Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DPYL2_HUMAN

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DPYL2_HUMAN
GO:0019900 kinase binding 23.3645 4 no
GO:0017076 purine nucleotide binding 23.3645 4 no
GO:0032555 purine ribonucleotide binding 22.4299 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.4299 4 no
GO:0046872 metal ion binding 20.5607 4 no
GO:0015631 tubulin binding 13.0841 4 yes
GO:0008017 microtubule binding 10.2804 5 yes
GO:0004157 dihydropyrimidinase activity 1.8692 5 yes
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1.8692 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DPYL2_HUMAN
GO:0048522 positive regulation of cellular process 56.0748 4 no
GO:0051128 regulation of cellular component organization 50.4673 4 yes
GO:0060255 regulation of macromolecule metabolic process 45.7944 4 no
GO:0010646 regulation of cell communication 44.8598 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.9252 4 no
GO:0048523 negative regulation of cellular process 42.9907 4 no
GO:0080090 regulation of primary metabolic process 42.9907 4 no
GO:0006996 organelle organization 41.1215 4 yes
GO:0031323 regulation of cellular metabolic process 39.2523 4 no
GO:0009966 regulation of signal transduction 37.3832 4 no
GO:0051246 regulation of protein metabolic process 34.5794 5 no
GO:0009893 positive regulation of metabolic process 32.7103 4 no
GO:0008104 protein localization 32.7103 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.8411 5 no
GO:0009892 negative regulation of metabolic process 29.9065 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.9065 5 no
GO:0022607 cellular component assembly 29.9065 4 no
GO:0051049 regulation of transport 29.9065 4 no
GO:0031344 regulation of cell projection organization 29.9065 5 no
GO:0030030 cell projection organization 28.9720 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.9720 6 no
GO:0010605 negative regulation of macromolecule metabolic process 27.1028 5 no
GO:0051130 positive regulation of cellular component organization 27.1028 5 no
GO:0045595 regulation of cell differentiation 26.1682 4 yes
GO:0031325 positive regulation of cellular metabolic process 26.1682 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.1682 5 no
GO:0010468 regulation of gene expression 25.2336 5 no
GO:0031399 regulation of protein modification process 25.2336 6 no
GO:0051247 positive regulation of protein metabolic process 25.2336 6 no
GO:0010647 positive regulation of cell communication 25.2336 5 no
GO:0023056 positive regulation of signaling 25.2336 4 no
GO:0048584 positive regulation of response to stimulus 25.2336 4 no
GO:0007010 cytoskeleton organization 24.2991 5 yes
GO:0009889 regulation of biosynthetic process 24.2991 4 no
GO:0010556 regulation of macromolecule biosynthetic process 24.2991 5 no
GO:0031324 negative regulation of cellular metabolic process 24.2991 5 no
GO:0043412 macromolecule modification 24.2991 4 no
GO:1902531 regulation of intracellular signal transduction 24.2991 5 no
GO:0071702 organic substance transport 24.2991 4 no
GO:0071705 nitrogen compound transport 24.2991 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.3645 5 yes
GO:0019220 regulation of phosphate metabolic process 23.3645 6 no
GO:0036211 protein modification process 23.3645 4 no
GO:0043085 positive regulation of catalytic activity 23.3645 4 no
GO:0051174 regulation of phosphorus metabolic process 23.3645 5 no
GO:0050804 modulation of chemical synaptic transmission 23.3645 5 no
GO:0099177 regulation of trans-synaptic signaling 23.3645 4 no
GO:0031326 regulation of cellular biosynthetic process 22.4299 5 no
GO:0042325 regulation of phosphorylation 22.4299 7 no
GO:0051248 negative regulation of protein metabolic process 22.4299 6 no
GO:0060341 regulation of cellular localization 22.4299 4 no
GO:0010941 regulation of cell death 22.4299 4 no
GO:0009967 positive regulation of signal transduction 22.4299 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.4299 4 no
GO:0044087 regulation of cellular component biogenesis 22.4299 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.4953 5 no
GO:0015031 protein transport 21.4953 4 no
GO:0051336 regulation of hydrolase activity 21.4953 4 no
GO:0033043 regulation of organelle organization 21.4953 5 no
GO:0001932 regulation of protein phosphorylation 20.5607 7 no
GO:0006796 phosphate-containing compound metabolic process 20.5607 4 no
GO:0051338 regulation of transferase activity 20.5607 4 no
GO:0043933 protein-containing complex organization 20.5607 4 no
GO:0042981 regulation of apoptotic process 20.5607 6 no
GO:0043067 regulation of programmed cell death 20.5607 5 no
GO:0051129 negative regulation of cellular component organization 20.5607 5 no
GO:0016192 vesicle-mediated transport 19.6262 4 yes
GO:0031175 neuron projection development 19.6262 6 yes
GO:0001558 regulation of cell growth 14.9533 4 yes
GO:0006897 endocytosis 11.2150 5 yes
GO:0097485 neuron projection guidance 11.2150 7 yes
GO:0007411 axon guidance 10.2804 8 yes
GO:0007399 nervous system development 9.3458 4 yes
GO:0030516 regulation of axon extension 9.3458 5 yes
GO:0048638 regulation of developmental growth 9.3458 4 yes
GO:0061387 regulation of extent of cell growth 9.3458 5 yes
GO:0007420 brain development 8.4112 4 yes
GO:0045664 regulation of neuron differentiation 4.6729 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in DPYL2_HUMAN
DOID:0050700 cardiomyopathy 1.8692 4 no
DOID:0060036 intrinsic cardiomyopathy 1.8692 5 no
DOID:114 heart disease 1.8692 3 no
DOID:2843 long QT syndrome 1.8692 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NCAM1_HUMAN [view entry] [view interactions] Low throughput yes no
PREX1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
PLXA3_HUMAN [view entry] [view interactions] Low throughput yes no
DPYL2_HUMAN [view entry] [view interactions] Low throughput yes yes
DPYL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1B_HUMAN [view interactions] Low throughput no yes
MILK1_HUMAN [view interactions] Low throughput no yes
DPYL5_HUMAN [view entry] [view interactions] Low throughput yes yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
TRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] Low throughput yes yes
MT3_HUMAN [view entry] [view interactions] Low throughput yes yes
SCN9A_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
PRDX2_HUMAN [view entry] [view interactions] Low throughput yes yes
NGB_HUMAN [view interactions] High throughput no yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
BRSK1_HUMAN [view entry] [view interactions] High throughput yes no
CAD23_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
FZD2_HUMAN [view interactions] High throughput no no
LIPA2_HUMAN [view entry] [view interactions] High throughput yes no
MYO3B_HUMAN [view interactions] High throughput no yes
CAVN3_HUMAN [view interactions] High throughput no no
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT3_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
ULA1_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DSC2_HUMAN [view interactions] High throughput no no
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
MAP9_HUMAN [view interactions] High throughput no no
PKHH1_HUMAN [view interactions] High throughput no no
SEPT9_HUMAN [view interactions] High throughput no no
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
CPSF5_HUMAN [view interactions] High throughput no yes
CSN8_HUMAN [view interactions] High throughput no yes
DHX8_HUMAN [view interactions] High throughput no yes
DPOLN_HUMAN [view interactions] High throughput no no
LAR4B_HUMAN [view interactions] High throughput no yes
LDB1_HUMAN [view interactions] High throughput no yes
PEO1_HUMAN [view interactions] High throughput no yes
SMD2_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
ZBT41_HUMAN [view interactions] High throughput no yes
IMPA3_HUMAN [view interactions] High throughput no yes
KAD5_HUMAN [view entry] [view interactions] High throughput yes yes
LIPN_HUMAN [view interactions] High throughput no no
NDUC2_HUMAN [view interactions] High throughput no yes
NDUCR_HUMAN [view interactions] High throughput no yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NEUA_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPX_HUMAN [view entry] [view interactions] High throughput yes yes
CBPC1_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
RL12_HUMAN [view entry] [view interactions] High throughput yes yes
RS17_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
UBA5_HUMAN [view interactions] High throughput no yes
SYN3_HUMAN [view entry] [view interactions] High throughput yes yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
VP33B_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
CD72_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
CA216_HUMAN [view interactions] High throughput no yes
CB39L_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
CHMP3_HUMAN [view interactions] High throughput no yes
FGD6_HUMAN [view interactions] High throughput no yes
GALD1_HUMAN [view interactions] High throughput no yes
RAI1_HUMAN [view interactions] High throughput no yes
SEPT6_HUMAN [view interactions] High throughput no yes
SRSF3_HUMAN [view interactions] High throughput no yes
SPG17_HUMAN [view interactions] High throughput no no
TPPC9_HUMAN [view entry] [view interactions] High throughput yes no
NMDE1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
CGRF1_HUMAN [view interactions] High throughput no yes
MARH2_HUMAN [view interactions] High throughput no yes
MARH3_HUMAN [view interactions] High throughput no no
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
WDR5_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
NUBP1_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SPSB3_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
BLVRB_HUMAN [view entry] [view interactions] High throughput yes yes
CDC23_HUMAN [view interactions] High throughput no yes
RGAP1_HUMAN [view interactions] High throughput no no
STT3B_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3J_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
PDE3A_HUMAN [view interactions] High throughput no no
PUS7_HUMAN [view interactions] High throughput no yes
RNBP6_HUMAN [view interactions] High throughput no yes
ARFP1_HUMAN [view interactions] High throughput no no
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDD_HUMAN [view interactions] High throughput no no
DPH2_HUMAN [view interactions] High throughput no no
LYPA1_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
UN13D_HUMAN [view interactions] High throughput no yes
NTM1A_HUMAN [view interactions] High throughput no yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DPYL4_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
TF2LY_HUMAN [view interactions] High throughput no no
DPYS_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
KLDC3_HUMAN [view interactions] High throughput no yes
WDR83_HUMAN [view interactions] High throughput no yes
DPYL3_HUMAN [view entry] [view interactions] High throughput yes yes
LEG7_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
MTR1B_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI63_HUMAN [view interactions] High throughput no no
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
NEK7_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF1_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNH2_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
RD3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
LEF1_HUMAN [view interactions] High throughput no no
GORS2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
LUC7L_HUMAN [view interactions] High throughput no yes
EXOS7_HUMAN [view interactions] High throughput no yes
KIF9_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
APH1A_HUMAN [view interactions] High throughput no yes
APH1B_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
KTNA1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
RRP7A_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
TAFA3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
MGDP1_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
GNAT3_HUMAN [view interactions] Computational no no
GNAT2_HUMAN [view interactions] Computational no no
FES_HUMAN [view entry] [view interactions] Computational yes no
NF1_HUMAN [view entry] [view interactions] Computational yes no
KLC1_HUMAN [view entry] [view interactions] Computational yes no
RB27B_HUMAN [view interactions] Computational no no
STX1A_HUMAN [view entry] [view interactions] Computational yes yes
CDK5_HUMAN [view entry] [view interactions] Computational yes yes
PLXA2_HUMAN [view entry] [view interactions] Computational yes yes
GNAT1_HUMAN [view interactions] Computational no no
PLXA4_HUMAN [view entry] [view interactions] Computational yes no
SEM3A_HUMAN [view interactions] Computational no no