KCD16_HUMAN
Evidence for PS localization
Functions
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCD16_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
| GO:0046982 | protein heterodimerization activity | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCD16_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 61.5385 | 4 | yes |
| GO:0022607 | cellular component assembly | 53.8462 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.1538 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 46.1538 | 4 | yes |
| GO:0051259 | protein complex oligomerization | 46.1538 | 6 | yes |
| GO:0051260 | protein homooligomerization | 46.1538 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 46.1538 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 30.7692 | 5 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 30.7692 | 4 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.7692 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.7692 | 4 | no |
| GO:0008104 | protein localization | 30.7692 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.0769 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 23.0769 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 23.0769 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 23.0769 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.0769 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.0769 | 8 | no |
| GO:0009893 | positive regulation of metabolic process | 23.0769 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.0769 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0033674 | positive regulation of kinase activity | 23.0769 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.0769 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0043086 | negative regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.0769 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 23.0769 | 6 | no |
| GO:0045860 | positive regulation of protein kinase activity | 23.0769 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.0769 | 7 | no |
| GO:0050807 | regulation of synapse organization | 23.0769 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 23.0769 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.0769 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0051338 | regulation of transferase activity | 23.0769 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 23.0769 | 5 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 23.0769 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0010941 | regulation of cell death | 23.0769 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.0769 | 5 | no |
| GO:0043269 | regulation of ion transport | 23.0769 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0060548 | negative regulation of cell death | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCD16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZF69B_HUMAN | [view interactions] | High throughput | no | yes |
| KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCTD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |