EHD1_HUMAN
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed, PubMed, PubMed). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth . Plays a role in myoblast fusion . Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EHD1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 52.6316 | 4 | yes |
GO:0000166 | nucleotide binding | 47.3684 | 4 | yes |
GO:0017076 | purine nucleotide binding | 45.6140 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 45.6140 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 45.6140 | 4 | yes |
GO:0005525 | GTP binding | 31.5789 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 31.5789 | 6 | yes |
GO:0032561 | guanyl ribonucleotide binding | 31.5789 | 5 | yes |
GO:0043169 | cation binding | 29.8246 | 4 | yes |
GO:0046872 | metal ion binding | 29.8246 | 5 | yes |
GO:0003924 | GTPase activity | 24.5614 | 7 | no |
GO:0016462 | pyrophosphatase activity | 24.5614 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.5614 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.5614 | 6 | no |
GO:0005524 | ATP binding | 21.0526 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 21.0526 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 21.0526 | 5 | yes |
GO:0019900 | kinase binding | 21.0526 | 4 | no |
GO:0051020 | GTPase binding | 14.0351 | 4 | yes |
GO:0031267 | small GTPase binding | 12.2807 | 5 | yes |
GO:0045296 | cadherin binding | 12.2807 | 4 | yes |
GO:0005509 | calcium ion binding | 10.5263 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EHD1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.1754 | 4 | yes |
GO:0008104 | protein localization | 56.1404 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 54.3860 | 4 | yes |
GO:0071702 | organic substance transport | 49.1228 | 4 | yes |
GO:0010646 | regulation of cell communication | 47.3684 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 47.3684 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.6140 | 4 | no |
GO:0006996 | organelle organization | 45.6140 | 4 | yes |
GO:0071705 | nitrogen compound transport | 45.6140 | 4 | yes |
GO:0022607 | cellular component assembly | 43.8596 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 42.1053 | 4 | no |
GO:0015031 | protein transport | 42.1053 | 4 | yes |
GO:0051049 | regulation of transport | 42.1053 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 36.8421 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.8421 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 36.8421 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 35.0877 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.0877 | 5 | no |
GO:0043067 | regulation of programmed cell death | 31.5789 | 4 | no |
GO:0010468 | regulation of gene expression | 31.5789 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 29.8246 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.8246 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 29.8246 | 5 | no |
GO:0042981 | regulation of apoptotic process | 29.8246 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 29.8246 | 5 | no |
GO:0060341 | regulation of cellular localization | 29.8246 | 4 | yes |
GO:0098657 | import into cell | 28.0702 | 4 | yes |
GO:0006886 | intracellular protein transport | 28.0702 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 28.0702 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 26.3158 | 5 | no |
GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
GO:0030030 | cell projection organization | 26.3158 | 4 | yes |
GO:0043933 | protein-containing complex organization | 26.3158 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 24.5614 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 24.5614 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.5614 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 24.5614 | 6 | no |
GO:2000145 | regulation of cell motility | 24.5614 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 24.5614 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.5614 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 24.5614 | 5 | no |
GO:0032880 | regulation of protein localization | 24.5614 | 5 | no |
GO:0051050 | positive regulation of transport | 24.5614 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 24.5614 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 22.8070 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.8070 | 4 | no |
GO:0030334 | regulation of cell migration | 22.8070 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.8070 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 22.8070 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 21.0526 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 21.0526 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 21.0526 | 5 | no |
GO:0141124 | intracellular signaling cassette | 21.0526 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.0526 | 6 | no |
GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.0526 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | no |
GO:0051046 | regulation of secretion | 21.0526 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.0526 | 5 | no |
GO:0061024 | membrane organization | 21.0526 | 4 | no |
GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | yes |
GO:0072657 | protein localization to membrane | 19.2982 | 4 | yes |
GO:0033365 | protein localization to organelle | 19.2982 | 5 | yes |
GO:0072659 | protein localization to plasma membrane | 17.5439 | 5 | yes |
GO:1990778 | protein localization to cell periphery | 17.5439 | 5 | yes |
GO:0032456 | endocytic recycling | 17.5439 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 15.7895 | 5 | yes |
GO:0030031 | cell projection assembly | 14.0351 | 5 | yes |
GO:0070925 | organelle assembly | 14.0351 | 5 | yes |
GO:0071363 | cellular response to growth factor stimulus | 14.0351 | 4 | yes |
GO:0031346 | positive regulation of cell projection organization | 12.2807 | 6 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 10.5263 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 10.5263 | 7 | yes |
GO:0031175 | neuron projection development | 10.5263 | 6 | yes |
GO:0032386 | regulation of intracellular transport | 10.5263 | 5 | yes |
GO:0051259 | protein complex oligomerization | 10.5263 | 6 | yes |
GO:1905952 | regulation of lipid localization | 8.7719 | 4 | yes |
GO:0010976 | positive regulation of neuron projection development | 8.7719 | 7 | yes |
GO:0044782 | cilium organization | 8.7719 | 5 | yes |
GO:0051260 | protein homooligomerization | 8.7719 | 7 | yes |
GO:0060271 | cilium assembly | 8.7719 | 6 | yes |
GO:1990089 | response to nerve growth factor | 7.0175 | 4 | yes |
GO:1990090 | cellular response to nerve growth factor stimulus | 7.0175 | 5 | yes |
GO:0032388 | positive regulation of intracellular transport | 7.0175 | 5 | yes |
GO:0061512 | protein localization to cilium | 7.0175 | 6 | yes |
GO:1905954 | positive regulation of lipid localization | 5.2632 | 4 | yes |
GO:2001135 | regulation of endocytic recycling | 5.2632 | 5 | yes |
GO:0042632 | cholesterol homeostasis | 5.2632 | 5 | yes |
GO:0055092 | sterol homeostasis | 5.2632 | 4 | yes |
GO:1901739 | regulation of myoblast fusion | 3.5088 | 5 | yes |
GO:1901741 | positive regulation of myoblast fusion | 3.5088 | 6 | yes |
GO:2001137 | positive regulation of endocytic recycling | 3.5088 | 6 | yes |
GO:0010883 | regulation of lipid storage | 3.5088 | 4 | yes |
GO:0010884 | positive regulation of lipid storage | 3.5088 | 5 | yes |
GO:0010885 | regulation of cholesterol storage | 3.5088 | 5 | yes |
GO:0010886 | positive regulation of cholesterol storage | 3.5088 | 6 | yes |
GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 3.5088 | 4 | yes |
GO:0060143 | positive regulation of syncytium formation by plasma membrane fusion | 3.5088 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RFFL_HUMAN | [view interactions] | Low throughput | no | yes |
CD44_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MUL1_HUMAN | [view interactions] | Low throughput | no | no |
ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPN3_HUMAN | [view interactions] | Low throughput | no | no |
MICA1_HUMAN | [view interactions] | Low throughput | no | yes |
RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PA24A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTMP_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
PAPD5_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC5A5_HUMAN | [view interactions] | High throughput | no | no |
RIGI_HUMAN | [view interactions] | High throughput | no | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
EHD2_HUMAN | [view interactions] | High throughput | no | no |
DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
SPXN5_HUMAN | [view interactions] | High throughput | no | no |
SCP2D_HUMAN | [view interactions] | High throughput | no | no |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
PLCA_HUMAN | [view interactions] | High throughput | no | yes |
NDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IL25_HUMAN | [view interactions] | High throughput | no | no |
NTNG1_HUMAN | [view interactions] | High throughput | no | no |
PHF11_HUMAN | [view interactions] | High throughput | no | no |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
HXB1_HUMAN | [view interactions] | High throughput | no | no |
MAP7_HUMAN | [view interactions] | High throughput | no | yes |
CQ082_HUMAN | [view interactions] | High throughput | no | no |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
CD79A_HUMAN | [view interactions] | High throughput | no | no |
SERB1_HUMAN | [view interactions] | High throughput | no | yes |
TRI11_HUMAN | [view interactions] | High throughput | no | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SLUR1_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AQ12B_HUMAN | [view interactions] | High throughput | no | no |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
CLD4_HUMAN | [view interactions] | High throughput | no | yes |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGKQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
API5_HUMAN | [view interactions] | High throughput | no | no |
ARI2_HUMAN | [view interactions] | High throughput | no | no |
ATE1_HUMAN | [view interactions] | High throughput | no | yes |
PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DRG2_HUMAN | [view interactions] | High throughput | no | yes |
FKBP9_HUMAN | [view interactions] | High throughput | no | yes |
PDC10_HUMAN | [view interactions] | High throughput | no | yes |
STAT6_HUMAN | [view interactions] | High throughput | no | yes |
TF3C4_HUMAN | [view interactions] | High throughput | no | no |
KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
NOL3_HUMAN | [view interactions] | High throughput | no | yes |
NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
PDE12_HUMAN | [view interactions] | High throughput | no | yes |
PGTB1_HUMAN | [view interactions] | High throughput | no | no |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBA6_HUMAN | [view interactions] | High throughput | no | no |
SYWC_HUMAN | [view interactions] | High throughput | no | yes |
XPP1_HUMAN | [view interactions] | High throughput | no | yes |
NNRE_HUMAN | [view interactions] | High throughput | no | yes |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TECR_HUMAN | [view interactions] | High throughput | no | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
FADD_HUMAN | [view interactions] | High throughput | no | yes |
FA98B_HUMAN | [view interactions] | High throughput | no | yes |
OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYTC_HUMAN | [view interactions] | High throughput | no | yes |
PPCE_HUMAN | [view interactions] | High throughput | no | yes |
DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
ARL14_HUMAN | [view interactions] | High throughput | no | no |
RAB25_HUMAN | [view interactions] | High throughput | no | no |
CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
SSR3_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TINF2_HUMAN | [view interactions] | High throughput | no | no |
EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMX1_HUMAN | [view interactions] | High throughput | no | no |
KI67_HUMAN | [view interactions] | High throughput | no | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
CD177_HUMAN | [view interactions] | High throughput | no | no |
RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STON2_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
TNR6_HUMAN | [view interactions] | High throughput | no | no |
TMM25_HUMAN | [view interactions] | High throughput | no | yes |
CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
SPXN3_HUMAN | [view interactions] | High throughput | no | no |