NSF1C_HUMAN
Evidence for PS localization
Functions
Reduces the ATPase activity of VCP . Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis . May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) . Inhibits the activity of CTSL (in vitro) (PubMed). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed). Also, regulates spindle orientation during mitosis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NSF1C_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 37.2881 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.2881 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.2881 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 27.1186 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.1186 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.1186 | 6 | no |
| GO:0005524 | ATP binding | 22.0339 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0339 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.0339 | 5 | no |
| GO:0003723 | RNA binding | 20.3390 | 4 | no |
| GO:0019900 | kinase binding | 20.3390 | 4 | no |
| GO:0019901 | protein kinase binding | 20.3390 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.3390 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.3390 | 4 | no |
| GO:0043130 | ubiquitin binding | 3.3898 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NSF1C_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.3220 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.2373 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.1525 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.1525 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.7627 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.0678 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.6780 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.9831 | 5 | no |
| GO:0006996 | organelle organization | 37.2881 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.2881 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.2881 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.2881 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.2881 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.2881 | 5 | no |
| GO:0060341 | regulation of cellular localization | 35.5932 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.5932 | 5 | no |
| GO:0010941 | regulation of cell death | 33.8983 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.8983 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 32.2034 | 4 | yes |
| GO:0032880 | regulation of protein localization | 32.2034 | 5 | yes |
| GO:0036211 | protein modification process | 32.2034 | 4 | no |
| GO:0043412 | macromolecule modification | 32.2034 | 4 | no |
| GO:0044265 | cellular macromolecule catabolic process | 30.5085 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.5085 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.5085 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.5085 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.5085 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.5085 | 5 | no |
| GO:0006508 | proteolysis | 28.8136 | 4 | yes |
| GO:0008104 | protein localization | 28.8136 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.8136 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.8136 | 5 | no |
| GO:0051049 | regulation of transport | 28.8136 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 27.1186 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 27.1186 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.1186 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.1186 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.1186 | 6 | no |
| GO:0019941 | modification-dependent protein catabolic process | 25.4237 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 25.4237 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 25.4237 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.4237 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.4237 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.4237 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.7288 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.7288 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.7288 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.7288 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.7288 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.7288 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.7288 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.7288 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.7288 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.0339 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 22.0339 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 22.0339 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 22.0339 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.0339 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.0339 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.0339 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.0339 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.0339 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.0339 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.0339 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0339 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.3390 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.3390 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.3390 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 20.3390 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.3390 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.3390 | 5 | no |
| GO:0061024 | membrane organization | 18.6441 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 16.9492 | 7 | yes |
| GO:0010564 | regulation of cell cycle process | 16.9492 | 5 | yes |
| GO:0030163 | protein catabolic process | 16.9492 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 16.9492 | 4 | yes |
| GO:0010498 | proteasomal protein catabolic process | 15.2542 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 13.5593 | 6 | yes |
| GO:0007030 | Golgi organization | 10.1695 | 5 | yes |
| GO:0045787 | positive regulation of cell cycle | 10.1695 | 5 | yes |
| GO:0090068 | positive regulation of cell cycle process | 10.1695 | 6 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 10.1695 | 4 | yes |
| GO:0070925 | organelle assembly | 8.4746 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 8.4746 | 5 | yes |
| GO:0061025 | membrane fusion | 6.7797 | 5 | yes |
| GO:0071709 | membrane assembly | 5.0847 | 5 | yes |
| GO:1904779 | regulation of protein localization to centrosome | 5.0847 | 6 | yes |
| GO:0000045 | autophagosome assembly | 3.3898 | 6 | yes |
| GO:0000132 | establishment of mitotic spindle orientation | 3.3898 | 6 | yes |
| GO:0007033 | vacuole organization | 3.3898 | 5 | yes |
| GO:0031468 | nuclear membrane reassembly | 3.3898 | 6 | yes |
| GO:0040001 | establishment of mitotic spindle localization | 3.3898 | 5 | yes |
| GO:0046602 | regulation of mitotic centrosome separation | 3.3898 | 6 | yes |
| GO:0046604 | positive regulation of mitotic centrosome separation | 3.3898 | 7 | yes |
| GO:0051293 | establishment of spindle localization | 3.3898 | 4 | yes |
| GO:0051294 | establishment of spindle orientation | 3.3898 | 5 | yes |
| GO:0071763 | nuclear membrane organization | 3.3898 | 5 | yes |
| GO:1904780 | negative regulation of protein localization to centrosome | 3.3898 | 6 | yes |
| GO:1905037 | autophagosome organization | 3.3898 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NPL4_HUMAN | [view interactions] | Low throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UFD1_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | Low throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
| STX5_HUMAN | [view interactions] | Low throughput | no | yes |
| NGLY1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBP_HUMAN | [view interactions] | High throughput | no | yes |
| PHAX_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| TZAP_HUMAN | [view interactions] | High throughput | no | no |
| BAX_HUMAN | [view interactions] | High throughput | no | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN54_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| LIPS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| FA32A_HUMAN | [view interactions] | High throughput | no | no |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| RB33B_HUMAN | [view interactions] | High throughput | no | no |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB19_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| UBR1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| PPB1_HUMAN | [view interactions] | High throughput | no | no |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| F104A_HUMAN | [view interactions] | High throughput | no | yes |
| UBX10_HUMAN | [view interactions] | High throughput | no | yes |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| MYH13_HUMAN | [view interactions] | High throughput | no | no |
| UBX2A_HUMAN | [view interactions] | High throughput | no | no |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| FGGY_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1RB_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBX2B_HUMAN | [view interactions] | High throughput | no | no |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN2_HUMAN | [view interactions] | High throughput | no | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ULA1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP6_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPA_HUMAN | [view interactions] | High throughput | no | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
| MCL1_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PSMF1_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFN2B_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2B_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DJC22_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SVIP_HUMAN | [view interactions] | Computational | no | yes |