Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STK39_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in STK39_HUMAN
GO:0017076 purine nucleotide binding 47.8261 4 yes
GO:0032555 purine ribonucleotide binding 47.8261 4 yes
GO:0019900 kinase binding 43.4783 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.4783 4 yes
GO:0019901 protein kinase binding 39.1304 5 yes
GO:0030554 adenyl nucleotide binding 34.7826 5 yes
GO:0032559 adenyl ribonucleotide binding 34.7826 5 yes
GO:0046872 metal ion binding 34.7826 4 no
GO:0005524 ATP binding 30.4348 5 yes
GO:0004674 protein serine/threonine kinase activity 21.7391 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.7391 4 yes
GO:0016301 kinase activity 21.7391 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.7391 4 yes
GO:0106310 protein serine kinase activity 21.7391 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STK39_HUMAN
GO:0048522 positive regulation of cellular process 69.5652 4 yes
GO:0048523 negative regulation of cellular process 65.2174 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.8696 4 no
GO:0010468 regulation of gene expression 56.5217 5 no
GO:0010646 regulation of cell communication 56.5217 4 yes
GO:0051049 regulation of transport 52.1739 4 yes
GO:0031323 regulation of cellular metabolic process 52.1739 4 no
GO:0051171 regulation of nitrogen compound metabolic process 52.1739 4 no
GO:0080090 regulation of primary metabolic process 52.1739 4 no
GO:0009889 regulation of biosynthetic process 47.8261 4 no
GO:0071310 cellular response to organic substance 43.4783 4 yes
GO:0043269 regulation of ion transport 39.1304 5 yes
GO:0009892 negative regulation of metabolic process 39.1304 4 no
GO:0010556 regulation of macromolecule biosynthetic process 39.1304 5 no
GO:0031326 regulation of cellular biosynthetic process 39.1304 5 no
GO:0051246 regulation of protein metabolic process 39.1304 5 no
GO:0009966 regulation of signal transduction 39.1304 4 yes
GO:0010647 positive regulation of cell communication 39.1304 5 yes
GO:0023056 positive regulation of signaling 39.1304 4 yes
GO:0043412 macromolecule modification 34.7826 4 yes
GO:0048584 positive regulation of response to stimulus 34.7826 4 yes
GO:0051241 negative regulation of multicellular organismal process 34.7826 4 yes
GO:0006996 organelle organization 34.7826 4 no
GO:0009893 positive regulation of metabolic process 34.7826 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.7826 5 no
GO:0022607 cellular component assembly 34.7826 4 no
GO:0051128 regulation of cellular component organization 34.7826 4 no
GO:0009967 positive regulation of signal transduction 34.7826 5 yes
GO:0036211 protein modification process 30.4348 4 yes
GO:0048878 chemical homeostasis 30.4348 4 yes
GO:0051046 regulation of secretion 30.4348 5 yes
GO:1902531 regulation of intracellular signal transduction 30.4348 5 yes
GO:1902533 positive regulation of intracellular signal transduction 30.4348 6 yes
GO:2000145 regulation of cell motility 30.4348 4 yes
GO:0006355 regulation of DNA-templated transcription 30.4348 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 no
GO:0031324 negative regulation of cellular metabolic process 30.4348 5 no
GO:0051252 regulation of RNA metabolic process 30.4348 5 no
GO:0061024 membrane organization 30.4348 4 no
GO:1903506 regulation of nucleic acid-templated transcription 30.4348 7 no
GO:2001141 regulation of RNA biosynthetic process 30.4348 6 no
GO:0043933 protein-containing complex organization 30.4348 4 no
GO:0006796 phosphate-containing compound metabolic process 30.4348 4 yes
GO:0050801 ion homeostasis 26.0870 5 yes
GO:0051050 positive regulation of transport 26.0870 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 26.0870 7 no
GO:0008285 negative regulation of cell population proliferation 26.0870 5 no
GO:0010941 regulation of cell death 26.0870 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.0870 4 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0042127 regulation of cell population proliferation 26.0870 4 no
GO:0042981 regulation of apoptotic process 26.0870 6 no
GO:0043067 regulation of programmed cell death 26.0870 5 no
GO:0045595 regulation of cell differentiation 26.0870 4 no
GO:0051094 positive regulation of developmental process 26.0870 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 26.0870 5 no
GO:0051247 positive regulation of protein metabolic process 26.0870 6 no
GO:2000026 regulation of multicellular organismal development 26.0870 4 no
GO:0006811 ion transport 26.0870 4 no
GO:0006812 cation transport 26.0870 5 no
GO:0071705 nitrogen compound transport 26.0870 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.0870 5 no
GO:0065003 protein-containing complex assembly 26.0870 5 no
GO:0002684 positive regulation of immune system process 26.0870 4 yes
GO:0010959 regulation of metal ion transport 26.0870 6 yes
GO:0030334 regulation of cell migration 26.0870 5 yes
GO:0034097 response to cytokine 26.0870 4 yes
GO:0040017 positive regulation of locomotion 21.7391 4 yes
GO:0043270 positive regulation of ion transport 21.7391 5 yes
GO:0060249 anatomical structure homeostasis 21.7391 4 yes
GO:0071345 cellular response to cytokine stimulus 21.7391 5 yes
GO:2000147 positive regulation of cell motility 21.7391 5 yes
GO:0001932 regulation of protein phosphorylation 21.7391 7 no
GO:0010243 response to organonitrogen compound 21.7391 4 no
GO:0010628 positive regulation of gene expression 21.7391 6 no
GO:0010648 negative regulation of cell communication 21.7391 5 no
GO:0010942 positive regulation of cell death 21.7391 5 no
GO:0014070 response to organic cyclic compound 21.7391 4 no
GO:0019220 regulation of phosphate metabolic process 21.7391 6 no
GO:0023057 negative regulation of signaling 21.7391 4 no
GO:0030030 cell projection organization 21.7391 4 no
GO:0030155 regulation of cell adhesion 21.7391 4 no
GO:0032535 regulation of cellular component size 21.7391 4 no
GO:0042325 regulation of phosphorylation 21.7391 7 no
GO:0043065 positive regulation of apoptotic process 21.7391 7 no
GO:0043068 positive regulation of programmed cell death 21.7391 6 no
GO:0043085 positive regulation of catalytic activity 21.7391 4 no
GO:0048585 negative regulation of response to stimulus 21.7391 4 no
GO:0051093 negative regulation of developmental process 21.7391 4 no
GO:0051129 negative regulation of cellular component organization 21.7391 5 no
GO:0051130 positive regulation of cellular component organization 21.7391 5 no
GO:0051174 regulation of phosphorus metabolic process 21.7391 5 no
GO:0051240 positive regulation of multicellular organismal process 21.7391 4 no
GO:0051336 regulation of hydrolase activity 21.7391 4 no
GO:1901701 cellular response to oxygen-containing compound 21.7391 4 no
GO:0008104 protein localization 21.7391 4 no
GO:0030001 metal ion transport 21.7391 6 no
GO:0050804 modulation of chemical synaptic transmission 21.7391 5 no
GO:0071702 organic substance transport 21.7391 4 no
GO:0099177 regulation of trans-synaptic signaling 21.7391 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.7391 5 no
GO:0001894 tissue homeostasis 21.7391 5 yes
GO:0006468 protein phosphorylation 21.7391 5 yes
GO:0016310 phosphorylation 21.7391 5 yes
GO:0030335 positive regulation of cell migration 21.7391 6 yes
GO:0043408 regulation of MAPK cascade 17.3913 6 yes
GO:0043410 positive regulation of MAPK cascade 17.3913 7 yes
GO:0044057 regulation of system process 17.3913 4 yes
GO:0051051 negative regulation of transport 17.3913 4 yes
GO:0080134 regulation of response to stress 17.3913 4 yes
GO:1990868 response to chemokine 17.3913 5 yes
GO:1990869 cellular response to chemokine 17.3913 6 yes
GO:0002685 regulation of leukocyte migration 17.3913 4 yes
GO:0002687 positive regulation of leukocyte migration 17.3913 5 yes
GO:0018105 peptidyl-serine phosphorylation 17.3913 6 yes
GO:0018193 peptidyl-amino acid modification 17.3913 5 yes
GO:0018209 peptidyl-serine modification 17.3913 6 yes
GO:0032101 regulation of response to external stimulus 17.3913 4 yes
GO:0034762 regulation of transmembrane transport 17.3913 4 yes
GO:0034763 negative regulation of transmembrane transport 13.0435 5 yes
GO:0034765 regulation of ion transmembrane transport 13.0435 5 yes
GO:0046777 protein autophosphorylation 13.0435 6 yes
GO:0050920 regulation of chemotaxis 13.0435 4 yes
GO:0050921 positive regulation of chemotaxis 13.0435 5 yes
GO:0062197 cellular response to chemical stress 13.0435 4 yes
GO:0071675 regulation of mononuclear cell migration 13.0435 5 yes
GO:0071677 positive regulation of mononuclear cell migration 13.0435 6 yes
GO:0080135 regulation of cellular response to stress 13.0435 4 yes
GO:1904062 regulation of cation transmembrane transport 13.0435 6 yes
GO:2000401 regulation of lymphocyte migration 13.0435 6 yes
GO:2000403 positive regulation of lymphocyte migration 13.0435 7 yes
GO:2000404 regulation of T cell migration 13.0435 7 yes
GO:2000406 positive regulation of T cell migration 13.0435 8 yes
GO:0002028 regulation of sodium ion transport 13.0435 7 yes
GO:0002688 regulation of leukocyte chemotaxis 13.0435 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 13.0435 6 yes
GO:0018107 peptidyl-threonine phosphorylation 13.0435 6 yes
GO:0018210 peptidyl-threonine modification 13.0435 6 yes
GO:0032103 positive regulation of response to external stimulus 13.0435 5 yes
GO:0034764 positive regulation of transmembrane transport 8.6957 5 yes
GO:0034766 negative regulation of ion transmembrane transport 8.6957 6 yes
GO:0034767 positive regulation of ion transmembrane transport 8.6957 6 yes
GO:0036438 maintenance of lens transparency 8.6957 6 yes
GO:0038146 chemokine (C-X-C motif) ligand 12 signaling pathway 8.6957 6 yes
GO:0043266 regulation of potassium ion transport 8.6957 7 yes
GO:0043267 negative regulation of potassium ion transport 8.6957 6 yes
GO:0043268 positive regulation of potassium ion transport 8.6957 6 yes
GO:0043271 negative regulation of ion transport 8.6957 5 yes
GO:0044058 regulation of digestive system process 8.6957 5 yes
GO:0050727 regulation of inflammatory response 8.6957 5 yes
GO:0051048 negative regulation of secretion 8.6957 5 yes
GO:0060457 negative regulation of digestive system process 8.6957 5 yes
GO:0070098 chemokine-mediated signaling pathway 8.6957 5 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 8.6957 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 8.6957 6 yes
GO:0071470 cellular response to osmotic stress 8.6957 4 yes
GO:0071476 cellular hypotonic response 8.6957 5 yes
GO:0090186 regulation of pancreatic juice secretion 8.6957 4 yes
GO:0090188 negative regulation of pancreatic juice secretion 8.6957 5 yes
GO:0140131 positive regulation of lymphocyte chemotaxis 8.6957 7 yes
GO:1900744 regulation of p38MAPK cascade 8.6957 7 yes
GO:1900745 positive regulation of p38MAPK cascade 8.6957 8 yes
GO:1901016 regulation of potassium ion transmembrane transporter activity 8.6957 6 yes
GO:1901017 negative regulation of potassium ion transmembrane transporter activity 8.6957 6 yes
GO:1901379 regulation of potassium ion transmembrane transport 8.6957 7 yes
GO:1901380 negative regulation of potassium ion transmembrane transport 8.6957 7 yes
GO:1901623 regulation of lymphocyte chemotaxis 8.6957 6 yes
GO:1902305 regulation of sodium ion transmembrane transport 8.6957 7 yes
GO:1902306 negative regulation of sodium ion transmembrane transport 8.6957 7 yes
GO:1904063 negative regulation of cation transmembrane transport 8.6957 7 yes
GO:1905407 regulation of creatine transmembrane transporter activity 8.6957 6 yes
GO:1905408 negative regulation of creatine transmembrane transporter activity 8.6957 6 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 8.6957 6 yes
GO:2000650 negative regulation of sodium ion transmembrane transporter activity 8.6957 6 yes
GO:0006971 hypotonic response 8.6957 4 yes
GO:0010766 negative regulation of sodium ion transport 8.6957 6 yes
GO:0010819 regulation of T cell chemotaxis 8.6957 7 yes
GO:0010820 positive regulation of T cell chemotaxis 8.6957 8 yes
GO:0019221 cytokine-mediated signaling pathway 8.6957 4 yes
GO:0022898 regulation of transmembrane transporter activity 8.6957 4 yes
GO:0031347 regulation of defense response 8.6957 5 yes
GO:0032410 negative regulation of transporter activity 8.6957 4 yes
GO:0032411 positive regulation of transporter activity 8.6957 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 8.6957 5 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 8.6957 5 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 8.6957 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 8.6957 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 8.6957 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLK1_HUMAN [view interactions] Low throughput no yes
STK39_HUMAN [view entry] [view interactions] Low throughput yes yes
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
S12A6_HUMAN [view interactions] Low throughput no yes
S12A2_HUMAN [view entry] [view interactions] Low throughput yes yes
OTOF_HUMAN [view interactions] Low throughput no yes
WNK4_HUMAN [view interactions] Low throughput no yes
HS105_HUMAN [view entry] [view interactions] Low throughput yes yes
CAB39_HUMAN [view interactions] Low throughput no yes
MK14_HUMAN [view interactions] Low throughput no yes
MCP_HUMAN [view interactions] Low throughput no no
LMTK1_HUMAN [view interactions] Low throughput no yes
GELS_HUMAN [view entry] [view interactions] Low throughput yes no
DDB1_HUMAN [view interactions] Low throughput no yes
WDR6_HUMAN [view entry] [view interactions] Low throughput yes yes
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
DYR2_HUMAN [view interactions] High throughput no yes
OSTM1_HUMAN [view interactions] High throughput no yes
RBX2_HUMAN [view interactions] High throughput no yes
VMAT2_HUMAN [view entry] [view interactions] High throughput yes no
SV2A_HUMAN [view entry] [view interactions] High throughput yes yes
CSTL1_HUMAN [view interactions] High throughput no no
DB136_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
EFNA4_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
CST8_HUMAN [view interactions] High throughput no no
LY86_HUMAN [view interactions] High throughput no no
S22A4_HUMAN [view interactions] High throughput no yes
CRLF2_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
KLK15_HUMAN [view interactions] High throughput no no
MIA40_HUMAN [view interactions] High throughput no yes
I12R1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
API5_HUMAN [view interactions] High throughput no no
NOL3_HUMAN [view interactions] High throughput no yes
NUBP1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
EHD1_HUMAN [view entry] [view interactions] High throughput yes no
FKBP9_HUMAN [view interactions] High throughput no yes
XPP1_HUMAN [view interactions] High throughput no yes
KS6A2_HUMAN [view interactions] High throughput no yes
S12A1_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ARX_HUMAN [view interactions] High throughput no no
ATLA2_HUMAN [view entry] [view interactions] High throughput yes yes
KLRG2_HUMAN [view interactions] High throughput no no
RELL1_HUMAN [view interactions] High throughput no yes
SIA8D_HUMAN [view interactions] High throughput no yes
TR19L_HUMAN [view interactions] High throughput no no
PI2R_HUMAN [view interactions] High throughput no no
TOM22_HUMAN [view interactions] High throughput no yes
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
RELL2_HUMAN [view interactions] High throughput no no
SH3L1_HUMAN [view interactions] High throughput no yes
MK07_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ASHWN_HUMAN [view interactions] High throughput no yes
WNK3_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
OSTP_HUMAN [view interactions] High throughput no yes
T22D2_HUMAN [view interactions] High throughput no yes
PSG1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
MPIP2_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RAMP2_HUMAN [view interactions] High throughput no no
HNRC2_HUMAN [view interactions] High throughput no no
BAFL_HUMAN [view interactions] High throughput no no
CD80_HUMAN [view interactions] Computational no no
S12A3_HUMAN [view interactions] Computational no no
CD86_HUMAN [view interactions] Computational no yes
CD28_HUMAN [view interactions] Computational no no
KPCT_HUMAN [view interactions] Computational no no