EPB41_HUMAN
Evidence for PS localization
Functions
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPB41_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 37.2093 | 4 | no |
| GO:0000166 | nucleotide binding | 32.5581 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.5581 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.5581 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.3953 | 4 | no |
| GO:0003723 | RNA binding | 24.4186 | 4 | no |
| GO:0003779 | actin binding | 18.6047 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 5.8140 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPB41_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6744 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.1860 | 4 | no |
| GO:0006996 | organelle organization | 39.5349 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.3721 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.3721 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.2093 | 4 | no |
| GO:0051049 | regulation of transport | 34.8837 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 34.8837 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.8837 | 4 | no |
| GO:0008104 | protein localization | 33.7209 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.3953 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.2326 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.0698 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.0698 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.9070 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.9070 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.7442 | 5 | yes |
| GO:0071702 | organic substance transport | 26.7442 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.5814 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.5814 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.5814 | 4 | no |
| GO:0022607 | cellular component assembly | 24.4186 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.4186 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.2558 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.2558 | 5 | no |
| GO:0071705 | nitrogen compound transport | 23.2558 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.2558 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.0930 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 22.0930 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.9302 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.9302 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 15.1163 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 12.7907 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 12.7907 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 10.4651 | 5 | yes |
| GO:0030865 | cortical cytoskeleton organization | 9.3023 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 8.1395 | 6 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 8.1395 | 4 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 8.1395 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 6.9767 | 4 | yes |
| GO:1904377 | positive regulation of protein localization to cell periphery | 6.9767 | 6 | yes |
| GO:0051099 | positive regulation of binding | 5.8140 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 5.8140 | 7 | yes |
| GO:0032092 | positive regulation of protein binding | 4.6512 | 5 | yes |
| GO:0043393 | regulation of protein binding | 4.6512 | 4 | yes |
| GO:0044057 | regulation of system process | 4.6512 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLPC_HUMAN | [view interactions] | Low throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CENPJ_HUMAN | [view interactions] | Low throughput | no | no |
| EIF3G_HUMAN | [view interactions] | Low throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANF_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPTB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK10_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| NSD3_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| NH2L1_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| COX5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT63_HUMAN | [view interactions] | High throughput | no | yes |
| DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| FHL1_HUMAN | [view interactions] | High throughput | no | no |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| PHS_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1_HUMAN | [view interactions] | High throughput | no | no |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR112_HUMAN | [view interactions] | High throughput | no | yes |
| PIN4_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| HIG1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| RWD2B_HUMAN | [view interactions] | High throughput | no | no |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| C2C2L_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| LSAMP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |