Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCD16_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCD16_HUMAN
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCD16_HUMAN
GO:0010646 regulation of cell communication 68.7500 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 yes
GO:0022607 cellular component assembly 62.5000 4 yes
GO:0048522 positive regulation of cellular process 43.7500 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0043933 protein-containing complex organization 37.5000 4 yes
GO:0065003 protein-containing complex assembly 37.5000 5 yes
GO:0008104 protein localization 37.5000 4 no
GO:0080090 regulation of primary metabolic process 31.2500 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0051259 protein complex oligomerization 31.2500 6 yes
GO:0051260 protein homooligomerization 31.2500 7 yes
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0006996 organelle organization 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 25.0000 5 yes
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCD16_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR2_HUMAN [view entry] [view interactions] Low throughput yes yes
HUTH_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
SMAD3_HUMAN [view interactions] High throughput no yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
ZF69B_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
OTU7A_HUMAN [view interactions] High throughput no no
SPPL3_HUMAN [view interactions] High throughput no no
KCTD8_HUMAN [view entry] [view interactions] High throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes