EHD3_HUMAN
Evidence for PS localization
Functions
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed). In vitro causes tubulation of endocytic membranes (PubMed). Binding to phosphatidic acid induces its membrane tubulation activity . Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed, PubMed, PubMed, PubMed). Involved in the recycling of internalized D1 dopamine receptor (PubMed). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction . In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function . Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EHD3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 40.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 40.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 35.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.0000 | 4 | yes |
| GO:0043168 | anion binding | 35.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 30.0000 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | yes |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0005525 | GTP binding | 25.0000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 25.0000 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0005509 | calcium ion binding | 20.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EHD3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 65.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 65.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 65.0000 | 4 | no |
| GO:0006996 | organelle organization | 55.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0098657 | import into cell | 50.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | no |
| GO:0071702 | organic substance transport | 45.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.0000 | 4 | yes |
| GO:0070925 | organelle assembly | 40.0000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 40.0000 | 4 | yes |
| GO:0015031 | protein transport | 35.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 35.0000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 35.0000 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 35.0000 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 35.0000 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 35.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 35.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 35.0000 | 4 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | yes |
| GO:0051259 | protein complex oligomerization | 30.0000 | 6 | yes |
| GO:0051260 | protein homooligomerization | 30.0000 | 7 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0061024 | membrane organization | 30.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.0000 | 4 | no |
| GO:0030031 | cell projection assembly | 25.0000 | 5 | yes |
| GO:0032456 | endocytic recycling | 25.0000 | 4 | yes |
| GO:0044782 | cilium organization | 25.0000 | 5 | yes |
| GO:0060271 | cilium assembly | 25.0000 | 6 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 25.0000 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0030100 | regulation of endocytosis | 25.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0007034 | vacuolar transport | 20.0000 | 4 | yes |
| GO:0007041 | lysosomal transport | 20.0000 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 20.0000 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 20.0000 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 20.0000 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 15.0000 | 4 | yes |
| GO:0006896 | Golgi to vacuole transport | 15.0000 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 15.0000 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 15.0000 | 7 | yes |
| GO:0016482 | cytosolic transport | 15.0000 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 15.0000 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 15.0000 | 7 | yes |
| GO:0090160 | Golgi to lysosome transport | 15.0000 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 15.0000 | 5 | yes |
| GO:1903779 | regulation of cardiac conduction | 15.0000 | 7 | yes |
| GO:0001881 | receptor recycling | 10.0000 | 5 | yes |
| GO:0034498 | early endosome to Golgi transport | 10.0000 | 4 | yes |
| GO:0043112 | receptor metabolic process | 10.0000 | 4 | yes |
| GO:0086036 | regulation of cardiac muscle cell membrane potential | 10.0000 | 4 | yes |
| GO:1903358 | regulation of Golgi organization | 10.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1H_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1G_HUMAN | [view interactions] | Low throughput | no | no |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| EHD2_HUMAN | [view interactions] | High throughput | no | no |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCP2D_HUMAN | [view interactions] | High throughput | no | no |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTNA_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |