Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

UBP5_HUMAN

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored Lys-48-linked polyubiquitin disassembly. Binds linear and Lys-63-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in UBP5_HUMAN
GO:0003723 RNA binding 40.8163 4 no
GO:0000166 nucleotide binding 30.6122 4 no
GO:0017076 purine nucleotide binding 30.6122 5 no
GO:0043168 anion binding 30.6122 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043169 cation binding 26.5306 4 yes
GO:0046872 metal ion binding 26.5306 5 yes
GO:0019900 kinase binding 24.4898 4 no
GO:0030554 adenyl nucleotide binding 22.4490 6 no
GO:0019901 protein kinase binding 22.4490 5 no
GO:0005524 ATP binding 20.4082 5 no
GO:0032559 adenyl ribonucleotide binding 20.4082 5 no
GO:0031625 ubiquitin protein ligase binding 20.4082 5 no
GO:0044389 ubiquitin-like protein ligase binding 20.4082 4 no
GO:0046914 transition metal ion binding 12.2449 6 yes
GO:0008270 zinc ion binding 10.2041 7 yes
GO:0004175 endopeptidase activity 4.0816 4 yes
GO:0043130 ubiquitin binding 4.0816 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in UBP5_HUMAN
GO:0048522 positive regulation of cellular process 61.2245 4 no
GO:0060255 regulation of macromolecule metabolic process 53.0612 4 yes
GO:0031323 regulation of cellular metabolic process 53.0612 4 no
GO:0048523 negative regulation of cellular process 48.9796 4 no
GO:0009893 positive regulation of metabolic process 46.9388 4 yes
GO:0051128 regulation of cellular component organization 46.9388 4 no
GO:0080090 regulation of primary metabolic process 44.8980 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 yes
GO:0009889 regulation of biosynthetic process 40.8163 4 no
GO:0010556 regulation of macromolecule biosynthetic process 40.8163 5 no
GO:0031326 regulation of cellular biosynthetic process 40.8163 5 no
GO:0010646 regulation of cell communication 38.7755 4 no
GO:0010468 regulation of gene expression 38.7755 6 no
GO:0051246 regulation of protein metabolic process 36.7347 5 yes
GO:0031325 positive regulation of cellular metabolic process 36.7347 5 no
GO:0036211 protein modification process 34.6939 4 yes
GO:0043412 macromolecule modification 34.6939 4 yes
GO:0009966 regulation of signal transduction 34.6939 4 no
GO:0022607 cellular component assembly 34.6939 4 no
GO:0009894 regulation of catabolic process 32.6531 4 yes
GO:0051247 positive regulation of protein metabolic process 32.6531 6 yes
GO:0051130 positive regulation of cellular component organization 32.6531 5 no
GO:0009892 negative regulation of metabolic process 32.6531 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.6531 5 no
GO:0031324 negative regulation of cellular metabolic process 32.6531 5 no
GO:0048584 positive regulation of response to stimulus 30.6122 4 no
GO:0009891 positive regulation of biosynthetic process 30.6122 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.6122 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.6122 6 no
GO:0009890 negative regulation of biosynthetic process 30.6122 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 30.6122 6 no
GO:0031327 negative regulation of cellular biosynthetic process 30.6122 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:0044087 regulation of cellular component biogenesis 26.5306 4 no
GO:0071310 cellular response to organic substance 26.5306 4 no
GO:0033043 regulation of organelle organization 26.5306 5 no
GO:0006996 organelle organization 26.5306 4 no
GO:0051252 regulation of RNA metabolic process 26.5306 5 no
GO:1902531 regulation of intracellular signal transduction 24.4898 5 no
GO:0008104 protein localization 24.4898 4 no
GO:0010629 negative regulation of gene expression 24.4898 7 no
GO:0090304 nucleic acid metabolic process 24.4898 4 no
GO:0006508 proteolysis 22.4490 4 yes
GO:0009896 positive regulation of catabolic process 22.4490 5 yes
GO:0030162 regulation of proteolysis 22.4490 6 yes
GO:0043687 post-translational protein modification 22.4490 5 yes
GO:0051049 regulation of transport 22.4490 4 no
GO:0032880 regulation of protein localization 22.4490 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.4490 5 no
GO:0060341 regulation of cellular localization 22.4490 4 no
GO:0031399 regulation of protein modification process 22.4490 6 no
GO:0010628 positive regulation of gene expression 22.4490 7 no
GO:0051094 positive regulation of developmental process 22.4490 4 no
GO:0009057 macromolecule catabolic process 22.4490 4 no
GO:0016070 RNA metabolic process 22.4490 5 no
GO:0045862 positive regulation of proteolysis 20.4082 7 yes
GO:0010647 positive regulation of cell communication 20.4082 5 no
GO:0023056 positive regulation of signaling 20.4082 4 no
GO:1902903 regulation of supramolecular fiber organization 20.4082 5 no
GO:0032101 regulation of response to external stimulus 20.4082 4 no
GO:0032446 protein modification by small protein conjugation 18.3673 7 yes
GO:0042176 regulation of protein catabolic process 18.3673 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 18.3673 6 yes
GO:0070647 protein modification by small protein conjugation or removal 18.3673 6 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 18.3673 7 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 16.3265 6 yes
GO:0045732 positive regulation of protein catabolic process 16.3265 6 yes
GO:1901800 positive regulation of proteasomal protein catabolic process 16.3265 7 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 16.3265 8 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 16.3265 5 yes
GO:0016567 protein ubiquitination 14.2857 8 yes
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 14.2857 7 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 14.2857 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBP13_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIML_HUMAN [view interactions] Low throughput no no
STK33_HUMAN [view interactions] Low throughput no no
RAD18_HUMAN [view interactions] Low throughput no yes
UBTD2_HUMAN [view interactions] Low throughput no yes
UBA1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMUF1_HUMAN [view interactions] Low throughput no yes
CAC1H_HUMAN [view entry] [view interactions] Low throughput yes yes
FOXM1_HUMAN [view interactions] Low throughput no yes
G3BP1_HUMAN [view interactions] Low throughput no yes
MAF_HUMAN [view interactions] Low throughput no yes
MAFB_HUMAN [view interactions] Low throughput no yes
MYC_HUMAN [view interactions] Low throughput no yes
SNAI2_HUMAN [view interactions] Low throughput no yes
OSBL8_HUMAN [view interactions] Low throughput no yes
EFTU_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC2_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
MTA70_HUMAN [view interactions] Low throughput no no
IKKB_HUMAN [view interactions] Low throughput no yes
ELAV1_HUMAN [view entry] [view interactions] Low throughput yes yes
ROA1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYCN_HUMAN [view interactions] Low throughput no no
KLF4_HUMAN [view interactions] Low throughput no no
NLRP3_HUMAN [view interactions] Low throughput no no
CASP1_HUMAN [view interactions] Low throughput no yes
ASC_HUMAN [view interactions] Low throughput no no
CCND1_HUMAN [view interactions] Low throughput no yes
PD1L1_HUMAN [view interactions] Low throughput no no
SGTA_HUMAN [view interactions] Low throughput no yes
USF1_HUMAN [view interactions] Low throughput no yes
ISG15_HUMAN [view interactions] Low throughput no no
PABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYWC_HUMAN [view interactions] High throughput no yes
GDE_HUMAN [view entry] [view interactions] High throughput yes no
LAGE3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
MLH1_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD1_HUMAN [view interactions] High throughput no no
YTHD2_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
XPOT_HUMAN [view interactions] High throughput no no
ANM3_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
GILT_HUMAN [view interactions] High throughput no no
DNLI1_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF3_HUMAN [view interactions] High throughput no yes
HMCS1_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
H1BP3_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
NUDC1_HUMAN [view interactions] High throughput no no
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
DCTN5_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
SAE2_HUMAN [view interactions] High throughput no yes
NFS1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
TNR6_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
KBTB4_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
EREP1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
TADA3_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
B2L14_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
TR10D_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
DAZP2_HUMAN [view interactions] High throughput no no
TM239_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP19_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
TRI26_HUMAN [view interactions] High throughput no yes
TRI39_HUMAN [view interactions] High throughput no no
TRIM5_HUMAN [view interactions] High throughput no yes
RN216_HUMAN [view entry] [view interactions] High throughput yes yes
SPART_HUMAN [view interactions] High throughput no yes
TRIM8_HUMAN [view interactions] High throughput no yes
PMS1_HUMAN [view interactions] High throughput no no
PSA3_HUMAN [view interactions] High throughput no no
RD23A_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
ITCH_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DUS19_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
OTUL_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
TMM31_HUMAN [view interactions] High throughput no no
TCAL1_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL5_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PP14B_HUMAN [view interactions] High throughput no yes
METL5_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ITB1_HUMAN [view entry] [view interactions] High throughput yes no
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2S_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
PJA1_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
TRI55_HUMAN [view interactions] High throughput no no
TRI54_HUMAN [view interactions] High throughput no no
UBP28_HUMAN [view interactions] High throughput no yes
PA2GA_HUMAN [view interactions] High throughput no no
THTPA_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
UBR1_HUMAN [view interactions] High throughput no yes
ZN593_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
ZFP91_HUMAN [view interactions] High throughput no yes
URM1_HUMAN [view interactions] High throughput no yes
XIAP_HUMAN [view interactions] High throughput no yes
UCHL3_HUMAN [view interactions] High throughput no yes
TXD17_HUMAN [view interactions] High throughput no yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
TOPK_HUMAN [view interactions] High throughput no no
UBIP1_HUMAN [view interactions] High throughput no no
PSME1_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
KDM5C_HUMAN [view interactions] High throughput no no
UB2R1_HUMAN [view interactions] High throughput no yes
GNPI1_HUMAN [view interactions] High throughput no yes
HERC4_HUMAN [view interactions] High throughput no no
IPO9_HUMAN [view interactions] High throughput no no
PDIA1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
TCAL4_HUMAN [view interactions] High throughput no no
ICLN_HUMAN [view interactions] High throughput no yes
MCTS1_HUMAN [view interactions] High throughput no no
5NTC_HUMAN [view interactions] High throughput no yes
OXSR1_HUMAN [view interactions] High throughput no yes
TRNT1_HUMAN [view interactions] High throughput no yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no