Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GABR1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002074 TRG_ER_diArg_1 TRG 923 926 -
ELMI002074 TRG_ER_diArg_1 TRG 923 926 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GABR1_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 30.3030 5 no
GO:0019900 kinase binding 24.2424 4 no
GO:0019901 protein kinase binding 24.2424 5 no
GO:0004930 G protein-coupled receptor activity 18.1818 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 15.1515 4 yes
GO:0016917 GABA receptor activity 12.1212 4 yes
GO:0004965 G protein-coupled GABA receptor activity 9.0909 5 yes
GO:0046982 protein heterodimerization activity 9.0909 4 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 9.0909 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 9.0909 5 yes
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 9.0909 5 yes
GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6.0606 5 yes
GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential 6.0606 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GABR1_HUMAN
GO:0010646 regulation of cell communication 57.5758 4 yes
GO:0048522 positive regulation of cellular process 57.5758 4 yes
GO:0023056 positive regulation of signaling 45.4545 4 yes
GO:0051049 regulation of transport 45.4545 4 yes
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0010647 positive regulation of cell communication 42.4242 5 yes
GO:0048523 negative regulation of cellular process 42.4242 4 yes
GO:0031323 regulation of cellular metabolic process 42.4242 4 no
GO:0010243 response to organonitrogen compound 39.3939 4 no
GO:0048584 positive regulation of response to stimulus 39.3939 4 no
GO:0080090 regulation of primary metabolic process 39.3939 4 no
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 yes
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 yes
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0014070 response to organic cyclic compound 30.3030 4 no
GO:1901701 cellular response to oxygen-containing compound 30.3030 4 no
GO:1902531 regulation of intracellular signal transduction 30.3030 5 no
GO:0007268 chemical synaptic transmission 27.2727 7 yes
GO:0098916 anterograde trans-synaptic signaling 27.2727 6 yes
GO:0099536 synaptic signaling 27.2727 4 yes
GO:0099537 trans-synaptic signaling 27.2727 5 yes
GO:0071417 cellular response to organonitrogen compound 27.2727 4 no
GO:1901699 cellular response to nitrogen compound 27.2727 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 24.2424 4 yes
GO:0010648 negative regulation of cell communication 24.2424 5 yes
GO:0023057 negative regulation of signaling 24.2424 4 yes
GO:0051050 positive regulation of transport 24.2424 4 yes
GO:0097305 response to alcohol 24.2424 4 yes
GO:0008104 protein localization 24.2424 4 no
GO:0019220 regulation of phosphate metabolic process 24.2424 6 no
GO:0022607 cellular component assembly 24.2424 4 no
GO:0030030 cell projection organization 24.2424 4 no
GO:0031399 regulation of protein modification process 24.2424 6 no
GO:0043408 regulation of MAPK cascade 24.2424 6 no
GO:0051174 regulation of phosphorus metabolic process 24.2424 5 no
GO:0051240 positive regulation of multicellular organismal process 24.2424 4 no
GO:1902533 positive regulation of intracellular signal transduction 24.2424 6 no
GO:0071702 organic substance transport 24.2424 4 no
GO:0071705 nitrogen compound transport 24.2424 4 no
GO:0042127 regulation of cell population proliferation 21.2121 4 yes
GO:0051046 regulation of secretion 21.2121 5 yes
GO:0001932 regulation of protein phosphorylation 21.2121 7 no
GO:0009891 positive regulation of biosynthetic process 21.2121 5 no
GO:0009892 negative regulation of metabolic process 21.2121 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.2121 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.2121 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.2121 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.2121 4 no
GO:0031324 negative regulation of cellular metabolic process 21.2121 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.2121 6 no
GO:0033993 response to lipid 21.2121 4 no
GO:0034762 regulation of transmembrane transport 21.2121 4 no
GO:0036211 protein modification process 21.2121 4 no
GO:0042325 regulation of phosphorylation 21.2121 7 no
GO:0043269 regulation of monoatomic ion transport 21.2121 5 no
GO:0043412 macromolecule modification 21.2121 4 no
GO:0044057 regulation of system process 21.2121 4 no
GO:0045595 regulation of cell differentiation 21.2121 4 no
GO:0048638 regulation of developmental growth 21.2121 4 no
GO:0050890 cognition 21.2121 4 no
GO:0051247 positive regulation of protein metabolic process 21.2121 6 no
GO:0051252 regulation of RNA metabolic process 21.2121 5 no
GO:0071407 cellular response to organic cyclic compound 21.2121 5 no
GO:0098657 import into cell 21.2121 4 no
GO:0006811 monoatomic ion transport 21.2121 4 no
GO:1903530 regulation of secretion by cell 18.1818 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 15.1515 5 yes
GO:0008285 negative regulation of cell population proliferation 15.1515 5 yes
GO:0050805 negative regulation of synaptic transmission 15.1515 5 yes
GO:0051047 positive regulation of secretion 15.1515 5 yes
GO:0051952 regulation of amine transport 15.1515 5 yes
GO:0007214 gamma-aminobutyric acid signaling pathway 12.1212 4 yes
GO:0032890 regulation of organic acid transport 12.1212 5 yes
GO:0045471 response to ethanol 12.1212 5 yes
GO:0051051 negative regulation of transport 12.1212 4 yes
GO:0051932 synaptic transmission, GABAergic 12.1212 8 yes
GO:0051953 negative regulation of amine transport 12.1212 5 yes
GO:0051954 positive regulation of amine transport 12.1212 5 yes
GO:0051955 regulation of amino acid transport 12.1212 6 yes
GO:1903532 positive regulation of secretion by cell 12.1212 5 yes
GO:0001649 osteoblast differentiation 9.0909 4 yes
GO:0002791 regulation of peptide secretion 9.0909 6 yes
GO:0002793 positive regulation of peptide secretion 9.0909 6 yes
GO:0014052 regulation of gamma-aminobutyric acid secretion 9.0909 6 yes
GO:0014059 regulation of dopamine secretion 9.0909 6 yes
GO:0032891 negative regulation of organic acid transport 9.0909 5 yes
GO:0032892 positive regulation of organic acid transport 9.0909 5 yes
GO:0033602 negative regulation of dopamine secretion 9.0909 7 yes
GO:0033604 negative regulation of catecholamine secretion 9.0909 6 yes
GO:0046883 regulation of hormone secretion 9.0909 4 yes
GO:0046887 positive regulation of hormone secretion 9.0909 5 yes
GO:0050433 regulation of catecholamine secretion 9.0909 5 yes
GO:0051048 negative regulation of secretion 9.0909 5 yes
GO:0051956 negative regulation of amino acid transport 9.0909 6 yes
GO:0051957 positive regulation of amino acid transport 9.0909 6 yes
GO:0060123 regulation of growth hormone secretion 9.0909 6 yes
GO:0060124 positive regulation of growth hormone secretion 9.0909 7 yes
GO:0090087 regulation of peptide transport 9.0909 5 yes
GO:0090276 regulation of peptide hormone secretion 9.0909 5 yes
GO:0090277 positive regulation of peptide hormone secretion 9.0909 6 yes
GO:0150099 neuron-glial cell signaling 9.0909 4 yes
GO:1903531 negative regulation of secretion by cell 9.0909 5 yes
GO:0014048 regulation of glutamate secretion 6.0606 5 yes
GO:0014049 positive regulation of glutamate secretion 6.0606 6 yes
GO:0014053 negative regulation of gamma-aminobutyric acid secretion 6.0606 6 yes
GO:0014060 regulation of epinephrine secretion 6.0606 6 yes
GO:0032811 negative regulation of epinephrine secretion 6.0606 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR37_HUMAN [view interactions] Low throughput no no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ATF5_HUMAN [view interactions] Low throughput no yes
ATF4_HUMAN [view interactions] Low throughput no no
JKIP1_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF1B_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP14_HUMAN [view entry] [view interactions] Low throughput yes yes
DDIT3_HUMAN [view interactions] Low throughput no yes
KCD16_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ3_HUMAN [view interactions] Low throughput no yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
CASR_HUMAN [view interactions] Low throughput no no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ6_HUMAN [view entry] [view interactions] Low throughput yes no
RGS4_HUMAN [view entry] [view interactions] Low throughput yes no
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
GGYF1_HUMAN [view interactions] High throughput no yes
CHFR_HUMAN [view interactions] High throughput no no
BKRB1_HUMAN [view interactions] High throughput no yes
CCR8_HUMAN [view interactions] High throughput no no
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
SMO_HUMAN [view entry] [view interactions] High throughput yes yes
MAX_HUMAN [view interactions] High throughput no yes
CPEB2_HUMAN [view entry] [view interactions] High throughput yes no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
GOGA5_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
ZZEF1_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
MFSD8_HUMAN [view interactions] High throughput no yes
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
CREL1_HUMAN [view interactions] High throughput no yes
MTFR2_HUMAN [view interactions] High throughput no no
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
ORML2_HUMAN [view interactions] High throughput no no
ORML3_HUMAN [view interactions] High throughput no no
GBRG2_HUMAN [view entry] [view interactions] High throughput yes no
LNP_HUMAN [view interactions] High throughput no yes
PTK7_HUMAN [view interactions] High throughput no yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes