RIMS1_HUMAN
Rab effector involved in exocytosis . May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
820 | Arg | His | Cone-roddystrophy7(CORD7) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RIMS1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 28.2609 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.2609 | 4 | no |
GO:0046872 | metal ion binding | 26.0870 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
GO:0003723 | RNA binding | 13.0435 | 4 | yes |
GO:0031267 | small GTPase binding | 13.0435 | 5 | yes |
GO:0051020 | GTPase binding | 13.0435 | 4 | yes |
GO:0030695 | GTPase regulator activity | 10.8696 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RIMS1_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 58.6957 | 4 | yes |
GO:0010646 | regulation of cell communication | 58.6957 | 4 | yes |
GO:0051049 | regulation of transport | 56.5217 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 54.3478 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 52.1739 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 52.1739 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
GO:0015031 | protein transport | 47.8261 | 4 | yes |
GO:0071702 | organic substance transport | 47.8261 | 4 | yes |
GO:0071705 | nitrogen compound transport | 47.8261 | 4 | yes |
GO:0046903 | secretion | 45.6522 | 4 | yes |
GO:0022607 | cellular component assembly | 41.3043 | 4 | yes |
GO:0006887 | exocytosis | 39.1304 | 4 | yes |
GO:0023061 | signal release | 39.1304 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 34.7826 | 5 | yes |
GO:0023056 | positive regulation of signaling | 34.7826 | 4 | yes |
GO:0043933 | protein-containing complex organization | 34.7826 | 4 | yes |
GO:0051046 | regulation of secretion | 34.7826 | 5 | yes |
GO:0065003 | protein-containing complex assembly | 34.7826 | 5 | yes |
GO:0099643 | signal release from synapse | 34.7826 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 34.7826 | 4 | yes |
GO:0007268 | chemical synaptic transmission | 34.7826 | 6 | no |
GO:0031323 | regulation of cellular metabolic process | 34.7826 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 34.7826 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 34.7826 | 4 | no |
GO:0098916 | anterograde trans-synaptic signaling | 34.7826 | 5 | no |
GO:0099537 | trans-synaptic signaling | 34.7826 | 4 | no |
GO:0006996 | organelle organization | 34.7826 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 34.7826 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | yes |
GO:0072657 | protein localization to membrane | 32.6087 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | yes |
GO:0045055 | regulated exocytosis | 30.4348 | 5 | yes |
GO:0043269 | regulation of ion transport | 30.4348 | 5 | no |
GO:0048523 | negative regulation of cellular process | 28.2609 | 4 | no |
GO:0009966 | regulation of signal transduction | 26.0870 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
GO:0016079 | synaptic vesicle exocytosis | 23.9130 | 4 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.9130 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 23.9130 | 5 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 23.9130 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 23.9130 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.9130 | 6 | no |
GO:0006836 | neurotransmitter transport | 23.9130 | 4 | no |
GO:0017157 | regulation of exocytosis | 23.9130 | 5 | no |
GO:1990778 | protein localization to cell periphery | 23.9130 | 5 | no |
GO:0010468 | regulation of gene expression | 21.7391 | 5 | yes |
GO:0017156 | calcium-ion regulated exocytosis | 21.7391 | 6 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 21.7391 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | yes |
GO:0051588 | regulation of neurotransmitter transport | 21.7391 | 5 | yes |
GO:0051050 | positive regulation of transport | 21.7391 | 4 | no |
GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
GO:0010941 | regulation of cell death | 21.7391 | 4 | no |
GO:0006886 | intracellular protein transport | 19.5652 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 19.5652 | 5 | yes |
GO:0061024 | membrane organization | 17.3913 | 4 | yes |
GO:0022604 | regulation of cell morphogenesis | 15.2174 | 5 | yes |
GO:0044057 | regulation of system process | 15.2174 | 4 | yes |
GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 13.0435 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 13.0435 | 4 | yes |
GO:0001558 | regulation of cell growth | 10.8696 | 4 | yes |
GO:0031644 | regulation of nervous system process | 10.8696 | 5 | yes |
GO:0048638 | regulation of developmental growth | 10.8696 | 4 | yes |
GO:0061025 | membrane fusion | 10.8696 | 5 | yes |
GO:0098815 | modulation of excitatory postsynaptic potential | 10.8696 | 4 | yes |
GO:2000463 | positive regulation of excitatory postsynaptic potential | 10.8696 | 5 | yes |
GO:0007600 | sensory perception | 8.6957 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 8.6957 | 6 | yes |
GO:0030307 | positive regulation of cell growth | 8.6957 | 5 | yes |
GO:0045927 | positive regulation of growth | 8.6957 | 4 | yes |
GO:0048639 | positive regulation of developmental growth | 8.6957 | 5 | yes |
GO:1903859 | regulation of dendrite extension | 8.6957 | 5 | yes |
GO:1903861 | positive regulation of dendrite extension | 8.6957 | 6 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 6.5217 | 4 | yes |
GO:0007601 | visual perception | 4.3478 | 6 | yes |
GO:0031646 | positive regulation of nervous system process | 4.3478 | 5 | yes |
GO:0050953 | sensory perception of light stimulus | 4.3478 | 5 | yes |
GO:0097151 | positive regulation of inhibitory postsynaptic potential | 4.3478 | 5 | yes |
GO:0098828 | modulation of inhibitory postsynaptic potential | 4.3478 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in RIMS1_HUMAN |
---|---|---|---|---|
DOID:0050155 | sensory system disease | 4.3478 | 3 | yes |
DOID:0050572 | cone-rod dystrophy | 4.3478 | 7 | yes |
DOID:0111012 | cone-rod dystrophy 7 | 4.3478 | 8 | yes |
DOID:5614 | eye disease | 4.3478 | 4 | yes |
DOID:8466 | retinal degeneration | 4.3478 | 6 | yes |
DOID:9799 | eye degenerative disease | 4.3478 | 5 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RB6I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
FXL20_HUMAN | [view interactions] | Low throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UN13B_HUMAN | [view interactions] | Low throughput | no | no |
ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RB11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
CA094_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
RAB3B_HUMAN | [view interactions] | High throughput | no | no |
RAB3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3D_HUMAN | [view interactions] | High throughput | no | yes |
RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB26_HUMAN | [view interactions] | High throughput | no | no |
RAB37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
SGO1_HUMAN | [view interactions] | High throughput | no | no |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN3_HUMAN | [view interactions] | High throughput | no | yes |
CP135_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
RIMS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH1_HUMAN | [view interactions] | High throughput | no | no |
LIPA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
APBA1_HUMAN | [view interactions] | Computational | no | no |
SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UN13A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RIMB1_HUMAN | [view interactions] | Computational | no | yes |
LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LIPA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LIPA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CPLX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RIMB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |