Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OPHN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OPHN1_HUMAN
GO:0005096 GTPase activator activity 26.0870 4 yes
GO:0030695 GTPase regulator activity 26.0870 4 yes
GO:0019900 kinase binding 26.0870 4 no
GO:0003779 actin binding 21.7391 4 yes
GO:0019901 protein kinase binding 21.7391 5 no
GO:0003723 RNA binding 21.7391 4 no
GO:0017076 purine nucleotide binding 21.7391 4 no
GO:0032555 purine ribonucleotide binding 21.7391 4 no
GO:0046872 metal ion binding 21.7391 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in OPHN1_HUMAN
GO:0051128 regulation of cellular component organization 56.5217 4 yes
GO:0048523 negative regulation of cellular process 56.5217 4 no
GO:0060255 regulation of macromolecule metabolic process 52.1739 4 yes
GO:0080090 regulation of primary metabolic process 52.1739 4 yes
GO:0048522 positive regulation of cellular process 52.1739 4 no
GO:0010646 regulation of cell communication 47.8261 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.8261 4 yes
GO:0031323 regulation of cellular metabolic process 47.8261 4 no
GO:0051130 positive regulation of cellular component organization 47.8261 5 no
GO:0006996 organelle organization 43.4783 4 yes
GO:0009966 regulation of signal transduction 43.4783 4 yes
GO:0022607 cellular component assembly 43.4783 4 yes
GO:0051246 regulation of protein metabolic process 43.4783 5 yes
GO:0009893 positive regulation of metabolic process 43.4783 4 no
GO:0033043 regulation of organelle organization 39.1304 5 no
GO:0051049 regulation of transport 39.1304 4 yes
GO:1902531 regulation of intracellular signal transduction 39.1304 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:0009892 negative regulation of metabolic process 34.7826 4 yes
GO:0030030 cell projection organization 34.7826 4 yes
GO:0010468 regulation of gene expression 34.7826 5 no
GO:0022603 regulation of anatomical structure morphogenesis 34.7826 4 no
GO:0044087 regulation of cellular component biogenesis 34.7826 4 no
GO:0051094 positive regulation of developmental process 34.7826 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.7826 5 no
GO:0010638 positive regulation of organelle organization 34.7826 6 no
GO:0007010 cytoskeleton organization 30.4348 5 yes
GO:0007015 actin filament organization 30.4348 5 no
GO:0097435 supramolecular fiber organization 30.4348 4 no
GO:0010941 regulation of cell death 30.4348 4 no
GO:0019220 regulation of phosphate metabolic process 30.4348 6 no
GO:0023056 positive regulation of signaling 30.4348 4 no
GO:0042325 regulation of phosphorylation 30.4348 7 no
GO:0042981 regulation of apoptotic process 30.4348 6 no
GO:0043067 regulation of programmed cell death 30.4348 5 no
GO:0045595 regulation of cell differentiation 30.4348 4 no
GO:0048584 positive regulation of response to stimulus 30.4348 4 no
GO:0051174 regulation of phosphorus metabolic process 30.4348 5 no
GO:0051247 positive regulation of protein metabolic process 30.4348 6 no
GO:0071310 cellular response to organic substance 30.4348 4 no
GO:0051129 negative regulation of cellular component organization 30.4348 5 no
GO:0061024 membrane organization 26.0870 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.0870 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 26.0870 6 yes
GO:0060627 regulation of vesicle-mediated transport 26.0870 4 yes
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 yes
GO:0001932 regulation of protein phosphorylation 26.0870 7 no
GO:0009889 regulation of biosynthetic process 26.0870 4 no
GO:0009967 positive regulation of signal transduction 26.0870 5 no
GO:0010562 positive regulation of phosphorus metabolic process 26.0870 6 no
GO:0010647 positive regulation of cell communication 26.0870 5 no
GO:0010942 positive regulation of cell death 26.0870 5 no
GO:0030334 regulation of cell migration 26.0870 5 no
GO:0031326 regulation of cellular biosynthetic process 26.0870 5 no
GO:0031344 regulation of cell projection organization 26.0870 5 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0034097 response to cytokine 26.0870 4 no
GO:0042327 positive regulation of phosphorylation 26.0870 8 no
GO:0043065 positive regulation of apoptotic process 26.0870 7 no
GO:0043068 positive regulation of programmed cell death 26.0870 6 no
GO:0043085 positive regulation of catalytic activity 26.0870 4 no
GO:0043254 regulation of protein-containing complex assembly 26.0870 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.0870 7 no
GO:0051336 regulation of hydrolase activity 26.0870 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.0870 6 no
GO:2000145 regulation of cell motility 26.0870 4 no
GO:0045597 positive regulation of cell differentiation 26.0870 5 no
GO:0051493 regulation of cytoskeleton organization 21.7391 6 no
GO:0110053 regulation of actin filament organization 21.7391 6 no
GO:1902903 regulation of supramolecular fiber organization 21.7391 5 no
GO:0051051 negative regulation of transport 21.7391 4 no
GO:0030031 cell projection assembly 21.7391 5 yes
GO:0030162 regulation of proteolysis 21.7391 6 yes
GO:0030855 epithelial cell differentiation 21.7391 4 yes
GO:0031175 neuron projection development 21.7391 6 yes
GO:0120031 plasma membrane bounded cell projection assembly 21.7391 6 yes
GO:0001934 positive regulation of protein phosphorylation 21.7391 8 no
GO:0030335 positive regulation of cell migration 21.7391 6 no
GO:0031324 negative regulation of cellular metabolic process 21.7391 5 no
GO:0031346 positive regulation of cell projection organization 21.7391 6 no
GO:0031401 positive regulation of protein modification process 21.7391 7 no
GO:0036211 protein modification process 21.7391 4 no
GO:0040017 positive regulation of locomotion 21.7391 4 no
GO:0042127 regulation of cell population proliferation 21.7391 4 no
GO:0043412 macromolecule modification 21.7391 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.7391 5 no
GO:0051241 negative regulation of multicellular organismal process 21.7391 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.7391 6 no
GO:2000026 regulation of multicellular organismal development 21.7391 4 no
GO:2000147 positive regulation of cell motility 21.7391 5 no
GO:0007264 small GTPase mediated signal transduction 21.7391 4 no
GO:0022604 regulation of cell morphogenesis 21.7391 5 no
GO:0032956 regulation of actin cytoskeleton organization 21.7391 5 no
GO:0032970 regulation of actin filament-based process 21.7391 4 no
GO:0009894 regulation of catabolic process 17.3913 4 yes
GO:0016192 vesicle-mediated transport 17.3913 4 yes
GO:0030100 regulation of endocytosis 17.3913 5 yes
GO:0046578 regulation of Ras protein signal transduction 17.3913 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 17.3913 5 yes
GO:0051248 negative regulation of protein metabolic process 17.3913 6 yes
GO:0000904 cell morphogenesis involved in differentiation 13.0435 4 yes
GO:0006897 endocytosis 13.0435 5 yes
GO:0007399 nervous system development 13.0435 4 yes
GO:0009895 negative regulation of catabolic process 13.0435 5 yes
GO:0030859 polarized epithelial cell differentiation 13.0435 5 yes
GO:0034329 cell junction assembly 13.0435 5 yes
GO:0034330 cell junction organization 13.0435 4 yes
GO:0035023 regulation of Rho protein signal transduction 13.0435 8 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 13.0435 4 yes
GO:0035089 establishment of apical/basal cell polarity 13.0435 5 yes
GO:0042176 regulation of protein catabolic process 13.0435 5 yes
GO:0042177 negative regulation of protein catabolic process 13.0435 6 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 13.0435 5 yes
GO:0045198 establishment of epithelial cell apical/basal polarity 13.0435 5 yes
GO:0048259 regulation of receptor-mediated endocytosis 13.0435 6 yes
GO:0061162 establishment of monopolar cell polarity 13.0435 4 yes
GO:0090162 establishment of epithelial cell polarity 13.0435 4 yes
GO:0002090 regulation of receptor internalization 8.6957 7 yes
GO:0007411 axon guidance 8.6957 8 yes
GO:0030182 neuron differentiation 8.6957 4 yes
GO:0050804 modulation of chemical synaptic transmission 8.6957 5 yes
GO:0050808 synapse organization 8.6957 5 yes
GO:0061136 regulation of proteasomal protein catabolic process 8.6957 6 yes
GO:0097485 neuron projection guidance 8.6957 7 yes
GO:0099177 regulation of trans-synaptic signaling 8.6957 4 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 8.6957 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in OPHN1_HUMAN
DOID:0080000 muscular disease 8.6957 3 no
DOID:423 myopathy 8.6957 5 no
DOID:66 muscle tissue disease 8.6957 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
GT2D1_HUMAN [view interactions] High throughput no yes
RBM22_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
PPIF_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ATPO_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
RT31_HUMAN [view interactions] High throughput no yes
NASP_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
PRDX4_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
MD2L1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
SRGP1_HUMAN [view interactions] High throughput no no
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE2_HUMAN [view interactions] High throughput no no
NR1D1_HUMAN [view interactions] Computational no yes
OPN3_HUMAN [view interactions] Computational no yes
SH3G2_HUMAN [view entry] [view interactions] Computational yes yes
OPN5_HUMAN [view interactions] Computational no no
IRPL1_HUMAN [view entry] [view interactions] Computational yes no
ARHG6_HUMAN [view interactions] Computational no no