Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OPHN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OPHN1_HUMAN
GO:0043168 anion binding 38.0952 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0005096 GTPase activator activity 28.5714 4 yes
GO:0030695 GTPase regulator activity 28.5714 4 yes
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0043169 cation binding 28.5714 4 no
GO:0003779 actin binding 23.8095 4 yes
GO:0003723 RNA binding 23.8095 4 no
GO:0032555 purine ribonucleotide binding 23.8095 4 no
GO:0046872 metal ion binding 23.8095 5 no
GO:0019901 protein kinase binding 23.8095 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in OPHN1_HUMAN
GO:0051128 regulation of cellular component organization 61.9048 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 yes
GO:0080090 regulation of primary metabolic process 52.3810 4 yes
GO:0051130 positive regulation of cellular component organization 52.3810 5 no
GO:0009966 regulation of signal transduction 52.3810 4 yes
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0031323 regulation of cellular metabolic process 47.6190 4 no
GO:0033043 regulation of organelle organization 47.6190 5 no
GO:0006996 organelle organization 47.6190 4 yes
GO:0051246 regulation of protein metabolic process 42.8571 5 yes
GO:1902531 regulation of intracellular signal transduction 42.8571 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0051049 regulation of transport 38.0952 4 yes
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0042981 regulation of apoptotic process 38.0952 5 no
GO:0043067 regulation of programmed cell death 38.0952 4 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0010638 positive regulation of organelle organization 38.0952 6 no
GO:0009892 negative regulation of metabolic process 38.0952 4 yes
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 28.5714 6 yes
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 yes
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0030335 positive regulation of cell migration 28.5714 6 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0040017 positive regulation of locomotion 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:2000147 positive regulation of cell motility 28.5714 5 no
GO:0007015 actin filament organization 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0043254 regulation of protein-containing complex assembly 28.5714 5 no
GO:0034097 response to cytokine 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 23.8095 6 yes
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 yes
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0001934 positive regulation of protein phosphorylation 23.8095 8 no
GO:0007264 small GTPase-mediated signal transduction 23.8095 5 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0019220 regulation of phosphate metabolic process 23.8095 6 no
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0043065 positive regulation of apoptotic process 23.8095 6 no
GO:0043068 positive regulation of programmed cell death 23.8095 5 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0045595 regulation of cell differentiation 23.8095 4 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0051174 regulation of phosphorus metabolic process 23.8095 5 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0141124 intracellular signaling cassette 23.8095 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.8095 6 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0032956 regulation of actin cytoskeleton organization 23.8095 5 no
GO:0032970 regulation of actin filament-based process 23.8095 4 no
GO:0051493 regulation of cytoskeleton organization 23.8095 6 no
GO:0061024 membrane organization 23.8095 4 no
GO:0110053 regulation of actin filament organization 23.8095 6 no
GO:1902903 regulation of supramolecular fiber organization 23.8095 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 yes
GO:0030031 cell projection assembly 23.8095 5 yes
GO:0030100 regulation of endocytosis 23.8095 5 yes
GO:0030855 epithelial cell differentiation 23.8095 4 yes
GO:0048259 regulation of receptor-mediated endocytosis 19.0476 6 yes
GO:0098657 import into cell 19.0476 4 yes
GO:0009894 regulation of catabolic process 19.0476 4 yes
GO:0030162 regulation of proteolysis 19.0476 6 yes
GO:0031175 neuron projection development 19.0476 6 yes
GO:0034330 cell junction organization 14.2857 4 yes
GO:0035023 regulation of Rho protein signal transduction 14.2857 7 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 14.2857 4 yes
GO:0035089 establishment of apical/basal cell polarity 14.2857 5 yes
GO:0042176 regulation of protein catabolic process 14.2857 5 yes
GO:0042177 negative regulation of protein catabolic process 14.2857 6 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 14.2857 5 yes
GO:0045198 establishment of epithelial cell apical/basal polarity 14.2857 5 yes
GO:0050804 modulation of chemical synaptic transmission 14.2857 5 yes
GO:0051248 negative regulation of protein metabolic process 14.2857 6 yes
GO:0061162 establishment of monopolar cell polarity 14.2857 4 yes
GO:0090162 establishment of epithelial cell polarity 14.2857 4 yes
GO:0099177 regulation of trans-synaptic signaling 14.2857 4 yes
GO:0002090 regulation of receptor internalization 14.2857 7 yes
GO:0007399 nervous system development 14.2857 4 yes
GO:0009895 negative regulation of catabolic process 14.2857 5 yes
GO:0030859 polarized epithelial cell differentiation 14.2857 5 yes
GO:0034329 cell junction assembly 14.2857 5 yes
GO:0050808 synapse organization 9.5238 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 9.5238 6 yes
GO:0097485 neuron projection guidance 9.5238 7 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 9.5238 7 yes
GO:0007411 axon guidance 9.5238 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
GT2D1_HUMAN [view interactions] High throughput no yes
PPIF_HUMAN [view interactions] High throughput no no
RFOX2_HUMAN [view interactions] High throughput no yes
RBM22_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ATPO_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
RT31_HUMAN [view interactions] High throughput no yes
NASP_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
PRDX4_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
MD2L1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SRGP1_HUMAN [view interactions] High throughput no no
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE2_HUMAN [view interactions] High throughput no no