EHD1_HUMAN
Evidence for PS localization
Functions
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed, PubMed, PubMed). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth . Plays a role in myoblast fusion . Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EHD1_HUMAN |
|---|---|---|---|---|
| GO:0032555 | purine ribonucleotide binding | 47.9167 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 47.9167 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 47.9167 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 33.3333 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0005525 | GTP binding | 33.3333 | 5 | yes |
| GO:0046872 | metal ion binding | 27.0833 | 4 | yes |
| GO:0019900 | kinase binding | 27.0833 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0003924 | GTPase activity | 25.0000 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 22.9167 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.9167 | 5 | yes |
| GO:0005524 | ATP binding | 22.9167 | 5 | yes |
| GO:0051020 | GTPase binding | 14.5833 | 4 | yes |
| GO:0031267 | small GTPase binding | 12.5000 | 5 | yes |
| GO:0045296 | cadherin binding | 12.5000 | 4 | yes |
| GO:0005509 | calcium ion binding | 12.5000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EHD1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0008104 | protein localization | 54.1667 | 4 | yes |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 47.9167 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | yes |
| GO:0071702 | organic substance transport | 45.8333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | no |
| GO:0022607 | cellular component assembly | 43.7500 | 4 | yes |
| GO:0051049 | regulation of transport | 43.7500 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 43.7500 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0015031 | protein transport | 41.6667 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.4167 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.4167 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.2500 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.1667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0006886 | intracellular protein transport | 29.1667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 29.1667 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 29.1667 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.0833 | 5 | no |
| GO:0010941 | regulation of cell death | 27.0833 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 27.0833 | 5 | no |
| GO:0006897 | endocytosis | 27.0833 | 5 | yes |
| GO:0030030 | cell projection organization | 27.0833 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0016197 | endosomal transport | 25.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.9167 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.9167 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.9167 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.9167 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.9167 | 5 | no |
| GO:2000145 | regulation of cell motility | 22.9167 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.8333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.8333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.8333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 20.8333 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.8333 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.8333 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 20.8333 | 4 | yes |
| GO:0032456 | endocytic recycling | 18.7500 | 5 | yes |
| GO:0033365 | protein localization to organelle | 18.7500 | 5 | yes |
| GO:0072657 | protein localization to membrane | 18.7500 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 18.7500 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 18.7500 | 5 | yes |
| GO:0030031 | cell projection assembly | 16.6667 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 16.6667 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 16.6667 | 5 | yes |
| GO:0070925 | organelle assembly | 16.6667 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 16.6667 | 6 | yes |
| GO:0031175 | neuron projection development | 14.5833 | 6 | yes |
| GO:0070848 | response to growth factor | 14.5833 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 14.5833 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.5000 | 6 | yes |
| GO:0048878 | chemical homeostasis | 12.5000 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 12.5000 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 10.4167 | 7 | yes |
| GO:0032386 | regulation of intracellular transport | 10.4167 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 10.4167 | 5 | yes |
| GO:0044782 | cilium organization | 10.4167 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 10.4167 | 6 | yes |
| GO:0060271 | cilium assembly | 10.4167 | 6 | yes |
| GO:0051260 | protein homooligomerization | 8.3333 | 7 | yes |
| GO:1905952 | regulation of lipid localization | 8.3333 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 8.3333 | 4 | yes |
| GO:0010976 | positive regulation of neuron projection development | 6.2500 | 7 | yes |
| GO:0042632 | cholesterol homeostasis | 6.2500 | 7 | yes |
| GO:0055088 | lipid homeostasis | 6.2500 | 5 | yes |
| GO:0055092 | sterol homeostasis | 6.2500 | 6 | yes |
| GO:0061512 | protein localization to cilium | 6.2500 | 6 | yes |
| GO:1905954 | positive regulation of lipid localization | 6.2500 | 4 | yes |
| GO:2001137 | positive regulation of endocytic recycling | 4.1667 | 6 | yes |
| GO:0010883 | regulation of lipid storage | 4.1667 | 4 | yes |
| GO:0010884 | positive regulation of lipid storage | 4.1667 | 5 | yes |
| GO:0010885 | regulation of cholesterol storage | 4.1667 | 5 | yes |
| GO:0010886 | positive regulation of cholesterol storage | 4.1667 | 6 | yes |
| GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 4.1667 | 4 | yes |
| GO:0060143 | positive regulation of syncytium formation by plasma membrane fusion | 4.1667 | 5 | yes |
| GO:1901739 | regulation of myoblast fusion | 4.1667 | 5 | yes |
| GO:1901741 | positive regulation of myoblast fusion | 4.1667 | 6 | yes |
| GO:2001135 | regulation of endocytic recycling | 4.1667 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EHD1_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 4.1667 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 4.1667 | 3 | no |
| DOID:331 | central nervous system disease | 4.1667 | 3 | no |
| DOID:574 | peripheral nervous system disease | 4.1667 | 3 | no |
| DOID:870 | neuropathy | 4.1667 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
| SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPN3_HUMAN | [view interactions] | Low throughput | no | no |
| MICA1_HUMAN | [view interactions] | Low throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PA24A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFFL_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN3_HUMAN | [view interactions] | High throughput | no | no |
| CS054_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPD5_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC5A5_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| EHD2_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN5_HUMAN | [view interactions] | High throughput | no | no |
| SCP2D_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| NDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL25_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| HXB1_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| CQ082_HUMAN | [view interactions] | High throughput | no | no |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQ12B_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| API5_HUMAN | [view interactions] | High throughput | no | no |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
| PDC10_HUMAN | [view interactions] | High throughput | no | yes |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| NOL3_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| PGTB1_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| FA98B_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |