Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPB41_HUMAN

GO
G2C
SynGO

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in EPB41_HUMAN
GO:0017076 purine nucleotide binding 31.6456 4 no
GO:0032555 purine ribonucleotide binding 31.6456 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.3797 4 no
GO:0003723 RNA binding 22.7848 4 no
GO:0003779 actin binding 15.1899 4 yes
GO:0035091 phosphatidylinositol binding 5.0633 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPB41_HUMAN
GO:0048522 positive regulation of cellular process 43.0380 4 yes
GO:0048523 negative regulation of cellular process 41.7722 4 no
GO:0006996 organelle organization 35.4430 4 yes
GO:0031323 regulation of cellular metabolic process 34.1772 4 no
GO:0080090 regulation of primary metabolic process 34.1772 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.9114 4 no
GO:0010646 regulation of cell communication 31.6456 4 no
GO:0051128 regulation of cellular component organization 31.6456 4 no
GO:0060255 regulation of macromolecule metabolic process 31.6456 4 no
GO:0051049 regulation of transport 30.3797 4 yes
GO:0008104 protein localization 30.3797 4 no
GO:0051246 regulation of protein metabolic process 27.8481 5 no
GO:0009893 positive regulation of metabolic process 26.5823 4 no
GO:0071702 organic substance transport 26.5823 4 no
GO:0007010 cytoskeleton organization 25.3165 5 yes
GO:0009966 regulation of signal transduction 25.3165 4 no
GO:0022607 cellular component assembly 24.0506 4 no
GO:0044087 regulation of cellular component biogenesis 22.7848 4 no
GO:0030030 cell projection organization 22.7848 4 no
GO:0010468 regulation of gene expression 21.5190 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.5190 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.5190 5 no
GO:0019220 regulation of phosphate metabolic process 20.2532 6 no
GO:0031325 positive regulation of cellular metabolic process 20.2532 5 no
GO:0051174 regulation of phosphorus metabolic process 20.2532 5 no
GO:0071705 nitrogen compound transport 20.2532 4 no
GO:0060341 regulation of cellular localization 17.7215 4 yes
GO:0032880 regulation of protein localization 16.4557 5 yes
GO:0043269 regulation of ion transport 12.6582 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 11.3924 4 yes
GO:1903829 positive regulation of protein localization 11.3924 5 yes
GO:0022604 regulation of cell morphogenesis 10.1266 5 yes
GO:0008360 regulation of cell shape 8.8608 6 yes
GO:0030865 cortical cytoskeleton organization 8.8608 6 yes
GO:0010959 regulation of metal ion transport 7.5949 6 yes
GO:0030866 cortical actin cytoskeleton organization 7.5949 4 yes
GO:0031032 actomyosin structure organization 7.5949 4 yes
GO:1904375 regulation of protein localization to cell periphery 7.5949 6 yes
GO:0044057 regulation of system process 6.3291 4 yes
GO:0051099 positive regulation of binding 6.3291 4 yes
GO:0051924 regulation of calcium ion transport 6.3291 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 6.3291 6 yes
GO:0032092 positive regulation of protein binding 5.0633 5 yes
GO:0043393 regulation of protein binding 5.0633 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
GLPC_HUMAN [view interactions] Low throughput no yes
NUMA1_HUMAN [view interactions] Low throughput no yes
ZO2_HUMAN [view entry] [view interactions] Low throughput yes no
CENPJ_HUMAN [view interactions] Low throughput no no
EIF3G_HUMAN [view interactions] Low throughput no yes
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANF_HUMAN [view interactions] Low throughput no no
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
NSD3_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
EF2K_HUMAN [view entry] [view interactions] High throughput yes no
CHK2_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
MYH1_HUMAN [view interactions] High throughput no no
PRS6B_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
ELOC_HUMAN [view interactions] High throughput no no
NH2L1_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
TIM13_HUMAN [view interactions] High throughput no yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
MTPN_HUMAN [view interactions] High throughput no yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
SRP09_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
PPAC_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
FKB1A_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
CDN2A_HUMAN [view interactions] High throughput no yes
CLIC1_HUMAN [view interactions] High throughput no no
PA1B2_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
TSN_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
RT63_HUMAN [view interactions] High throughput no yes
DAD1_HUMAN [view entry] [view interactions] High throughput yes yes
NU155_HUMAN [view interactions] High throughput no yes
TXD17_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
EF1B_HUMAN [view entry] [view interactions] High throughput yes yes
KAD2_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
SCP2_HUMAN [view interactions] High throughput no no
RANG_HUMAN [view interactions] High throughput no no
FHL1_HUMAN [view interactions] High throughput no no
PSME3_HUMAN [view interactions] High throughput no yes
PUR4_HUMAN [view interactions] High throughput no yes
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
PSA7_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
CDK2_HUMAN [view interactions] High throughput no yes
UB2L3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
COPZ1_HUMAN [view interactions] High throughput no no
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
DLRB1_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
PHS_HUMAN [view interactions] High throughput no yes
ATP5L_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
SYVC_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
SLIRP_HUMAN [view interactions] High throughput no yes
HPRT_HUMAN [view interactions] High throughput no yes
EIF1_HUMAN [view interactions] High throughput no no
PSB7_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
TR112_HUMAN [view interactions] High throughput no yes
PIN4_HUMAN [view interactions] High throughput no yes
U520_HUMAN [view interactions] High throughput no yes
PNPH_HUMAN [view interactions] High throughput no no
HIG1A_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
S10AB_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
FABP5_HUMAN [view entry] [view interactions] High throughput yes no
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
DHX9_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
PSB1_HUMAN [view interactions] High throughput no yes
CYTB_HUMAN [view interactions] High throughput no no
PSB3_HUMAN [view interactions] High throughput no yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
KDM4C_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view interactions] High throughput no yes
MED4_HUMAN [view interactions] High throughput no yes
ICLN_HUMAN [view interactions] High throughput no yes
RWD2B_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
CAH2_HUMAN [view entry] [view interactions] High throughput yes no
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
KIBRA_HUMAN [view interactions] High throughput no yes
KT222_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
C2CD2_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
NECP1_HUMAN [view interactions] High throughput no no
WDR3_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A1_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
C2C2L_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
LSAMP_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
SEC62_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
UFO_HUMAN [view interactions] High throughput no no
CNTP1_HUMAN [view entry] [view interactions] Computational yes yes
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
SDC2_HUMAN [view interactions] Computational no yes
CNTP2_HUMAN [view entry] [view interactions] Computational yes yes
B3AT_HUMAN [view entry] [view interactions] Computational yes no
TRPC4_HUMAN [view interactions] Computational no no
CD44_HUMAN [view interactions] Computational no yes