Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GABR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002074 TRG_ER_diArg_1 TRG 923 926 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GABR1_HUMAN
GO:0046872 metal ion binding 34.4828 4 no
GO:0016462 pyrophosphatase activity 24.1379 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.1379 4 no
GO:0017076 purine nucleotide binding 24.1379 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.1379 6 no
GO:0032555 purine ribonucleotide binding 24.1379 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.1379 4 no
GO:0001664 G protein-coupled receptor binding 20.6897 4 no
GO:0003924 GTPase activity 20.6897 7 no
GO:0019900 kinase binding 20.6897 4 no
GO:0019901 protein kinase binding 20.6897 5 no
GO:0004930 G protein-coupled receptor activity 17.2414 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 17.2414 4 yes
GO:0016917 GABA receptor activity 13.7931 4 yes
GO:0046982 protein heterodimerization activity 13.7931 4 yes
GO:0004965 G protein-coupled GABA receptor activity 10.3448 5 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 10.3448 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 10.3448 5 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 10.3448 5 yes
GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6.8966 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GABR1_HUMAN
GO:0048522 positive regulation of cellular process 62.0690 4 yes
GO:0010646 regulation of cell communication 55.1724 4 yes
GO:0031323 regulation of cellular metabolic process 51.7241 4 no
GO:0048523 negative regulation of cellular process 51.7241 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.2759 4 no
GO:0009966 regulation of signal transduction 44.8276 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.8276 4 no
GO:0080090 regulation of primary metabolic process 44.8276 4 no
GO:0051049 regulation of transport 44.8276 4 yes
GO:0009893 positive regulation of metabolic process 41.3793 4 no
GO:0010243 response to organonitrogen compound 37.9310 4 no
GO:0031325 positive regulation of cellular metabolic process 37.9310 5 no
GO:0043085 positive regulation of catalytic activity 37.9310 4 no
GO:0051246 regulation of protein metabolic process 37.9310 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 37.9310 4 yes
GO:0023056 positive regulation of signaling 37.9310 4 yes
GO:0071310 cellular response to organic substance 34.4828 4 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0010647 positive regulation of cell communication 34.4828 5 yes
GO:0043086 negative regulation of catalytic activity 34.4828 4 yes
GO:0043269 regulation of ion transport 34.4828 5 yes
GO:0050804 modulation of chemical synaptic transmission 34.4828 5 yes
GO:0099177 regulation of trans-synaptic signaling 34.4828 4 yes
GO:0071417 cellular response to organonitrogen compound 31.0345 4 no
GO:1901699 cellular response to nitrogen compound 31.0345 4 no
GO:1901701 cellular response to oxygen-containing compound 31.0345 4 no
GO:0051128 regulation of cellular component organization 31.0345 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.0345 5 no
GO:0010468 regulation of gene expression 31.0345 5 no
GO:0051336 regulation of hydrolase activity 31.0345 4 no
GO:0051050 positive regulation of transport 31.0345 4 yes
GO:0014070 response to organic cyclic compound 27.5862 4 no
GO:0048585 negative regulation of response to stimulus 27.5862 4 no
GO:0009967 positive regulation of signal transduction 27.5862 5 no
GO:0048584 positive regulation of response to stimulus 27.5862 4 no
GO:0009892 negative regulation of metabolic process 27.5862 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5862 5 no
GO:0019220 regulation of phosphate metabolic process 27.5862 6 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0031399 regulation of protein modification process 27.5862 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.5862 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.5862 5 no
