CAC1H_HUMAN
Evidence for PS localization
Functions
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed, PubMed, PubMed). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAC1H_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 70.0000 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 70.0000 | 4 | yes |
| GO:0015267 | channel activity | 70.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 70.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 70.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 70.0000 | 5 | yes |
| GO:0005244 | voltage-gated ion channel activity | 65.0000 | 4 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 65.0000 | 6 | yes |
| GO:0005261 | cation channel activity | 65.0000 | 5 | yes |
| GO:0005262 | calcium channel activity | 65.0000 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 65.0000 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 65.0000 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 65.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAC1H_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 80.0000 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 75.0000 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 75.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 75.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 60.0000 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 55.0000 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 55.0000 | 5 | no |
| GO:2001257 | regulation of cation channel activity | 55.0000 | 6 | no |
| GO:0006811 | ion transport | 45.0000 | 4 | yes |
| GO:0006812 | cation transport | 45.0000 | 5 | yes |
| GO:0030001 | metal ion transport | 45.0000 | 6 | yes |
| GO:0051050 | positive regulation of transport | 45.0000 | 4 | yes |
| GO:0006816 | calcium ion transport | 40.0000 | 7 | yes |
| GO:0016192 | vesicle-mediated transport | 35.0000 | 4 | no |
| GO:0008104 | protein localization | 35.0000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 35.0000 | 6 | no |
| GO:0034764 | positive regulation of transmembrane transport | 35.0000 | 5 | no |
| GO:0034767 | positive regulation of ion transmembrane transport | 35.0000 | 6 | no |
| GO:0043270 | positive regulation of ion transport | 35.0000 | 5 | no |
| GO:0051924 | regulation of calcium ion transport | 35.0000 | 7 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 35.0000 | 7 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 35.0000 | 7 | no |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0071702 | organic substance transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | no |
| GO:0032411 | positive regulation of transporter activity | 30.0000 | 4 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 30.0000 | 5 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 30.0000 | 6 | no |
| GO:2001259 | positive regulation of cation channel activity | 30.0000 | 6 | no |
| GO:0006897 | endocytosis | 30.0000 | 5 | no |
| GO:0007034 | vacuolar transport | 30.0000 | 4 | no |
| GO:0007041 | lysosomal transport | 30.0000 | 5 | no |
| GO:0008333 | endosome to lysosome transport | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0031623 | receptor internalization | 25.0000 | 7 | no |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 25.0000 | 5 | no |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0061462 | protein localization to lysosome | 25.0000 | 7 | no |
| GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | no |
| GO:0072665 | protein localization to vacuole | 25.0000 | 6 | no |
| GO:0072666 | establishment of protein localization to vacuole | 25.0000 | 5 | no |
| GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 25.0000 | 4 | no |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
| GO:0099601 | regulation of neurotransmitter receptor activity | 25.0000 | 4 | no |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
| GO:2000311 | regulation of AMPA receptor activity | 25.0000 | 5 | no |
| GO:0008016 | regulation of heart contraction | 25.0000 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 25.0000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | no |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 25.0000 | 7 | no |
| GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 25.0000 | 6 | no |
| GO:0051899 | membrane depolarization | 20.0000 | 4 | yes |
| GO:0098655 | cation transmembrane transport | 20.0000 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 20.0000 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 20.0000 | 5 | yes |
| GO:0001508 | action potential | 15.0000 | 4 | yes |
| GO:0070509 | calcium ion import | 15.0000 | 8 | yes |
| GO:0086010 | membrane depolarization during action potential | 15.0000 | 5 | yes |
| GO:0006936 | muscle contraction | 10.0000 | 4 | yes |
| GO:0007520 | myoblast fusion | 10.0000 | 4 | yes |
| GO:0010038 | response to metal ion | 10.0000 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 10.0000 | 4 | yes |
| GO:0051046 | regulation of secretion | 10.0000 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 10.0000 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 10.0000 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 10.0000 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 10.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLHL1_HUMAN | [view interactions] | Low throughput | no | no |
| UBP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCD10_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NOS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TRPC5_HUMAN | [view interactions] | Computational | no | no |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CAC1G_HUMAN | [view interactions] | Computational | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TRPC4_HUMAN | [view interactions] | Computational | no | no |
| CAV3_HUMAN | [view interactions] | Computational | no | no |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RYR1_HUMAN | [view interactions] | Computational | no | no |
| ESR2_HUMAN | [view interactions] | Computational | no | no |
| CACB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D4_HUMAN | [view interactions] | Computational | no | no |
| TRPC1_HUMAN | [view interactions] | Computational | no | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1I_HUMAN | [view interactions] | Computational | no | no |
| CA2D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| CTSRB_HUMAN | [view interactions] | Computational | no | no |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |