Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

XPO2_HUMAN

GO
G2C
SynGO

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in XPO2_HUMAN
GO:0017076 purine nucleotide binding 39.0625 4 no
GO:0032555 purine ribonucleotide binding 39.0625 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0046872 metal ion binding 31.2500 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 23.4375 5 no
GO:0032559 adenyl ribonucleotide binding 23.4375 5 no
GO:0003723 RNA binding 23.4375 4 no
GO:0019901 protein kinase binding 23.4375 5 no
GO:0005524 ATP binding 21.8750 5 no
GO:0031267 small GTPase binding 6.2500 5 yes
GO:0051020 GTPase binding 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in XPO2_HUMAN
GO:0048522 positive regulation of cellular process 53.1250 4 no
GO:0031323 regulation of cellular metabolic process 51.5625 4 no
GO:0060255 regulation of macromolecule metabolic process 48.4375 4 no
GO:0080090 regulation of primary metabolic process 46.8750 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.3125 4 no
GO:0010646 regulation of cell communication 43.7500 4 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0051128 regulation of cellular component organization 34.3750 4 no
GO:0010468 regulation of gene expression 34.3750 5 no
GO:0008104 protein localization 31.2500 4 yes
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0009893 positive regulation of metabolic process 29.6875 4 no
GO:0006996 organelle organization 29.6875 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.1250 5 no
GO:0031325 positive regulation of cellular metabolic process 28.1250 5 no
GO:0009889 regulation of biosynthetic process 28.1250 4 no
GO:0031326 regulation of cellular biosynthetic process 28.1250 5 no
GO:0009892 negative regulation of metabolic process 26.5625 4 no
GO:0051049 regulation of transport 26.5625 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 26.5625 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.5625 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0071702 organic substance transport 23.4375 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 23.4375 5 no
GO:0032880 regulation of protein localization 23.4375 5 no
GO:0006796 phosphate-containing compound metabolic process 23.4375 4 no
GO:0010941 regulation of cell death 23.4375 4 no
GO:0042981 regulation of apoptotic process 23.4375 6 no
GO:0043067 regulation of programmed cell death 23.4375 5 no
GO:0071705 nitrogen compound transport 21.8750 4 yes
GO:0019220 regulation of phosphate metabolic process 21.8750 6 no
GO:0031399 regulation of protein modification process 21.8750 6 no
GO:0051174 regulation of phosphorus metabolic process 21.8750 5 no
GO:0010647 positive regulation of cell communication 21.8750 5 no
GO:0023056 positive regulation of signaling 21.8750 4 no
GO:0048584 positive regulation of response to stimulus 21.8750 4 no
GO:0051252 regulation of RNA metabolic process 21.8750 5 no
GO:0007010 cytoskeleton organization 21.8750 5 no
GO:0036211 protein modification process 21.8750 4 no
GO:0043412 macromolecule modification 21.8750 4 no
GO:0015031 protein transport 20.3125 4 yes
GO:0042325 regulation of phosphorylation 20.3125 7 no
GO:0010243 response to organonitrogen compound 20.3125 4 no
GO:0071310 cellular response to organic substance 20.3125 4 no
GO:1903829 positive regulation of protein localization 20.3125 5 no
GO:0009967 positive regulation of signal transduction 20.3125 5 no
GO:0022607 cellular component assembly 20.3125 4 no
GO:0051247 positive regulation of protein metabolic process 20.3125 6 no
GO:0006355 regulation of DNA-templated transcription 20.3125 6 no
GO:1903506 regulation of nucleic acid-templated transcription 20.3125 7 no
GO:2001141 regulation of RNA biosynthetic process 20.3125 6 no
GO:0006886 intracellular protein transport 18.7500 4 yes
GO:0033365 protein localization to organelle 15.6250 5 yes
GO:0006913 nucleocytoplasmic transport 10.9375 5 yes
GO:0034504 protein localization to nucleus 10.9375 6 yes
GO:0051169 nuclear transport 10.9375 4 yes
GO:0006606 protein import into nucleus 9.3750 5 yes
GO:0051170 import into nucleus 9.3750 6 yes
GO:0072594 establishment of protein localization to organelle 9.3750 4 yes
GO:0006611 protein export from nucleus 4.6875 5 yes
GO:0051168 nuclear export 4.6875 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in XPO2_HUMAN
DOID:331 central nervous system disease 4.6875 3 no
DOID:1289 neurodegenerative disease 3.1250 4 no
DOID:936 brain disease 3.1250 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMA5_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA3_HUMAN [view interactions] Low throughput no yes
RAN_HUMAN [view entry] [view interactions] Low throughput yes no
LRRK2_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
IMA1_HUMAN [view entry] [view interactions] Low throughput yes yes
4ET_HUMAN [view interactions] Low throughput no yes
NRIP1_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
BIRC2_HUMAN [view interactions] Low throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
PPAP_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
DUS23_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
PTPRM_HUMAN [view interactions] High throughput no yes
PTPRU_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
RHG36_HUMAN [view interactions] High throughput no yes
ARGAL_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
RBM45_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
PAGE4_HUMAN [view interactions] High throughput no no
MALL_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
TNR5_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
ENPP3_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
VIPR1_HUMAN [view interactions] High throughput no yes
CD70_HUMAN [view interactions] High throughput no no
MAP7_HUMAN [view interactions] High throughput no yes
RM42_HUMAN [view interactions] High throughput no yes
FPR1_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
OPALI_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
PAIRB_HUMAN [view interactions] High throughput no yes
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
GPR45_HUMAN [view interactions] High throughput no no
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
AQP3_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
NUP50_HUMAN [view interactions] High throughput no yes
SRP54_HUMAN [view interactions] High throughput no yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP8_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ATG10_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
SUMO2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
SYDC_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
UN45A_HUMAN [view interactions] High throughput no yes
TXND5_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
UCHL3_HUMAN [view interactions] High throughput no yes
UBR1_HUMAN [view interactions] High throughput no yes
UBXN1_HUMAN [view interactions] High throughput no no
PSME1_HUMAN [view interactions] High throughput no yes
UBP1_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
BCCIP_HUMAN [view interactions] High throughput no no
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
CHRD1_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGB_HUMAN [view interactions] High throughput no yes
TCEA1_HUMAN [view interactions] High throughput no no
GUAD_HUMAN [view interactions] High throughput no yes
PSF3_HUMAN [view interactions] High throughput no yes
KYNU_HUMAN [view interactions] High throughput no no
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
MVD1_HUMAN [view interactions] High throughput no yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
SCLY_HUMAN [view interactions] High throughput no yes
NHRF1_HUMAN [view interactions] High throughput no no
SPSY_HUMAN [view interactions] High throughput no no
TBCB_HUMAN [view entry] [view interactions] High throughput yes yes
TGM2_HUMAN [view interactions] High throughput no no
UBFD1_HUMAN [view interactions] High throughput no no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
MTAP_HUMAN [view interactions] High throughput no no
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1B_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes
UBP19_HUMAN [view interactions] High throughput no no
MTREX_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
XPP1_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
NFAC2_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
ST1C3_HUMAN [view interactions] High throughput no no
MMS19_HUMAN [view interactions] High throughput no yes
ST1C4_HUMAN [view interactions] High throughput no no
CIA2B_HUMAN [view interactions] High throughput no yes
TIPRL_HUMAN [view interactions] High throughput no yes
URM1_HUMAN [view interactions] High throughput no yes
TPP2_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
IMA7_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
DPPA3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RN183_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
DPP4_HUMAN [view interactions] High throughput no no
MOT11_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
PTPRE_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
DUX4_HUMAN [view interactions] High throughput no no
HACD1_HUMAN [view interactions] High throughput no no
M4A4A_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
TN13B_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
FAF2_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
GRK6_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
COQ8A_HUMAN [view interactions] High throughput no no
SG196_HUMAN [view interactions] High throughput no yes
LAT_HUMAN [view interactions] High throughput no no
ZAP70_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
TX101_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
TMM62_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
TNR1B_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
HDAC5_HUMAN [view interactions] High throughput no yes
AMFR_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
CAH9_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
CLN3_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
ASB16_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
TM171_HUMAN [view interactions] High throughput no yes
VSIG2_HUMAN [view interactions] High throughput no no
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
KI18A_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
CRY2_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
NKX21_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
PTPRN_HUMAN [view interactions] High throughput no yes
PACC1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
FOXA1_HUMAN [view interactions] High throughput no no
CCND2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
TPTE_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RN181_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
R144A_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
IMA6_HUMAN [view interactions] Computational no yes
IMA8_HUMAN [view interactions] Computational no no
IMA4_HUMAN [view interactions] Computational no yes
XPOT_HUMAN [view interactions] Computational no no
RNBP6_HUMAN [view interactions] Computational no yes
NU155_HUMAN [view interactions] Computational no yes
IPO4_HUMAN [view interactions] Computational no no
EFS_HUMAN [view interactions] Computational no no