Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIPA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

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Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004551 LIG_CaMK_CASK_1 LIG 977 984 -
ELMI004551 LIG_CaMK_CASK_1 LIG 977 984 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LIPA2_HUMAN
GO:0043169 cation binding 32.1429 4 no
GO:0046872 metal ion binding 32.1429 5 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LIPA2_HUMAN
GO:0010646 regulation of cell communication 64.2857 4 yes
GO:0051128 regulation of cellular component organization 60.7143 4 yes
GO:0048523 negative regulation of cellular process 53.5714 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 46.4286 4 no
GO:0048522 positive regulation of cellular process 46.4286 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0036211 protein modification process 39.2857 4 no
GO:0043412 macromolecule modification 39.2857 4 no
GO:0031324 negative regulation of cellular metabolic process 39.2857 5 no
GO:0080090 regulation of primary metabolic process 39.2857 4 no
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 yes
GO:0048585 negative regulation of response to stimulus 35.7143 4 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0022603 regulation of anatomical structure morphogenesis 32.1429 4 yes
GO:1902531 regulation of intracellular signal transduction 32.1429 5 no
GO:0034330 cell junction organization 28.5714 4 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0051049 regulation of transport 28.5714 4 yes
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0050808 synapse organization 25.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010975 regulation of neuron projection development 21.4286 7 yes
GO:0017157 regulation of exocytosis 21.4286 5 yes
GO:0031344 regulation of cell projection organization 21.4286 5 yes
GO:0046928 regulation of neurotransmitter secretion 21.4286 5 yes
GO:0051046 regulation of secretion 21.4286 5 yes
GO:0051588 regulation of neurotransmitter transport 21.4286 5 yes
GO:0099175 regulation of postsynapse organization 21.4286 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 yes
GO:1903530 regulation of secretion by cell 21.4286 4 yes
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 5 no
GO:0043067 regulation of programmed cell death 21.4286 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0010629 negative regulation of gene expression 21.4286 7 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:1902532 negative regulation of intracellular signal transduction 21.4286 6 no
GO:0046903 secretion 21.4286 4 no
GO:0001558 regulation of cell growth 21.4286 4 no
GO:0006996 organelle organization 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0007160 cell-matrix adhesion 17.8571 4 yes
GO:1903305 regulation of regulated secretory pathway 17.8571 6 yes
GO:2000300 regulation of synaptic vesicle exocytosis 17.8571 6 yes
GO:0051650 establishment of vesicle localization 14.2857 4 yes
GO:0060998 regulation of dendritic spine development 10.7143 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 10.7143 5 yes
GO:0016482 cytosolic transport 7.1429 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 7.1429 4 yes
GO:0032252 secretory granule localization 7.1429 4 yes
GO:0032253 dense core granule localization 7.1429 5 yes
GO:0099518 vesicle cytoskeletal trafficking 7.1429 5 yes
GO:0099519 dense core granule cytoskeletal transport 7.1429 6 yes
GO:1901950 dense core granule transport 7.1429 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPB1_HUMAN [view interactions] Low throughput no yes
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA2_HUMAN [view entry] [view interactions] Low throughput yes no
CDC5L_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MD13L_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
TLK2_HUMAN [view interactions] High throughput no no
SMCA2_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SETD6_HUMAN [view interactions] High throughput no yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
LIPA3_HUMAN [view entry] [view interactions] High throughput yes yes
LIPB2_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
APBA1_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
BRK1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes