EHD3_HUMAN
Evidence for PS localization
Functions
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed). In vitro causes tubulation of endocytic membranes (PubMed). Binding to phosphatidic acid induces its membrane tubulation activity . Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed, PubMed, PubMed, PubMed). Involved in the recycling of internalized D1 dopamine receptor (PubMed). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction . In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function . Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EHD3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 43.7500 | 4 | yes |
| GO:0005525 | GTP binding | 31.2500 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 31.2500 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 31.2500 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 31.2500 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.2500 | 4 | yes |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | yes |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0031267 | small GTPase binding | 25.0000 | 5 | no |
| GO:0051020 | GTPase binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EHD3_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 87.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
| GO:0008104 | protein localization | 68.7500 | 4 | yes |
| GO:0006996 | organelle organization | 62.5000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 62.5000 | 4 | yes |
| GO:0022607 | cellular component assembly | 62.5000 | 4 | yes |
| GO:0051050 | positive regulation of transport | 56.2500 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.2500 | 4 | yes |
| GO:0006897 | endocytosis | 50.0000 | 5 | yes |
| GO:0030030 | cell projection organization | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0072657 | protein localization to membrane | 50.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 50.0000 | 4 | no |
| GO:0015031 | protein transport | 43.7500 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 43.7500 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 43.7500 | 5 | yes |
| GO:0043269 | regulation of ion transport | 43.7500 | 5 | yes |
| GO:0070925 | organelle assembly | 43.7500 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 43.7500 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 43.7500 | 5 | yes |
| GO:0016197 | endosomal transport | 37.5000 | 4 | yes |
| GO:0044057 | regulation of system process | 37.5000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 37.5000 | 5 | yes |
| GO:0061024 | membrane organization | 37.5000 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 31.2500 | 4 | yes |
| GO:0030031 | cell projection assembly | 31.2500 | 5 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 31.2500 | 5 | yes |
| GO:0032456 | endocytic recycling | 31.2500 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 31.2500 | 4 | yes |
| GO:0044782 | cilium organization | 31.2500 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 31.2500 | 6 | yes |
| GO:0051260 | protein homooligomerization | 31.2500 | 7 | yes |
| GO:0060271 | cilium assembly | 31.2500 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 31.2500 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 31.2500 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 31.2500 | 6 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 31.2500 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 31.2500 | 6 | yes |
| GO:0010646 | regulation of cell communication | 31.2500 | 4 | no |
| GO:0030100 | regulation of endocytosis | 31.2500 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.2500 | 5 | no |
| GO:0008016 | regulation of heart contraction | 25.0000 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 25.0000 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 25.0000 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 25.0000 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 25.0000 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 25.0000 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 25.0000 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 25.0000 | 7 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 25.0000 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 25.0000 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 25.0000 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 25.0000 | 7 | yes |
| GO:2001259 | positive regulation of cation channel activity | 25.0000 | 6 | yes |
| GO:0032990 | cell part morphogenesis | 25.0000 | 4 | no |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0048858 | cell projection morphogenesis | 25.0000 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 18.7500 | 6 | yes |
| GO:0006896 | Golgi to vacuole transport | 18.7500 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 18.7500 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 18.7500 | 7 | yes |
| GO:0007034 | vacuolar transport | 18.7500 | 4 | yes |
| GO:0007041 | lysosomal transport | 18.7500 | 5 | yes |
| GO:0016482 | cytosolic transport | 18.7500 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 18.7500 | 5 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 18.7500 | 5 | yes |
| GO:0048193 | Golgi vesicle transport | 18.7500 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 18.7500 | 6 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 18.7500 | 7 | yes |
| GO:0090160 | Golgi to lysosome transport | 18.7500 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 18.7500 | 5 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 18.7500 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 18.7500 | 7 | yes |
| GO:1903779 | regulation of cardiac conduction | 18.7500 | 4 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 18.7500 | 7 | yes |
| GO:0001881 | receptor recycling | 12.5000 | 5 | yes |
| GO:0034498 | early endosome to Golgi transport | 12.5000 | 6 | yes |
| GO:0043112 | receptor metabolic process | 12.5000 | 4 | yes |
| GO:0086036 | regulation of cardiac muscle cell membrane potential | 12.5000 | 4 | yes |
| GO:1901387 | positive regulation of voltage-gated calcium channel activity | 12.5000 | 7 | yes |
| GO:1903358 | regulation of Golgi organization | 12.5000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1G_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1H_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| EHD2_HUMAN | [view interactions] | High throughput | no | no |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCP2D_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| PACN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EHBP1_HUMAN | [view interactions] | Computational | no | yes |
| MYOF_HUMAN | [view interactions] | Computational | no | yes |