PRRT2_HUMAN
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
266 | Arg | Trp | Episodickinesigenicdyskinesia1(EKD1) | - |
281 | Trp | Arg | Episodickinesigenicdyskinesia1(EKD1) | - |
287 | Ala | Thr | Episodickinesigenicdyskinesia1(EKD1) | - |
305 | Gly | Arg | Episodickinesigenicdyskinesia1(EKD1) | - |
308 | Arg | Cys | Episodickinesigenicdyskinesia1(EKD1) | - |
317 | Ser | Asn | Convulsions,familialinfantile,withparoxysmalchoreoathetosis(ICCA) | - |
323 | Gly | Glu | Seizures,benignfamilialinfantile,2(BFIS2) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PRRT2_HUMAN |
---|---|---|---|---|
GO:0017075 | syntaxin-1 binding | 25.0000 | 5 | yes |
GO:0019905 | syntaxin binding | 25.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PRRT2_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 81.2500 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 68.7500 | 5 | yes |
GO:0051049 | regulation of transport | 68.7500 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 68.7500 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 68.7500 | 5 | no |
GO:0023056 | positive regulation of signaling | 68.7500 | 4 | no |
GO:0051128 | regulation of cellular component organization | 56.2500 | 4 | yes |
GO:0006897 | endocytosis | 50.0000 | 5 | no |
GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 50.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 43.7500 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | yes |
GO:0051050 | positive regulation of transport | 43.7500 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 43.7500 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 43.7500 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 43.7500 | 5 | no |
GO:0022607 | cellular component assembly | 43.7500 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 43.7500 | 4 | no |
GO:0006996 | organelle organization | 37.5000 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 37.5000 | 6 | yes |
GO:0050890 | cognition | 37.5000 | 4 | no |
GO:0032880 | regulation of protein localization | 37.5000 | 5 | no |
GO:0043933 | protein-containing complex organization | 37.5000 | 4 | no |
GO:0065003 | protein-containing complex assembly | 37.5000 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 37.5000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 31.2500 | 4 | yes |
GO:0043269 | regulation of ion transport | 31.2500 | 5 | no |
GO:0051046 | regulation of secretion | 31.2500 | 5 | no |
GO:0051223 | regulation of protein transport | 31.2500 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 31.2500 | 6 | no |
GO:1903530 | regulation of secretion by cell | 31.2500 | 4 | no |
GO:0000165 | MAPK cascade | 31.2500 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
GO:0010468 | regulation of gene expression | 31.2500 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
GO:0010628 | positive regulation of gene expression | 31.2500 | 6 | no |
GO:0031323 | regulation of cellular metabolic process | 31.2500 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.2500 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 31.2500 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 31.2500 | 6 | no |
GO:0060255 | regulation of macromolecule metabolic process | 31.2500 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 31.2500 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.2500 | 5 | no |
GO:0006906 | vesicle fusion | 25.0000 | 6 | yes |
GO:0016050 | vesicle organization | 25.0000 | 5 | yes |
GO:0048284 | organelle fusion | 25.0000 | 5 | yes |
GO:0061024 | membrane organization | 25.0000 | 4 | yes |
GO:0061025 | membrane fusion | 25.0000 | 5 | yes |
GO:0090174 | organelle membrane fusion | 25.0000 | 6 | yes |
GO:0007268 | chemical synaptic transmission | 25.0000 | 6 | no |
GO:0098916 | anterograde trans-synaptic signaling | 25.0000 | 5 | no |
GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0044057 | regulation of system process | 25.0000 | 4 | no |
GO:0048168 | regulation of neuronal synaptic plasticity | 25.0000 | 4 | no |
GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
GO:0006887 | exocytosis | 25.0000 | 4 | no |
GO:0016079 | synaptic vesicle exocytosis | 25.0000 | 4 | no |
GO:0023061 | signal release | 25.0000 | 4 | no |
GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
GO:0045055 | regulated exocytosis | 25.0000 | 5 | no |
GO:0046903 | secretion | 25.0000 | 4 | no |
GO:0099003 | vesicle-mediated transport in synapse | 25.0000 | 5 | no |
GO:0099643 | signal release from synapse | 25.0000 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
GO:0002684 | positive regulation of immune system process | 25.0000 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 25.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
GO:0032386 | regulation of intracellular transport | 25.0000 | 5 | no |
GO:0032872 | regulation of stress-activated MAPK cascade | 25.0000 | 6 | no |
GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 25.0000 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 25.0000 | 5 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
GO:0017157 | regulation of exocytosis | 25.0000 | 5 | no |
GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 18.7500 | 4 | yes |
GO:0048499 | synaptic vesicle membrane organization | 18.7500 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 12.5000 | 6 | yes |
GO:0031338 | regulation of vesicle fusion | 12.5000 | 5 | yes |
GO:0031340 | positive regulation of vesicle fusion | 12.5000 | 5 | yes |
GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 12.5000 | 6 | yes |
GO:0031632 | positive regulation of synaptic vesicle fusion to presynaptic active zone membrane | 12.5000 | 6 | yes |
GO:0043254 | regulation of protein-containing complex assembly | 12.5000 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 12.5000 | 5 | yes |
GO:0099502 | calcium-dependent activation of synaptic vesicle fusion | 12.5000 | 7 | yes |
GO:1901632 | regulation of synaptic vesicle membrane organization | 12.5000 | 5 | yes |
GO:1901634 | positive regulation of synaptic vesicle membrane organization | 12.5000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SMIM5_HUMAN | [view interactions] | High throughput | no | yes |
SOAT_HUMAN | [view interactions] | High throughput | no | no |
TLCD4_HUMAN | [view interactions] | High throughput | no | no |
MF14B_HUMAN | [view interactions] | High throughput | no | no |
GPC5D_HUMAN | [view interactions] | High throughput | no | yes |
AQP6_HUMAN | [view interactions] | High throughput | no | no |
PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
DDI1_HUMAN | [view interactions] | High throughput | no | no |
LCLT1_HUMAN | [view interactions] | High throughput | no | no |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
F234A_HUMAN | [view interactions] | High throughput | no | yes |
BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAR11_HUMAN | [view interactions] | Computational | no | no |
VGFR3_HUMAN | [view interactions] | Computational | no | yes |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ASPH1_HUMAN | [view interactions] | Computational | no | yes |
VEGFC_HUMAN | [view interactions] | Computational | no | no |
VEGFD_HUMAN | [view interactions] | Computational | no | no |
S1PR1_HUMAN | [view interactions] | Computational | no | no |
KIT_HUMAN | [view interactions] | Computational | no | no |
SDC3_HUMAN | [view interactions] | Computational | no | yes |
SDC2_HUMAN | [view interactions] | Computational | no | yes |
KPCD1_HUMAN | [view interactions] | Computational | no | yes |
ITK_HUMAN | [view interactions] | Computational | no | no |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ADA1B_HUMAN | [view interactions] | Computational | no | no |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYT13_HUMAN | [view interactions] | Computational | no | no |
RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |