PPIL1_HUMAN
Evidence for PS localization
Functions
Involved in pre-mRNA splicing as component of the spliceosome (PubMed, PubMed, PubMed). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 99 | Ala | Thr | Pontocerebellarhypoplasia14(PCH14) | - |
| 127 | Thr | Ala | Pontocerebellarhypoplasia14(PCH14) | - |
| 131 | Arg | Gln | Pontocerebellarhypoplasia14(PCH14) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PPIL1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 81.8182 | 4 | no |
| GO:0003729 | mRNA binding | 54.5455 | 5 | no |
| GO:0003677 | DNA binding | 36.3636 | 4 | no |
| GO:0003727 | single-stranded RNA binding | 27.2727 | 5 | no |
| GO:0003730 | mRNA 3-UTR binding | 27.2727 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PPIL1_HUMAN |
|---|---|---|---|---|
| GO:0006396 | RNA processing | 90.9091 | 6 | yes |
| GO:0008380 | RNA splicing | 90.9091 | 7 | yes |
| GO:0016070 | RNA metabolic process | 90.9091 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 90.9091 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 81.8182 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 81.8182 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 81.8182 | 4 | no |
| GO:0010468 | regulation of gene expression | 81.8182 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 81.8182 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 81.8182 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 72.7273 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 72.7273 | 5 | no |
| GO:0000375 | RNA splicing, via transesterification reactions | 72.7273 | 8 | yes |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 72.7273 | 9 | yes |
| GO:0000398 | mRNA splicing, via spliceosome | 72.7273 | 8 | yes |
| GO:0006397 | mRNA processing | 72.7273 | 7 | yes |
| GO:0016071 | mRNA metabolic process | 72.7273 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 72.7273 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 72.7273 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 63.6364 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 63.6364 | 5 | no |
| GO:1903311 | regulation of mRNA metabolic process | 63.6364 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 63.6364 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 54.5455 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 54.5455 | 5 | no |
| GO:0043484 | regulation of RNA splicing | 54.5455 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 54.5455 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 54.5455 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 54.5455 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 54.5455 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 54.5455 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 54.5455 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 45.4545 | 6 | no |
| GO:1903312 | negative regulation of mRNA metabolic process | 45.4545 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 45.4545 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 45.4545 | 6 | no |
| GO:0071702 | organic substance transport | 36.3636 | 4 | no |
| GO:0071705 | nitrogen compound transport | 36.3636 | 4 | no |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | 36.3636 | 7 | no |
| GO:0050684 | regulation of mRNA processing | 36.3636 | 7 | no |
| GO:0051052 | regulation of DNA metabolic process | 36.3636 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 36.3636 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.3636 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.3636 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 36.3636 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 36.3636 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 36.3636 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.3636 | 6 | no |
| GO:0048255 | mRNA stabilization | 27.2727 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.2727 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.2727 | 6 | no |
| GO:0061013 | regulation of mRNA catabolic process | 27.2727 | 6 | no |
| GO:1902369 | negative regulation of RNA catabolic process | 27.2727 | 7 | no |
| GO:1902373 | negative regulation of mRNA catabolic process | 27.2727 | 7 | no |
| GO:0015931 | nucleobase-containing compound transport | 27.2727 | 5 | no |
| GO:0050657 | nucleic acid transport | 27.2727 | 6 | no |
| GO:0050658 | RNA transport | 27.2727 | 4 | no |
| GO:0051028 | mRNA transport | 27.2727 | 5 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0010941 | regulation of cell death | 27.2727 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 5 | no |
| GO:0006913 | nucleocytoplasmic transport | 27.2727 | 5 | no |
| GO:0032204 | regulation of telomere maintenance | 27.2727 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
| GO:0033044 | regulation of chromosome organization | 27.2727 | 6 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 27.2727 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0051169 | nuclear transport | 27.2727 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.2727 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 27.2727 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.2727 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0043412 | macromolecule modification | 27.2727 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 27.2727 | 4 | no |
| GO:0009895 | negative regulation of catabolic process | 27.2727 | 5 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 27.2727 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 27.2727 | 5 | no |
| GO:0031330 | negative regulation of cellular catabolic process | 27.2727 | 6 | no |
| GO:0043488 | regulation of mRNA stability | 27.2727 | 4 | no |
| GO:0043489 | RNA stabilization | 27.2727 | 4 | no |
| GO:0018193 | peptidyl-amino acid modification | 18.1818 | 5 | yes |
| GO:0036211 | protein modification process | 18.1818 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PPIL1_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 18.1818 | 4 | yes |
| DOID:331 | central nervous system disease | 18.1818 | 3 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNW1_HUMAN | [view interactions] | Low throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| THOC5_HUMAN | [view interactions] | High throughput | no | no |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEOC_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| RIM3A_HUMAN | [view interactions] | High throughput | no | no |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| N42L2_HUMAN | [view interactions] | High throughput | no | yes |
| SPDE4_HUMAN | [view interactions] | High throughput | no | no |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| PO6F2_HUMAN | [view interactions] | High throughput | no | no |
| COHA1_HUMAN | [view interactions] | High throughput | no | no |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| AQR_HUMAN | [view interactions] | High throughput | no | no |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRR22_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| GPAM1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| DJC17_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| SAT2_HUMAN | [view interactions] | High throughput | no | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| SYF2_HUMAN | [view interactions] | High throughput | no | yes |
| CWC15_HUMAN | [view interactions] | High throughput | no | yes |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| C19L1_HUMAN | [view interactions] | High throughput | no | yes |
| ISY1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX35_HUMAN | [view interactions] | High throughput | no | yes |
| PRP17_HUMAN | [view interactions] | High throughput | no | no |
| GPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CCD12_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| GCFC2_HUMAN | [view interactions] | High throughput | no | no |
| BUD31_HUMAN | [view interactions] | High throughput | no | yes |
| CRNL1_HUMAN | [view interactions] | High throughput | no | no |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| GA45G_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| LSM3_HUMAN | [view interactions] | High throughput | no | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| SMD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| FRG1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | Computational | no | yes |
| R113A_HUMAN | [view interactions] | Computational | no | yes |
| PPWD1_HUMAN | [view interactions] | Computational | no | yes |
| CASC3_HUMAN | [view interactions] | Computational | no | yes |
| CIR1_HUMAN | [view interactions] | Computational | no | yes |
| DHX16_HUMAN | [view interactions] | Computational | no | yes |
| SLU7_HUMAN | [view interactions] | Computational | no | yes |
| U520_HUMAN | [view interactions] | Computational | no | yes |
| SF3B6_HUMAN | [view interactions] | Computational | no | yes |
| CWC25_HUMAN | [view interactions] | Computational | no | yes |
| NKAP_HUMAN | [view interactions] | Computational | no | yes |
| CATIN_HUMAN | [view interactions] | Computational | no | yes |
| PPIG_HUMAN | [view interactions] | Computational | no | yes |
| CWC22_HUMAN | [view interactions] | Computational | no | yes |
| RUXE_HUMAN | [view interactions] | Computational | no | no |
| SDE2_HUMAN | [view interactions] | Computational | no | yes |
| RUXG_HUMAN | [view interactions] | Computational | no | yes |
| SF3B5_HUMAN | [view interactions] | Computational | no | yes |
| PKRI1_HUMAN | [view interactions] | Computational | no | no |
| FA32A_HUMAN | [view interactions] | Computational | no | no |
| PHF5A_HUMAN | [view interactions] | Computational | no | yes |
| WDR70_HUMAN | [view interactions] | Computational | no | no |
| CWC27_HUMAN | [view interactions] | Computational | no | yes |
| RU2A_HUMAN | [view interactions] | Computational | no | yes |
| YJU2_HUMAN | [view interactions] | Computational | no | yes |
| MGN_HUMAN | [view interactions] | Computational | no | yes |
| PLRG1_HUMAN | [view interactions] | Computational | no | yes |
| RU2B_HUMAN | [view interactions] | Computational | no | yes |
| SF3A3_HUMAN | [view interactions] | Computational | no | yes |
| SNR40_HUMAN | [view interactions] | Computational | no | yes |
| DHX8_HUMAN | [view interactions] | Computational | no | yes |
| U5S1_HUMAN | [view interactions] | Computational | no | yes |
| SF3A2_HUMAN | [view interactions] | Computational | no | yes |
| BUD13_HUMAN | [view interactions] | Computational | no | yes |
| WDR25_HUMAN | [view interactions] | Computational | no | yes |
| RBMX2_HUMAN | [view interactions] | Computational | no | yes |
| PRP16_HUMAN | [view interactions] | Computational | no | yes |
| DHX15_HUMAN | [view interactions] | Computational | no | yes |
| SF3B2_HUMAN | [view interactions] | Computational | no | yes |
| MGN2_HUMAN | [view interactions] | Computational | no | yes |
| SF3B4_HUMAN | [view interactions] | Computational | no | yes |