LIPS_HUMAN
Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed, PubMed, PubMed, PubMed). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs . Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor . In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LIPS_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 58.3333 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 58.3333 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 58.3333 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 58.3333 | 5 | no |
GO:0030551 | cyclic nucleotide binding | 41.6667 | 4 | no |
GO:0019900 | kinase binding | 41.6667 | 4 | no |
GO:0019901 | protein kinase binding | 41.6667 | 5 | no |
GO:0031625 | ubiquitin protein ligase binding | 41.6667 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 41.6667 | 4 | no |
GO:0004860 | protein kinase inhibitor activity | 33.3333 | 5 | no |
GO:0004862 | cAMP-dependent protein kinase inhibitor activity | 33.3333 | 6 | no |
GO:0008603 | cAMP-dependent protein kinase regulator activity | 33.3333 | 5 | no |
GO:0019210 | kinase inhibitor activity | 33.3333 | 4 | no |
GO:0019887 | protein kinase regulator activity | 33.3333 | 4 | no |
GO:0030291 | protein serine/threonine kinase inhibitor activity | 33.3333 | 6 | no |
GO:0030552 | cAMP binding | 33.3333 | 4 | no |
GO:0034236 | protein kinase A catalytic subunit binding | 33.3333 | 4 | no |
GO:0004674 | protein serine/threonine kinase activity | 25.0000 | 4 | no |
GO:0004690 | cyclic nucleotide-dependent protein kinase activity | 25.0000 | 5 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 25.0000 | 4 | no |
GO:0005524 | ATP binding | 25.0000 | 5 | no |
GO:0016301 | kinase activity | 25.0000 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
GO:0106310 | protein serine kinase activity | 25.0000 | 4 | no |
GO:0004771 | sterol esterase activity | 16.6667 | 5 | yes |
GO:0004806 | triglyceride lipase activity | 16.6667 | 5 | yes |
GO:0016298 | lipase activity | 16.6667 | 4 | yes |
GO:0052689 | carboxylic ester hydrolase activity | 16.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LIPS_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 58.3333 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 50.0000 | 4 | yes |
GO:0036211 | protein modification process | 50.0000 | 4 | yes |
GO:0043412 | macromolecule modification | 50.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0006468 | protein phosphorylation | 41.6667 | 5 | yes |
GO:0016310 | phosphorylation | 41.6667 | 5 | yes |
GO:0051049 | regulation of transport | 41.6667 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 41.6667 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 41.6667 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 41.6667 | 5 | no |
GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
GO:0048878 | chemical homeostasis | 33.3333 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 33.3333 | 7 | no |
GO:0001933 | negative regulation of protein phosphorylation | 33.3333 | 8 | no |
GO:0006469 | negative regulation of protein kinase activity | 33.3333 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 33.3333 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 33.3333 | 7 | no |
GO:0033673 | negative regulation of kinase activity | 33.3333 | 6 | no |
GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
GO:0042326 | negative regulation of phosphorylation | 33.3333 | 8 | no |
GO:0043086 | negative regulation of catalytic activity | 33.3333 | 4 | no |
GO:0043549 | regulation of kinase activity | 33.3333 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 33.3333 | 6 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 33.3333 | 7 | no |
GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 33.3333 | 6 | no |
GO:0051338 | regulation of transferase activity | 33.3333 | 4 | no |
GO:0051348 | negative regulation of transferase activity | 33.3333 | 5 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 33.3333 | 7 | no |
GO:0071901 | negative regulation of protein serine/threonine kinase activity | 33.3333 | 8 | no |
GO:2000479 | regulation of cAMP-dependent protein kinase activity | 33.3333 | 8 | no |
GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 33.3333 | 9 | no |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0006869 | lipid transport | 25.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
GO:0008202 | steroid metabolic process | 16.6667 | 4 | yes |
GO:0008203 | cholesterol metabolic process | 16.6667 | 5 | yes |
GO:0016042 | lipid catabolic process | 16.6667 | 4 | yes |
GO:0016125 | sterol metabolic process | 16.6667 | 4 | yes |
GO:0044242 | cellular lipid catabolic process | 16.6667 | 4 | yes |
GO:0046486 | glycerolipid metabolic process | 16.6667 | 4 | yes |
GO:1902652 | secondary alcohol metabolic process | 16.6667 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FABP9_HUMAN | [view interactions] | Low throughput | no | no |
CAVN1_HUMAN | [view interactions] | Low throughput | no | no |
STAR_HUMAN | [view interactions] | Low throughput | no | no |
PLIN1_HUMAN | [view interactions] | Low throughput | no | no |
PLIN5_HUMAN | [view interactions] | Low throughput | no | no |
PLIN2_HUMAN | [view interactions] | Low throughput | no | no |
PLIN3_HUMAN | [view interactions] | Low throughput | no | yes |
FABP4_HUMAN | [view interactions] | Low throughput | no | no |
MTR1A_HUMAN | [view interactions] | High throughput | no | no |
T10IP_HUMAN | [view interactions] | High throughput | no | no |
NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
LIPC_HUMAN | [view interactions] | Computational | no | no |
PLPL3_HUMAN | [view interactions] | Computational | no | no |
KAP0_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLPL4_HUMAN | [view interactions] | Computational | no | yes |
AAKG2_HUMAN | [view interactions] | Computational | no | yes |
AAKG3_HUMAN | [view interactions] | Computational | no | no |
AAPK2_HUMAN | [view interactions] | Computational | no | yes |
KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAPK1_HUMAN | [view interactions] | Computational | no | no |
LIPG_HUMAN | [view interactions] | Computational | no | no |
LIPE_HUMAN | [view interactions] | Computational | no | no |
PLPL2_HUMAN | [view interactions] | Computational | no | no |
FABP5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACSF2_HUMAN | [view interactions] | Computational | no | no |
FABPH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AAKB2_HUMAN | [view interactions] | Computational | no | yes |
AAKB1_HUMAN | [view interactions] | Computational | no | yes |
KAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIPP_HUMAN | [view interactions] | Computational | no | no |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
CEL_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DGAT1_HUMAN | [view interactions] | Computational | no | yes |
LIPR3_HUMAN | [view interactions] | Computational | no | no |
KGP1_HUMAN | [view interactions] | Computational | no | yes |
KAP3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AAKG1_HUMAN | [view interactions] | Computational | no | no |