LONM_HUMAN
Evidence for PS localization
Functions
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed, PubMed, PubMed, PubMed). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LONM_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 37.6812 | 4 | yes |
| GO:0043168 | anion binding | 37.6812 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.9565 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6087 | 4 | yes |
| GO:0043169 | cation binding | 28.2609 | 4 | no |
| GO:0046872 | metal ion binding | 27.5362 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.8116 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.1884 | 5 | yes |
| GO:0003723 | RNA binding | 22.4638 | 4 | yes |
| GO:0005524 | ATP binding | 22.4638 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 20.2899 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.2899 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.2899 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 11.5942 | 7 | yes |
| GO:0003677 | DNA binding | 5.7971 | 4 | yes |
| GO:0003697 | single-stranded DNA binding | 3.6232 | 5 | yes |
| GO:0004175 | endopeptidase activity | 3.6232 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 3.6232 | 5 | yes |
| GO:0003727 | single-stranded RNA binding | 2.1739 | 5 | yes |
| GO:0004252 | serine-type endopeptidase activity | 2.1739 | 5 | yes |
| GO:0008236 | serine-type peptidase activity | 2.1739 | 4 | yes |
| GO:0043531 | ADP binding | 2.1739 | 5 | yes |
| GO:0070182 | DNA polymerase binding | 2.1739 | 4 | yes |
| GO:0042731 | PH domain binding | 1.4493 | 4 | yes |
| GO:0051880 | G-quadruplex DNA binding | 1.4493 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LONM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 45.6522 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.3043 | 4 | yes |
| GO:0006996 | organelle organization | 39.1304 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.1304 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.4058 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 36.2319 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.2319 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.5072 | 4 | no |
| GO:0043933 | protein-containing complex organization | 31.8841 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.1594 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.4348 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 28.9855 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.9855 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2609 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.2609 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.5362 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 26.8116 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.8116 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.3623 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 24.6377 | 5 | no |
| GO:0051049 | regulation of transport | 23.1884 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.4638 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.4638 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 4 | no |
| GO:0008104 | protein localization | 21.0145 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.0145 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.0145 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.2899 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.2899 | 6 | no |
| GO:0031399 | regulation of protein modification process | 19.5652 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 18.8406 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 18.8406 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 17.3913 | 7 | yes |
| GO:0001932 | regulation of protein phosphorylation | 16.6667 | 7 | yes |
| GO:0010648 | negative regulation of cell communication | 15.9420 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 15.9420 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.2174 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 15.2174 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 13.7681 | 4 | yes |
| GO:0007005 | mitochondrion organization | 12.3188 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 11.5942 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 7.9710 | 4 | yes |
| GO:0010038 | response to metal ion | 7.9710 | 4 | yes |
| GO:0006508 | proteolysis | 7.2464 | 4 | yes |
| GO:0030163 | protein catabolic process | 6.5217 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 6.5217 | 4 | yes |
| GO:0006259 | DNA metabolic process | 5.7971 | 5 | yes |
| GO:0034599 | cellular response to oxidative stress | 5.7971 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 5.7971 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 4.3478 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 4.3478 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 4.3478 | 5 | yes |
| GO:0051131 | chaperone-mediated protein complex assembly | 3.6232 | 6 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 2.8986 | 8 | yes |
| GO:0000002 | mitochondrial genome maintenance | 2.1739 | 6 | yes |
| GO:0032042 | mitochondrial DNA metabolic process | 2.1739 | 6 | yes |
| GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins | 1.4493 | 6 | yes |
| GO:0010044 | response to aluminum ion | 1.4493 | 5 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 1.4493 | 5 | yes |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | 1.4493 | 6 | yes |
| GO:0070407 | oxidation-dependent protein catabolic process | 1.4493 | 7 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 1.4493 | 4 | yes |
| GO:1900077 | negative regulation of cellular response to insulin stimulus | 1.4493 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAR_HUMAN | [view interactions] | Low throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMRB_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM04_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUR4_HUMAN | [view interactions] | High throughput | no | no |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXRD1_HUMAN | [view interactions] | High throughput | no | no |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| REN3A_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| GATB_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCDH_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABG_HUMAN | [view interactions] | High throughput | no | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| GUF1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAF17_HUMAN | [view interactions] | High throughput | no | no |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LYRM7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RM20_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM03_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| RT14_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| FOXF2_HUMAN | [view interactions] | High throughput | no | no |
| RT33_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| CCD69_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1C_HUMAN | [view interactions] | High throughput | no | no |
| KGD4_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| CF015_HUMAN | [view interactions] | High throughput | no | no |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| KLH33_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA2GD_HUMAN | [view interactions] | High throughput | no | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| NDUF3_HUMAN | [view interactions] | High throughput | no | yes |
| PRR27_HUMAN | [view interactions] | High throughput | no | no |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF7_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| DALD3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA68_HUMAN | [view interactions] | High throughput | no | no |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR132_HUMAN | [view interactions] | High throughput | no | no |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| OXA1L_HUMAN | [view interactions] | High throughput | no | yes |
| RCC1L_HUMAN | [view interactions] | High throughput | no | yes |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CF107_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSF3_HUMAN | [view interactions] | High throughput | no | no |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXB8_HUMAN | [view interactions] | High throughput | no | no |
| PLPL8_HUMAN | [view interactions] | High throughput | no | yes |
| ABHDA_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| DC4L1_HUMAN | [view interactions] | High throughput | no | no |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| DC4L2_HUMAN | [view interactions] | High throughput | no | no |
| GATA_HUMAN | [view interactions] | High throughput | no | yes |
| IKBD_HUMAN | [view interactions] | High throughput | no | no |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP2_HUMAN | [view interactions] | High throughput | no | no |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PED1A_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL15_HUMAN | [view interactions] | High throughput | no | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM37_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMIP8_HUMAN | [view interactions] | High throughput | no | no |
| ZNT9_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITLN2_HUMAN | [view interactions] | High throughput | no | no |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMA1C_HUMAN | [view interactions] | High throughput | no | no |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TM10C_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SYYC_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED10_HUMAN | [view interactions] | High throughput | no | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ESPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| SMIP6_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLD8A_HUMAN | [view interactions] | High throughput | no | no |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| DC122_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAXO5_HUMAN | [view interactions] | High throughput | no | no |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMX3_HUMAN | [view interactions] | High throughput | no | no |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| SIK1_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| ERN2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQOR_HUMAN | [view interactions] | High throughput | no | yes |
| UHMK1_HUMAN | [view interactions] | High throughput | no | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| SRMS_HUMAN | [view interactions] | High throughput | no | no |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| GLI3_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| GCM1_HUMAN | [view interactions] | High throughput | no | no |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA2_HUMAN | [view interactions] | High throughput | no | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| GATA1_HUMAN | [view interactions] | High throughput | no | no |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| NKX25_HUMAN | [view interactions] | High throughput | no | no |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| MCES_HUMAN | [view interactions] | High throughput | no | yes |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| NFIC_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| TAF6_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2C8_HUMAN | [view interactions] | High throughput | no | no |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIT5_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL4_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF32_HUMAN | [view interactions] | High throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| MKLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDT5_HUMAN | [view interactions] | High throughput | no | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCS1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STPG3_HUMAN | [view interactions] | High throughput | no | no |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |