RHG26_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein for RHOA and CDC42. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG26_HUMAN |
|---|---|---|---|---|
| GO:0030695 | GTPase regulator activity | 35.1351 | 4 | yes |
| GO:0043169 | cation binding | 32.4324 | 4 | no |
| GO:0046872 | metal ion binding | 32.4324 | 5 | no |
| GO:0005096 | GTPase activator activity | 27.0270 | 4 | yes |
| GO:0003779 | actin binding | 21.6216 | 4 | no |
| GO:0031267 | small GTPase binding | 21.6216 | 5 | no |
| GO:0051020 | GTPase binding | 21.6216 | 4 | no |
| GO:0019900 | kinase binding | 21.6216 | 4 | no |
| GO:0019901 | protein kinase binding | 21.6216 | 5 | no |
| GO:0000166 | nucleotide binding | 21.6216 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.6216 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.6216 | 4 | no |
| GO:0043168 | anion binding | 21.6216 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG26_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 75.6757 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 64.8649 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.1622 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.3514 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 51.3514 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.6486 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.9459 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.9459 | 4 | no |
| GO:0022607 | cellular component assembly | 43.2432 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.2432 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.5405 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.5405 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 40.5405 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.5405 | 4 | no |
| GO:0030030 | cell projection organization | 40.5405 | 4 | no |
| GO:0006996 | organelle organization | 40.5405 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 37.8378 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.1351 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 35.1351 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.1351 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:0008104 | protein localization | 35.1351 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.4324 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.4324 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 32.4324 | 4 | no |
| GO:0007010 | cytoskeleton organization | 32.4324 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 32.4324 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.7297 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 29.7297 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.7297 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 29.7297 | 5 | no |
| GO:0023057 | negative regulation of signaling | 29.7297 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.7297 | 5 | no |
| GO:0031399 | regulation of protein modification process | 29.7297 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.7297 | 6 | no |
| GO:0051049 | regulation of transport | 29.7297 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.0270 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.0270 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.0270 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 27.0270 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 27.0270 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 27.0270 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.0270 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.0270 | 5 | no |
| GO:0030334 | regulation of cell migration | 27.0270 | 5 | no |
| GO:2000145 | regulation of cell motility | 27.0270 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.3243 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.3243 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.3243 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.3243 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 24.3243 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 24.3243 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.3243 | 5 | no |
| GO:0030031 | cell projection assembly | 24.3243 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.3243 | 4 | no |
| GO:0120031 | plasma membrane bounded cell projection assembly | 24.3243 | 6 | no |
| GO:0031175 | neuron projection development | 24.3243 | 6 | no |
| GO:0034330 | cell junction organization | 24.3243 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 24.3243 | 7 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 24.3243 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.6216 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.6216 | 7 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.6216 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 21.6216 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.6216 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.6216 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 21.6216 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 21.6216 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 21.6216 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.6216 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.6216 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.6216 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.6216 | 4 | no |
| GO:0007399 | nervous system development | 5.4054 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SMUF1_HUMAN | [view interactions] | Low throughput | no | yes |
| CEMIP_HUMAN | [view interactions] | Low throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKN3_HUMAN | [view interactions] | Low throughput | no | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG42_HUMAN | [view interactions] | High throughput | no | yes |
| OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA1_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NYAP2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| REPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHSL3_HUMAN | [view interactions] | High throughput | no | yes |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPP7_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG40_HUMAN | [view interactions] | High throughput | no | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| GLI2_HUMAN | [view interactions] | High throughput | no | yes |
| LHX5_HUMAN | [view interactions] | High throughput | no | no |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE6B_HUMAN | [view interactions] | High throughput | no | no |
| PRIC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR2_HUMAN | [view interactions] | High throughput | no | no |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| CEGT_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAL_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL7_HUMAN | [view interactions] | High throughput | no | yes |
| LMA1L_HUMAN | [view interactions] | High throughput | no | no |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPGF4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGF1B_HUMAN | [view interactions] | High throughput | no | no |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| NYAP1_HUMAN | [view interactions] | High throughput | no | no |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPSF4_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEP1_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM14_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QPCTL_HUMAN | [view interactions] | High throughput | no | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B6_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| THOC6_HUMAN | [view interactions] | High throughput | no | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| TOX4_HUMAN | [view interactions] | High throughput | no | yes |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| PLMN_HUMAN | [view interactions] | High throughput | no | no |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| BORG1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP1_HUMAN | [view interactions] | High throughput | no | no |
| RHG10_HUMAN | [view interactions] | High throughput | no | no |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |