Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LSAMP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LSAMP_HUMAN
GO:0015631 tubulin binding 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0003779 actin binding 22.2222 4 no
GO:0004866 endopeptidase inhibitor activity 22.2222 5 no
GO:0005507 copper ion binding 22.2222 6 no
GO:0005509 calcium ion binding 22.2222 5 no
GO:0030414 peptidase inhibitor activity 22.2222 4 no
GO:0046872 metal ion binding 22.2222 4 no
GO:0046914 transition metal ion binding 22.2222 5 no
GO:0061135 endopeptidase regulator activity 22.2222 4 no
GO:1903136 cuprous ion binding 22.2222 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in LSAMP_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031344 regulation of cell projection organization 55.5556 5 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0051049 regulation of transport 55.5556 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 55.5556 6 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0006996 organelle organization 44.4444 4 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0010959 regulation of metal ion transport 44.4444 6 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043269 regulation of ion transport 44.4444 5 no
GO:0043549 regulation of kinase activity 44.4444 5 no
GO:0045859 regulation of protein kinase activity 44.4444 6 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:0051924 regulation of calcium ion transport 44.4444 7 no
GO:0050807 regulation of synapse organization 44.4444 5 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0010942 positive regulation of cell death 33.3333 5 no
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0031648 protein destabilization 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0034765 regulation of ion transmembrane transport 33.3333 5 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043065 positive regulation of apoptotic process 33.3333 7 no
GO:0043066 negative regulation of apoptotic process 33.3333 7 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0043068 positive regulation of programmed cell death 33.3333 6 no
GO:0043069 negative regulation of programmed cell death 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0060548 negative regulation of cell death 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1903169 regulation of calcium ion transmembrane transport 33.3333 7 no
GO:1904062 regulation of cation transmembrane transport 33.3333 6 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0071241 cellular response to inorganic substance 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0007399 nervous system development 22.2222 4 yes
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0010506 regulation of autophagy 22.2222 6 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031329 regulation of cellular catabolic process 22.2222 5 no
GO:0031331 positive regulation of cellular catabolic process 22.2222 6 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0034764 positive regulation of transmembrane transport 22.2222 5 no
GO:0034767 positive regulation of ion transmembrane transport 22.2222 6 no
GO:0043270 positive regulation of ion transport 22.2222 5 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0050848 regulation of calcium-mediated signaling 22.2222 6 no
GO:0050890 cognition 22.2222 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 22.2222 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 22.2222 6 no
GO:0051282 regulation of sequestering of calcium ion 22.2222 4 no
GO:0051650 establishment of vesicle localization 22.2222 4 no
GO:0051928 positive regulation of calcium ion transport 22.2222 6 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:1904064 positive regulation of cation transmembrane transport 22.2222 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 22.2222 7 no
GO:0051963 regulation of synapse assembly 22.2222 6 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:0006469 negative regulation of protein kinase activity 22.2222 7 no
GO:0006887 exocytosis 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0033673 negative regulation of kinase activity 22.2222 6 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0046903 secretion 22.2222 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0051046 regulation of secretion 22.2222 5 no
GO:0051048 negative regulation of secretion 22.2222 5 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0061097 regulation of protein tyrosine kinase activity 22.2222 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0099175 regulation of postsynapse organization 22.2222 6 no
GO:1903530 regulation of secretion by cell 22.2222 4 no
GO:1903531 negative regulation of secretion by cell 22.2222 5 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0008360 regulation of cell shape 22.2222 6 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904375 regulation of protein localization to cell periphery 22.2222 6 no
GO:1904377 positive regulation of protein localization to cell periphery 22.2222 6 no
GO:0002694 regulation of leukocyte activation 22.2222 4 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0031347 regulation of defense response 22.2222 5 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0034248 regulation of cellular amide metabolic process 22.2222 5 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0044070 regulation of anion transport 22.2222 6 no
GO:0045861 negative regulation of proteolysis 22.2222 7 no
GO:0046688 response to copper ion 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050865 regulation of cell activation 22.2222 4 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0051259 protein complex oligomerization 22.2222 6 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0071248 cellular response to metal ion 22.2222 5 no
GO:0071280 cellular response to copper ion 22.2222 6 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:1901216 positive regulation of neuron death 22.2222 6 no
GO:0002683 negative regulation of immune system process 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1901652 response to peptide 22.2222 4 no
GO:1901653 cellular response to peptide 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CRK_HUMAN [view entry] [view interactions] High throughput yes no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
H3C_HUMAN [view interactions] High throughput no yes
CENPV_HUMAN [view interactions] High throughput no yes
MET27_HUMAN [view interactions] High throughput no yes
THAP3_HUMAN [view interactions] High throughput no yes
LRC61_HUMAN [view interactions] High throughput no yes
CD248_HUMAN [view interactions] High throughput no no
CENPR_HUMAN [view interactions] High throughput no yes
DELE1_HUMAN [view interactions] High throughput no yes
MED21_HUMAN [view interactions] High throughput no yes
BECN1_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
ELK3_HUMAN [view interactions] High throughput no yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
LSAMP_HUMAN [view entry] [view interactions] High throughput yes no
NTRI_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no