Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ETFB_HUMAN

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed, PubMed, PubMed). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed, PubMed). ETFB binds an AMP molecule that probably has a purely structural role (PubMed, PubMed, PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
164 Arg Gln Glutaricaciduria2B(GA2B) -
128 Asp Asn Glutaricaciduria2B(GA2B) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ETFB_HUMAN
GO:0043168 anion binding 32.9787 4 no
GO:0000166 nucleotide binding 30.8511 4 no
GO:0017076 purine nucleotide binding 28.7234 5 no
GO:0030554 adenyl nucleotide binding 24.4681 6 no
GO:0043169 cation binding 20.2128 4 no
GO:0003723 RNA binding 20.2128 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ETFB_HUMAN
GO:0022607 cellular component assembly 32.9787 4 no
GO:0048522 positive regulation of cellular process 32.9787 4 no
GO:0060255 regulation of macromolecule metabolic process 30.8511 4 no
GO:0006796 phosphate-containing compound metabolic process 29.7872 4 no
GO:0031323 regulation of cellular metabolic process 29.7872 4 no
GO:0019752 carboxylic acid metabolic process 28.7234 5 yes
GO:0043436 oxoacid metabolic process 28.7234 4 yes
GO:0048523 negative regulation of cellular process 28.7234 4 no
GO:0080090 regulation of primary metabolic process 28.7234 4 no
GO:0043933 protein-containing complex organization 27.6596 4 no
GO:0006996 organelle organization 26.5957 4 no
GO:0010646 regulation of cell communication 26.5957 4 no
GO:0065003 protein-containing complex assembly 26.5957 5 no
GO:0009889 regulation of biosynthetic process 25.5319 4 no
GO:0009893 positive regulation of metabolic process 25.5319 4 no
GO:0031326 regulation of cellular biosynthetic process 24.4681 5 no
GO:0010468 regulation of gene expression 23.4043 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.4043 5 no
GO:0009966 regulation of signal transduction 22.3404 4 no
GO:0051128 regulation of cellular component organization 22.3404 4 no
GO:1901566 organonitrogen compound biosynthetic process 22.3404 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.2766 5 no
GO:1901362 organic cyclic compound biosynthetic process 21.2766 4 no
GO:0006163 purine nucleotide metabolic process 21.2766 5 no
GO:0006753 nucleoside phosphate metabolic process 21.2766 4 no
GO:0009117 nucleotide metabolic process 21.2766 5 no
GO:0072521 purine-containing compound metabolic process 21.2766 4 no
GO:0032787 monocarboxylic acid metabolic process 20.2128 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.2128 5 no
GO:0009150 purine ribonucleotide metabolic process 20.2128 6 no
GO:0009259 ribonucleotide metabolic process 20.2128 5 no
GO:0019693 ribose phosphate metabolic process 20.2128 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 20.2128 4 no
GO:0016054 organic acid catabolic process 18.0851 4 yes
GO:0046395 carboxylic acid catabolic process 18.0851 5 yes
GO:0022900 electron transport chain 17.0213 4 yes
GO:0022904 respiratory electron transport chain 17.0213 5 yes
GO:0006631 fatty acid metabolic process 13.8298 4 yes
GO:0009063 amino acid catabolic process 12.7660 4 yes
GO:0016042 lipid catabolic process 12.7660 4 yes
GO:0030258 lipid modification 11.7021 4 yes
GO:0006635 fatty acid beta-oxidation 10.6383 6 yes
GO:0009062 fatty acid catabolic process 10.6383 5 yes
GO:0019395 fatty acid oxidation 10.6383 5 yes
GO:0034440 lipid oxidation 10.6383 5 yes
GO:0044242 cellular lipid catabolic process 10.6383 4 yes
GO:0072329 monocarboxylic acid catabolic process 10.6383 6 yes
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 2.1277 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ETFA_HUMAN [view interactions] Low throughput no yes
GCDH_HUMAN [view interactions] Low throughput no yes
ACADM_HUMAN [view interactions] Low throughput no yes
FAKD2_HUMAN [view interactions] High throughput no no
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
RRF2M_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
MCUB_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
FMT_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
TMM70_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
SYAM_HUMAN [view interactions] High throughput no yes
TMT1A_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
ATPB_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
BT3L4_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
GLYR1_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
RT27_HUMAN [view interactions] High throughput no yes
RT31_HUMAN [view interactions] High throughput no yes
RT35_HUMAN [view interactions] High throughput no yes
RT05_HUMAN [view interactions] High throughput no yes
RT09_HUMAN [view interactions] High throughput no yes
NACAM_HUMAN [view interactions] High throughput no no
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA6_HUMAN [view interactions] High throughput no no
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
NOS1_HUMAN [view entry] [view interactions] High throughput yes yes
NT5D3_HUMAN [view interactions] High throughput no no
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
PDK2_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
PDK3_HUMAN [view entry] [view interactions] High throughput yes yes
BMR1A_HUMAN [view interactions] High throughput no no
PTCD3_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
P5CR2_HUMAN [view interactions] High throughput no yes
ATLA3_HUMAN [view interactions] High throughput no no
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
GOT1B_HUMAN [view interactions] High throughput no yes
TIM44_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
TM10C_HUMAN [view interactions] High throughput no yes
ETFR1_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
IVD_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CISD3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
COQ6_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
FMC1_HUMAN [view interactions] High throughput no no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NDKM_HUMAN [view interactions] High throughput no yes
OPA3_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
PLD3B_HUMAN [view interactions] High throughput no yes
PHIPL_HUMAN [view interactions] High throughput no yes
SUCHY_HUMAN [view interactions] High throughput no yes
PRS35_HUMAN [view interactions] High throughput no no
MET14_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
TMIG1_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
IKKE_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
FAKD3_HUMAN [view interactions] High throughput no yes
HLAA_HUMAN [view interactions] High throughput no no
DRC5_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
SWAP1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
TISB_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
WDTC1_HUMAN [view interactions] High throughput no yes
EYA2_HUMAN [view interactions] High throughput no yes
GMCL1_HUMAN [view interactions] High throughput no yes
AKA11_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
ACPM_HUMAN [view interactions] High throughput no yes
KNL1_HUMAN [view interactions] High throughput no no
DSN1_HUMAN [view interactions] High throughput no yes
PLCH1_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
TBB8_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
CH082_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ASSY_HUMAN [view interactions] High throughput no yes
BLVRB_HUMAN [view entry] [view interactions] High throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT3_HUMAN [view interactions] High throughput no yes
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
RER1_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
CL16A_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAA_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
I2BPL_HUMAN [view interactions] High throughput no yes
CAPG_HUMAN [view entry] [view interactions] High throughput yes no
GRHPR_HUMAN [view entry] [view interactions] High throughput yes no
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
PGTA_HUMAN [view interactions] High throughput no yes
GPX4_HUMAN [view entry] [view interactions] High throughput yes no
PIPNB_HUMAN [view interactions] High throughput no no
KAD2_HUMAN [view interactions] High throughput no no
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
ACADS_HUMAN [view interactions] High throughput no yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
CLYBL_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
ECH1_HUMAN [view interactions] High throughput no yes
ECI1_HUMAN [view interactions] High throughput no yes
HIBCH_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
ACADL_HUMAN [view interactions] High throughput no no
ACADV_HUMAN [view interactions] High throughput no yes
ECHM_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB2_HUMAN [view interactions] High throughput no no
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
HMGCL_HUMAN [view interactions] High throughput no yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
GABT_HUMAN [view interactions] High throughput no yes
PGM2_HUMAN [view interactions] High throughput no no
GLTP_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
MRM1_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
MRES1_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes