TXNL1_HUMAN
Evidence for PS localization
Functions
Active thioredoxin with a redox potential of about -250 mV. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TXNL1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 23.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.3333 | 4 | no |
| GO:0015036 | disulfide oxidoreductase activity | 5.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TXNL1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0008104 | protein localization | 28.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.6667 | 4 | no |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0006508 | proteolysis | 23.3333 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 23.3333 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 23.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 21.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.6667 | 5 | no |
| GO:0010941 | regulation of cell death | 21.6667 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.6667 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 21.6667 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 21.6667 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 21.6667 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 21.6667 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TXNL1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.0000 | 3 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.3333 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.3333 | 6 | no |
| DOID:440 | neuromuscular disease | 3.3333 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.3333 | 3 | no |
| DOID:870 | neuropathy | 3.3333 | 4 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 3.3333 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 3.3333 | 6 | no |
| DOID:1289 | neurodegenerative disease | 3.3333 | 4 | no |
| DOID:231 | motor neuron disease | 3.3333 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PSDE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | Low throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA6_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| WFDC9_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| XPOT_HUMAN | [view interactions] | High throughput | no | no |
| URM1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP16_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| ZFN2B_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DJC22_HUMAN | [view interactions] | High throughput | no | no |
| DNJC4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5G_HUMAN | [view interactions] | High throughput | no | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPA_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| DHX40_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |