PRDX6_HUMAN
Evidence for PS localization
Functions
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed, PubMed). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed, PubMed). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PRDX6_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 27.9412 | 4 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.5882 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 19.1176 | 5 | yes |
| GO:0045296 | cadherin binding | 19.1176 | 4 | yes |
| GO:0008379 | thioredoxin peroxidase activity | 7.3529 | 5 | yes |
| GO:0140824 | thioredoxin-dependent peroxiredoxin activity | 7.3529 | 4 | yes |
| GO:0004620 | phospholipase activity | 5.8824 | 5 | yes |
| GO:0016298 | lipase activity | 5.8824 | 4 | yes |
| GO:0004623 | phospholipase A2 activity | 4.4118 | 5 | yes |
| GO:0008374 | O-acyltransferase activity | 4.4118 | 5 | yes |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4.4118 | 4 | yes |
| GO:0047499 | calcium-independent phospholipase A2 activity | 4.4118 | 6 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 4.4118 | 4 | yes |
| GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity | 2.9412 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PRDX6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.4118 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.0588 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.5882 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.5882 | 4 | yes |
| GO:0010468 | regulation of gene expression | 42.6471 | 5 | yes |
| GO:0010646 | regulation of cell communication | 41.1765 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.7059 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.2941 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 33.8235 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.8235 | 5 | yes |
| GO:0010941 | regulation of cell death | 33.8235 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 32.3529 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 32.3529 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.8824 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.8824 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 30.8824 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.8824 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.8824 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.8824 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.8824 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 29.4118 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.4118 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.9412 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.4706 | 5 | no |
| GO:0043412 | macromolecule modification | 26.4706 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.4706 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.4706 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.4706 | 6 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 6 | no |
| GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.5294 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:0008104 | protein localization | 23.5294 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 22.0588 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 22.0588 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.0588 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.0588 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.0588 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.0588 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.0588 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.5882 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.5882 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5882 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.5882 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 20.5882 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 17.6471 | 6 | yes |
| GO:0016042 | lipid catabolic process | 8.8235 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 7.3529 | 4 | yes |
| GO:0044242 | cellular lipid catabolic process | 7.3529 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 7.3529 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 5.8824 | 5 | yes |
| GO:0009395 | phospholipid catabolic process | 5.8824 | 5 | yes |
| GO:0046434 | organophosphate catabolic process | 5.8824 | 4 | yes |
| GO:0046475 | glycerophospholipid catabolic process | 5.8824 | 6 | yes |
| GO:0046503 | glycerolipid catabolic process | 5.8824 | 5 | yes |
| GO:1903311 | regulation of mRNA metabolic process | 5.8824 | 6 | yes |
| GO:0033120 | positive regulation of RNA splicing | 4.4118 | 7 | yes |
| GO:0043484 | regulation of RNA splicing | 4.4118 | 6 | yes |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | 4.4118 | 7 | yes |
| GO:0048026 | positive regulation of mRNA splicing, via spliceosome | 4.4118 | 8 | yes |
| GO:0050684 | regulation of mRNA processing | 4.4118 | 7 | yes |
| GO:0050685 | positive regulation of mRNA processing | 4.4118 | 8 | yes |
| GO:1903313 | positive regulation of mRNA metabolic process | 4.4118 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PRDX6_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.8824 | 3 | no |
| DOID:574 | peripheral nervous system disease | 4.4118 | 3 | no |
| DOID:870 | neuropathy | 4.4118 | 4 | no |
| DOID:1289 | neurodegenerative disease | 4.4118 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 2.9412 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 2.9412 | 6 | no |
| DOID:440 | neuromuscular disease | 2.9412 | 5 | no |
| DOID:0050890 | synucleinopathy | 2.9412 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 2.9412 | 7 | no |
| DOID:14330 | Parkinsons disease | 2.9412 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCF2_HUMAN | [view interactions] | Low throughput | no | no |
| GSTP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CASPA_HUMAN | [view interactions] | Low throughput | no | yes |
| STH_HUMAN | [view interactions] | Low throughput | no | no |
| F168B_HUMAN | [view interactions] | Low throughput | no | yes |
| APEX1_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
| SFTA1_HUMAN | [view interactions] | Low throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAN3_HUMAN | [view interactions] | High throughput | no | no |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM9_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PDES1_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| CAPG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENOPH_HUMAN | [view interactions] | High throughput | no | yes |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAAI_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
| RISC_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGL_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUFU_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA3_HUMAN | [view interactions] | High throughput | no | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| A1AG2_HUMAN | [view interactions] | High throughput | no | no |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD52_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| CDKL3_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPSP_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| HNF4G_HUMAN | [view interactions] | High throughput | no | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| ASB12_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| MARH6_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| TRXR1_HUMAN | [view interactions] | Computational | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| HPGDS_HUMAN | [view interactions] | Computational | no | no |
| CNDP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHAC2_HUMAN | [view interactions] | Computational | no | no |
| GGT7_HUMAN | [view interactions] | Computational | no | yes |
| THIO_HUMAN | [view interactions] | Computational | no | yes |
| GGT1_HUMAN | [view interactions] | Computational | no | no |
| GGT5_HUMAN | [view interactions] | Computational | no | yes |