SYT3_HUMAN
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SYT3_HUMAN |
---|---|---|---|---|
GO:0019905 | syntaxin binding | 28.5714 | 4 | yes |
GO:0046872 | metal ion binding | 28.5714 | 4 | yes |
GO:0005509 | calcium ion binding | 23.8095 | 5 | yes |
GO:0019900 | kinase binding | 23.8095 | 4 | no |
GO:0005544 | calcium-dependent phospholipid binding | 19.0476 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SYT3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | yes |
GO:0051049 | regulation of transport | 52.3810 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 47.6190 | 4 | yes |
GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | no |
GO:0048523 | negative regulation of cellular process | 38.0952 | 4 | no |
GO:0043269 | regulation of ion transport | 38.0952 | 5 | yes |
GO:0046903 | secretion | 38.0952 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0006887 | exocytosis | 33.3333 | 4 | yes |
GO:0051046 | regulation of secretion | 33.3333 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
GO:0045055 | regulated exocytosis | 28.5714 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 28.5714 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 23.8095 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.8095 | 5 | no |
GO:0010941 | regulation of cell death | 23.8095 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 23.8095 | 4 | no |
GO:0042981 | regulation of apoptotic process | 23.8095 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.8095 | 5 | no |
GO:0043270 | positive regulation of ion transport | 23.8095 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
GO:0043933 | protein-containing complex organization | 23.8095 | 4 | no |
GO:0065003 | protein-containing complex assembly | 23.8095 | 5 | no |
GO:0008104 | protein localization | 23.8095 | 4 | no |
GO:0015031 | protein transport | 23.8095 | 4 | no |
GO:0071702 | organic substance transport | 23.8095 | 4 | no |
GO:0071705 | nitrogen compound transport | 23.8095 | 4 | no |
GO:0017156 | calcium-ion regulated exocytosis | 23.8095 | 6 | yes |
GO:0017157 | regulation of exocytosis | 23.8095 | 5 | yes |
GO:0017158 | regulation of calcium ion-dependent exocytosis | 23.8095 | 7 | yes |
GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | yes |
GO:0051952 | regulation of amine transport | 23.8095 | 5 | yes |
GO:1903305 | regulation of regulated secretory pathway | 23.8095 | 6 | yes |
GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:0010038 | response to metal ion | 19.0476 | 4 | yes |
GO:0014059 | regulation of dopamine secretion | 19.0476 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 19.0476 | 4 | yes |
GO:0045927 | positive regulation of growth | 19.0476 | 4 | yes |
GO:0050433 | regulation of catecholamine secretion | 19.0476 | 5 | yes |
GO:0051592 | response to calcium ion | 19.0476 | 5 | yes |
GO:0071241 | cellular response to inorganic substance | 19.0476 | 4 | yes |
GO:0071248 | cellular response to metal ion | 19.0476 | 5 | yes |
GO:0071277 | cellular response to calcium ion | 19.0476 | 6 | yes |
GO:0001558 | regulation of cell growth | 14.2857 | 4 | yes |
GO:0022604 | regulation of cell morphogenesis | 14.2857 | 5 | yes |
GO:0030307 | positive regulation of cell growth | 14.2857 | 5 | yes |
GO:0048638 | regulation of developmental growth | 14.2857 | 4 | yes |
GO:0048639 | positive regulation of developmental growth | 14.2857 | 5 | yes |
GO:1903859 | regulation of dendrite extension | 14.2857 | 5 | yes |
GO:1903861 | positive regulation of dendrite extension | 14.2857 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MYH4_HUMAN | [view interactions] | High throughput | no | no |
SYT10_HUMAN | [view interactions] | High throughput | no | no |
MYH7_HUMAN | [view interactions] | High throughput | no | no |
PGK2_HUMAN | [view interactions] | High throughput | no | no |
CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
ASF1A_HUMAN | [view interactions] | High throughput | no | no |
KCNJ6_HUMAN | [view interactions] | High throughput | no | no |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
CATD_HUMAN | [view interactions] | High throughput | no | yes |
NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF11_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYT9_HUMAN | [view interactions] | High throughput | no | no |
SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FND3A_HUMAN | [view interactions] | High throughput | no | yes |
MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMF2_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
KLHL9_HUMAN | [view interactions] | High throughput | no | no |
YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLH13_HUMAN | [view interactions] | High throughput | no | no |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |