Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIPS_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed, PubMed, PubMed, PubMed). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs . Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor . In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LIPS_HUMAN
GO:0000166 nucleotide binding 40.0000 4 no
GO:0017076 purine nucleotide binding 40.0000 5 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0043168 anion binding 40.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LIPS_HUMAN
GO:0048523 negative regulation of cellular process 80.0000 4 no
GO:0010646 regulation of cell communication 60.0000 4 no
GO:0022607 cellular component assembly 60.0000 4 no
GO:0032880 regulation of protein localization 60.0000 5 no
GO:0044087 regulation of cellular component biogenesis 60.0000 4 no
GO:0048522 positive regulation of cellular process 60.0000 4 no
GO:0051049 regulation of transport 60.0000 4 no
GO:0051128 regulation of cellular component organization 60.0000 4 no
GO:0060341 regulation of cellular localization 60.0000 4 no
GO:0006996 organelle organization 60.0000 4 no
GO:0006468 protein phosphorylation 40.0000 5 yes
GO:0006796 phosphate-containing compound metabolic process 40.0000 4 yes
GO:0016310 phosphorylation 40.0000 5 yes
GO:0036211 protein modification process 40.0000 4 yes
GO:0043412 macromolecule modification 40.0000 4 yes
GO:0006886 intracellular protein transport 40.0000 4 no
GO:0008104 protein localization 40.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0015031 protein transport 40.0000 4 no
GO:0033365 protein localization to organelle 40.0000 5 no
GO:0050708 regulation of protein secretion 40.0000 5 no
GO:0050714 positive regulation of protein secretion 40.0000 6 no
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 no
GO:0051046 regulation of secretion 40.0000 5 no
GO:0051047 positive regulation of secretion 40.0000 5 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:0051222 positive regulation of protein transport 40.0000 5 no
GO:0051223 regulation of protein transport 40.0000 5 no
GO:0051726 regulation of cell cycle 40.0000 4 no
GO:0070201 regulation of establishment of protein localization 40.0000 6 no
GO:0071702 organic substance transport 40.0000 4 no
GO:0071705 nitrogen compound transport 40.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 no
GO:1901888 regulation of cell junction assembly 40.0000 5 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:1903530 regulation of secretion by cell 40.0000 4 no
GO:1903532 positive regulation of secretion by cell 40.0000 5 no
GO:1903829 positive regulation of protein localization 40.0000 5 no
GO:1904951 positive regulation of establishment of protein localization 40.0000 6 no
GO:0007010 cytoskeleton organization 40.0000 5 no
GO:0061024 membrane organization 40.0000 4 no
GO:0061025 membrane fusion 40.0000 5 no
GO:1903828 negative regulation of protein localization 40.0000 5 no
GO:0033043 regulation of organelle organization 40.0000 5 no
GO:0043254 regulation of protein-containing complex assembly 40.0000 5 no
GO:0051051 negative regulation of transport 40.0000 4 no
GO:0051129 negative regulation of cellular component organization 40.0000 5 no
GO:0060627 regulation of vesicle-mediated transport 40.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
FABP9_HUMAN [view interactions] Low throughput no no
CAVN1_HUMAN [view interactions] Low throughput no no
STAR_HUMAN [view interactions] Low throughput no no
PLIN1_HUMAN [view interactions] Low throughput no no
PLIN5_HUMAN [view interactions] Low throughput no no
PLIN2_HUMAN [view interactions] Low throughput no no
PLIN3_HUMAN [view interactions] Low throughput no yes
FABP4_HUMAN [view interactions] Low throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
GP182_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes