DOC2A_HUMAN
Evidence for PS localization
Functions
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DOC2A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | yes |
| GO:0019900 | kinase binding | 50.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 50.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DOC2A_HUMAN |
|---|---|---|---|---|
| GO:0033043 | regulation of organelle organization | 100.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 100.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 100.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 75.0000 | 7 | yes |
| GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
| GO:0051046 | regulation of secretion | 75.0000 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 75.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 75.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 75.0000 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 75.0000 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 50.0000 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 50.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 50.0000 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 50.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 50.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 50.0000 | 5 | no |
| GO:0006836 | neurotransmitter transport | 50.0000 | 4 | yes |
| GO:0007269 | neurotransmitter secretion | 50.0000 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 50.0000 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 50.0000 | 5 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 50.0000 | 7 | yes |
| GO:0023061 | signal release | 50.0000 | 4 | yes |
| GO:0031338 | regulation of vesicle fusion | 50.0000 | 5 | yes |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 50.0000 | 6 | yes |
| GO:0046903 | secretion | 50.0000 | 4 | yes |
| GO:0051050 | positive regulation of transport | 50.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 50.0000 | 4 | yes |
| GO:0099643 | signal release from synapse | 50.0000 | 5 | yes |
| GO:1901632 | regulation of synaptic vesicle membrane organization | 50.0000 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 50.0000 | 6 | yes |
| GO:0006915 | apoptotic process | 50.0000 | 4 | no |
| GO:0010821 | regulation of mitochondrion organization | 50.0000 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEGN_HUMAN | [view interactions] | Low throughput | no | no |
| UN13B_HUMAN | [view interactions] | Low throughput | no | no |
| G137B_HUMAN | [view interactions] | High throughput | no | yes |
| SETMR_HUMAN | [view interactions] | High throughput | no | no |
| DOC2B_HUMAN | [view interactions] | High throughput | no | no |
| KCD21_HUMAN | [view interactions] | High throughput | no | no |
| TT21B_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRNT1_HUMAN | [view interactions] | High throughput | no | yes |
| S22AN_HUMAN | [view interactions] | High throughput | no | yes |
| KIME_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |