Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GUAD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GUAD_HUMAN
GO:0019900 kinase binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0016301 kinase activity 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043169 cation binding 23.8095 4 yes
GO:0046872 metal ion binding 23.8095 5 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.8095 4 no
GO:0019902 phosphatase binding 23.8095 4 no
GO:0046914 transition metal ion binding 19.0476 6 yes
GO:0008270 zinc ion binding 14.2857 7 yes
GO:0008892 guanine deaminase activity 9.5238 5 yes
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 9.5238 4 yes
GO:0019239 deaminase activity 9.5238 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GUAD_HUMAN
GO:0048523 negative regulation of cellular process 61.9048 4 no
GO:0048522 positive regulation of cellular process 52.3810 4 no
GO:0060255 regulation of macromolecule metabolic process 47.6190 4 no
GO:0080090 regulation of primary metabolic process 47.6190 4 no
GO:0008104 protein localization 47.6190 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051246 regulation of protein metabolic process 42.8571 5 no
GO:0006996 organelle organization 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0009966 regulation of signal transduction 38.0952 4 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0033993 response to lipid 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043066 negative regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043069 negative regulation of programmed cell death 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0033365 protein localization to organelle 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 yes
GO:1901565 organonitrogen compound catabolic process 23.8095 4 yes
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0007268 chemical synaptic transmission 23.8095 7 no
GO:0009891 positive regulation of biosynthetic process 23.8095 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.8095 6 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0098916 anterograde trans-synaptic signaling 23.8095 6 no
GO:0099536 synaptic signaling 23.8095 4 no
GO:0099537 trans-synaptic signaling 23.8095 5 no
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0019220 regulation of phosphate metabolic process 23.8095 6 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0043113 receptor clustering 23.8095 5 no
GO:0051174 regulation of phosphorus metabolic process 23.8095 5 no
GO:0072657 protein localization to membrane 23.8095 4 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0030030 cell projection organization 23.8095 4 no
GO:0031175 neuron projection development 23.8095 6 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0034330 cell junction organization 23.8095 4 no
GO:0050890 cognition 23.8095 4 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0033043 regulation of organelle organization 23.8095 5 no
GO:0043269 regulation of monoatomic ion transport 23.8095 5 no
GO:0044087 regulation of cellular component biogenesis 23.8095 4 no
GO:0071702 organic substance transport 23.8095 4 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0007399 nervous system development 14.2857 4 yes
GO:0009116 nucleoside metabolic process 9.5238 4 yes
GO:0009117 nucleotide metabolic process 9.5238 5 yes
GO:0009120 deoxyribonucleoside metabolic process 9.5238 5 yes
GO:0009123 nucleoside monophosphate metabolic process 9.5238 5 yes
GO:0009125 nucleoside monophosphate catabolic process 9.5238 6 yes
GO:0009126 purine nucleoside monophosphate metabolic process 9.5238 6 yes
GO:0009128 purine nucleoside monophosphate catabolic process 9.5238 7 yes
GO:0009150 purine ribonucleotide metabolic process 9.5238 6 yes
GO:0009151 purine deoxyribonucleotide metabolic process 9.5238 6 yes
GO:0009154 purine ribonucleotide catabolic process 9.5238 6 yes
GO:0009155 purine deoxyribonucleotide catabolic process 9.5238 6 yes
GO:0009158 ribonucleoside monophosphate catabolic process 9.5238 7 yes
GO:0009159 deoxyribonucleoside monophosphate catabolic process 9.5238 7 yes
GO:0009161 ribonucleoside monophosphate metabolic process 9.5238 6 yes
GO:0009162 deoxyribonucleoside monophosphate metabolic process 9.5238 6 yes
GO:0009164 nucleoside catabolic process 9.5238 5 yes
GO:0009166 nucleotide catabolic process 9.5238 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 9.5238 7 yes
GO:0009169 purine ribonucleoside monophosphate catabolic process 9.5238 8 yes
GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 9.5238 7 yes
GO:0009172 purine deoxyribonucleoside monophosphate catabolic process 9.5238 8 yes
GO:0009259 ribonucleotide metabolic process 9.5238 5 yes
GO:0009261 ribonucleotide catabolic process 9.5238 5 yes
GO:0009262 deoxyribonucleotide metabolic process 9.5238 4 yes
GO:0009264 deoxyribonucleotide catabolic process 9.5238 5 yes
GO:0009394 2-deoxyribonucleotide metabolic process 9.5238 5 yes
GO:0019692 deoxyribose phosphate metabolic process 9.5238 4 yes
GO:0019693 ribose phosphate metabolic process 9.5238 4 yes
GO:0034655 nucleobase-containing compound catabolic process 9.5238 4 yes
GO:0034656 nucleobase-containing small molecule catabolic process 9.5238 4 yes
GO:0042278 purine nucleoside metabolic process 9.5238 5 yes
GO:0042453 deoxyguanosine metabolic process 9.5238 7 yes
GO:0046037 GMP metabolic process 9.5238 7 yes
GO:0046038 GMP catabolic process 9.5238 7 yes
GO:0046054 dGMP metabolic process 9.5238 7 yes
GO:0046055 dGMP catabolic process 9.5238 7 yes
GO:0046098 guanine metabolic process 9.5238 6 yes
GO:0046113 nucleobase catabolic process 9.5238 5 yes
GO:0046121 deoxyribonucleoside catabolic process 9.5238 6 yes
GO:0046122 purine deoxyribonucleoside metabolic process 9.5238 6 yes
GO:0046124 purine deoxyribonucleoside catabolic process 9.5238 7 yes
GO:0046386 deoxyribose phosphate catabolic process 9.5238 5 yes
GO:0046434 organophosphate catabolic process 9.5238 4 yes
GO:0072521 purine-containing compound metabolic process 9.5238 4 yes
GO:0072523 purine-containing compound catabolic process 9.5238 5 yes
GO:1901136 carbohydrate derivative catabolic process 9.5238 4 yes
GO:1901292 nucleoside phosphate catabolic process 9.5238 5 yes
GO:1901361 organic cyclic compound catabolic process 9.5238 4 yes
GO:1901657 glycosyl compound metabolic process 9.5238 4 yes
GO:1901658 glycosyl compound catabolic process 9.5238 5 yes
GO:0006144 purine nucleobase metabolic process 9.5238 5 yes
GO:0006145 purine nucleobase catabolic process 9.5238 6 yes
GO:0006147 guanine catabolic process 9.5238 7 yes
GO:0006152 purine nucleoside catabolic process 9.5238 6 yes
GO:0006161 deoxyguanosine catabolic process 9.5238 8 yes
GO:0006163 purine nucleotide metabolic process 9.5238 5 yes
GO:0006195 purine nucleotide catabolic process 9.5238 6 yes
GO:0006753 nucleoside phosphate metabolic process 9.5238 4 yes
GO:0009112 nucleobase metabolic process 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GUAD_HUMAN [view entry] [view interactions] Low throughput yes yes
MATN3_HUMAN [view interactions] High throughput no no
SMIP4_HUMAN [view interactions] High throughput no no
HERC3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AP4AT_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SPAG6_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MCM2_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
DTX3_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
P4R3A_HUMAN [view interactions] High throughput no yes
ZN154_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
STPG2_HUMAN [view interactions] High throughput no no
SRS11_HUMAN [view interactions] High throughput no yes
SH24A_HUMAN [view interactions] High throughput no no
TX13A_HUMAN [view interactions] High throughput no no
S13A2_HUMAN [view interactions] High throughput no no
TEFM_HUMAN [view interactions] High throughput no no
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
O13C3_HUMAN [view interactions] High throughput no no
S38A6_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
TSN6_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
BCCIP_HUMAN [view interactions] High throughput no no
IF5A1_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
GNS_HUMAN [view interactions] High throughput no yes
PEPD_HUMAN [view interactions] High throughput no yes
DHSO_HUMAN [view interactions] High throughput no no
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
KYNU_HUMAN [view interactions] High throughput no no
LDH6B_HUMAN [view interactions] High throughput no no
MVD1_HUMAN [view interactions] High throughput no yes
NAGK_HUMAN [view interactions] High throughput no no
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
NHRF1_HUMAN [view interactions] High throughput no no
SMAP_HUMAN [view interactions] High throughput no yes
SPSY_HUMAN [view interactions] High throughput no no
GABT_HUMAN [view interactions] High throughput no yes
HUTI_HUMAN [view interactions] High throughput no yes
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
ATRIP_HUMAN [view interactions] High throughput no yes
FAHD1_HUMAN [view interactions] High throughput no yes
ASNS_HUMAN [view interactions] High throughput no yes
CPIN1_HUMAN [view interactions] High throughput no no
SYLC_HUMAN [view interactions] High throughput no yes
TYW4_HUMAN [view interactions] High throughput no yes
PEPL1_HUMAN [view interactions] High throughput no yes
TIPRL_HUMAN [view interactions] High throughput no yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
CARME_HUMAN [view interactions] High throughput no yes
FAK2_HUMAN [view entry] [view interactions] High throughput yes yes
CACO2_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes