_HUMAN [view entry] [view interactions] Low throughput yes yes
VINC_HUMAN [view entry] [view interactions] Low throughput yes no
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
ID2_HUMAN [view interactions] Low throughput no no
ID3_HUMAN [view interactions] Low throughput no yes
ID1_HUMAN [view interactions] Low throughput no yes
CAC1B_HUMAN [view interactions] Low throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
SYT11_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
PDE4D_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
MKNK1_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
TRI29_HUMAN [view interactions] High throughput no no
RM04_HUMAN [view interactions] High throughput no yes
GCP6_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
SOCS6_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
ZBT38_HUMAN [view interactions] High throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
SMAD3_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI18_HUMAN [view interactions] High throughput no no
DTX3L_HUMAN [view interactions] High throughput no yes
HAKAI_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
TRI56_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
HERC5_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CDPF1_HUMAN [view interactions] High throughput no no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
BNIP5_HUMAN [view interactions] High throughput no no
DHB1_HUMAN [view interactions] High throughput no no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
AT7L1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ZN785_HUMAN [view interactions] High throughput no no
RMD1_HUMAN [view interactions] High throughput no no
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
UBR3_HUMAN [view interactions] High throughput no yes
FACE1_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
ITA2B_HUMAN [view interactions] High throughput no no
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
SIN3A_HUMAN [view interactions] High throughput no yes
MDEAS_HUMAN [view interactions] High throughput no yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
CALU_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
TRMB_HUMAN [view interactions] High throughput no yes
NPL4_HUMAN [view interactions] High throughput no yes
PDE12_HUMAN [view interactions] High throughput no yes
AN32A_HUMAN [view interactions] High throughput no yes
CBS_HUMAN [view interactions] High throughput no yes
IPO11_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
PLIN3_HUMAN [view interactions] High throughput no yes
SRP14_HUMAN [view interactions] High throughput no no
SAE2_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
TPD52_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
ARFP2_HUMAN [view interactions] High throughput no no
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
GLYG_HUMAN [view interactions] High throughput no yes
ABLM2_HUMAN [view entry] [view interactions] High throughput yes yes
RHG44_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
PDE1B_HUMAN [view interactions] High throughput no yes
PDE1C_HUMAN [view interactions] High throughput no no
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
STAM1_HUMAN [view interactions] High throughput no yes
SYNE2_HUMAN [view interactions] High throughput no no
TM1L2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
TOM70_HUMAN [view interactions] High throughput no yes
FHL1_HUMAN [view interactions] High throughput no no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG35_HUMAN [view interactions] High throughput no yes
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
CBPB2_HUMAN [view interactions] High throughput no no
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
NS1BP_HUMAN [view interactions] High throughput no yes
LMA1L_HUMAN [view interactions] High throughput no no
LPXN_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG19_HUMAN [view interactions] High throughput no yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
RHG42_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
DNMBP_HUMAN [view interactions] High throughput no no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
GLI2_HUMAN [view interactions] High throughput no yes
GNAL_HUMAN [view interactions] High throughput no yes
KLHL7_HUMAN [view interactions] High throughput no yes
KMT5B_HUMAN [view interactions] High throughput no no
LHX3_HUMAN [view interactions] High throughput no no
LMA2L_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
PDE6B_HUMAN [view interactions] High throughput no no
PIAS3_HUMAN [view interactions] High throughput no yes
PREX1_HUMAN [view entry] [view interactions] High throughput yes no
PRIC1_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
S26A1_HUMAN [view interactions] High throughput no no
CTR2_HUMAN [view interactions] High throughput no no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SPOPL_HUMAN [view interactions] High throughput no yes
STRP2_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM44_HUMAN [view interactions] High throughput no yes
CEGT_HUMAN [view interactions] High throughput no yes
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
RGF1B_HUMAN [view interactions] High throughput no no
S26A7_HUMAN [view interactions] High throughput no no
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STA13_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
Z3H7A_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
SQSTM_HUMAN [view interactions] High throughput no yes
ZO2_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GFI1B_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
TTLL5_HUMAN [view interactions] High throughput no yes
PSMD5_HUMAN [view interactions] High throughput no yes
KIFC1_HUMAN [view interactions] High throughput no yes
NUD18_HUMAN [view interactions] High throughput no no
CENPF_HUMAN [view interactions] High throughput no no
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TTC3_HUMAN [view interactions] High throughput no yes
IMPCT_HUMAN [view interactions] High throughput no yes
IFT22_HUMAN [view interactions] High throughput no yes
ODBA_HUMAN [view interactions] High throughput no yes
GL8D1_HUMAN [view interactions] High throughput no yes
P121A_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
METL6_HUMAN [view interactions] High throughput no yes
EMIL1_HUMAN [view interactions] High throughput no no
NF2IP_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
RWD2B_HUMAN [view interactions] High throughput no no
DENR_HUMAN [view interactions] High throughput no yes
PHF19_HUMAN [view interactions] High throughput no no
BAKOR_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
SH2D3_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TRI54_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
HSC20_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
KR107_HUMAN [view interactions] High throughput no no
ZYX_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
CC136_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
JPH3_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
TRI39_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
ADIP_HUMAN [view interactions] High throughput no yes
MED4_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
NOD2_HUMAN [view interactions] High throughput no yes
MYOZ2_HUMAN [view interactions] Computational no no