P5CR1_HUMAN
Evidence for PS localization
Functions
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in P5CR1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.1905 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.8095 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | no |
| GO:0003677 | DNA binding | 21.4286 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.4286 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0004735 | pyrroline-5-carboxylate reductase activity | 4.7619 | 5 | yes |
| GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in P5CR1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 45.2381 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.2381 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.2381 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.2381 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.4762 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.4762 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.0952 | 5 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.9524 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.9524 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.9524 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9524 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.9524 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.1905 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.1905 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 26.1905 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 26.1905 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.8095 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.8095 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.8095 | 6 | no |
| GO:0010941 | regulation of cell death | 23.8095 | 4 | yes |
| GO:0010646 | regulation of cell communication | 21.4286 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 21.4286 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
| GO:0009966 | regulation of signal transduction | 21.4286 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 19.0476 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 16.6667 | 5 | yes |
| GO:0080134 | regulation of response to stress | 16.6667 | 4 | yes |
| GO:0018130 | heterocycle biosynthetic process | 14.2857 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 14.2857 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 14.2857 | 4 | yes |
| GO:0034599 | cellular response to oxidative stress | 11.9048 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 11.9048 | 4 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 11.9048 | 4 | yes |
| GO:0006560 | proline metabolic process | 9.5238 | 6 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 9.5238 | 5 | yes |
| GO:0016053 | organic acid biosynthetic process | 9.5238 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 9.5238 | 5 | yes |
| GO:1900407 | regulation of cellular response to oxidative stress | 9.5238 | 5 | yes |
| GO:1901031 | regulation of response to reactive oxygen species | 9.5238 | 6 | yes |
| GO:1901032 | negative regulation of response to reactive oxygen species | 9.5238 | 6 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 9.5238 | 4 | yes |
| GO:1902882 | regulation of response to oxidative stress | 9.5238 | 5 | yes |
| GO:1902883 | negative regulation of response to oxidative stress | 9.5238 | 5 | yes |
| GO:1903201 | regulation of oxidative stress-induced cell death | 9.5238 | 5 | yes |
| GO:1903202 | negative regulation of oxidative stress-induced cell death | 9.5238 | 6 | yes |
| GO:1903205 | regulation of hydrogen peroxide-induced cell death | 9.5238 | 6 | yes |
| GO:1903206 | negative regulation of hydrogen peroxide-induced cell death | 9.5238 | 7 | yes |
| GO:0051881 | regulation of mitochondrial membrane potential | 7.1429 | 4 | yes |
| GO:0006561 | proline biosynthetic process | 4.7619 | 7 | yes |
| GO:0008652 | cellular amino acid biosynthetic process | 4.7619 | 4 | yes |
| GO:0009084 | glutamine family amino acid biosynthetic process | 4.7619 | 6 | yes |
| GO:0055129 | L-proline biosynthetic process | 4.7619 | 5 | yes |
| GO:1901607 | alpha-amino acid biosynthetic process | 4.7619 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in P5CR1_HUMAN |
|---|---|---|---|---|
| DOID:700 | mitochondrial metabolism disease | 7.1429 | 3 | no |
| DOID:0060286 | combined oxidative phosphorylation deficiency | 4.7619 | 4 | no |
| DOID:1289 | neurodegenerative disease | 4.7619 | 4 | no |
| DOID:331 | central nervous system disease | 4.7619 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR3_HUMAN | [view interactions] | Low throughput | no | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| BNIPL_HUMAN | [view interactions] | High throughput | no | no |
| CDKA2_HUMAN | [view interactions] | High throughput | no | no |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| CEP78_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5_HUMAN | [view interactions] | High throughput | no | no |
| NUDT5_HUMAN | [view interactions] | High throughput | no | no |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| KLD10_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ZHX1R_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9Y_HUMAN | [view interactions] | High throughput | no | no |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB3_HUMAN | [view interactions] | High throughput | no | yes |
| POTEF_HUMAN | [view interactions] | High throughput | no | no |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APC16_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| APC4_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| COBA1_HUMAN | [view interactions] | High throughput | no | no |
| MAOM_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX4_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| FMT_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| NGRN_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OAT_HUMAN | [view interactions] | Computational | no | yes |
| P4HA2_HUMAN | [view interactions] | Computational | no | no |
| JAG2_HUMAN | [view interactions] | Computational | no | yes |
| SOX_HUMAN | [view interactions] | Computational | no | no |
| AMPL_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PROD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCF11_HUMAN | [view interactions] | Computational | no | no |
| HYPDH_HUMAN | [view interactions] | Computational | no | no |
| P4HA1_HUMAN | [view interactions] | Computational | no | yes |
| P5CS_HUMAN | [view interactions] | Computational | no | yes |