UBP5_HUMAN
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored Lys-48-linked polyubiquitin disassembly. Binds linear and Lys-63-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in UBP5_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 40.8163 | 4 | no |
GO:0000166 | nucleotide binding | 30.6122 | 4 | no |
GO:0017076 | purine nucleotide binding | 30.6122 | 5 | no |
GO:0043168 | anion binding | 30.6122 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | no |
GO:0043169 | cation binding | 26.5306 | 4 | yes |
GO:0046872 | metal ion binding | 26.5306 | 5 | yes |
GO:0019900 | kinase binding | 24.4898 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 22.4490 | 6 | no |
GO:0019901 | protein kinase binding | 22.4490 | 5 | no |
GO:0005524 | ATP binding | 20.4082 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.4082 | 5 | no |
GO:0031625 | ubiquitin protein ligase binding | 20.4082 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 20.4082 | 4 | no |
GO:0046914 | transition metal ion binding | 12.2449 | 6 | yes |
GO:0008270 | zinc ion binding | 10.2041 | 7 | yes |
GO:0004175 | endopeptidase activity | 4.0816 | 4 | yes |
GO:0043130 | ubiquitin binding | 4.0816 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in UBP5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.2245 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.0612 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 53.0612 | 4 | no |
GO:0048523 | negative regulation of cellular process | 48.9796 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 46.9388 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 46.9388 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 44.8980 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.8571 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 40.8163 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 40.8163 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 40.8163 | 5 | no |
GO:0010646 | regulation of cell communication | 38.7755 | 4 | no |
GO:0010468 | regulation of gene expression | 38.7755 | 6 | no |
GO:0051246 | regulation of protein metabolic process | 36.7347 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 36.7347 | 5 | no |
GO:0036211 | protein modification process | 34.6939 | 4 | yes |
GO:0043412 | macromolecule modification | 34.6939 | 4 | yes |
GO:0009966 | regulation of signal transduction | 34.6939 | 4 | no |
GO:0022607 | cellular component assembly | 34.6939 | 4 | no |
GO:0009894 | regulation of catabolic process | 32.6531 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 32.6531 | 6 | yes |
GO:0051130 | positive regulation of cellular component organization | 32.6531 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 32.6531 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 32.6531 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 32.6531 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 30.6122 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 30.6122 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.6122 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 30.6122 | 6 | no |
GO:0009890 | negative regulation of biosynthetic process | 30.6122 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.6122 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 30.6122 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
GO:0080134 | regulation of response to stress | 28.5714 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.5306 | 4 | no |
GO:0071310 | cellular response to organic substance | 26.5306 | 4 | no |
GO:0033043 | regulation of organelle organization | 26.5306 | 5 | no |
GO:0006996 | organelle organization | 26.5306 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 26.5306 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.4898 | 5 | no |
GO:0008104 | protein localization | 24.4898 | 4 | no |
GO:0010629 | negative regulation of gene expression | 24.4898 | 7 | no |
GO:0090304 | nucleic acid metabolic process | 24.4898 | 4 | no |
GO:0006508 | proteolysis | 22.4490 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 22.4490 | 5 | yes |
GO:0030162 | regulation of proteolysis | 22.4490 | 6 | yes |
GO:0043687 | post-translational protein modification | 22.4490 | 5 | yes |
GO:0051049 | regulation of transport | 22.4490 | 4 | no |
GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.4490 | 5 | no |
GO:0060341 | regulation of cellular localization | 22.4490 | 4 | no |
GO:0031399 | regulation of protein modification process | 22.4490 | 6 | no |
GO:0010628 | positive regulation of gene expression | 22.4490 | 7 | no |
GO:0051094 | positive regulation of developmental process | 22.4490 | 4 | no |
GO:0009057 | macromolecule catabolic process | 22.4490 | 4 | no |
GO:0016070 | RNA metabolic process | 22.4490 | 5 | no |
GO:0045862 | positive regulation of proteolysis | 20.4082 | 7 | yes |
GO:0010647 | positive regulation of cell communication | 20.4082 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.4082 | 4 | no |
GO:1902903 | regulation of supramolecular fiber organization | 20.4082 | 5 | no |
GO:0032101 | regulation of response to external stimulus | 20.4082 | 4 | no |
GO:0032446 | protein modification by small protein conjugation | 18.3673 | 7 | yes |
GO:0042176 | regulation of protein catabolic process | 18.3673 | 5 | yes |
GO:0061136 | regulation of proteasomal protein catabolic process | 18.3673 | 6 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 18.3673 | 6 | yes |
GO:1903050 | regulation of proteolysis involved in protein catabolic process | 18.3673 | 7 | yes |
GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 16.3265 | 6 | yes |
GO:0045732 | positive regulation of protein catabolic process | 16.3265 | 6 | yes |
GO:1901800 | positive regulation of proteasomal protein catabolic process | 16.3265 | 7 | yes |
GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 16.3265 | 8 | yes |
GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 16.3265 | 5 | yes |
GO:0016567 | protein ubiquitination | 14.2857 | 8 | yes |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 14.2857 | 7 | yes |
GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 14.2857 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
UBP13_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRIML_HUMAN | [view interactions] | Low throughput | no | no |
STK33_HUMAN | [view interactions] | Low throughput | no | no |
RAD18_HUMAN | [view interactions] | Low throughput | no | yes |
UBTD2_HUMAN | [view interactions] | Low throughput | no | yes |
UBA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
CAC1H_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FOXM1_HUMAN | [view interactions] | Low throughput | no | yes |
G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
MAF_HUMAN | [view interactions] | Low throughput | no | yes |
MAFB_HUMAN | [view interactions] | Low throughput | no | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
SNAI2_HUMAN | [view interactions] | Low throughput | no | yes |
OSBL8_HUMAN | [view interactions] | Low throughput | no | yes |
EFTU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HDAC2_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTA70_HUMAN | [view interactions] | Low throughput | no | no |
IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ROA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MYCN_HUMAN | [view interactions] | Low throughput | no | no |
KLF4_HUMAN | [view interactions] | Low throughput | no | no |
NLRP3_HUMAN | [view interactions] | Low throughput | no | no |
CASP1_HUMAN | [view interactions] | Low throughput | no | yes |
ASC_HUMAN | [view interactions] | Low throughput | no | no |
CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
PD1L1_HUMAN | [view interactions] | Low throughput | no | no |
SGTA_HUMAN | [view interactions] | Low throughput | no | yes |
USF1_HUMAN | [view interactions] | Low throughput | no | yes |
ISG15_HUMAN | [view interactions] | Low throughput | no | no |
PABP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYWC_HUMAN | [view interactions] | High throughput | no | yes |
GDE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
MLH1_HUMAN | [view interactions] | High throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPOT_HUMAN | [view interactions] | High throughput | no | no |
ANM3_HUMAN | [view interactions] | High throughput | no | yes |
XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
GILT_HUMAN | [view interactions] | High throughput | no | no |
DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
PSA5_HUMAN | [view interactions] | High throughput | no | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
H1BP3_HUMAN | [view interactions] | High throughput | no | yes |
PABP2_HUMAN | [view interactions] | High throughput | no | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
NUDC1_HUMAN | [view interactions] | High throughput | no | no |
COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAE2_HUMAN | [view interactions] | High throughput | no | yes |
NFS1_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
RN183_HUMAN | [view interactions] | High throughput | no | no |
TNR6_HUMAN | [view interactions] | High throughput | no | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RNF11_HUMAN | [view interactions] | High throughput | no | yes |
EREP1_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
HLAA_HUMAN | [view interactions] | High throughput | no | no |
TADA3_HUMAN | [view interactions] | High throughput | no | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
MTR1A_HUMAN | [view interactions] | High throughput | no | no |
B2L14_HUMAN | [view interactions] | High throughput | no | yes |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
TR10D_HUMAN | [view interactions] | High throughput | no | no |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
CEP63_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
DAZP2_HUMAN | [view interactions] | High throughput | no | no |
TM239_HUMAN | [view interactions] | High throughput | no | no |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP19_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
TRI26_HUMAN | [view interactions] | High throughput | no | yes |
TRI39_HUMAN | [view interactions] | High throughput | no | no |
TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
RN216_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPART_HUMAN | [view interactions] | High throughput | no | yes |
TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
PMS1_HUMAN | [view interactions] | High throughput | no | no |
PSA3_HUMAN | [view interactions] | High throughput | no | no |
RD23A_HUMAN | [view interactions] | High throughput | no | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
ITCH_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUC_HUMAN | [view interactions] | High throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS19_HUMAN | [view interactions] | High throughput | no | yes |
DUS22_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
OTUL_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
TMM31_HUMAN | [view interactions] | High throughput | no | no |
TCAL1_HUMAN | [view interactions] | High throughput | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F4_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP14B_HUMAN | [view interactions] | High throughput | no | yes |
METL5_HUMAN | [view interactions] | High throughput | no | yes |
PML_HUMAN | [view interactions] | High throughput | no | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2S_HUMAN | [view interactions] | High throughput | no | no |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
PJA1_HUMAN | [view interactions] | High throughput | no | yes |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
TRI54_HUMAN | [view interactions] | High throughput | no | no |
UBP28_HUMAN | [view interactions] | High throughput | no | yes |
PA2GA_HUMAN | [view interactions] | High throughput | no | no |
THTPA_HUMAN | [view interactions] | High throughput | no | yes |
UBA5_HUMAN | [view interactions] | High throughput | no | yes |
UBR1_HUMAN | [view interactions] | High throughput | no | yes |
ZN593_HUMAN | [view interactions] | High throughput | no | yes |
TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFP91_HUMAN | [view interactions] | High throughput | no | yes |
URM1_HUMAN | [view interactions] | High throughput | no | yes |
XIAP_HUMAN | [view interactions] | High throughput | no | yes |
UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
TXD17_HUMAN | [view interactions] | High throughput | no | yes |
PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOPK_HUMAN | [view interactions] | High throughput | no | no |
UBIP1_HUMAN | [view interactions] | High throughput | no | no |
PSME1_HUMAN | [view interactions] | High throughput | no | yes |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KDM5C_HUMAN | [view interactions] | High throughput | no | no |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
GNPI1_HUMAN | [view interactions] | High throughput | no | yes |
HERC4_HUMAN | [view interactions] | High throughput | no | no |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
TCAL4_HUMAN | [view interactions] | High throughput | no | no |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
MCTS1_HUMAN | [view interactions] | High throughput | no | no |
5NTC_HUMAN | [view interactions] | High throughput | no | yes |
OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
TRNT1_HUMAN | [view interactions] | High throughput | no | yes |
TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |