Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P5CR1_HUMAN

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in P5CR1_HUMAN
GO:0003723 RNA binding 48.9796 4 no
GO:0000166 nucleotide binding 30.6122 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0043168 anion binding 28.5714 4 no
GO:0030554 adenyl nucleotide binding 26.5306 6 no
GO:0032555 purine ribonucleotide binding 24.4898 4 no
GO:0032559 adenyl ribonucleotide binding 22.4490 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.4490 4 no
GO:0005524 ATP binding 20.4082 5 no
GO:0004735 pyrroline-5-carboxylate reductase activity 4.0816 5 yes
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4.0816 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in P5CR1_HUMAN
GO:0031323 regulation of cellular metabolic process 46.9388 4 no
GO:0060255 regulation of macromolecule metabolic process 46.9388 4 no
GO:0080090 regulation of primary metabolic process 46.9388 4 no
GO:0048522 positive regulation of cellular process 44.8980 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 yes
GO:0009889 regulation of biosynthetic process 38.7755 4 no
GO:0010468 regulation of gene expression 38.7755 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.7755 5 no
GO:0022607 cellular component assembly 38.7755 4 no
GO:0031326 regulation of cellular biosynthetic process 38.7755 5 no
GO:0006996 organelle organization 36.7347 4 no
GO:0009893 positive regulation of metabolic process 36.7347 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.7347 5 no
GO:0010646 regulation of cell communication 36.7347 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 32.6531 5 no
GO:0051252 regulation of RNA metabolic process 32.6531 5 no
GO:0009966 regulation of signal transduction 32.6531 4 yes
GO:0031325 positive regulation of cellular metabolic process 30.6122 5 no
GO:0043933 protein-containing complex organization 30.6122 4 no
GO:0051246 regulation of protein metabolic process 30.6122 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 26.5306 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 26.5306 5 no
GO:0065003 protein-containing complex assembly 26.5306 5 no
GO:1902531 regulation of intracellular signal transduction 24.4898 5 yes
GO:0006355 regulation of DNA-templated transcription 24.4898 7 no
GO:0008104 protein localization 24.4898 4 no
GO:0051128 regulation of cellular component organization 24.4898 4 no
GO:0071705 nitrogen compound transport 24.4898 4 no
GO:2001141 regulation of RNA biosynthetic process 24.4898 6 no
GO:0090304 nucleic acid metabolic process 24.4898 4 no
GO:0009968 negative regulation of signal transduction 24.4898 5 yes
GO:0010648 negative regulation of cell communication 24.4898 5 yes
GO:0023057 negative regulation of signaling 24.4898 4 yes
GO:0042981 regulation of apoptotic process 24.4898 5 yes
GO:0043067 regulation of programmed cell death 24.4898 4 yes
GO:0009891 positive regulation of biosynthetic process 22.4490 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.4490 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.4490 6 no
GO:0048584 positive regulation of response to stimulus 22.4490 4 no
GO:0051247 positive regulation of protein metabolic process 22.4490 6 no
GO:0010647 positive regulation of cell communication 20.4082 5 no
GO:0023056 positive regulation of signaling 20.4082 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.4082 5 no
GO:0009890 negative regulation of biosynthetic process 20.4082 5 no
GO:0009894 regulation of catabolic process 20.4082 4 no
GO:0031324 negative regulation of cellular metabolic process 20.4082 5 no
GO:0071310 cellular response to organic substance 20.4082 4 no
GO:0019752 carboxylic acid metabolic process 20.4082 5 yes
GO:0043436 oxoacid metabolic process 20.4082 4 yes
GO:1902532 negative regulation of intracellular signal transduction 18.3673 6 yes
GO:0043066 negative regulation of apoptotic process 18.3673 6 yes
GO:0043069 negative regulation of programmed cell death 18.3673 5 yes
GO:1901362 organic cyclic compound biosynthetic process 14.2857 4 yes
GO:0062197 cellular response to chemical stress 12.2449 4 yes
GO:2001233 regulation of apoptotic signaling pathway 12.2449 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 12.2449 6 yes
GO:0034599 cellular response to oxidative stress 12.2449 4 yes
GO:0043523 regulation of neuron apoptotic process 12.2449 6 yes
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 10.2041 7 yes
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 10.2041 8 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 10.2041 6 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 10.2041 7 yes
GO:0051881 regulation of mitochondrial membrane potential 8.1633 4 yes
GO:0170033 L-amino acid metabolic process 8.1633 5 yes
GO:0170039 proteinogenic amino acid metabolic process 8.1633 4 yes
GO:1901566 organonitrogen compound biosynthetic process 8.1633 4 yes
GO:1901605 alpha-amino acid metabolic process 8.1633 4 yes
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 8.1633 7 yes
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 8.1633 8 yes
GO:0016053 organic acid biosynthetic process 8.1633 4 yes
GO:0043524 negative regulation of neuron apoptotic process 8.1633 7 yes
GO:0046394 carboxylic acid biosynthetic process 8.1633 5 yes
GO:0006560 proline metabolic process 6.1224 6 yes
GO:0009064 glutamine family amino acid metabolic process 6.1224 5 yes
GO:0055129 L-proline biosynthetic process 4.0816 5 yes
GO:0170034 L-amino acid biosynthetic process 4.0816 6 yes
GO:0170038 proteinogenic amino acid biosynthetic process 4.0816 5 yes
GO:1901607 alpha-amino acid biosynthetic process 4.0816 5 yes
GO:0006561 proline biosynthetic process 4.0816 7 yes
GO:0008652 amino acid biosynthetic process 4.0816 4 yes
GO:0009084 glutamine family amino acid biosynthetic process 4.0816 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SIR3_HUMAN [view interactions] Low throughput no yes
CBP_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
P5CR1_HUMAN [view entry] [view interactions] Low throughput yes yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
PARL_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO2_HUMAN [view interactions] High throughput no yes
MDC1_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
SUZ12_HUMAN [view interactions] High throughput no no
RING2_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
KLD10_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
UCHL3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
SET1A_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
PD1L1_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
ZHX1R_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
USP9Y_HUMAN [view interactions] High throughput no no
AL4A1_HUMAN [view entry] [view interactions] High throughput yes yes
MIPEP_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
GTPB3_HUMAN [view interactions] High throughput no yes
POTEF_HUMAN [view interactions] High throughput no no
MRPP3_HUMAN [view interactions] High throughput no yes
MET15_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
APC16_HUMAN [view interactions] High throughput no yes
ANC2_HUMAN [view interactions] High throughput no no
APC4_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
GATA4_HUMAN [view interactions] High throughput no no
TBX5_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
MILK2_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO10_HUMAN [view interactions] High throughput no no
UBE2O_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CL16A_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
COBA1_HUMAN [view interactions] High throughput no no
MAOM_HUMAN [view interactions] High throughput no yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
CLPP_HUMAN [view interactions] High throughput no yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX4_HUMAN [view interactions] High throughput no yes
RCN2_HUMAN [view interactions] High throughput no yes
AMPN_HUMAN [view interactions] High throughput no no
MCP_HUMAN [view interactions] High throughput no no
SPS1_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
MRES1_HUMAN [view interactions] High throughput no yes
CH082_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CHCH1_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
DDX28_HUMAN [view interactions] High throughput no yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD2_HUMAN [view interactions] High throughput no no
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
RRF2M_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MCU_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
FMT_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
COX8A_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
COP1_HUMAN [view interactions] High throughput no no
SMU1_HUMAN [view interactions] High throughput no yes
TLE2_HUMAN [view interactions] High throughput no yes
BNIPL_HUMAN [view interactions] High throughput no no
CDKA2_HUMAN [view interactions] High throughput no no
CPSF5_HUMAN [view interactions] High throughput no yes
SIR4_HUMAN [view interactions] High throughput no yes
NUP98_HUMAN [view interactions] High throughput no no
CDC16_HUMAN [view interactions] High throughput no yes
CDC23_HUMAN [view interactions] High throughput no yes
CEP78_HUMAN [view interactions] High throughput no yes
ARMC6_HUMAN [view interactions] High throughput no yes
HNRH2_HUMAN [view entry] [view interactions] High throughput yes yes
RT29_HUMAN [view interactions] High throughput no yes
CE162_HUMAN [view interactions] High throughput no yes
LCA5_HUMAN [view interactions] High throughput no no
P5CR3_HUMAN [view interactions] High throughput no no
P5CR2_HUMAN [view interactions] High throughput no yes
NUDT5_HUMAN [view interactions] High throughput no no
COQ2_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYDE1_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
DUS14_HUMAN [view interactions] High throughput no yes
ZN213_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SOAT1_HUMAN [view interactions] High throughput no no
ASCC3_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
B2L14_HUMAN [view interactions] High throughput no yes
IFIT3_HUMAN [view interactions] High throughput no yes
5NT3A_HUMAN [view interactions] High throughput no yes
TR10A_HUMAN [view interactions] High throughput no no
SIM26_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
FAKD3_HUMAN [view interactions] High throughput no yes
GCP4_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes