SYT3_HUMAN
Evidence for PS localization
Functions
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis . Plays a role in dendrite formation by melanocytes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.4348 | 4 | yes |
| GO:0046872 | metal ion binding | 30.4348 | 5 | yes |
| GO:0005509 | calcium ion binding | 21.7391 | 6 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 17.3913 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.2174 | 4 | yes |
| GO:0051049 | regulation of transport | 65.2174 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.8261 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.1304 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 34.7826 | 4 | yes |
| GO:0006996 | organelle organization | 34.7826 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.7826 | 4 | no |
| GO:0046903 | secretion | 30.4348 | 4 | yes |
| GO:0051046 | regulation of secretion | 30.4348 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.4348 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.4348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 26.0870 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.0870 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0098657 | import into cell | 26.0870 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0017156 | calcium-ion regulated exocytosis | 21.7391 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 21.7391 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 21.7391 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.7391 | 4 | yes |
| GO:0045055 | regulated exocytosis | 21.7391 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 21.7391 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 21.7391 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.7391 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.7391 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.7391 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 21.7391 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 21.7391 | 5 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.7391 | 4 | no |
| GO:0043412 | macromolecule modification | 21.7391 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0010038 | response to metal ion | 17.3913 | 4 | yes |
| GO:0014059 | regulation of dopamine secretion | 17.3913 | 6 | yes |
| GO:0045927 | positive regulation of growth | 17.3913 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 17.3913 | 4 | yes |
| GO:0050433 | regulation of catecholamine secretion | 17.3913 | 5 | yes |
| GO:0051592 | response to calcium ion | 17.3913 | 5 | yes |
| GO:0051952 | regulation of amine transport | 17.3913 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 17.3913 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 17.3913 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 17.3913 | 6 | yes |
| GO:0001558 | regulation of cell growth | 13.0435 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 13.0435 | 5 | yes |
| GO:0030307 | positive regulation of cell growth | 13.0435 | 5 | yes |
| GO:0048639 | positive regulation of developmental growth | 13.0435 | 5 | yes |
| GO:1903859 | regulation of dendrite extension | 13.0435 | 5 | yes |
| GO:1903861 | positive regulation of dendrite extension | 13.0435 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WNK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGK2_HUMAN | [view interactions] | High throughput | no | no |
| MYH7_HUMAN | [view interactions] | High throughput | no | no |
| SYT10_HUMAN | [view interactions] | High throughput | no | no |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT9_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL9_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH13_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |