PROF2_HUMAN
Evidence for PS localization
Functions
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PROF2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 36.8421 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.0877 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.5789 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.5789 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.3158 | 5 | no |
| GO:0005524 | ATP binding | 22.8070 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.8070 | 5 | no |
| GO:0019900 | kinase binding | 22.8070 | 4 | no |
| GO:0003723 | RNA binding | 22.8070 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 19.2982 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 19.2982 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 19.2982 | 6 | yes |
| GO:0035091 | phosphatidylinositol binding | 12.2807 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 10.5263 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 10.5263 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 8.7719 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 8.7719 | 7 | yes |
| GO:0003785 | actin monomer binding | 5.2632 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PROF2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.3860 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.3860 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.6316 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 49.1228 | 4 | yes |
| GO:0006996 | organelle organization | 49.1228 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.1228 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.6140 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.8596 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 43.8596 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.8596 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 42.1053 | 5 | yes |
| GO:0022607 | cellular component assembly | 40.3509 | 4 | no |
| GO:0051049 | regulation of transport | 38.5965 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 38.5965 | 6 | yes |
| GO:0010468 | regulation of gene expression | 36.8421 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 35.0877 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 35.0877 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 31.5789 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 31.5789 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 31.5789 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.8246 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 28.0702 | 6 | yes |
| GO:0008104 | protein localization | 28.0702 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0702 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.0702 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.0702 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 28.0702 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.0702 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.3158 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 26.3158 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 26.3158 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 26.3158 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 24.5614 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 24.5614 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.5614 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.5614 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.5614 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.5614 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.5614 | 5 | no |
| GO:0030030 | cell projection organization | 24.5614 | 4 | no |
| GO:0034330 | cell junction organization | 24.5614 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 24.5614 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 24.5614 | 7 | yes |
| GO:0097435 | supramolecular fiber organization | 22.8070 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.8070 | 5 | no |
| GO:0036211 | protein modification process | 22.8070 | 4 | no |
| GO:0043412 | macromolecule modification | 22.8070 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.8070 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.8070 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.8070 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.8070 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.8070 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.8070 | 6 | yes |
| GO:0007015 | actin filament organization | 21.0526 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.0526 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.0526 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | no |
| GO:0032271 | regulation of protein polymerization | 21.0526 | 6 | yes |
| GO:0050808 | synapse organization | 21.0526 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 19.2982 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 19.2982 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 19.2982 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 19.2982 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 19.2982 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 17.5439 | 4 | yes |
| GO:2000145 | regulation of cell motility | 17.5439 | 4 | yes |
| GO:0030334 | regulation of cell migration | 17.5439 | 5 | yes |
| GO:0032535 | regulation of cellular component size | 17.5439 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 17.5439 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 15.7895 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 15.7895 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 15.7895 | 7 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 15.7895 | 5 | yes |
| GO:0051046 | regulation of secretion | 15.7895 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 14.0351 | 4 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 14.0351 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 14.0351 | 4 | yes |
| GO:0010639 | negative regulation of organelle organization | 14.0351 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 14.0351 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 14.0351 | 7 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 14.0351 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 14.0351 | 6 | yes |
| GO:0051492 | regulation of stress fiber assembly | 14.0351 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 12.2807 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 12.2807 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 12.2807 | 7 | yes |
| GO:0050821 | protein stabilization | 12.2807 | 4 | yes |
| GO:0099563 | modification of synaptic structure | 10.5263 | 6 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 10.5263 | 6 | yes |
| GO:0010632 | regulation of epithelial cell migration | 10.5263 | 4 | yes |
| GO:0031345 | negative regulation of cell projection organization | 10.5263 | 6 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 10.5263 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 10.5263 | 8 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 10.5263 | 7 | yes |
| GO:1900027 | regulation of ruffle assembly | 8.7719 | 7 | yes |
| GO:2000146 | negative regulation of cell motility | 8.7719 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 8.7719 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 8.7719 | 6 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 8.7719 | 7 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 8.7719 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 8.7719 | 4 | yes |
| GO:0051496 | positive regulation of stress fiber assembly | 8.7719 | 7 | yes |
| GO:0098885 | modification of postsynaptic actin cytoskeleton | 7.0175 | 8 | yes |
| GO:0099010 | modification of postsynaptic structure | 7.0175 | 7 | yes |
| GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 7.0175 | 7 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 7.0175 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 7.0175 | 8 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 7.0175 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 7.0175 | 7 | yes |
| GO:0032272 | negative regulation of protein polymerization | 7.0175 | 7 | yes |
| GO:0032781 | positive regulation of ATP-dependent activity | 7.0175 | 4 | yes |
| GO:1900028 | negative regulation of ruffle assembly | 5.2632 | 8 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 5.2632 | 5 | yes |
| GO:0010633 | negative regulation of epithelial cell migration | 5.2632 | 5 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 5.2632 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 5.2632 | 5 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 3.5088 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 3.5088 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VASP_HUMAN | [view interactions] | Low throughput | no | yes |
| MUC7_HUMAN | [view interactions] | Low throughput | no | no |
| GOGB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FHOD1_HUMAN | [view interactions] | Low throughput | no | no |
| MO4L1_HUMAN | [view interactions] | Low throughput | no | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIN3A_HUMAN | [view interactions] | Low throughput | no | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | Low throughput | no | yes |
| EVL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSD3_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT5_HUMAN | [view interactions] | High throughput | no | no |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| DDX11_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC113_HUMAN | [view interactions] | High throughput | no | no |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| ANKMT_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UPAR_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| RPGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN146_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3L_HUMAN | [view interactions] | High throughput | no | no |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB12_HUMAN | [view interactions] | High throughput | no | no |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA80_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| BLVRB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUXE_HUMAN | [view interactions] | High throughput | no | no |
| GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |