Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANXA1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response . Promotes resolution of inflammation and wound healing (PubMed). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed, PubMed). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed). Has no effect on unstimulated T cells (PubMed). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions . Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed, PubMed). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ANXA1_HUMAN
GO:0017076 purine nucleotide binding 34.4262 4 no
GO:0032555 purine ribonucleotide binding 32.7869 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.7869 4 no
GO:0019900 kinase binding 26.2295 4 no
GO:0030554 adenyl nucleotide binding 26.2295 5 no
GO:0046872 metal ion binding 24.5902 4 yes
GO:0005524 ATP binding 24.5902 5 no
GO:0032559 adenyl ribonucleotide binding 24.5902 5 no
GO:0003723 RNA binding 24.5902 4 no
GO:0019901 protein kinase binding 24.5902 5 no
GO:0045296 cadherin binding 19.6721 4 yes
GO:0005509 calcium ion binding 11.4754 5 yes
GO:0005544 calcium-dependent phospholipid binding 9.8361 4 yes
GO:0004859 phospholipase inhibitor activity 6.5574 5 yes
GO:0055102 lipase inhibitor activity 6.5574 4 yes
GO:0019834 phospholipase A2 inhibitor activity 4.9180 6 yes
GO:0098631 cell adhesion mediator activity 4.9180 4 yes
GO:0098632 cell-cell adhesion mediator activity 4.9180 5 yes
GO:0098641 cadherin binding involved in cell-cell adhesion 4.9180 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANXA1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 67.2131 4 yes
GO:0048522 positive regulation of cellular process 65.5738 4 yes
GO:0048523 negative regulation of cellular process 65.5738 4 yes
GO:0080090 regulation of primary metabolic process 65.5738 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.2951 4 no
GO:0031323 regulation of cellular metabolic process 62.2951 4 yes
GO:0010468 regulation of gene expression 55.7377 5 yes
GO:0009893 positive regulation of metabolic process 54.0984 4 yes
GO:0009892 negative regulation of metabolic process 52.4590 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 52.4590 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.8197 5 yes
GO:0009889 regulation of biosynthetic process 47.5410 4 yes
GO:0031326 regulation of cellular biosynthetic process 47.5410 5 yes
GO:0010646 regulation of cell communication 44.2623 4 yes
GO:0031325 positive regulation of cellular metabolic process 44.2623 5 yes
GO:0051128 regulation of cellular component organization 42.6230 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.9836 5 no
GO:0051246 regulation of protein metabolic process 40.9836 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.9836 5 no
GO:0010556 regulation of macromolecule biosynthetic process 40.9836 5 no
GO:0009966 regulation of signal transduction 39.3443 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 39.3443 5 no
GO:0051049 regulation of transport 36.0656 4 yes
GO:0006996 organelle organization 36.0656 4 yes
GO:0031324 negative regulation of cellular metabolic process 36.0656 5 no
GO:0051252 regulation of RNA metabolic process 36.0656 5 no
GO:0048584 positive regulation of response to stimulus 34.4262 4 yes
GO:1902531 regulation of intracellular signal transduction 34.4262 5 no
GO:0022607 cellular component assembly 34.4262 4 no
GO:0071310 cellular response to organic substance 32.7869 4 yes
GO:0006355 regulation of DNA-templated transcription 32.7869 6 no
GO:1903506 regulation of nucleic acid-templated transcription 32.7869 7 no
GO:2001141 regulation of RNA biosynthetic process 32.7869 6 no
GO:0033043 regulation of organelle organization 32.7869 5 yes
GO:0006796 phosphate-containing compound metabolic process 31.1475 4 no
GO:0010941 regulation of cell death 31.1475 4 yes
GO:0042981 regulation of apoptotic process 31.1475 6 yes
GO:0043067 regulation of programmed cell death 31.1475 5 yes
GO:0060548 negative regulation of cell death 29.5082 5 yes
GO:0010628 positive regulation of gene expression 29.5082 6 yes
GO:0043066 negative regulation of apoptotic process 29.5082 7 yes
GO:0043069 negative regulation of programmed cell death 29.5082 6 yes
GO:0051247 positive regulation of protein metabolic process 27.8689 6 no
GO:0036211 protein modification process 27.8689 4 yes
GO:0043412 macromolecule modification 27.8689 4 yes
GO:0048585 negative regulation of response to stimulus 26.2295 4 yes
GO:0051726 regulation of cell cycle 26.2295 4 yes
GO:0031399 regulation of protein modification process 26.2295 6 no
GO:0023056 positive regulation of signaling 26.2295 4 no
GO:0010648 negative regulation of cell communication 26.2295 5 no
GO:0023057 negative regulation of signaling 26.2295 4 no
GO:0042127 regulation of cell population proliferation 26.2295 4 yes
GO:0051050 positive regulation of transport 24.5902 4 yes
GO:0080134 regulation of response to stress 24.5902 4 yes
GO:0010629 negative regulation of gene expression 24.5902 6 yes
GO:0009967 positive regulation of signal transduction 24.5902 5 no
GO:0010647 positive regulation of cell communication 24.5902 5 no
GO:0051248 negative regulation of protein metabolic process 24.5902 6 no
GO:0051130 positive regulation of cellular component organization 22.9508 5 yes
GO:0051240 positive regulation of multicellular organismal process 22.9508 4 yes
GO:0008104 protein localization 22.9508 4 yes
GO:0019220 regulation of phosphate metabolic process 22.9508 6 no
GO:0051174 regulation of phosphorus metabolic process 22.9508 5 no
GO:0009894 regulation of catabolic process 22.9508 4 no
GO:0044087 regulation of cellular component biogenesis 22.9508 4 no
GO:0009890 negative regulation of biosynthetic process 22.9508 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.9508 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.9508 6 no
GO:0009968 negative regulation of signal transduction 22.9508 5 no
GO:0045595 regulation of cell differentiation 22.9508 4 yes
GO:0007010 cytoskeleton organization 21.3115 5 yes
GO:0009891 positive regulation of biosynthetic process 21.3115 5 yes
GO:0010638 positive regulation of organelle organization 21.3115 6 yes
GO:1902533 positive regulation of intracellular signal transduction 21.3115 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.3115 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.3115 6 no
GO:0060341 regulation of cellular localization 21.3115 4 no
GO:0030155 regulation of cell adhesion 21.3115 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 21.3115 6 yes
GO:0001817 regulation of cytokine production 19.6721 4 yes
GO:1901701 cellular response to oxygen-containing compound 19.6721 4 yes
GO:0016192 vesicle-mediated transport 19.6721 4 yes
GO:0050776 regulation of immune response 18.0328 4 yes
GO:0051094 positive regulation of developmental process 18.0328 4 yes
GO:0071702 organic substance transport 18.0328 4 yes
GO:0010243 response to organonitrogen compound 18.0328 4 yes
GO:2000145 regulation of cell motility 18.0328 4 yes
GO:0010564 regulation of cell cycle process 18.0328 5 yes
GO:0014070 response to organic cyclic compound 18.0328 4 yes
GO:0030334 regulation of cell migration 18.0328 5 yes
GO:0001819 positive regulation of cytokine production 16.3934 5 yes
GO:0002684 positive regulation of immune system process 16.3934 4 yes
GO:2000026 regulation of multicellular organismal development 16.3934 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 16.3934 4 yes
GO:0033993 response to lipid 16.3934 4 yes
GO:0045785 positive regulation of cell adhesion 14.7541 5 yes
GO:0051051 negative regulation of transport 14.7541 4 yes
GO:0051241 negative regulation of multicellular organismal process 14.7541 4 yes
GO:0071407 cellular response to organic cyclic compound 14.7541 5 yes
GO:0071705 nitrogen compound transport 14.7541 4 yes
GO:0008284 positive regulation of cell population proliferation 14.7541 5 yes
GO:0032101 regulation of response to external stimulus 14.7541 4 yes
GO:0032870 cellular response to hormone stimulus 14.7541 4 yes
GO:0043086 negative regulation of catalytic activity 14.7541 4 yes
GO:0045597 positive regulation of cell differentiation 14.7541 5 yes
GO:0048545 response to steroid hormone 13.1148 4 yes
GO:0051046 regulation of secretion 13.1148 5 yes
GO:0060627 regulation of vesicle-mediated transport 13.1148 4 yes
GO:0062197 cellular response to chemical stress 13.1148 4 yes
GO:0071396 cellular response to lipid 13.1148 5 yes
GO:1901652 response to peptide 13.1148 4 yes
GO:1903530 regulation of secretion by cell 13.1148 4 yes
GO:0022407 regulation of cell-cell adhesion 13.1148 5 yes
GO:0034097 response to cytokine 13.1148 4 yes
GO:0048732 gland development 11.4754 4 yes
GO:0050778 positive regulation of immune response 11.4754 5 yes
GO:0050865 regulation of cell activation 11.4754 4 yes
GO:0050867 positive regulation of cell activation 11.4754 5 yes
GO:0051336 regulation of hydrolase activity 11.4754 4 yes
GO:0070848 response to growth factor 11.4754 4 yes
GO:0071363 cellular response to growth factor stimulus 11.4754 5 yes
GO:0002694 regulation of leukocyte activation 11.4754 4 yes
GO:0002696 positive regulation of leukocyte activation 11.4754 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 11.4754 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 11.4754 7 yes
GO:2000147 positive regulation of cell motility 11.4754 5 yes
GO:0015031 protein transport 11.4754 4 yes
GO:0022409 positive regulation of cell-cell adhesion 11.4754 6 yes
GO:0030335 positive regulation of cell migration 11.4754 6 yes
GO:0034599 cellular response to oxidative stress 11.4754 4 yes
GO:0040017 positive regulation of locomotion 11.4754 4 yes
GO:0050863 regulation of T cell activation 9.8361 6 yes
GO:0050870 positive regulation of T cell activation 9.8361 7 yes
GO:0051093 negative regulation of developmental process 9.8361 4 yes
GO:0051249 regulation of lymphocyte activation 9.8361 5 yes
GO:0051251 positive regulation of lymphocyte activation 9.8361 6 yes
GO:0051346 negative regulation of hydrolase activity 9.8361 5 yes
GO:0071383 cellular response to steroid hormone stimulus 9.8361 5 yes
GO:0006811 ion transport 9.8361 4 yes
GO:0007162 negative regulation of cell adhesion 9.8361 5 yes
GO:0007346 regulation of mitotic cell cycle 9.8361 5 yes
GO:0010632 regulation of epithelial cell migration 9.8361 4 yes
GO:0010942 positive regulation of cell death 9.8361 5 yes
GO:0031347 regulation of defense response 9.8361 5 yes
GO:0031960 response to corticosteroid 9.8361 5 yes
GO:0043434 response to peptide hormone 9.8361 4 yes
GO:0045596 negative regulation of cell differentiation 9.8361 5 yes
GO:0045787 positive regulation of cell cycle 8.1967 5 yes
GO:0046903 secretion 8.1967 4 yes
GO:0050727 regulation of inflammatory response 8.1967 5 yes
GO:0051384 response to glucocorticoid 8.1967 6 yes
GO:0061041 regulation of wound healing 8.1967 6 yes
GO:0062012 regulation of small molecule metabolic process 8.1967 4 yes
GO:0070555 response to interleukin-1 8.1967 5 yes
GO:1901987 regulation of cell cycle phase transition 8.1967 6 yes
GO:1903034 regulation of response to wounding 8.1967 5 yes
GO:0010634 positive regulation of epithelial cell migration 8.1967 5 yes
GO:0015849 organic acid transport 8.1967 5 yes
GO:0022604 regulation of cell morphogenesis 8.1967 5 yes
GO:0032677 regulation of interleukin-8 production 8.1967 5 yes
GO:0043065 positive regulation of apoptotic process 8.1967 7 yes
GO:0043068 positive regulation of programmed cell death 8.1967 6 yes
GO:0045834 positive regulation of lipid metabolic process 6.5574 5 yes
GO:0046883 regulation of hormone secretion 6.5574 4 yes
GO:0046942 carboxylic acid transport 6.5574 6 yes
GO:0048872 homeostasis of number of cells 6.5574 4 yes
GO:0051048 negative regulation of secretion 6.5574 5 yes
GO:0062013 positive regulation of small molecule metabolic process 6.5574 5 yes
GO:0070301 cellular response to hydrogen peroxide 6.5574 5 yes
GO:0000302 response to reactive oxygen species 6.5574 4 yes
GO:0001818 negative regulation of cytokine production 6.5574 5 yes
GO:0090303 positive regulation of wound healing 6.5574 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 6.5574 6 yes
GO:0006820 anion transport 6.5574 5 yes
GO:0006869 lipid transport 6.5574 5 yes
GO:0006954 inflammatory response 6.5574 4 yes
GO:1903036 positive regulation of response to wounding 6.5574 5 yes
GO:0008360 regulation of cell shape 6.5574 6 yes
GO:1903531 negative regulation of secretion by cell 6.5574 5 yes
GO:1903706 regulation of hemopoiesis 6.5574 4 yes
GO:0010594 regulation of endothelial cell migration 6.5574 5 yes
GO:0010595 positive regulation of endothelial cell migration 6.5574 6 yes
GO:0015711 organic anion transport 6.5574 5 yes
GO:0015908 fatty acid transport 6.5574 6 yes
GO:0015909 long-chain fatty acid transport 6.5574 7 yes
GO:0017157 regulation of exocytosis 6.5574 5 yes
GO:0019216 regulation of lipid metabolic process 6.5574 5 yes
GO:0022008 neurogenesis 6.5574 4 yes
GO:0034614 cellular response to reactive oxygen species 6.5574 5 yes
GO:0035924 cellular response to vascular endothelial growth factor stimulus 6.5574 6 yes
GO:0042542 response to hydrogen peroxide 6.5574 4 yes
GO:0045931 positive regulation of mitotic cell cycle 4.9180 6 yes
GO:0046889 positive regulation of lipid biosynthetic process 4.9180 6 yes
GO:0046890 regulation of lipid biosynthetic process 4.9180 5 yes
GO:0050482 arachidonic acid secretion 4.9180 6 yes
GO:0050777 negative regulation of immune response 4.9180 5 yes
GO:0060191 regulation of lipase activity 4.9180 5 yes
GO:0060326 cell chemotaxis 4.9180 4 yes
GO:0071384 cellular response to corticosteroid stimulus 4.9180 6 yes
GO:0071385 cellular response to glucocorticoid stimulus 4.9180 7 yes
GO:0071621 granulocyte chemotaxis 4.9180 4 yes
GO:0002683 negative regulation of immune system process 4.9180 4 yes
GO:0071715 icosanoid transport 4.9180 7 yes
GO:0002685 regulation of leukocyte migration 4.9180 4 yes
GO:0090068 positive regulation of cell cycle process 4.9180 6 yes
GO:0097530 granulocyte migration 4.9180 4 yes
GO:0002819 regulation of adaptive immune response 4.9180 5 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4.9180 6 yes
GO:0002825 regulation of T-helper 1 type immune response 4.9180 7 yes
GO:0006909 phagocytosis 4.9180 5 yes
GO:1902806 regulation of cell cycle G1/S phase transition 4.9180 7 yes
GO:1903963 arachidonate transport 4.9180 8 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 4.9180 7 yes
GO:0010212 response to ionizing radiation 4.9180 4 yes
GO:2000106 regulation of leukocyte apoptotic process 4.9180 7 yes
GO:0010517 regulation of phospholipase activity 4.9180 6 yes
GO:0010565 regulation of cellular ketone metabolic process 4.9180 5 yes
GO:0015718 monocarboxylic acid transport 4.9180 7 yes
GO:0019217 regulation of fatty acid metabolic process 4.9180 6 yes
GO:0022408 negative regulation of cell-cell adhesion 4.9180 6 yes
GO:0030855 epithelial cell differentiation 4.9180 4 yes
GO:0031338 regulation of vesicle fusion 4.9180 5 yes
GO:0031340 positive regulation of vesicle fusion 4.9180 5 yes
GO:0032309 icosanoid secretion 4.9180 5 yes
GO:0032652 regulation of interleukin-1 production 4.9180 5 yes
GO:0033032 regulation of myeloid cell apoptotic process 4.9180 7 yes
GO:0042110 T cell activation 4.9180 4 yes
GO:0043535 regulation of blood vessel endothelial cell migration 4.9180 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 4.9180 7 yes
GO:0045620 negative regulation of lymphocyte differentiation 3.2787 7 yes
GO:0045621 positive regulation of lymphocyte differentiation 3.2787 7 yes
GO:0045622 regulation of T-helper cell differentiation 3.2787 5 yes
GO:0045623 negative regulation of T-helper cell differentiation 3.2787 6 yes
GO:0045624 positive regulation of T-helper cell differentiation 3.2787 6 yes
GO:0045625 regulation of T-helper 1 cell differentiation 3.2787 6 yes
GO:0045627 positive regulation of T-helper 1 cell differentiation 3.2787 7 yes
GO:0045628 regulation of T-helper 2 cell differentiation 3.2787 6 yes
GO:0045629 negative regulation of T-helper 2 cell differentiation 3.2787 7 yes
GO:0045723 positive regulation of fatty acid biosynthetic process 3.2787 7 yes
GO:0045920 negative regulation of exocytosis 3.2787 6 yes
GO:0045923 positive regulation of fatty acid metabolic process 3.2787 6 yes
GO:0046631 alpha-beta T cell activation 3.2787 5 yes
GO:0046632 alpha-beta T cell differentiation 3.2787 6 yes
GO:0046634 regulation of alpha-beta T cell activation 3.2787 7 yes
GO:0046635 positive regulation of alpha-beta T cell activation 3.2787 8 yes
GO:0046636 negative regulation of alpha-beta T cell activation 3.2787 8 yes
GO:0046637 regulation of alpha-beta T cell differentiation 3.2787 8 yes
GO:0046638 positive regulation of alpha-beta T cell differentiation 3.2787 9 yes
GO:0046639 negative regulation of alpha-beta T cell differentiation 3.2787 9 yes
GO:0046879 hormone secretion 3.2787 5 yes
GO:0050670 regulation of lymphocyte proliferation 3.2787 6 yes
GO:0050671 positive regulation of lymphocyte proliferation 3.2787 7 yes
GO:0050866 negative regulation of cell activation 3.2787 5 yes
GO:0050868 negative regulation of T cell activation 3.2787 7 yes
GO:0051250 negative regulation of lymphocyte activation 3.2787 6 yes
GO:0051276 chromosome organization 3.2787 5 yes
GO:0051451 myoblast migration 3.2787 5 yes
GO:0060192 negative regulation of lipase activity 3.2787 6 yes
GO:0070365 hepatocyte differentiation 3.2787 5 yes
GO:0070459 prolactin secretion 3.2787 5 yes
GO:0070663 regulation of leukocyte proliferation 3.2787 5 yes
GO:0070665 positive regulation of leukocyte proliferation 3.2787 6 yes
GO:0071103 DNA conformation change 3.2787 6 yes
GO:0071692 protein localization to extracellular region 3.2787 5 yes
GO:0002521 leukocyte differentiation 3.2787 4 yes
GO:0002548 monocyte chemotaxis 3.2787 4 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 3.2787 7 yes
GO:0002695 negative regulation of leukocyte activation 3.2787 5 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 3.2787 8 yes
GO:0002697 regulation of immune effector process 3.2787 4 yes
GO:0002698 negative regulation of immune effector process 3.2787 5 yes
GO:0097350 neutrophil clearance 3.2787 7 yes
GO:0002699 positive regulation of immune effector process 3.2787 5 yes
GO:0002790 peptide secretion 3.2787 5 yes
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 3.2787 8 yes
GO:1900138 negative regulation of phospholipase A2 activity 3.2787 8 yes
GO:0002828 regulation of type 2 immune response 3.2787 5 yes
GO:0002829 negative regulation of type 2 immune response 3.2787 6 yes
GO:1901989 positive regulation of cell cycle phase transition 3.2787 7 yes
GO:1901992 positive regulation of mitotic cell cycle phase transition 3.2787 7 yes
GO:1902105 regulation of leukocyte differentiation 3.2787 5 yes
GO:1902106 negative regulation of leukocyte differentiation 3.2787 6 yes
GO:1902107 positive regulation of leukocyte differentiation 3.2787 6 yes
GO:1902808 positive regulation of cell cycle G1/S phase transition 3.2787 8 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 3.2787 4 yes
GO:1903038 negative regulation of leukocyte cell-cell adhesion 3.2787 7 yes
GO:1903131 mononuclear cell differentiation 3.2787 5 yes
GO:0009306 protein secretion 3.2787 4 yes
GO:1903707 negative regulation of hemopoiesis 3.2787 5 yes
GO:1903708 positive regulation of hemopoiesis 3.2787 5 yes
GO:0009913 epidermal cell differentiation 3.2787 5 yes
GO:0009914 hormone transport 3.2787 4 yes
GO:0010165 response to X-ray 3.2787 5 yes
GO:2000108 positive regulation of leukocyte apoptotic process 3.2787 8 yes
GO:0010519 negative regulation of phospholipase activity 3.2787 7 yes
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 3.2787 8 yes
GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 3.2787 9 yes
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 3.2787 9 yes
GO:2001279 regulation of unsaturated fatty acid biosynthetic process 3.2787 7 yes
GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process 3.2787 8 yes
GO:0014812 muscle cell migration 3.2787 4 yes
GO:0014839 myoblast migration involved in skeletal muscle regeneration 3.2787 6 yes
GO:0015833 peptide transport 3.2787 5 yes
GO:0018149 peptide cross-linking 3.2787 5 yes
GO:0023061 signal release 3.2787 4 yes
GO:0030072 peptide hormone secretion 3.2787 6 yes
GO:0030073 insulin secretion 3.2787 5 yes
GO:0030098 lymphocyte differentiation 3.2787 4 yes
GO:0030216 keratinocyte differentiation 3.2787 6 yes
GO:0030217 T cell differentiation 3.2787 5 yes
GO:0030850 prostate gland development 3.2787 4 yes
GO:0031392 regulation of prostaglandin biosynthetic process 3.2787 8 yes
GO:0031394 positive regulation of prostaglandin biosynthetic process 3.2787 9 yes
GO:0031532 actin cytoskeleton reorganization 3.2787 4 yes
GO:0032355 response to estradiol 3.2787 4 yes
GO:0032392 DNA geometric change 3.2787 7 yes
GO:0032429 regulation of phospholipase A2 activity 3.2787 7 yes
GO:0032508 DNA duplex unwinding 3.2787 8 yes
GO:0032663 regulation of interleukin-2 production 3.2787 5 yes
GO:0032717 negative regulation of interleukin-8 production 3.2787 6 yes
GO:0032743 positive regulation of interleukin-2 production 3.2787 6 yes
GO:0032944 regulation of mononuclear cell proliferation 3.2787 6 yes
GO:0032946 positive regulation of mononuclear cell proliferation 3.2787 7 yes
GO:0033029 regulation of neutrophil apoptotic process 3.2787 4 yes
GO:0033031 positive regulation of neutrophil apoptotic process 3.2787 5 yes
GO:0033034 positive regulation of myeloid cell apoptotic process 3.2787 8 yes
GO:0035592 establishment of protein localization to extracellular region 3.2787 4 yes
GO:0036230 granulocyte activation 3.2787 4 yes
GO:0042063 gliogenesis 3.2787 5 yes
GO:0042102 positive regulation of T cell proliferation 3.2787 8 yes
GO:0042119 neutrophil activation 3.2787 5 yes
GO:0042129 regulation of T cell proliferation 3.2787 7 yes
GO:0042304 regulation of fatty acid biosynthetic process 3.2787 6 yes
GO:0042886 amide transport 3.2787 5 yes
GO:0043277 apoptotic cell clearance 3.2787 6 yes
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 3.2787 9 yes
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 3.2787 10 yes
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 3.2787 10 yes
GO:0045580 regulation of T cell differentiation 3.2787 7 yes
GO:0045581 negative regulation of T cell differentiation 3.2787 8 yes
GO:0045582 positive regulation of T cell differentiation 3.2787 8 yes
GO:0045619 regulation of lymphocyte differentiation 3.2787 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ANXA1_HUMAN
DOID:0111198 autosomal dominant distal hereditary motor neuronopathy 3.2787 7 no
DOID:12377 spinal muscular atrophy 3.2787 6 no
DOID:1289 neurodegenerative disease 3.2787 4 no
DOID:231 motor neuron disease 3.2787 5 no
DOID:331 central nervous system disease 3.2787 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYSF_HUMAN [view interactions] Low throughput no no
NEMO_HUMAN [view interactions] Low throughput no yes
RIPK1_HUMAN [view interactions] Low throughput no yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
K2C8_HUMAN [view interactions] Low throughput no no
UBE3A_HUMAN [view interactions] Low throughput no yes
UBP7_HUMAN [view interactions] Low throughput no yes
ACTS_HUMAN [view interactions] Low throughput no no
PA24A_HUMAN [view entry] [view interactions] Low throughput yes yes
S10AB_HUMAN [view interactions] Low throughput no no
FPR1_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
EPHA2_HUMAN [view interactions] Low throughput no no
ANXA1_HUMAN [view entry] [view interactions] Low throughput yes no
UBC9_HUMAN [view interactions] Low throughput no yes
ANXA5_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] Low throughput no no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
GRDN_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
FRMD1_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
KI2S2_HUMAN [view interactions] High throughput no no
MTA70_HUMAN [view interactions] High throughput no no
FL2D_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
SHOC2_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
NTM2F_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
CSF1_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOST_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KS6A4_HUMAN [view interactions] High throughput no yes
GRK4_HUMAN [view interactions] High throughput no yes
BMX_HUMAN [view interactions] High throughput no no
JAK3_HUMAN [view interactions] High throughput no no
PKN2_HUMAN [view interactions] High throughput no yes
TEX14_HUMAN [view interactions] High throughput no no
PDK1L_HUMAN [view interactions] High throughput no no
SRPK3_HUMAN [view interactions] High throughput no no
AURKC_HUMAN [view interactions] High throughput no no
HMGA1_HUMAN [view interactions] High throughput no yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1B_HUMAN [view interactions] High throughput no yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
PTN6_HUMAN [view interactions] High throughput no no
CCAR2_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
KPYR_HUMAN [view entry] [view interactions] High throughput yes no
CO1A1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
WDCP_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
DDX41_HUMAN [view interactions] High throughput no yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
PABP2_HUMAN [view interactions] High throughput no yes
TLE3_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CXCR2_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ZHX1R_HUMAN [view interactions] High throughput no yes
EVA1B_HUMAN [view interactions] High throughput no yes
LEG1H_HUMAN [view interactions] High throughput no no
IKBA_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
RNF34_HUMAN [view interactions] High throughput no no
SMBT1_HUMAN [view interactions] High throughput no no
TIFAB_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CEP89_HUMAN [view interactions] High throughput no no
CE152_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CE128_HUMAN [view interactions] High throughput no yes
MEIS2_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
ATG4B_HUMAN [view interactions] High throughput no yes
MGMT_HUMAN [view interactions] High throughput no no
CD4_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
WWOX_HUMAN [view interactions] High throughput no yes
ZBTB1_HUMAN [view interactions] High throughput no no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
NSL1_HUMAN [view interactions] High throughput no no
UCP2_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
UD110_HUMAN [view interactions] High throughput no no
ZSC20_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
KIFC1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
U2AF2_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
MEP50_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
CGAS_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
COMP_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PEBB_HUMAN [view interactions] High throughput no no
NGB_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
OCRL_HUMAN [view interactions] High throughput no yes
OPHN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDCA5_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
RN208_HUMAN [view interactions] High throughput no no
SC5A5_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
PKHG6_HUMAN [view interactions] High throughput no yes
SIA7F_HUMAN [view interactions] High throughput no yes
PTSS1_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
STK11_HUMAN [view interactions] High throughput no yes
HSF2_HUMAN [view interactions] High throughput no no
PXL2A_HUMAN [view interactions] High throughput no yes
FA24B_HUMAN [view interactions] High throughput no no
SRRT_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
GBG8_HUMAN [view interactions] High throughput no no
CHMP3_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
COE2_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
CCR1_HUMAN [view interactions] High throughput no no
AMOL2_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
PRAM2_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SHIP2_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
UCHL5_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA4_HUMAN [view interactions] High throughput no no
ABHDB_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
FABPH_HUMAN [view entry] [view interactions] High throughput yes no
KGUA_HUMAN [view entry] [view interactions] High throughput yes yes
PTRD1_HUMAN [view interactions] High throughput no yes
TIGAR_HUMAN [view interactions] High throughput no yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
MSRB2_HUMAN [view interactions] High throughput no no
FRDA_HUMAN [view interactions] High throughput no yes
MTPN_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
SYCM_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
MPPA_HUMAN [view interactions] High throughput no yes
FAHD1_HUMAN [view interactions] High throughput no yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
CATZ_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
TGM2_HUMAN [view interactions] High throughput no no
S10AA_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DPPA3_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
IRAK1_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
ERG28_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
CZIB_HUMAN [view interactions] High throughput no no
CSN6_HUMAN [view interactions] High throughput no yes
CSAD_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
KLH23_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
KMT2B_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
UB2D1_HUMAN [view interactions] High throughput no yes
U119A_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
SLX1_HUMAN [view interactions] High throughput no yes
UBP25_HUMAN [view interactions] High throughput no yes
USPL1_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
NPHP1_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
MAP1S_HUMAN [view interactions] High throughput no no
STK4_HUMAN [view interactions] High throughput no yes
RASFA_HUMAN [view interactions] High throughput no no
KIF11_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
TFG_HUMAN [view interactions] High throughput no yes
IL13_HUMAN [view interactions] Computational no no
FPR3_HUMAN [view interactions] Computational no no
HSH2D_HUMAN [view interactions] Computational no no
CAV3_HUMAN [view interactions] Computational no no
ANXA6_HUMAN [view entry] [view interactions] Computational yes yes
CCL22_HUMAN [view interactions] Computational no no
CO1A2_HUMAN [view interactions] Computational no yes
F13A_HUMAN [view interactions] Computational no no
FPR2_HUMAN [view interactions] Computational no yes
GCR_HUMAN [view entry] [view interactions] Computational yes yes
IL4_HUMAN [view interactions] Computational no no
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
TRI72_HUMAN [view interactions] Computational no no