GO:0051174 regulation of phosphorus metabolic process 27.5862 5 no
GO:0051247 positive regulation of protein metabolic process 27.5862 6 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 27.5862 5 yes
GO:0010648 negative regulation of cell communication 27.5862 5 yes
GO:0023057 negative regulation of signaling 27.5862 4 yes
GO:0042127 regulation of cell population proliferation 27.5862 4 yes
GO:0071407 cellular response to organic cyclic compound 24.1379 5 no
GO:0010941 regulation of cell death 24.1379 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.1379 6 no
GO:0031401 positive regulation of protein modification process 24.1379 7 no
GO:0045937 positive regulation of phosphate metabolic process 24.1379 7 no
GO:0051248 negative regulation of protein metabolic process 24.1379 6 no
GO:0009889 regulation of biosynthetic process 24.1379 4 no
GO:0031326 regulation of cellular biosynthetic process 24.1379 5 no
GO:0043408 regulation of MAPK cascade 24.1379 6 no
GO:0080134 regulation of response to stress 24.1379 4 no
GO:1902533 positive regulation of intracellular signal transduction 24.1379 6 no
GO:0051046 regulation of secretion 24.1379 5 yes
GO:1903530 regulation of secretion by cell 24.1379 4 yes
GO:0036211 protein modification process 20.6897 4 no
GO:0043412 macromolecule modification 20.6897 4 no
GO:0009894 regulation of catabolic process 20.6897 4 no
GO:0060548 negative regulation of cell death 20.6897 5 no
GO:0022607 cellular component assembly 20.6897 4 no
GO:0030030 cell projection organization 20.6897 4 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0033043 regulation of organelle organization 20.6897 5 no
GO:0034762 regulation of transmembrane transport 20.6897 4 no
GO:0034765 regulation of ion transmembrane transport 20.6897 5 no
GO:0044057 regulation of system process 20.6897 4 no
GO:0045595 regulation of cell differentiation 20.6897 4 no
GO:0050807 regulation of synapse organization 20.6897 5 no
GO:0050890 cognition 20.6897 4 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:1904062 regulation of cation transmembrane transport 20.6897 6 no
GO:0001932 regulation of protein phosphorylation 20.6897 7 no
GO:0001934 positive regulation of protein phosphorylation 20.6897 8 no
GO:0016192 vesicle-mediated transport 20.6897 4 no
GO:0030334 regulation of cell migration 20.6897 5 no
GO:0042325 regulation of phosphorylation 20.6897 7 no
GO:0042327 positive regulation of phosphorylation 20.6897 8 no
GO:0060341 regulation of cellular localization 20.6897 4 no
GO:2000145 regulation of cell motility 20.6897 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.6897 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0043410 positive regulation of MAPK cascade 20.6897 7 no
GO:0051252 regulation of RNA metabolic process 20.6897 5 no
GO:0006811 ion transport 20.6897 4 no
GO:0007194 negative regulation of adenylate cyclase activity 20.6897 6 yes
GO:0031279 regulation of cyclase activity 20.6897 4 yes
GO:0031280 negative regulation of cyclase activity 20.6897 5 yes
GO:0043270 positive regulation of ion transport 20.6897 5 yes
GO:0045761 regulation of adenylate cyclase activity 20.6897 5 yes
GO:0051051 negative regulation of transport 20.6897 4 yes
GO:0051339 regulation of lyase activity 20.6897 4 yes
GO:0051350 negative regulation of lyase activity 20.6897 5 yes
GO:0097305 response to alcohol 20.6897 4 yes
GO:0008285 negative regulation of cell population proliferation 17.2414 5 yes
GO:0050805 negative regulation of synaptic transmission 17.2414 5 yes
GO:0051047 positive regulation of secretion 17.2414 5 yes
GO:0051048 negative regulation of secretion 17.2414 5 yes
GO:1903531 negative regulation of secretion by cell 17.2414 5 yes
GO:0043271 negative regulation of ion transport 13.7931 5 yes
GO:1903532 positive regulation of secretion by cell 13.7931 5 yes
GO:0002791 regulation of peptide secretion 10.3448 6 yes
GO:0002793 positive regulation of peptide secretion 10.3448 6 yes
GO:0014059 regulation of dopamine secretion 10.3448 6 yes
GO:0033602 negative regulation of dopamine secretion 10.3448 6 yes
GO:0033604 negative regulation of catecholamine secretion 10.3448 6 yes
GO:0045471 response to ethanol 10.3448 5 yes
GO:0046883 regulation of hormone secretion 10.3448 4 yes
GO:0046887 positive regulation of hormone secretion 10.3448 5 yes
GO:0050433 regulation of catecholamine secretion 10.3448 5 yes
GO:0051952 regulation of amine transport 10.3448 5 yes
GO:0051953 negative regulation of amine transport 10.3448 5 yes
GO:0051954 positive regulation of amine transport 10.3448 5 yes
GO:0060123 regulation of growth hormone secretion 10.3448 6 yes
GO:0060124 positive regulation of growth hormone secretion 10.3448 7 yes
GO:0090087 regulation of peptide transport 10.3448 5 yes
GO:0090276 regulation of peptide hormone secretion 10.3448 5 yes
GO:0090277 positive regulation of peptide hormone secretion 10.3448 6 yes
GO:1903792 negative regulation of anion transport 6.8966 6 yes
GO:1903793 positive regulation of anion transport 6.8966 6 yes
GO:0001649 osteoblast differentiation 6.8966 4 yes
GO:0014048 regulation of glutamate secretion 6.8966 5 yes
GO:0014049 positive regulation of glutamate secretion 6.8966 6 yes
GO:0014052 regulation of gamma-aminobutyric acid secretion 6.8966 6 yes
GO:0014053 negative regulation of gamma-aminobutyric acid secretion 6.8966 6 yes
GO:0014060 regulation of epinephrine secretion 6.8966 6 yes
GO:0032811 negative regulation of epinephrine secretion 6.8966 7 yes
GO:0032890 regulation of organic acid transport 6.8966 5 yes
GO:0032891 negative regulation of organic acid transport 6.8966 5 yes
GO:0032892 positive regulation of organic acid transport 6.8966 5 yes
GO:0044070 regulation of anion transport 6.8966 6 yes
GO:0051955 regulation of amino acid transport 6.8966 6 yes
GO:0051956 negative regulation of amino acid transport 6.8966 6 yes
GO:0051957 positive regulation of amino acid transport 6.8966 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR37_HUMAN [view interactions] Low throughput no no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATF5_HUMAN [view interactions] Low throughput no yes
ATF4_HUMAN [view interactions] Low throughput no no
JKIP1_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF1B_HUMAN [view interactions] Low throughput no yes
UBP14_HUMAN [view entry] [view interactions] Low throughput yes yes
DDIT3_HUMAN [view interactions] Low throughput no yes
KCD16_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ3_HUMAN [view interactions] Low throughput no yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
CASR_HUMAN [view interactions] Low throughput no no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ6_HUMAN [view interactions] Low throughput no no
RGS4_HUMAN [view interactions] Low throughput no no
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
CHFR_HUMAN [view interactions] High throughput no no
BKRB1_HUMAN [view interactions] High throughput no yes
CCR8_HUMAN [view interactions] High throughput no no
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
SMO_HUMAN [view interactions] High throughput no yes
MAX_HUMAN [view interactions] High throughput no yes
CPEB2_HUMAN [view entry] [view interactions] High throughput yes no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
GOGA5_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
ZZEF1_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
MFSD8_HUMAN [view interactions] High throughput no yes
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH17_HUMAN [view interactions] High throughput no yes
CREL1_HUMAN [view interactions] High throughput no yes
MTFR2_HUMAN [view interactions] High throughput no no
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
ORML2_HUMAN [view interactions] High throughput no no
ORML3_HUMAN [view interactions] High throughput no no
GBRG2_HUMAN [view entry] [view interactions] High throughput yes no
GP156_HUMAN [view interactions] Computational no no
KCNJ9_HUMAN [view interactions] Computational no yes
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes