CAC1H_HUMAN
Evidence for PS localization
Functions
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed, PubMed, PubMed). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004871 | DOC_PP2B_LxvP_1 | DOC | 2261 | 2264 | - |
| ELMI004771 | DOC_PP2B_PxIxIT_1 | DOC | 2264 | 2269 | - |
| ELMI004871 | DOC_PP2B_LxvP_1 | DOC | 2261 | 2264 | - |
| ELMI004771 | DOC_PP2B_PxIxIT_1 | DOC | 2264 | 2269 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAC1H_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 100.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 100.0000 | 5 | yes |
| GO:0005509 | calcium ion binding | 66.6667 | 6 | no |
| GO:0005216 | monoatomic ion channel activity | 33.3333 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0015267 | channel activity | 33.3333 | 4 | yes |
| GO:0022836 | gated channel activity | 33.3333 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 33.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAC1H_HUMAN |
|---|---|---|---|---|
| GO:0006811 | monoatomic ion transport | 33.3333 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 33.3333 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 33.3333 | 6 | yes |
| GO:0030001 | metal ion transport | 33.3333 | 6 | yes |
| GO:0044057 | regulation of system process | 33.3333 | 4 | yes |
| GO:0098657 | import into cell | 33.3333 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 33.3333 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0030031 | cell projection assembly | 33.3333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0120031 | plasma membrane bounded cell projection assembly | 33.3333 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLHL1_HUMAN | [view interactions] | Low throughput | no | no |
| UBP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| KDM5B_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |