EPB41_HUMAN
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EPB41_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 31.6456 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 31.6456 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.3797 | 4 | no |
GO:0003723 | RNA binding | 22.7848 | 4 | no |
GO:0003779 | actin binding | 15.1899 | 4 | yes |
GO:0035091 | phosphatidylinositol binding | 5.0633 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EPB41_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 43.0380 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 41.7722 | 4 | no |
GO:0006996 | organelle organization | 35.4430 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 34.1772 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 34.1772 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.9114 | 4 | no |
GO:0010646 | regulation of cell communication | 31.6456 | 4 | no |
GO:0051128 | regulation of cellular component organization | 31.6456 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 31.6456 | 4 | no |
GO:0051049 | regulation of transport | 30.3797 | 4 | yes |
GO:0008104 | protein localization | 30.3797 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 27.8481 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 26.5823 | 4 | no |
GO:0071702 | organic substance transport | 26.5823 | 4 | no |
GO:0007010 | cytoskeleton organization | 25.3165 | 5 | yes |
GO:0009966 | regulation of signal transduction | 25.3165 | 4 | no |
GO:0022607 | cellular component assembly | 24.0506 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 22.7848 | 4 | no |
GO:0030030 | cell projection organization | 22.7848 | 4 | no |
GO:0010468 | regulation of gene expression | 21.5190 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 21.5190 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.5190 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 20.2532 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 20.2532 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 20.2532 | 5 | no |
GO:0071705 | nitrogen compound transport | 20.2532 | 4 | no |
GO:0060341 | regulation of cellular localization | 17.7215 | 4 | yes |
GO:0032880 | regulation of protein localization | 16.4557 | 5 | yes |
GO:0043269 | regulation of ion transport | 12.6582 | 5 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 11.3924 | 4 | yes |
GO:1903829 | positive regulation of protein localization | 11.3924 | 5 | yes |
GO:0022604 | regulation of cell morphogenesis | 10.1266 | 5 | yes |
GO:0008360 | regulation of cell shape | 8.8608 | 6 | yes |
GO:0030865 | cortical cytoskeleton organization | 8.8608 | 6 | yes |
GO:0010959 | regulation of metal ion transport | 7.5949 | 6 | yes |
GO:0030866 | cortical actin cytoskeleton organization | 7.5949 | 4 | yes |
GO:0031032 | actomyosin structure organization | 7.5949 | 4 | yes |
GO:1904375 | regulation of protein localization to cell periphery | 7.5949 | 6 | yes |
GO:0044057 | regulation of system process | 6.3291 | 4 | yes |
GO:0051099 | positive regulation of binding | 6.3291 | 4 | yes |
GO:0051924 | regulation of calcium ion transport | 6.3291 | 7 | yes |
GO:1904377 | positive regulation of protein localization to cell periphery | 6.3291 | 6 | yes |
GO:0032092 | positive regulation of protein binding | 5.0633 | 5 | yes |
GO:0043393 | regulation of protein binding | 5.0633 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GLPC_HUMAN | [view interactions] | Low throughput | no | yes |
NUMA1_HUMAN | [view interactions] | Low throughput | no | yes |
ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CENPJ_HUMAN | [view interactions] | Low throughput | no | no |
EIF3G_HUMAN | [view interactions] | Low throughput | no | yes |
DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANF_HUMAN | [view interactions] | Low throughput | no | no |
SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SPTB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
NSD3_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CHK2_HUMAN | [view interactions] | High throughput | no | yes |
EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH1_HUMAN | [view interactions] | High throughput | no | no |
PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
CALR_HUMAN | [view interactions] | High throughput | no | yes |
ELOC_HUMAN | [view interactions] | High throughput | no | no |
NH2L1_HUMAN | [view interactions] | High throughput | no | yes |
CH10_HUMAN | [view interactions] | High throughput | no | yes |
TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM13_HUMAN | [view interactions] | High throughput | no | yes |
COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTPN_HUMAN | [view interactions] | High throughput | no | yes |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
PSA1_HUMAN | [view interactions] | High throughput | no | yes |
PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
PSA6_HUMAN | [view interactions] | High throughput | no | yes |
PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
CLIC1_HUMAN | [view interactions] | High throughput | no | no |
PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSN_HUMAN | [view interactions] | High throughput | no | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RT63_HUMAN | [view interactions] | High throughput | no | yes |
DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NU155_HUMAN | [view interactions] | High throughput | no | yes |
TXD17_HUMAN | [view interactions] | High throughput | no | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCP2_HUMAN | [view interactions] | High throughput | no | no |
RANG_HUMAN | [view interactions] | High throughput | no | no |
FHL1_HUMAN | [view interactions] | High throughput | no | no |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
PUR4_HUMAN | [view interactions] | High throughput | no | yes |
CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSA7_HUMAN | [view interactions] | High throughput | no | yes |
TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPZ1_HUMAN | [view interactions] | High throughput | no | no |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
PHS_HUMAN | [view interactions] | High throughput | no | yes |
ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
PSB5_HUMAN | [view interactions] | High throughput | no | yes |
SYVC_HUMAN | [view interactions] | High throughput | no | yes |
PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
HPRT_HUMAN | [view interactions] | High throughput | no | yes |
EIF1_HUMAN | [view interactions] | High throughput | no | no |
PSB7_HUMAN | [view interactions] | High throughput | no | yes |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TR112_HUMAN | [view interactions] | High throughput | no | yes |
PIN4_HUMAN | [view interactions] | High throughput | no | yes |
U520_HUMAN | [view interactions] | High throughput | no | yes |
PNPH_HUMAN | [view interactions] | High throughput | no | no |
HIG1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S10AB_HUMAN | [view interactions] | High throughput | no | no |
PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHX9_HUMAN | [view interactions] | High throughput | no | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB1_HUMAN | [view interactions] | High throughput | no | yes |
CYTB_HUMAN | [view interactions] | High throughput | no | no |
PSB3_HUMAN | [view interactions] | High throughput | no | yes |
RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
KDM4C_HUMAN | [view interactions] | High throughput | no | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
MED4_HUMAN | [view interactions] | High throughput | no | yes |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
RWD2B_HUMAN | [view interactions] | High throughput | no | no |
ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
CIC_HUMAN | [view interactions] | High throughput | no | yes |
CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SF01_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
KT222_HUMAN | [view interactions] | High throughput | no | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
NECP1_HUMAN | [view interactions] | High throughput | no | no |
WDR3_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
C2C2L_HUMAN | [view interactions] | High throughput | no | yes |
U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
LSAMP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
UFO_HUMAN | [view interactions] | High throughput | no | no |
CNTP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NRX1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SDC2_HUMAN | [view interactions] | Computational | no | yes |
CNTP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
B3AT_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TRPC4_HUMAN | [view interactions] | Computational | no | no |
CD44_HUMAN | [view interactions] | Computational | no | yes |