T22D4_HUMAN
Evidence for PS localization
Functions
Transcriptional repressor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in T22D4_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 36.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 36.0000 | 5 | no |
| GO:0046872 | metal ion binding | 28.0000 | 4 | no |
| GO:0003723 | RNA binding | 24.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in T22D4_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 76.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 72.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 68.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 68.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 68.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 64.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 56.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 56.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 56.0000 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 56.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 56.0000 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 56.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 56.0000 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 48.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 48.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 48.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 48.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 44.0000 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 44.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 40.0000 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 40.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 40.0000 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 36.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 36.0000 | 4 | no |
| GO:0023057 | negative regulation of signaling | 36.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 36.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 36.0000 | 5 | no |
| GO:0051049 | regulation of transport | 36.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 36.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 32.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 32.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 32.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 32.0000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.0000 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 32.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 32.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.0000 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 28.0000 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 28.0000 | 7 | no |
| GO:1901214 | regulation of neuron death | 28.0000 | 5 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 28.0000 | 6 | no |
| GO:0043412 | macromolecule modification | 28.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 28.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 28.0000 | 5 | no |
| GO:0071702 | organic substance transport | 28.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.0000 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 24.0000 | 7 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.0000 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.0000 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 24.0000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 24.0000 | 6 | no |
| GO:0043269 | regulation of ion transport | 24.0000 | 5 | no |
| GO:0043523 | regulation of neuron apoptotic process | 24.0000 | 6 | no |
| GO:0048878 | chemical homeostasis | 24.0000 | 4 | no |
| GO:0050801 | ion homeostasis | 24.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 24.0000 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 24.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
| GO:0036211 | protein modification process | 24.0000 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 24.0000 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 24.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
| GO:0010942 | positive regulation of cell death | 24.0000 | 5 | no |
| GO:0043065 | positive regulation of apoptotic process | 24.0000 | 7 | no |
| GO:0043068 | positive regulation of programmed cell death | 24.0000 | 6 | no |
| GO:0043549 | regulation of kinase activity | 24.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.0000 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 24.0000 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.0000 | 5 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 24.0000 | 5 | no |
| GO:0008104 | protein localization | 24.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 20.0000 | 6 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 16.0000 | 7 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 16.0000 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 16.0000 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 16.0000 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in T22D4_HUMAN |
|---|---|---|---|---|
| DOID:440 | neuromuscular disease | 8.0000 | 5 | no |
| DOID:574 | peripheral nervous system disease | 8.0000 | 3 | no |
| DOID:870 | neuropathy | 8.0000 | 4 | no |
| DOID:1289 | neurodegenerative disease | 8.0000 | 4 | no |
| DOID:331 | central nervous system disease | 8.0000 | 3 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 8.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NRBP_HUMAN | [view interactions] | Low throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| T22D1_HUMAN | [view interactions] | Low throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ZN558_HUMAN | [view interactions] | High throughput | no | no |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3H2_HUMAN | [view interactions] | High throughput | no | yes |
| SPO16_HUMAN | [view interactions] | High throughput | no | no |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| CAH10_HUMAN | [view interactions] | High throughput | no | yes |
| CDC45_HUMAN | [view interactions] | High throughput | no | no |
| SH2B3_HUMAN | [view interactions] | High throughput | no | yes |
| RPC4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCL1A_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LBP_HUMAN | [view interactions] | High throughput | no | no |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTL_HUMAN | [view interactions] | High throughput | no | no |
| PDPR_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
| T22D2_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZMY10_HUMAN | [view interactions] | High throughput | no | no |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| ZBT24_HUMAN | [view interactions] | High throughput | no | no |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLIP_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MTNB_HUMAN | [view interactions] | High throughput | no | yes |
| CBX8_HUMAN | [view interactions] | High throughput | no | yes |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG09_HUMAN | [view interactions] | High throughput | no | no |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| PCD17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBTN1_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| FRMD6_HUMAN | [view interactions] | High throughput | no | no |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX11_HUMAN | [view interactions] | High throughput | no | no |
| CD5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN580_HUMAN | [view interactions] | High throughput | no | yes |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD42_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CKS2_HUMAN | [view interactions] | High throughput | no | yes |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| NOC4L_HUMAN | [view interactions] | High throughput | no | no |
| SYT17_HUMAN | [view interactions] | High throughput | no | no |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| MTHFS_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| RIMB1_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GO45_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| SMG8_HUMAN | [view interactions] | High throughput | no | yes |
| T22D3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| IF172_HUMAN | [view interactions] | High throughput | no | no |
| LRWD1_HUMAN | [view interactions] | High throughput | no | no |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1X_HUMAN | [view interactions] | High throughput | no | yes |
| CG061_HUMAN | [view interactions] | Computational | no | no |