KCNJ6_HUMAN
Evidence for PS localization
Functions
This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 154 | Gly | Ser | Keppen-Lubinskysyndrome(KPLBS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCNJ6_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 28.5714 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 9.5238 | 4 | yes |
| GO:0005242 | inward rectifier potassium channel activity | 9.5238 | 7 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 9.5238 | 5 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 9.5238 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 9.5238 | 5 | yes |
| GO:0005267 | potassium channel activity | 9.5238 | 6 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 9.5238 | 6 | yes |
| GO:0015267 | channel activity | 9.5238 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 9.5238 | 5 | yes |
| GO:0015467 | G-protein activated inward rectifier potassium channel activity | 9.5238 | 8 | yes |
| GO:0022832 | voltage-gated channel activity | 9.5238 | 6 | yes |
| GO:0022834 | ligand-gated channel activity | 9.5238 | 6 | yes |
| GO:0022836 | gated channel activity | 9.5238 | 5 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 9.5238 | 6 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 9.5238 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 9.5238 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 9.5238 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCNJ6_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 57.1429 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.6190 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 47.6190 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0099536 | synaptic signaling | 33.3333 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 33.3333 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 28.5714 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 28.5714 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 28.5714 | 7 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 28.5714 | 6 | no |
| GO:0006811 | monoatomic ion transport | 23.8095 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 23.8095 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.8095 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0051051 | negative regulation of transport | 23.8095 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.8095 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.8095 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.8095 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.8095 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.8095 | 4 | no |
| GO:0098657 | import into cell | 19.0476 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 14.2857 | 5 | yes |
| GO:0030001 | metal ion transport | 14.2857 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 14.2857 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 14.2857 | 4 | yes |
| GO:0006813 | potassium ion transport | 9.5238 | 7 | yes |
| GO:0071805 | potassium ion transmembrane transport | 9.5238 | 5 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 9.5238 | 5 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 9.5238 | 4 | yes |
| GO:1990573 | potassium ion import across plasma membrane | 9.5238 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNJ9_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BIRC5_HUMAN | [view interactions] | Low throughput | no | no |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNJ6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIG1_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| CO4A5_HUMAN | [view interactions] | High throughput | no | no |
| VSTM1_HUMAN | [view interactions] | High throughput | no | no |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| RARG_HUMAN | [view interactions] | High throughput | no | yes |
| F118B_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| UFSP2_HUMAN | [view interactions] | High throughput | no | yes |
| HPF1_HUMAN | [view interactions] | High throughput | no | no |
| MY15B_HUMAN | [view interactions] | High throughput | no | no |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| XYLK_HUMAN | [view interactions] | High throughput | no | yes |
| DWORF_HUMAN | [view interactions] | High throughput | no | no |
| SCAM4_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH24_HUMAN | [view interactions] | High throughput | no | yes |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| RTP2_HUMAN | [view interactions] | High throughput | no | no |
| NRAC_HUMAN | [view interactions] | High throughput | no | no |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| ITAM_HUMAN | [view interactions] | High throughput | no | no |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ORML2_HUMAN | [view interactions] | High throughput | no | no |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPRM_HUMAN | [view interactions] | High throughput | no | no |
| UNC50_HUMAN | [view interactions] | High throughput | no | yes |
| TM203_HUMAN | [view interactions] | High throughput | no | no |
| PEX16_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF6_HUMAN | [view interactions] | High throughput | no | yes |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| THS7B_HUMAN | [view interactions] | High throughput | no | no |
| PLLP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| LIPR1_HUMAN | [view interactions] | High throughput | no | no |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| NINJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPAR3_HUMAN | [view interactions] | High throughput | no | no |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| FUND2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF1_HUMAN | [view interactions] | High throughput | no | no |
| B2CL2_HUMAN | [view interactions] | High throughput | no | yes |
| SREC_HUMAN | [view interactions] | High throughput | no | no |
| SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICMT_HUMAN | [view interactions] | High throughput | no | no |
| PMP22_HUMAN | [view interactions] | High throughput | no | no |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM107_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO2_HUMAN | [view interactions] | High throughput | no | no |
| SRTM1_HUMAN | [view interactions] | High throughput | no | no |
| UPK1B_HUMAN | [view interactions] | High throughput | no | no |
| TM6S2_HUMAN | [view interactions] | High throughput | no | no |
| STAT_HUMAN | [view interactions] | High throughput | no | no |
| PX11C_HUMAN | [view interactions] | High throughput | no | yes |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT38_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| CXXC5_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |