GABR2_HUMAN
Evidence for PS localization
Functions
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed, PubMed, PubMed). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed, PubMed, PubMed, PubMed). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed, PubMed). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed, PubMed, PubMed, PubMed). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GABR2_HUMAN |
|---|---|---|---|---|
| GO:0016917 | GABA receptor activity | 36.6667 | 4 | yes |
| GO:0005216 | ion channel activity | 33.3333 | 4 | no |
| GO:0015267 | channel activity | 33.3333 | 4 | no |
| GO:0015276 | ligand-gated ion channel activity | 33.3333 | 5 | no |
| GO:0022834 | ligand-gated channel activity | 33.3333 | 6 | no |
| GO:0022836 | gated channel activity | 33.3333 | 5 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 33.3333 | 4 | no |
| GO:0008509 | anion transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0015103 | inorganic anion transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0015108 | chloride transmembrane transporter activity | 30.0000 | 5 | no |
| GO:0004890 | GABA-A receptor activity | 26.6667 | 5 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 26.6667 | 6 | no |
| GO:0005253 | anion channel activity | 26.6667 | 5 | no |
| GO:0005254 | chloride channel activity | 26.6667 | 6 | no |
| GO:0022824 | transmitter-gated ion channel activity | 26.6667 | 5 | no |
| GO:0022835 | transmitter-gated channel activity | 26.6667 | 4 | no |
| GO:0022851 | GABA-gated chloride ion channel activity | 26.6667 | 5 | no |
| GO:0099095 | ligand-gated anion channel activity | 26.6667 | 6 | no |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 26.6667 | 5 | no |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 23.3333 | 6 | no |
| GO:0004930 | G protein-coupled receptor activity | 16.6667 | 4 | yes |
| GO:0004965 | G protein-coupled GABA receptor activity | 10.0000 | 5 | yes |
| GO:0046982 | protein heterodimerization activity | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GABR2_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 43.3333 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 43.3333 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 43.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 43.3333 | 4 | no |
| GO:0006811 | ion transport | 43.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 36.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.6667 | 4 | no |
| GO:0051049 | regulation of transport | 36.6667 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 36.6667 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 33.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
| GO:0006820 | anion transport | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 30.0000 | 4 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 30.0000 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 30.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 30.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0098656 | anion transmembrane transport | 30.0000 | 4 | no |
| GO:0043086 | negative regulation of catalytic activity | 26.6667 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0043269 | regulation of ion transport | 26.6667 | 5 | no |
| GO:0051051 | negative regulation of transport | 26.6667 | 4 | no |
| GO:0006821 | chloride transport | 26.6667 | 7 | no |
| GO:0015698 | inorganic anion transport | 26.6667 | 6 | no |
| GO:0098661 | inorganic anion transmembrane transport | 26.6667 | 5 | no |
| GO:1902476 | chloride transmembrane transport | 26.6667 | 6 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 23.3333 | 5 | yes |
| GO:0008104 | protein localization | 23.3333 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 23.3333 | 4 | no |
| GO:0060078 | regulation of postsynaptic membrane potential | 23.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 23.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.3333 | 4 | no |
| GO:0007194 | negative regulation of adenylate cyclase activity | 20.0000 | 6 | yes |
| GO:0031279 | regulation of cyclase activity | 20.0000 | 4 | yes |
| GO:0031280 | negative regulation of cyclase activity | 20.0000 | 5 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 20.0000 | 5 | yes |
| GO:0051339 | regulation of lyase activity | 20.0000 | 4 | yes |
| GO:0051350 | negative regulation of lyase activity | 20.0000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GABR2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.6667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NSF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| DDIT3_HUMAN | [view interactions] | Low throughput | no | yes |
| ATF4_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASR_HUMAN | [view interactions] | Low throughput | no | no |
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCD16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JKIP1_HUMAN | [view interactions] | Low throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| RADX_HUMAN | [view interactions] | High throughput | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBRG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCNJ6_HUMAN | [view interactions] | Computational | no | no |
| GBRE_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBRB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBRA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GP156_HUMAN | [view interactions] | Computational | no | no |
| GBRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBRA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCNJ9_HUMAN | [view interactions] | Computational | no | yes |