DOC2A_HUMAN
Evidence for PS localization
Functions
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DOC2A_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 50.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 50.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DOC2A_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 75.0000 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 50.0000 | 4 | yes |
| GO:0006887 | exocytosis | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 6 | yes |
| GO:0007269 | neurotransmitter secretion | 50.0000 | 4 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 50.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 50.0000 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 50.0000 | 7 | yes |
| GO:0023061 | signal release | 50.0000 | 4 | yes |
| GO:0045055 | regulated exocytosis | 50.0000 | 5 | yes |
| GO:0046903 | secretion | 50.0000 | 4 | yes |
| GO:0051046 | regulation of secretion | 50.0000 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 50.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 5 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 50.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0099643 | signal release from synapse | 50.0000 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 50.0000 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 50.0000 | 4 | yes |
| GO:0010941 | regulation of cell death | 50.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 50.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 50.0000 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 50.0000 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 50.0000 | 5 | no |
| GO:0043069 | negative regulation of programmed cell death | 50.0000 | 6 | no |
| GO:0043269 | regulation of ion transport | 50.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0060548 | negative regulation of cell death | 50.0000 | 5 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 50.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 50.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEGN_HUMAN | [view interactions] | Low throughput | no | no |
| UN13B_HUMAN | [view interactions] | Low throughput | no | no |
| G137B_HUMAN | [view interactions] | High throughput | no | yes |
| SETMR_HUMAN | [view interactions] | High throughput | no | no |
| DOC2B_HUMAN | [view interactions] | High throughput | no | no |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| TT21B_HUMAN | [view interactions] | High throughput | no | yes |
| KCD21_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRNT1_HUMAN | [view interactions] | High throughput | no | yes |
| S22AN_HUMAN | [view interactions] | High throughput | no | yes |
| KIME_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |