Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GSTO1_HUMAN

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GSTO1_HUMAN
GO:0043169 cation binding 21.8750 4 no
GO:0046872 metal ion binding 21.8750 5 no
GO:0004364 glutathione transferase activity 9.3750 4 yes
GO:0015036 disulfide oxidoreductase activity 9.3750 4 yes
GO:0015038 glutathione disulfide oxidoreductase activity 6.2500 5 yes
GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor 6.2500 4 yes
GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor 6.2500 4 yes
GO:0050610 methylarsonate reductase activity 6.2500 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GSTO1_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0048523 negative regulation of cellular process 43.7500 4 yes
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0009889 regulation of biosynthetic process 34.3750 4 no
GO:0009893 positive regulation of metabolic process 34.3750 4 no
GO:0010646 regulation of cell communication 34.3750 4 no
GO:0080090 regulation of primary metabolic process 34.3750 4 no
GO:0009966 regulation of signal transduction 31.2500 4 no
GO:0010468 regulation of gene expression 31.2500 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0019752 carboxylic acid metabolic process 28.1250 5 yes
GO:0043436 oxoacid metabolic process 28.1250 4 yes
GO:0006796 phosphate-containing compound metabolic process 28.1250 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.1250 5 no
GO:0022607 cellular component assembly 28.1250 4 no
GO:0042981 regulation of apoptotic process 28.1250 5 no
GO:0043067 regulation of programmed cell death 28.1250 4 no
GO:0043412 macromolecule modification 28.1250 4 no
GO:0051246 regulation of protein metabolic process 28.1250 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0051049 regulation of transport 21.8750 4 yes
GO:0006996 organelle organization 21.8750 4 no
GO:0009892 negative regulation of metabolic process 21.8750 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.8750 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.8750 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.8750 5 no
GO:0019220 regulation of phosphate metabolic process 21.8750 6 no
GO:0031324 negative regulation of cellular metabolic process 21.8750 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.8750 6 no
GO:0031399 regulation of protein modification process 21.8750 6 no
GO:0032101 regulation of response to external stimulus 21.8750 4 no
GO:0051174 regulation of phosphorus metabolic process 21.8750 5 no
GO:0080134 regulation of response to stress 21.8750 4 no
GO:1902531 regulation of intracellular signal transduction 21.8750 5 no
GO:0022898 regulation of transmembrane transporter activity 18.7500 4 yes
GO:0034762 regulation of transmembrane transport 18.7500 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 15.6250 5 yes
GO:0141124 intracellular signaling cassette 15.6250 4 yes
GO:0044057 regulation of system process 12.5000 4 yes
GO:0051050 positive regulation of transport 12.5000 4 yes
GO:0006937 regulation of muscle contraction 9.3750 6 yes
GO:0006942 regulation of striated muscle contraction 9.3750 7 yes
GO:0008016 regulation of heart contraction 9.3750 6 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 9.3750 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 9.3750 7 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 9.3750 6 yes
GO:0010959 regulation of metal ion transport 9.3750 6 yes
GO:0019722 calcium-mediated signaling 9.3750 5 yes
GO:0032410 negative regulation of transporter activity 9.3750 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 9.3750 5 yes
GO:0034763 negative regulation of transmembrane transport 9.3750 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 9.3750 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 9.3750 6 yes
GO:0043269 regulation of monoatomic ion transport 9.3750 5 yes
GO:0043271 negative regulation of monoatomic ion transport 9.3750 5 yes
GO:0051051 negative regulation of transport 9.3750 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 9.3750 5 yes
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 9.3750 6 yes
GO:0051282 regulation of sequestering of calcium ion 9.3750 4 yes
GO:0051284 positive regulation of sequestering of calcium ion 9.3750 5 yes
GO:0051924 regulation of calcium ion transport 9.3750 7 yes
GO:0051926 negative regulation of calcium ion transport 9.3750 6 yes
GO:0055117 regulation of cardiac muscle contraction 9.3750 7 yes
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 9.3750 6 yes
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 9.3750 7 yes
GO:0071243 cellular response to arsenic-containing substance 9.3750 4 yes
GO:0090257 regulation of muscle system process 9.3750 5 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 9.3750 6 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 9.3750 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 9.3750 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 9.3750 7 yes
GO:1903522 regulation of blood circulation 9.3750 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 9.3750 6 yes
GO:1904063 negative regulation of cation transmembrane transport 9.3750 7 yes
GO:2001257 regulation of cation channel activity 9.3750 6 yes
GO:2001258 negative regulation of cation channel activity 9.3750 6 yes
GO:0006767 water-soluble vitamin metabolic process 6.2500 4 yes
GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling 6.2500 6 yes
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 6.2500 7 yes
GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 6.2500 7 yes
GO:0014819 regulation of skeletal muscle contraction 6.2500 8 yes
GO:0019852 L-ascorbic acid metabolic process 6.2500 4 yes
GO:0032411 positive regulation of transporter activity 6.2500 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 6.2500 5 yes
GO:0034764 positive regulation of transmembrane transport 6.2500 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 6.2500 6 yes
GO:0042178 xenobiotic catabolic process 6.2500 4 yes
GO:0043270 positive regulation of monoatomic ion transport 6.2500 5 yes
GO:0045933 positive regulation of muscle contraction 6.2500 5 yes
GO:0045989 positive regulation of striated muscle contraction 6.2500 6 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 6.2500 6 yes
GO:0051928 positive regulation of calcium ion transport 6.2500 6 yes
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 6.2500 7 yes
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 6.2500 6 yes
GO:1901334 lactone metabolic process 6.2500 4 yes
GO:1904064 positive regulation of cation transmembrane transport 6.2500 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 6.2500 7 yes
GO:2001259 positive regulation of cation channel activity 6.2500 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNAP3_HUMAN [view interactions] Low throughput no yes
GSTO1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBA5_HUMAN [view interactions] High throughput no yes
FGR_HUMAN [view interactions] High throughput no no
SH2D3_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
MED20_HUMAN [view interactions] High throughput no no
P55G_HUMAN [view interactions] High throughput no yes
LARP1_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
RBM48_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CE126_HUMAN [view interactions] High throughput no no
KAT5_HUMAN [view interactions] High throughput no yes
SETB1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
SPB5_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
PPME1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
CPNE7_HUMAN [view interactions] High throughput no no
GSTO2_HUMAN [view interactions] High throughput no no
TRAF3_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TET5C_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
GSTT1_HUMAN [view interactions] High throughput no no
CK054_HUMAN [view interactions] High throughput no no
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
CAN9_HUMAN [view interactions] High throughput no no
DUT_HUMAN [view interactions] High throughput no yes
ECH1_HUMAN [view interactions] High throughput no yes
FKB1B_HUMAN [view entry] [view interactions] High throughput yes yes
GSTA4_HUMAN [view interactions] High throughput no yes
ATP5J_HUMAN [view interactions] High throughput no yes
FKBP7_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA1_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
CH10_HUMAN [view interactions] High throughput no yes
LYPA2_HUMAN [view interactions] High throughput no no
NUDT9_HUMAN [view interactions] High throughput no yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL_HUMAN [view interactions] High throughput no no
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
YTDC2_HUMAN [view interactions] High throughput no no
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
ACSF2_HUMAN [view interactions] High throughput no no
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
HINT2_HUMAN [view interactions] High throughput no yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
HEBP1_HUMAN [view interactions] High throughput no yes
SUCB2_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ETFA_HUMAN [view interactions] High throughput no yes
GCSH_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
PREY_HUMAN [view interactions] High throughput no yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
DOC10_HUMAN [view entry] [view interactions] High throughput yes yes
CCS_HUMAN [view interactions] High throughput no yes
ETHE1_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] High throughput no no
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
PLGT3_HUMAN [view interactions] High throughput no no
NNRE_HUMAN [view interactions] High throughput no yes
NIT2_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
PGM1_HUMAN [view interactions] High throughput no no
MPPB_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
UFC1_HUMAN [view interactions] High throughput no yes
ATOX1_HUMAN [view interactions] High throughput no no
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
HMGCL_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
CAH13_HUMAN [view interactions] High throughput no yes
TIGAR_HUMAN [view interactions] High throughput no yes
PPIL1_HUMAN [view entry] [view interactions] High throughput yes no
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes