GABR2_HUMAN
Evidence for PS localization
Functions
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed, PubMed, PubMed). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed, PubMed, PubMed, PubMed). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed, PubMed). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed, PubMed, PubMed, PubMed). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GABR2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.2727 | 4 | no |
| GO:0046872 | metal ion binding | 22.7273 | 5 | no |
| GO:0004930 | G protein-coupled receptor activity | 18.1818 | 4 | yes |
| GO:0004965 | G protein-coupled GABA receptor activity | 13.6364 | 5 | yes |
| GO:0016917 | GABA receptor activity | 13.6364 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 13.6364 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GABR2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0051049 | regulation of transport | 40.9091 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.9091 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 36.3636 | 4 | yes |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 31.8182 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 31.8182 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.8182 | 4 | no |
| GO:0043933 | protein-containing complex organization | 31.8182 | 4 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 27.2727 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 27.2727 | 4 | no |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 22.7273 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 22.7273 | 7 | yes |
| GO:0043086 | negative regulation of catalytic activity | 22.7273 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 22.7273 | 6 | yes |
| GO:0099536 | synaptic signaling | 22.7273 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 22.7273 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0033993 | response to lipid | 22.7273 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.7273 | 4 | no |
| GO:0051051 | negative regulation of transport | 22.7273 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.7273 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7273 | 5 | no |
| GO:0071396 | cellular response to lipid | 22.7273 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 22.7273 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.7273 | 4 | no |
| GO:0097305 | response to alcohol | 22.7273 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 22.7273 | 4 | no |
| GO:0006811 | monoatomic ion transport | 22.7273 | 4 | no |
| GO:0006812 | monoatomic cation transport | 22.7273 | 5 | no |
| GO:0030001 | metal ion transport | 22.7273 | 6 | no |
| GO:0071407 | cellular response to organic cyclic compound | 22.7273 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 22.7273 | 5 | no |
| GO:0051046 | regulation of secretion | 22.7273 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.7273 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 22.7273 | 4 | no |
| GO:0031279 | regulation of cyclase activity | 18.1818 | 4 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 18.1818 | 5 | yes |
| GO:0051339 | regulation of lyase activity | 18.1818 | 4 | yes |
| GO:0007194 | negative regulation of adenylate cyclase activity | 13.6364 | 6 | yes |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 13.6364 | 4 | yes |
| GO:0031280 | negative regulation of cyclase activity | 13.6364 | 5 | yes |
| GO:0051350 | negative regulation of lyase activity | 13.6364 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 13.6364 | 8 | yes |
| GO:0150099 | neuron-glial cell signaling | 13.6364 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NSF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| DDIT3_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF4_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASR_HUMAN | [view interactions] | Low throughput | no | no |
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCD16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JKIP1_HUMAN | [view interactions] | Low throughput | no | no |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| RADX_HUMAN | [view interactions] | High throughput | no | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |