LONM_HUMAN
Evidence for PS localization
Functions
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed, PubMed, PubMed, PubMed). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LONM_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.8943 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.8943 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0813 | 4 | yes |
| GO:0046872 | metal ion binding | 27.6423 | 4 | no |
| GO:0003723 | RNA binding | 20.3252 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.5122 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.5122 | 5 | yes |
| GO:0005524 | ATP binding | 18.6992 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 17.0732 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 17.0732 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 17.0732 | 6 | yes |
| GO:0003677 | DNA binding | 6.5041 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 5.6911 | 7 | yes |
| GO:0003690 | double-stranded DNA binding | 4.0650 | 5 | yes |
| GO:0003697 | single-stranded DNA binding | 4.0650 | 5 | yes |
| GO:0004175 | endopeptidase activity | 4.0650 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 4.0650 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 4.0650 | 6 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 3.2520 | 5 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 3.2520 | 4 | yes |
| GO:0001018 | mitochondrial promoter sequence-specific DNA binding | 2.4390 | 6 | yes |
| GO:0003727 | single-stranded RNA binding | 2.4390 | 5 | yes |
| GO:0004252 | serine-type endopeptidase activity | 2.4390 | 5 | yes |
| GO:0008236 | serine-type peptidase activity | 2.4390 | 4 | yes |
| GO:0043531 | ADP binding | 2.4390 | 4 | yes |
| GO:0051880 | G-quadruplex DNA binding | 1.6260 | 5 | yes |
| GO:0070182 | DNA polymerase binding | 1.6260 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LONM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 43.9024 | 4 | no |
| GO:0006996 | organelle organization | 43.0894 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.8374 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 37.3984 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.1463 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.5203 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.5203 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.2683 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.6423 | 4 | yes |
| GO:0010646 | regulation of cell communication | 26.8293 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0163 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 25.2033 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 25.2033 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.2033 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.2033 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7642 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7642 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.7642 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.1382 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.1382 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.1382 | 4 | no |
| GO:0010941 | regulation of cell death | 21.1382 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.1382 | 5 | no |
| GO:0007005 | mitochondrion organization | 13.8211 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 9.7561 | 4 | yes |
| GO:0006508 | proteolysis | 8.1301 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 6.5041 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 6.5041 | 4 | yes |
| GO:0006259 | DNA metabolic process | 5.6911 | 4 | yes |
| GO:0034599 | cellular response to oxidative stress | 5.6911 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 4.8780 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 4.8780 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 4.8780 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 4.8780 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 4.8780 | 5 | yes |
| GO:0000002 | mitochondrial genome maintenance | 2.4390 | 6 | yes |
| GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins | 2.4390 | 6 | yes |
| GO:0032042 | mitochondrial DNA metabolic process | 2.4390 | 5 | yes |
| GO:0051131 | chaperone-mediated protein complex assembly | 2.4390 | 6 | yes |
| GO:0070407 | oxidation-dependent protein catabolic process | 1.6260 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LONM_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 2.4390 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.4390 | 5 | no |
| DOID:114 | heart disease | 2.4390 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.4390 | 4 | no |
| DOID:331 | central nervous system disease | 2.4390 | 3 | no |
| DOID:2843 | long QT syndrome | 1.6260 | 6 | no |
| DOID:700 | mitochondrial metabolism disease | 1.6260 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAR_HUMAN | [view interactions] | Low throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| ESPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| SMRP1_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLD8A_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC122_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX3_HUMAN | [view interactions] | High throughput | no | no |
| TEX45_HUMAN | [view interactions] | High throughput | no | no |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQOR_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SIK1_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| ERN2_HUMAN | [view interactions] | High throughput | no | yes |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| UHMK1_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRMS_HUMAN | [view interactions] | High throughput | no | no |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA2_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| GCM1_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLI3_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GATA1_HUMAN | [view interactions] | High throughput | no | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| NKX25_HUMAN | [view interactions] | High throughput | no | no |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| BCS1_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2C8_HUMAN | [view interactions] | High throughput | no | no |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIT5_HUMAN | [view interactions] | High throughput | no | no |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATB_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| GCDH_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKLN1_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GUF1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| CAF17_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM7_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| RM20_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| RT14_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| STPG3_HUMAN | [view interactions] | High throughput | no | no |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRB_HUMAN | [view interactions] | High throughput | no | no |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| NEUR4_HUMAN | [view interactions] | High throughput | no | no |
| RT33_HUMAN | [view interactions] | High throughput | no | no |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| REN3A_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABG_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF7_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXA1L_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL8_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| GATA_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXF2_HUMAN | [view interactions] | High throughput | no | no |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD69_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF1C_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CF015_HUMAN | [view interactions] | High throughput | no | no |
| ZNT9_HUMAN | [view interactions] | High throughput | no | yes |
| KLH33_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA2GD_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| PRR27_HUMAN | [view interactions] | High throughput | no | no |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| TM10C_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| DALD3_HUMAN | [view interactions] | High throughput | no | yes |
| SYYC_HUMAN | [view interactions] | High throughput | no | yes |
| CK001_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| KR132_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| RCC1L_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CF107_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| ACSF3_HUMAN | [view interactions] | High throughput | no | no |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXB8_HUMAN | [view interactions] | High throughput | no | no |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| DC4L1_HUMAN | [view interactions] | High throughput | no | no |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| TBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| DC4L2_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP2_HUMAN | [view interactions] | High throughput | no | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| PED1A_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL15_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| TEPP_HUMAN | [view interactions] | High throughput | no | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ITLN2_HUMAN | [view interactions] | High throughput | no | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OD3L1_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED10_HUMAN | [view interactions] | High throughput | no | no |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TECR_HUMAN | [view interactions] | Computational | no | yes |
| CLPP_HUMAN | [view interactions] | Computational | no | yes |
| YMEL1_HUMAN | [view interactions] | Computational | no | yes |