GSTO1_HUMAN
Evidence for PS localization
Functions
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GSTO1_HUMAN |
|---|---|---|---|---|
| GO:0004364 | glutathione transferase activity | 16.1290 | 4 | yes |
| GO:0015036 | disulfide oxidoreductase activity | 9.6774 | 4 | yes |
| GO:0015038 | glutathione disulfide oxidoreductase activity | 6.4516 | 5 | yes |
| GO:0016672 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor | 6.4516 | 4 | yes |
| GO:0030614 | oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor | 6.4516 | 4 | yes |
| GO:0050610 | methylarsonate reductase activity | 6.4516 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GSTO1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 45.1613 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 38.7097 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 38.7097 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.7097 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 32.2581 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.2581 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.2581 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.2581 | 4 | no |
| GO:0006518 | peptide metabolic process | 25.8065 | 4 | yes |
| GO:0006749 | glutathione metabolic process | 25.8065 | 4 | yes |
| GO:0043603 | cellular amide metabolic process | 25.8065 | 4 | yes |
| GO:0051049 | regulation of transport | 25.8065 | 4 | yes |
| GO:0010941 | regulation of cell death | 25.8065 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 25.8065 | 5 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 25.8065 | 6 | no |
| GO:0010468 | regulation of gene expression | 25.8065 | 5 | no |
| GO:0010646 | regulation of cell communication | 25.8065 | 4 | no |
| GO:0080134 | regulation of response to stress | 25.8065 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 22.5806 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 22.5806 | 4 | yes |
| GO:0043269 | regulation of ion transport | 22.5806 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 22.5806 | 6 | no |
| GO:0060548 | negative regulation of cell death | 22.5806 | 5 | no |
| GO:0043412 | macromolecule modification | 22.5806 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.5806 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 22.5806 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.5806 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 22.5806 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.5806 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5806 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5806 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.5806 | 5 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 19.3548 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 19.3548 | 5 | yes |
| GO:0051050 | positive regulation of transport | 19.3548 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 19.3548 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 19.3548 | 6 | yes |
| GO:0019722 | calcium-mediated signaling | 16.1290 | 5 | yes |
| GO:0019932 | second-messenger-mediated signaling | 16.1290 | 4 | yes |
| GO:0044057 | regulation of system process | 16.1290 | 4 | yes |
| GO:0051051 | negative regulation of transport | 16.1290 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 16.1290 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 12.9032 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 12.9032 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 12.9032 | 6 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 12.9032 | 6 | yes |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 12.9032 | 7 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 12.9032 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 12.9032 | 6 | yes |
| GO:0032410 | negative regulation of transporter activity | 12.9032 | 4 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 12.9032 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 12.9032 | 5 | yes |
| GO:0034766 | negative regulation of ion transmembrane transport | 12.9032 | 6 | yes |
| GO:0042178 | xenobiotic catabolic process | 12.9032 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 12.9032 | 5 | yes |
| GO:0043271 | negative regulation of ion transport | 12.9032 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 12.9032 | 4 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 12.9032 | 5 | yes |
| GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 12.9032 | 6 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 12.9032 | 4 | yes |
| GO:0051284 | positive regulation of sequestering of calcium ion | 12.9032 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 12.9032 | 7 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 12.9032 | 6 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 12.9032 | 7 | yes |
| GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 12.9032 | 6 | yes |
| GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 12.9032 | 7 | yes |
| GO:0090257 | regulation of muscle system process | 12.9032 | 5 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 12.9032 | 6 | yes |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 12.9032 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 12.9032 | 7 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 12.9032 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 12.9032 | 7 | yes |
| GO:2001258 | negative regulation of cation channel activity | 12.9032 | 6 | yes |
| GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling | 9.6774 | 6 | yes |
| GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | 9.6774 | 7 | yes |
| GO:0014819 | regulation of skeletal muscle contraction | 9.6774 | 8 | yes |
| GO:0032411 | positive regulation of transporter activity | 9.6774 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 9.6774 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 9.6774 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 9.6774 | 6 | yes |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 9.6774 | 6 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 9.6774 | 6 | yes |
| GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 9.6774 | 7 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 9.6774 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 9.6774 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 9.6774 | 7 | yes |
| GO:2001259 | positive regulation of cation channel activity | 9.6774 | 6 | yes |
| GO:0006767 | water-soluble vitamin metabolic process | 6.4516 | 4 | yes |
| GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | 6.4516 | 7 | yes |
| GO:0019852 | L-ascorbic acid metabolic process | 6.4516 | 4 | yes |
| GO:0045933 | positive regulation of muscle contraction | 6.4516 | 5 | yes |
| GO:0045989 | positive regulation of striated muscle contraction | 6.4516 | 6 | yes |
| GO:0071243 | cellular response to arsenic-containing substance | 6.4516 | 4 | yes |
| GO:1901334 | lactone metabolic process | 6.4516 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM48_HUMAN | [view interactions] | High throughput | no | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE126_HUMAN | [view interactions] | High throughput | no | no |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE7_HUMAN | [view interactions] | High throughput | no | no |
| GSTO2_HUMAN | [view interactions] | High throughput | no | no |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTT1_HUMAN | [view interactions] | High throughput | no | no |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN9_HUMAN | [view interactions] | High throughput | no | no |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| FKB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTA4_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| LYPA2_HUMAN | [view interactions] | High throughput | no | no |
| NUDT9_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTDC2_HUMAN | [view interactions] | High throughput | no | no |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACSF2_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| PREY_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOC10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCS_HUMAN | [view interactions] | High throughput | no | yes |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| NNRE_HUMAN | [view interactions] | High throughput | no | yes |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| MGST2_HUMAN | [view interactions] | Computational | no | no |
| GSTM3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STAT4_HUMAN | [view interactions] | Computational | no | yes |
| HPGDS_HUMAN | [view interactions] | Computational | no | no |
| GSHR_HUMAN | [view interactions] | Computational | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GPX4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GSTT2_HUMAN | [view interactions] | Computational | no | no |