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LIPS_HUMAN

GO
G2C
SynGO

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed, PubMed, PubMed, PubMed). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs . Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor . In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LIPS_HUMAN
GO:0017076 purine nucleotide binding 58.3333 4 no
GO:0030554 adenyl nucleotide binding 58.3333 5 no
GO:0032555 purine ribonucleotide binding 58.3333 4 no
GO:0032559 adenyl ribonucleotide binding 58.3333 5 no
GO:0030551 cyclic nucleotide binding 41.6667 4 no
GO:0019900 kinase binding 41.6667 4 no
GO:0019901 protein kinase binding 41.6667 5 no
GO:0031625 ubiquitin protein ligase binding 41.6667 5 no
GO:0044389 ubiquitin-like protein ligase binding 41.6667 4 no
GO:0004860 protein kinase inhibitor activity 33.3333 5 no
GO:0004862 cAMP-dependent protein kinase inhibitor activity 33.3333 6 no
GO:0008603 cAMP-dependent protein kinase regulator activity 33.3333 5 no
GO:0019210 kinase inhibitor activity 33.3333 4 no
GO:0019887 protein kinase regulator activity 33.3333 4 no
GO:0030291 protein serine/threonine kinase inhibitor activity 33.3333 6 no
GO:0030552 cAMP binding 33.3333 4 no
GO:0034236 protein kinase A catalytic subunit binding 33.3333 4 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0004690 cyclic nucleotide-dependent protein kinase activity 25.0000 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0106310 protein serine kinase activity 25.0000 4 no
GO:0004771 sterol esterase activity 16.6667 5 yes
GO:0004806 triglyceride lipase activity 16.6667 5 yes
GO:0016298 lipase activity 16.6667 4 yes
GO:0052689 carboxylic ester hydrolase activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LIPS_HUMAN
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 58.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 yes
GO:0043412 macromolecule modification 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0006468 protein phosphorylation 41.6667 5 yes
GO:0016310 phosphorylation 41.6667 5 yes
GO:0051049 regulation of transport 41.6667 4 no
GO:0099177 regulation of trans-synaptic signaling 41.6667 4 no
GO:0019220 regulation of phosphate metabolic process 41.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048878 chemical homeostasis 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0006469 negative regulation of protein kinase activity 33.3333 7 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0033673 negative regulation of kinase activity 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051348 negative regulation of transferase activity 33.3333 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 33.3333 7 no
GO:0071901 negative regulation of protein serine/threonine kinase activity 33.3333 8 no
GO:2000479 regulation of cAMP-dependent protein kinase activity 33.3333 8 no
GO:2000480 negative regulation of cAMP-dependent protein kinase activity 33.3333 9 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0006869 lipid transport 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0008202 steroid metabolic process 16.6667 4 yes
GO:0008203 cholesterol metabolic process 16.6667 5 yes
GO:0016042 lipid catabolic process 16.6667 4 yes
GO:0016125 sterol metabolic process 16.6667 4 yes
GO:0044242 cellular lipid catabolic process 16.6667 4 yes
GO:0046486 glycerolipid metabolic process 16.6667 4 yes
GO:1902652 secondary alcohol metabolic process 16.6667 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
FABP9_HUMAN [view interactions] Low throughput no no
CAVN1_HUMAN [view interactions] Low throughput no no
STAR_HUMAN [view interactions] Low throughput no no
PLIN1_HUMAN [view interactions] Low throughput no no
PLIN5_HUMAN [view interactions] Low throughput no no
PLIN2_HUMAN [view interactions] Low throughput no no
PLIN3_HUMAN [view interactions] Low throughput no yes
FABP4_HUMAN [view interactions] Low throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
GP182_HUMAN [view interactions] High throughput no no
LIPC_HUMAN [view interactions] Computational no no
PLPL3_HUMAN [view interactions] Computational no no
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
PLPL4_HUMAN [view interactions] Computational no yes
AAKG2_HUMAN [view interactions] Computational no yes
AAKG3_HUMAN [view interactions] Computational no no
AAPK2_HUMAN [view interactions] Computational no yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
AAPK1_HUMAN [view interactions] Computational no no
LIPG_HUMAN [view interactions] Computational no no
LIPE_HUMAN [view interactions] Computational no no
PLPL2_HUMAN [view interactions] Computational no no
FABP5_HUMAN [view entry] [view interactions] Computational yes no
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
ACSF2_HUMAN [view interactions] Computational no no
FABPH_HUMAN [view entry] [view interactions] Computational yes no
AAKB2_HUMAN [view interactions] Computational no yes
AAKB1_HUMAN [view interactions] Computational no yes
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
KAP2_HUMAN [view entry] [view interactions] Computational yes yes
LIPP_HUMAN [view interactions] Computational no no
KAPCG_HUMAN [view interactions] Computational no no
CEL_HUMAN [view entry] [view interactions] Computational yes no
DGAT1_HUMAN [view interactions] Computational no yes
LIPR3_HUMAN [view interactions] Computational no no
KGP1_HUMAN [view interactions] Computational no yes
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
AAKG1_HUMAN [view interactions] Computational no no