GDS1_HUMAN
Evidence for PS localization
Functions
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed, PubMed). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDS1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 58.6957 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 58.6957 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 58.6957 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 56.5217 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 56.5217 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 56.5217 | 6 | no |
| GO:0005525 | GTP binding | 50.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 50.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 50.0000 | 5 | no |
| GO:0003924 | GTPase activity | 47.8261 | 7 | no |
| GO:0019003 | GDP binding | 26.0870 | 4 | no |
| GO:0046872 | metal ion binding | 23.9130 | 4 | no |
| GO:0019900 | kinase binding | 21.7391 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
| GO:0030695 | GTPase regulator activity | 6.5217 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.3913 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.1739 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.3043 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3043 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.3043 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.3043 | 4 | no |
| GO:0008104 | protein localization | 36.9565 | 4 | no |
| GO:0006996 | organelle organization | 34.7826 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
| GO:0007264 | small GTPase mediated signal transduction | 34.7826 | 4 | no |
| GO:0071310 | cellular response to organic substance | 32.6087 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 32.6087 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.6087 | 4 | no |
| GO:0051049 | regulation of transport | 32.6087 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.6087 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.4348 | 5 | no |
| GO:0033043 | regulation of organelle organization | 30.4348 | 5 | no |
| GO:0030030 | cell projection organization | 28.2609 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.2609 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2609 | 5 | no |
| GO:2000145 | regulation of cell motility | 28.2609 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.0870 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.0870 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 26.0870 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.0870 | 4 | no |
| GO:0030334 | regulation of cell migration | 26.0870 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 26.0870 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.0870 | 6 | no |
| GO:0032880 | regulation of protein localization | 26.0870 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 23.9130 | 4 | yes |
| GO:0010941 | regulation of cell death | 23.9130 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.9130 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.9130 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.9130 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 23.9130 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.9130 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.9130 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0007015 | actin filament organization | 21.7391 | 5 | no |
| GO:0008360 | regulation of cell shape | 21.7391 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 21.7391 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.7391 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 15.2174 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 15.2174 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.0435 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 8.6957 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 8.6957 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 8.6957 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 8.6957 | 5 | yes |
| GO:0003018 | vascular process in circulatory system | 4.3478 | 4 | yes |
| GO:0006873 | cellular ion homeostasis | 4.3478 | 4 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 4.3478 | 7 | yes |
| GO:0006875 | cellular metal ion homeostasis | 4.3478 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 4.3478 | 5 | yes |
| GO:0035150 | regulation of tube size | 4.3478 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 4.3478 | 5 | yes |
| GO:0042310 | vasoconstriction | 4.3478 | 6 | yes |
| GO:0048878 | chemical homeostasis | 4.3478 | 4 | yes |
| GO:0050801 | ion homeostasis | 4.3478 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 4.3478 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 4.3478 | 8 | yes |
| GO:0055080 | cation homeostasis | 4.3478 | 6 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 4.3478 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 4.3478 | 7 | yes |
| GO:0097746 | blood vessel diameter maintenance | 4.3478 | 5 | yes |
| GO:0098771 | inorganic ion homeostasis | 4.3478 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIFA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB9_HUMAN | [view interactions] | High throughput | no | no |
| PRD10_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IIGP5_HUMAN | [view interactions] | High throughput | no | no |
| NT5C_HUMAN | [view interactions] | High throughput | no | yes |
| DNAL1_HUMAN | [view interactions] | High throughput | no | no |
| I13R1_HUMAN | [view interactions] | High throughput | no | no |
| RAB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALB_HUMAN | [view interactions] | High throughput | no | no |
| S18L2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHB1_HUMAN | [view interactions] | High throughput | no | no |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN451_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| RRAS_HUMAN | [view interactions] | High throughput | no | yes |
| RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB34_HUMAN | [view interactions] | High throughput | no | yes |
| RHES_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| APBB2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEP12_HUMAN | [view interactions] | High throughput | no | no |
| RAB31_HUMAN | [view interactions] | High throughput | no | yes |
| RSLAA_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CB048_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS23_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| VASH1_HUMAN | [view interactions] | High throughput | no | yes |
| KBRS2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASLC_HUMAN | [view interactions] | High throughput | no | no |
| RAB20_HUMAN | [view interactions] | High throughput | no | yes |
| IFT22_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSLBB_HUMAN | [view interactions] | High throughput | no | no |
| TMED8_HUMAN | [view interactions] | High throughput | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SL9A5_HUMAN | [view interactions] | High throughput | no | no |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| GBA3_HUMAN | [view interactions] | High throughput | no | no |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| RNF12_HUMAN | [view interactions] | High throughput | no | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAB5_HUMAN | [view interactions] | High throughput | no | no |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB28_HUMAN | [view interactions] | High throughput | no | yes |
| CRNN_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ULA1_HUMAN | [view interactions] | High throughput | no | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |