Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NSF1C_HUMAN

Reduces the ATPase activity of VCP . Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis . May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) . Inhibits the activity of CTSL (in vitro) (PubMed). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed). Also, regulates spindle orientation during mitosis (PubMed). [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI004588 LIG_VCP_SHPBox_1 LIG 252 261 -
ELMI004588 LIG_VCP_SHPBox_1 LIG 252 261 -

Molecular function

Term Name % Distance from the top of the tree Annotated in NSF1C_HUMAN
GO:0043168 anion binding 36.7647 4 no
GO:0000166 nucleotide binding 36.7647 4 no
GO:0017076 purine nucleotide binding 35.2941 5 no
GO:0032555 purine ribonucleotide binding 35.2941 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.2941 4 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0019900 kinase binding 22.0588 4 no
GO:0043169 cation binding 22.0588 4 no
GO:0005524 ATP binding 20.5882 5 no
GO:0030554 adenyl nucleotide binding 20.5882 6 no
GO:0032559 adenyl ribonucleotide binding 20.5882 5 no
GO:0019901 protein kinase binding 20.5882 5 no
GO:0046872 metal ion binding 20.5882 5 no
GO:0003723 RNA binding 20.5882 4 no
GO:0043130 ubiquitin binding 2.9412 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NSF1C_HUMAN
GO:0048522 positive regulation of cellular process 60.2941 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.9412 4 no
GO:0031323 regulation of cellular metabolic process 51.4706 4 no
GO:0048523 negative regulation of cellular process 48.5294 4 yes
GO:0080090 regulation of primary metabolic process 48.5294 4 no
GO:0009889 regulation of biosynthetic process 44.1176 4 no
GO:0051128 regulation of cellular component organization 44.1176 4 no
GO:0031326 regulation of cellular biosynthetic process 42.6471 5 no
GO:0006996 organelle organization 42.6471 4 yes
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0010556 regulation of macromolecule biosynthetic process 41.1765 5 no
GO:0010468 regulation of gene expression 38.2353 6 no
GO:0010604 positive regulation of macromolecule metabolic process 36.7647 5 no
GO:0010646 regulation of cell communication 36.7647 4 no
GO:0051246 regulation of protein metabolic process 35.2941 5 no
GO:0022607 cellular component assembly 35.2941 4 yes
GO:0008104 protein localization 33.8235 4 no
GO:0031325 positive regulation of cellular metabolic process 33.8235 5 no
GO:0009966 regulation of signal transduction 33.8235 4 no
GO:0060341 regulation of cellular localization 30.8824 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0032880 regulation of protein localization 27.9412 5 yes
GO:0036211 protein modification process 27.9412 4 no
GO:0043412 macromolecule modification 27.9412 4 no
GO:0009891 positive regulation of biosynthetic process 27.9412 5 no
GO:0042981 regulation of apoptotic process 27.9412 5 no
GO:0043067 regulation of programmed cell death 27.9412 4 no
GO:0045595 regulation of cell differentiation 27.9412 4 no
GO:0006508 proteolysis 27.9412 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 26.4706 6 no
GO:0051049 regulation of transport 26.4706 4 no
GO:0010647 positive regulation of cell communication 26.4706 5 no
GO:0023056 positive regulation of signaling 26.4706 4 no
GO:0007010 cytoskeleton organization 26.4706 5 yes
GO:0009057 macromolecule catabolic process 26.4706 4 yes
GO:0051726 regulation of cell cycle 25.0000 4 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051603 proteolysis involved in protein catabolic process 23.5294 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:0009968 negative regulation of signal transduction 23.5294 5 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0051240 positive regulation of multicellular organismal process 23.5294 4 no
GO:0071310 cellular response to organic substance 22.0588 4 no
GO:0006355 regulation of DNA-templated transcription 22.0588 7 no
GO:0051252 regulation of RNA metabolic process 22.0588 5 no
GO:2001141 regulation of RNA biosynthetic process 22.0588 6 no
GO:2000026 regulation of multicellular organismal development 22.0588 4 no
GO:0009967 positive regulation of signal transduction 22.0588 5 no
GO:0043632 modification-dependent macromolecule catabolic process 20.5882 5 yes
GO:0061024 membrane organization 20.5882 4 yes
GO:1901565 organonitrogen compound catabolic process 20.5882 4 yes
GO:0015031 protein transport 20.5882 4 no
GO:0071702 organic substance transport 20.5882 4 no
GO:0071705 nitrogen compound transport 20.5882 4 no
GO:0009894 regulation of catabolic process 20.5882 4 no
GO:0043933 protein-containing complex organization 20.5882 4 no
GO:0019220 regulation of phosphate metabolic process 20.5882 6 no
GO:0045597 positive regulation of cell differentiation 20.5882 5 no
GO:0051174 regulation of phosphorus metabolic process 20.5882 5 no
GO:0060284 regulation of cell development 20.5882 5 no
GO:0019941 modification-dependent protein catabolic process 20.5882 6 yes
GO:0030163 protein catabolic process 17.6471 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 17.6471 7 yes
GO:0010564 regulation of cell cycle process 17.6471 5 yes
GO:0010498 proteasomal protein catabolic process 14.7059 5 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 13.2353 6 yes
GO:0070925 organelle assembly 10.2941 5 yes
GO:0007030 Golgi organization 10.2941 5 yes
GO:0045787 positive regulation of cell cycle 8.8235 5 yes
GO:0090068 positive regulation of cell cycle process 8.8235 6 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 8.8235 4 yes
GO:1903828 negative regulation of protein localization 8.8235 5 yes
GO:0061025 membrane fusion 7.3529 5 yes
GO:0071709 membrane assembly 5.8824 5 yes
GO:0051293 establishment of spindle localization 4.4118 4 yes
GO:1904779 regulation of protein localization to centrosome 4.4118 6 yes
GO:0007033 vacuole organization 4.4118 5 yes
GO:0031468 nuclear membrane reassembly 2.9412 6 yes
GO:0040001 establishment of mitotic spindle localization 2.9412 5 yes
GO:0046602 regulation of mitotic centrosome separation 2.9412 6 yes
GO:0046604 positive regulation of mitotic centrosome separation 2.9412 7 yes
GO:0051294 establishment of spindle orientation 2.9412 5 yes
GO:0071763 nuclear membrane organization 2.9412 5 yes
GO:1904780 negative regulation of protein localization to centrosome 2.9412 6 yes
GO:1905037 autophagosome organization 2.9412 6 yes
GO:0000045 autophagosome assembly 2.9412 6 yes
GO:0000132 establishment of mitotic spindle orientation 2.9412 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBXN6_HUMAN [view entry] [view interactions] Low throughput yes yes
NSF1C_HUMAN [view entry] [view interactions] Low throughput yes yes
UFD1_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SPRTN_HUMAN [view interactions] Low throughput no yes
NF1_HUMAN [view entry] [view interactions] Low throughput yes no
NEMO_HUMAN [view interactions] Low throughput no yes
SNTG2_HUMAN [view interactions] Low throughput no no
STX5_HUMAN [view interactions] Low throughput no yes
NGLY1_HUMAN [view interactions] Low throughput no yes
TOPK_HUMAN [view interactions] Low throughput no no
CDK1_HUMAN [view interactions] Low throughput no no
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
NPL4_HUMAN [view interactions] Low throughput no yes
VCIP1_HUMAN [view entry] [view interactions] Low throughput yes no
UBE4B_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
LG3BP_HUMAN [view interactions] High throughput no no
AMFR_HUMAN [view interactions] High throughput no yes
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
CUL2_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TZAP_HUMAN [view interactions] High throughput no no
BAX_HUMAN [view interactions] High throughput no yes
PDK1_HUMAN [view interactions] High throughput no yes
P4R3A_HUMAN [view interactions] High throughput no yes
NUF2_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
LIN54_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
LIPS_HUMAN [view entry] [view interactions] High throughput yes no
RL22_HUMAN [view entry] [view interactions] High throughput yes no
AN32A_HUMAN [view interactions] High throughput no yes
FA32A_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
SRP14_HUMAN [view interactions] High throughput no no
RB33B_HUMAN [view interactions] High throughput no no
RAB21_HUMAN [view entry] [view interactions] High throughput yes yes
RAB19_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
UBR1_HUMAN [view interactions] High throughput no yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
HIF1A_HUMAN [view interactions] High throughput no no
PPB1_HUMAN [view interactions] High throughput no no
RD23B_HUMAN [view interactions] High throughput no yes
VCF1_HUMAN [view interactions] High throughput no yes
UBX10_HUMAN [view interactions] High throughput no yes
ASPC1_HUMAN [view interactions] High throughput no yes
MYH13_HUMAN [view interactions] High throughput no no
UBX2A_HUMAN [view interactions] High throughput no no
FAF1_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
ACD11_HUMAN [view interactions] High throughput no yes
FGGY_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PP1RB_HUMAN [view interactions] High throughput no yes
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
PINK1_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
UBX2B_HUMAN [view interactions] High throughput no no
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ISG15_HUMAN [view interactions] High throughput no no
OAT_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
UBXN1_HUMAN [view interactions] High throughput no no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GET3_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
TET5C_HUMAN [view interactions] High throughput no yes
FND3A_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
OTU7A_HUMAN [view interactions] High throughput no no
SPPL3_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
SH3L1_HUMAN [view interactions] High throughput no yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
DHX15_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
PUR9_HUMAN [view entry] [view interactions] High throughput yes yes
CDV3_HUMAN [view interactions] High throughput no no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
GMDS_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
ULA1_HUMAN [view entry] [view interactions] High throughput yes yes
PARP6_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
TATD1_HUMAN [view interactions] High throughput no yes
UBA3_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
PAPS1_HUMAN [view interactions] High throughput no yes
IPP2_HUMAN [view interactions] High throughput no no
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
ITPA_HUMAN [view interactions] High throughput no yes
CK054_HUMAN [view interactions] High throughput no no
PDXD1_HUMAN [view interactions] High throughput no no
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN4_HUMAN [view interactions] High throughput no yes
MCL1_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL5_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2A_HUMAN [view interactions] High throughput no yes
PSMF1_HUMAN [view interactions] High throughput no yes
RN181_HUMAN [view interactions] High throughput no no
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
UBCP1_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
ZFN2B_HUMAN [view interactions] High throughput no yes
IPP2B_HUMAN [view interactions] High throughput no no
UBFD1_HUMAN [view interactions] High throughput no no
UBQL4_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TRI14_HUMAN [view interactions] High throughput no yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
XRCC6_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
DJC22_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
BAP31_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR2_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
KDM1A_HUMAN [view interactions] High throughput no yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
K1C18_HUMAN [view interactions] High throughput no no
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
PXMP2_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
CCNF_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
BRSK2_HUMAN [view interactions] High throughput no no
COR1A_HUMAN [view entry] [view interactions] High throughput yes no
DHCR7_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
BACD1_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB4_HUMAN [view interactions] High throughput no yes
MOB2_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
ACBP_HUMAN [view interactions] High throughput no yes
PHAX_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no