GDS1_HUMAN
Evidence for PS localization
Functions
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed, PubMed). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDS1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 58.4906 | 4 | no |
| GO:0017076 | purine nucleotide binding | 58.4906 | 5 | no |
| GO:0043168 | anion binding | 56.6038 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 54.7170 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 54.7170 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 50.9434 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 50.9434 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 50.9434 | 6 | no |
| GO:0005525 | GTP binding | 43.3962 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 43.3962 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 43.3962 | 5 | no |
| GO:0003924 | GTPase activity | 41.5094 | 7 | no |
| GO:0043169 | cation binding | 22.6415 | 4 | no |
| GO:0046872 | metal ion binding | 22.6415 | 5 | no |
| GO:0019003 | GDP binding | 20.7547 | 5 | no |
| GO:0030695 | GTPase regulator activity | 7.5472 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.6604 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.2642 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.6038 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.8302 | 4 | yes |
| GO:0010646 | regulation of cell communication | 49.0566 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.2830 | 4 | yes |
| GO:0008104 | protein localization | 43.3962 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.3962 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3962 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.6226 | 4 | no |
| GO:0006996 | organelle organization | 37.7358 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 37.7358 | 4 | no |
| GO:0032880 | regulation of protein localization | 35.8491 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 35.8491 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 35.8491 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 35.8491 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.9623 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9623 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.0755 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 32.0755 | 5 | no |
| GO:2000145 | regulation of cell motility | 32.0755 | 4 | no |
| GO:0051049 | regulation of transport | 30.1887 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.1887 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.1887 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.1887 | 5 | no |
| GO:0030334 | regulation of cell migration | 30.1887 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.1887 | 4 | no |
| GO:0022607 | cellular component assembly | 28.3019 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.3019 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.3019 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.3019 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.3019 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.3019 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.3019 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.3019 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.3019 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.4151 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.5283 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.5283 | 5 | no |
| GO:0030030 | cell projection organization | 24.5283 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.5283 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.5283 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 24.5283 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.5283 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.6415 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.6415 | 6 | no |
| GO:0006915 | apoptotic process | 22.6415 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.6415 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.6415 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.6415 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.6415 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.6415 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.6415 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.6415 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.7547 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.7547 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.7547 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.7547 | 6 | no |
| GO:0031399 | regulation of protein modification process | 20.7547 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.7547 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.7547 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.7547 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.7547 | 5 | no |
| GO:0015031 | protein transport | 20.7547 | 4 | no |
| GO:0071702 | organic substance transport | 20.7547 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.7547 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 18.8679 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 15.0943 | 6 | yes |
| GO:0051046 | regulation of secretion | 15.0943 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 15.0943 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 15.0943 | 4 | yes |
| GO:0033365 | protein localization to organelle | 13.2075 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 13.2075 | 4 | yes |
| GO:0051223 | regulation of protein transport | 9.4340 | 5 | yes |
| GO:0034504 | protein localization to nucleus | 7.5472 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 7.5472 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 5.6604 | 4 | yes |
| GO:0010821 | regulation of mitochondrion organization | 5.6604 | 6 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 5.6604 | 5 | yes |
| GO:0051604 | protein maturation | 5.6604 | 4 | yes |
| GO:0055080 | monoatomic cation homeostasis | 5.6604 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 3.7736 | 4 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 3.7736 | 5 | yes |
| GO:0035150 | regulation of tube size | 3.7736 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 3.7736 | 5 | yes |
| GO:0042310 | vasoconstriction | 3.7736 | 6 | yes |
| GO:0050708 | regulation of protein secretion | 3.7736 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 3.7736 | 4 | yes |
| GO:0086103 | G protein-coupled receptor signaling pathway involved in heart process | 3.7736 | 4 | yes |
| GO:0097746 | blood vessel diameter maintenance | 3.7736 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIFA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DNAL1_HUMAN | [view interactions] | High throughput | no | no |
| NT5C_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| S18L2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHB1_HUMAN | [view interactions] | High throughput | no | no |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN451_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| RRAS_HUMAN | [view interactions] | High throughput | no | yes |
| RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB34_HUMAN | [view interactions] | High throughput | no | yes |
| RHES_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| APBB2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEP12_HUMAN | [view interactions] | High throughput | no | no |
| RAB31_HUMAN | [view interactions] | High throughput | no | yes |
| RSLAA_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CB048_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| VASH1_HUMAN | [view interactions] | High throughput | no | yes |
| KBRS2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASLC_HUMAN | [view interactions] | High throughput | no | no |
| RAB20_HUMAN | [view interactions] | High throughput | no | yes |
| IFT22_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSLBB_HUMAN | [view interactions] | High throughput | no | no |
| TMED8_HUMAN | [view interactions] | High throughput | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SL9A5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| GBA3_HUMAN | [view interactions] | High throughput | no | no |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| RNF12_HUMAN | [view interactions] | High throughput | no | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAB5_HUMAN | [view interactions] | High throughput | no | no |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB28_HUMAN | [view interactions] | High throughput | no | yes |
| CRNN_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ULA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB9_HUMAN | [view interactions] | High throughput | no | no |
| DIRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRD10_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I13R1_HUMAN | [view interactions] | High throughput | no | no |