CAPG_HUMAN
Evidence for PS localization
Functions
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAPG_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 33.3333 | 4 | yes |
| GO:0003779 | actin binding | 16.6667 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 16.6667 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 16.6667 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 16.6667 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAPG_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 41.6667 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 41.6667 | 4 | no |
| GO:0051049 | regulation of transport | 41.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | yes |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051223 | regulation of protein transport | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 25.0000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
| GO:0007015 | actin filament organization | 16.6667 | 5 | yes |
| GO:0008154 | actin polymerization or depolymerization | 16.6667 | 6 | yes |
| GO:0030030 | cell projection organization | 16.6667 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.6667 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 16.6667 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 16.6667 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 16.6667 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 16.6667 | 5 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| NEK8_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KI21B_HUMAN | [view interactions] | High throughput | no | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| CCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| SETMR_HUMAN | [view interactions] | High throughput | no | no |
| KLH11_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| OAZ3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC9_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTR2_HUMAN | [view interactions] | High throughput | no | no |
| SIA7F_HUMAN | [view interactions] | High throughput | no | yes |
| FCF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB1_HUMAN | [view interactions] | High throughput | no | no |
| ADK_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |