Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PROF2_HUMAN

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PROF2_HUMAN
GO:0043168 anion binding 38.3562 4 yes
GO:0003779 actin binding 34.2466 4 yes
GO:0000166 nucleotide binding 31.5068 4 no
GO:0017076 purine nucleotide binding 30.1370 5 no
GO:0032555 purine ribonucleotide binding 30.1370 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.7671 4 no
GO:0019900 kinase binding 24.6575 4 no
GO:0030554 adenyl nucleotide binding 23.2877 6 no
GO:0032559 adenyl ribonucleotide binding 23.2877 5 no
GO:0003723 RNA binding 21.9178 4 no
GO:0005524 ATP binding 21.9178 5 no
GO:0016462 pyrophosphatase activity 17.8082 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 17.8082 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 17.8082 6 yes
GO:0035091 phosphatidylinositol binding 10.9589 4 yes
GO:0016887 ATP hydrolysis activity 9.5890 7 yes
GO:1901981 phosphatidylinositol phosphate binding 9.5890 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 9.5890 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8.2192 5 yes
GO:0003785 actin monomer binding 4.1096 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PROF2_HUMAN
GO:0051128 regulation of cellular component organization 50.6849 4 yes
GO:0048522 positive regulation of cellular process 50.6849 4 yes
GO:0060255 regulation of macromolecule metabolic process 49.3151 4 yes
GO:0006996 organelle organization 49.3151 4 yes
GO:0031323 regulation of cellular metabolic process 47.9452 4 yes
GO:0048523 negative regulation of cellular process 47.9452 4 yes
GO:0010646 regulation of cell communication 46.5753 4 yes
GO:0080090 regulation of primary metabolic process 45.2055 4 yes
GO:0022607 cellular component assembly 43.8356 4 no
GO:0044087 regulation of cellular component biogenesis 42.4658 4 yes
GO:0009889 regulation of biosynthetic process 36.9863 4 no
GO:0010468 regulation of gene expression 36.9863 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.9863 5 no
GO:0031326 regulation of cellular biosynthetic process 36.9863 5 no
GO:0051049 regulation of transport 35.6164 4 yes
GO:0033043 regulation of organelle organization 35.6164 5 yes
GO:0009966 regulation of signal transduction 32.8767 4 no
GO:0051246 regulation of protein metabolic process 31.5068 5 yes
GO:0043933 protein-containing complex organization 31.5068 4 no
GO:0051129 negative regulation of cellular component organization 30.1370 5 yes
GO:0007010 cytoskeleton organization 30.1370 5 yes
GO:0051493 regulation of cytoskeleton organization 28.7671 6 yes
GO:0009892 negative regulation of metabolic process 28.7671 4 no
GO:0051130 positive regulation of cellular component organization 27.3973 5 yes
GO:1902903 regulation of supramolecular fiber organization 27.3973 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 27.3973 5 no
GO:0008104 protein localization 27.3973 4 no
GO:0009893 positive regulation of metabolic process 27.3973 4 yes
GO:0031325 positive regulation of cellular metabolic process 27.3973 5 yes
GO:0010647 positive regulation of cell communication 26.0274 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0274 5 no
GO:0023056 positive regulation of signaling 26.0274 4 no
GO:0048584 positive regulation of response to stimulus 26.0274 4 no
GO:0051252 regulation of RNA metabolic process 26.0274 5 no
GO:0010604 positive regulation of macromolecule metabolic process 26.0274 5 yes
GO:0031399 regulation of protein modification process 26.0274 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.2877 6 yes
GO:0030030 cell projection organization 23.2877 4 no
GO:0065003 protein-containing complex assembly 23.2877 5 no
GO:0097435 supramolecular fiber organization 23.2877 4 no
GO:0031324 negative regulation of cellular metabolic process 23.2877 5 no
GO:0032880 regulation of protein localization 23.2877 5 no
GO:0060341 regulation of cellular localization 23.2877 4 no
GO:0031344 regulation of cell projection organization 23.2877 5 yes
GO:0110053 regulation of actin filament organization 21.9178 6 yes
GO:0009894 regulation of catabolic process 21.9178 4 no
GO:0006355 regulation of DNA-templated transcription 21.9178 7 no
GO:0009967 positive regulation of signal transduction 21.9178 5 no
GO:0042981 regulation of apoptotic process 21.9178 5 no
GO:0043067 regulation of programmed cell death 21.9178 4 no
GO:2001141 regulation of RNA biosynthetic process 21.9178 6 no
GO:0032956 regulation of actin cytoskeleton organization 21.9178 5 yes
GO:0032970 regulation of actin filament-based process 21.9178 4 yes
GO:0044089 positive regulation of cellular component biogenesis 21.9178 5 yes
GO:0051174 regulation of phosphorus metabolic process 20.5479 5 yes
GO:0009890 negative regulation of biosynthetic process 20.5479 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.5479 6 no
GO:0031327 negative regulation of cellular biosynthetic process 20.5479 6 no
GO:0036211 protein modification process 20.5479 4 no
GO:0043412 macromolecule modification 20.5479 4 no
GO:0045595 regulation of cell differentiation 20.5479 4 no
GO:0071310 cellular response to organic substance 20.5479 4 no
GO:0080134 regulation of response to stress 20.5479 4 no
GO:0010638 positive regulation of organelle organization 20.5479 6 yes
GO:0019220 regulation of phosphate metabolic process 20.5479 6 yes
GO:0042325 regulation of phosphorylation 20.5479 7 yes
GO:0099177 regulation of trans-synaptic signaling 19.1781 4 yes
GO:0034330 cell junction organization 19.1781 4 yes
GO:0043254 regulation of protein-containing complex assembly 19.1781 5 yes
GO:0050804 modulation of chemical synaptic transmission 19.1781 5 yes
GO:0051495 positive regulation of cytoskeleton organization 17.8082 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 17.8082 6 yes
GO:0032271 regulation of protein polymerization 17.8082 6 yes
GO:0032535 regulation of cellular component size 17.8082 4 yes
GO:0051046 regulation of secretion 16.4384 5 yes
GO:0051247 positive regulation of protein metabolic process 16.4384 6 yes
GO:0060491 regulation of cell projection assembly 16.4384 5 yes
GO:0060627 regulation of vesicle-mediated transport 16.4384 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 16.4384 6 yes
GO:0001932 regulation of protein phosphorylation 16.4384 7 yes
GO:0010639 negative regulation of organelle organization 16.4384 6 yes
GO:0051241 negative regulation of multicellular organismal process 15.0685 4 yes
GO:2000145 regulation of cell motility 15.0685 4 yes
GO:0030334 regulation of cell migration 15.0685 5 yes
GO:0050808 synapse organization 15.0685 5 yes
GO:0050821 protein stabilization 13.6986 4 yes
GO:0051494 negative regulation of cytoskeleton organization 13.6986 7 yes
GO:1903530 regulation of secretion by cell 13.6986 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 13.6986 6 yes
GO:0030832 regulation of actin filament length 13.6986 5 yes
GO:0030833 regulation of actin filament polymerization 13.6986 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 12.3288 6 yes
GO:0031334 positive regulation of protein-containing complex assembly 12.3288 6 yes
GO:0032231 regulation of actin filament bundle assembly 12.3288 5 yes
GO:0032273 positive regulation of protein polymerization 12.3288 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 10.9589 6 yes
GO:0031401 positive regulation of protein modification process 10.9589 7 yes
GO:0045937 positive regulation of phosphate metabolic process 10.9589 7 yes
GO:0051492 regulation of stress fiber assembly 9.5890 6 yes
GO:0110020 regulation of actomyosin structure organization 9.5890 6 yes
GO:0031333 negative regulation of protein-containing complex assembly 9.5890 6 yes
GO:0031345 negative regulation of cell projection organization 9.5890 6 yes
GO:0042327 positive regulation of phosphorylation 9.5890 8 yes
GO:0001934 positive regulation of protein phosphorylation 8.2192 8 yes
GO:0010632 regulation of epithelial cell migration 8.2192 4 yes
GO:0017157 regulation of exocytosis 8.2192 5 yes
GO:0030837 negative regulation of actin filament polymerization 8.2192 7 yes
GO:0030838 positive regulation of actin filament polymerization 8.2192 7 yes
GO:0032272 negative regulation of protein polymerization 8.2192 7 yes
GO:0099563 modification of synaptic structure 6.8493 6 yes
GO:0120033 negative regulation of plasma membrane bounded cell projection assembly 6.8493 7 yes
GO:1900027 regulation of ruffle assembly 6.8493 7 yes
GO:2000146 negative regulation of cell motility 6.8493 5 yes
GO:0030336 negative regulation of cell migration 6.8493 6 yes
GO:0032233 positive regulation of actin filament bundle assembly 6.8493 6 yes
GO:0040013 negative regulation of locomotion 6.8493 4 yes
GO:0051496 positive regulation of stress fiber assembly 5.4795 7 yes
GO:0051588 regulation of neurotransmitter transport 5.4795 5 yes
GO:0098885 modification of postsynaptic actin cytoskeleton 5.4795 8 yes
GO:0099010 modification of postsynaptic structure 5.4795 7 yes
GO:1903305 regulation of regulated secretory pathway 5.4795 6 yes
GO:0032781 positive regulation of ATP-dependent activity 5.4795 4 yes
GO:0046928 regulation of neurotransmitter secretion 5.4795 5 yes
GO:1900028 negative regulation of ruffle assembly 4.1096 8 yes
GO:2000300 regulation of synaptic vesicle exocytosis 4.1096 6 yes
GO:0010633 negative regulation of epithelial cell migration 4.1096 5 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 2.7397 6 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 2.7397 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 2.7397 9 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GEPH_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
VASP_HUMAN [view entry] [view interactions] Low throughput yes yes
MUC7_HUMAN [view interactions] Low throughput no no
GOGB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
SMN_HUMAN [view interactions] Low throughput no yes
FHOD1_HUMAN [view interactions] Low throughput no no
MO4L1_HUMAN [view interactions] Low throughput no yes
ROCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SIN3A_HUMAN [view interactions] Low throughput no yes
FMNL1_HUMAN [view entry] [view interactions] Low throughput yes no
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ENAH_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
DIAP1_HUMAN [view interactions] Low throughput no yes
BIRC2_HUMAN [view interactions] Low throughput no yes
EVL_HUMAN [view entry] [view interactions] Low throughput yes yes
DTX3_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
TRI31_HUMAN [view interactions] High throughput no no
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
ERCC6_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
DHX15_HUMAN [view interactions] High throughput no yes
HMCS1_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
PPIH_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPC_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
PEPD_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
PSB1_HUMAN [view interactions] High throughput no yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
GFRA1_HUMAN [view interactions] High throughput no no
GTF2I_HUMAN [view interactions] High throughput no yes
PSME1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
ULA1_HUMAN [view entry] [view interactions] High throughput yes yes
GT251_HUMAN [view interactions] High throughput no no
UBA3_HUMAN [view interactions] High throughput no yes
RAD50_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
TSNAX_HUMAN [view interactions] High throughput no yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
PSD13_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1A_HUMAN [view interactions] High throughput no yes
COP1_HUMAN [view interactions] High throughput no no
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
AAKB1_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MSD3_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
SGTA_HUMAN [view interactions] High throughput no yes
SEPT5_HUMAN [view interactions] High throughput no no
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
TERF1_HUMAN [view interactions] High throughput no no
DDX11_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
CC113_HUMAN [view interactions] High throughput no no
RED_HUMAN [view interactions] High throughput no yes
NS1BP_HUMAN [view interactions] High throughput no yes
ANKMT_HUMAN [view interactions] High throughput no yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
UPAR_HUMAN [view interactions] High throughput no yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
WDR33_HUMAN [view interactions] High throughput no yes
RPGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RN146_HUMAN [view interactions] High throughput no yes
FLT3L_HUMAN [view interactions] High throughput no no
IDLC_HUMAN [view interactions] High throughput no no
KDM6B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
GELS_HUMAN [view entry] [view interactions] High throughput yes no
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
EIF3K_HUMAN [view interactions] High throughput no yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASB12_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA80_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
PALLD_HUMAN [view interactions] High throughput no yes
ACTBL_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
BLVRB_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RUXE_HUMAN [view interactions] High throughput no no
GEMI8_HUMAN [view interactions] High throughput no yes
STRAP_HUMAN [view entry] [view interactions] High throughput yes yes
RUXF_HUMAN [view interactions] High throughput no no
GEMI6_HUMAN [view interactions] High throughput no yes
GEMI2_HUMAN [view interactions] High throughput no yes
GEMI4_HUMAN [view interactions] High throughput no yes
DDX20_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
GEMI7_HUMAN [view interactions] High throughput no no
SMD2_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL2_HUMAN [view interactions] High throughput no yes
LRC15_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes