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EHD1_HUMAN

GO
G2C
SynGO

ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed, PubMed, PubMed). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth . Plays a role in myoblast fusion . Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in EHD1_HUMAN
GO:0043168 anion binding 52.6316 4 yes
GO:0000166 nucleotide binding 47.3684 4 yes
GO:0017076 purine nucleotide binding 45.6140 5 yes
GO:0032555 purine ribonucleotide binding 45.6140 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 45.6140 4 yes
GO:0005525 GTP binding 31.5789 5 yes
GO:0019001 guanyl nucleotide binding 31.5789 6 yes
GO:0032561 guanyl ribonucleotide binding 31.5789 5 yes
GO:0043169 cation binding 29.8246 4 yes
GO:0046872 metal ion binding 29.8246 5 yes
GO:0003924 GTPase activity 24.5614 7 no
GO:0016462 pyrophosphatase activity 24.5614 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.5614 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.5614 6 no
GO:0005524 ATP binding 21.0526 5 yes
GO:0030554 adenyl nucleotide binding 21.0526 6 yes
GO:0032559 adenyl ribonucleotide binding 21.0526 5 yes
GO:0019900 kinase binding 21.0526 4 no
GO:0051020 GTPase binding 14.0351 4 yes
GO:0031267 small GTPase binding 12.2807 5 yes
GO:0045296 cadherin binding 12.2807 4 yes
GO:0005509 calcium ion binding 10.5263 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EHD1_HUMAN
GO:0048522 positive regulation of cellular process 70.1754 4 yes
GO:0008104 protein localization 56.1404 4 yes
GO:0051128 regulation of cellular component organization 54.3860 4 yes
GO:0071702 organic substance transport 49.1228 4 yes
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0031323 regulation of cellular metabolic process 47.3684 4 no
GO:0048523 negative regulation of cellular process 45.6140 4 no
GO:0006996 organelle organization 45.6140 4 yes
GO:0071705 nitrogen compound transport 45.6140 4 yes
GO:0022607 cellular component assembly 43.8596 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.1053 4 no
GO:0015031 protein transport 42.1053 4 yes
GO:0051049 regulation of transport 42.1053 4 yes
GO:0009889 regulation of biosynthetic process 36.8421 4 no
GO:0009966 regulation of signal transduction 36.8421 4 no
GO:0031326 regulation of cellular biosynthetic process 36.8421 5 no
GO:0048584 positive regulation of response to stimulus 36.8421 4 no
GO:0080090 regulation of primary metabolic process 35.0877 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.0877 5 no
GO:0043067 regulation of programmed cell death 31.5789 4 no
GO:0010468 regulation of gene expression 31.5789 6 no
GO:0009893 positive regulation of metabolic process 29.8246 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.8246 5 no
GO:0031325 positive regulation of cellular metabolic process 29.8246 5 no
GO:0042981 regulation of apoptotic process 29.8246 5 no
GO:1902531 regulation of intracellular signal transduction 29.8246 5 no
GO:0060341 regulation of cellular localization 29.8246 4 yes
GO:0098657 import into cell 28.0702 4 yes
GO:0006886 intracellular protein transport 28.0702 4 yes
GO:0060627 regulation of vesicle-mediated transport 28.0702 4 yes
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0030030 cell projection organization 26.3158 4 yes
GO:0043933 protein-containing complex organization 26.3158 4 yes
GO:0009891 positive regulation of biosynthetic process 24.5614 5 no
GO:0009967 positive regulation of signal transduction 24.5614 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.5614 5 no
GO:0031328 positive regulation of cellular biosynthetic process 24.5614 6 no
GO:2000145 regulation of cell motility 24.5614 4 no
GO:0009892 negative regulation of metabolic process 24.5614 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.5614 5 no
GO:0051246 regulation of protein metabolic process 24.5614 5 no
GO:0032880 regulation of protein localization 24.5614 5 no
GO:0051050 positive regulation of transport 24.5614 4 yes
GO:0065003 protein-containing complex assembly 24.5614 5 yes
GO:0010648 negative regulation of cell communication 22.8070 5 no
GO:0023057 negative regulation of signaling 22.8070 4 no
GO:0030334 regulation of cell migration 22.8070 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.8070 6 no
GO:0051252 regulation of RNA metabolic process 22.8070 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.0526 6 yes
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 yes
GO:0042127 regulation of cell population proliferation 21.0526 4 no
GO:0043066 negative regulation of apoptotic process 21.0526 6 no
GO:0043069 negative regulation of programmed cell death 21.0526 5 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:0006355 regulation of DNA-templated transcription 21.0526 7 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0031399 regulation of protein modification process 21.0526 6 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0051046 regulation of secretion 21.0526 5 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0061024 membrane organization 21.0526 4 no
GO:0031344 regulation of cell projection organization 21.0526 5 yes
GO:0051094 positive regulation of developmental process 21.0526 4 yes
GO:0072657 protein localization to membrane 19.2982 4 yes
GO:0033365 protein localization to organelle 19.2982 5 yes
GO:0072659 protein localization to plasma membrane 17.5439 5 yes
GO:1990778 protein localization to cell periphery 17.5439 5 yes
GO:0032456 endocytic recycling 17.5439 4 yes
GO:0051130 positive regulation of cellular component organization 15.7895 5 yes
GO:0030031 cell projection assembly 14.0351 5 yes
GO:0070925 organelle assembly 14.0351 5 yes
GO:0071363 cellular response to growth factor stimulus 14.0351 4 yes
GO:0031346 positive regulation of cell projection organization 12.2807 6 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.5263 6 yes
GO:0010975 regulation of neuron projection development 10.5263 7 yes
GO:0031175 neuron projection development 10.5263 6 yes
GO:0032386 regulation of intracellular transport 10.5263 5 yes
GO:0051259 protein complex oligomerization 10.5263 6 yes
GO:1905952 regulation of lipid localization 8.7719 4 yes
GO:0010976 positive regulation of neuron projection development 8.7719 7 yes
GO:0044782 cilium organization 8.7719 5 yes
GO:0051260 protein homooligomerization 8.7719 7 yes
GO:0060271 cilium assembly 8.7719 6 yes
GO:1990089 response to nerve growth factor 7.0175 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 7.0175 5 yes
GO:0032388 positive regulation of intracellular transport 7.0175 5 yes
GO:0061512 protein localization to cilium 7.0175 6 yes
GO:1905954 positive regulation of lipid localization 5.2632 4 yes
GO:2001135 regulation of endocytic recycling 5.2632 5 yes
GO:0042632 cholesterol homeostasis 5.2632 5 yes
GO:0055092 sterol homeostasis 5.2632 4 yes
GO:1901739 regulation of myoblast fusion 3.5088 5 yes
GO:1901741 positive regulation of myoblast fusion 3.5088 6 yes
GO:2001137 positive regulation of endocytic recycling 3.5088 6 yes
GO:0010883 regulation of lipid storage 3.5088 4 yes
GO:0010884 positive regulation of lipid storage 3.5088 5 yes
GO:0010885 regulation of cholesterol storage 3.5088 5 yes
GO:0010886 positive regulation of cholesterol storage 3.5088 6 yes
GO:0060142 regulation of syncytium formation by plasma membrane fusion 3.5088 4 yes
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 3.5088 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RFFL_HUMAN [view interactions] Low throughput no yes
CD44_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
MUL1_HUMAN [view interactions] Low throughput no no
ANFY1_HUMAN [view entry] [view interactions] Low throughput yes yes
EHD1_HUMAN [view entry] [view interactions] Low throughput yes no
EHD3_HUMAN [view entry] [view interactions] Low throughput yes no
MILK1_HUMAN [view interactions] Low throughput no yes
RBNS5_HUMAN [view interactions] Low throughput no yes
SNP29_HUMAN [view interactions] Low throughput no yes
PACN2_HUMAN [view entry] [view interactions] Low throughput yes no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
EPN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN3_HUMAN [view interactions] Low throughput no no
MICA1_HUMAN [view interactions] Low throughput no yes
RFIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
VP26A_HUMAN [view entry] [view interactions] Low throughput yes no
PA24A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTMP_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
PAPD5_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SC5A5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
EHD2_HUMAN [view interactions] High throughput no no
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
STX17_HUMAN [view interactions] High throughput no yes
SPXN5_HUMAN [view interactions] High throughput no no
SCP2D_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
IL25_HUMAN [view interactions] High throughput no no
NTNG1_HUMAN [view interactions] High throughput no no
PHF11_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
F174A_HUMAN [view interactions] High throughput no yes
HXB1_HUMAN [view interactions] High throughput no no
MAP7_HUMAN [view interactions] High throughput no yes
CQ082_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
CD79A_HUMAN [view interactions] High throughput no no
SERB1_HUMAN [view interactions] High throughput no yes
TRI11_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
SLUR1_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
AQ12B_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
CLD4_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
DGKQ_HUMAN [view entry] [view interactions] High throughput yes yes
API5_HUMAN [view interactions] High throughput no no
ARI2_HUMAN [view interactions] High throughput no no
ATE1_HUMAN [view interactions] High throughput no yes
PYRG2_HUMAN [view interactions] High throughput no yes
ADPPT_HUMAN [view entry] [view interactions] High throughput yes yes
DRG2_HUMAN [view interactions] High throughput no yes
FKBP9_HUMAN [view interactions] High throughput no yes
PDC10_HUMAN [view interactions] High throughput no yes
STAT6_HUMAN [view interactions] High throughput no yes
TF3C4_HUMAN [view interactions] High throughput no no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMD1_HUMAN [view interactions] High throughput no yes
NOL3_HUMAN [view interactions] High throughput no yes
NUBP1_HUMAN [view interactions] High throughput no yes
PDE12_HUMAN [view interactions] High throughput no yes
PGTB1_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
STK39_HUMAN [view entry] [view interactions] High throughput yes yes
UBA6_HUMAN [view interactions] High throughput no no
SYWC_HUMAN [view interactions] High throughput no yes
XPP1_HUMAN [view interactions] High throughput no yes
NNRE_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TECR_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
WDFY1_HUMAN [view interactions] High throughput no yes
FADD_HUMAN [view interactions] High throughput no yes
FA98B_HUMAN [view interactions] High throughput no yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKRA_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
SYTC_HUMAN [view interactions] High throughput no yes
PPCE_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD1_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
ATG9A_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
ARL4C_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
RAB25_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
TINF2_HUMAN [view interactions] High throughput no no
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
TMX1_HUMAN [view interactions] High throughput no no
KI67_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
CD177_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
STON2_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
KCNK3_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
TNR6_HUMAN [view interactions] High throughput no no
TMM25_HUMAN [view interactions] High throughput no yes
CCNL2_HUMAN [view interactions] High throughput no yes
SPXN3_HUMAN [view interactions] High throughput no no