ERC2_HUMAN
Evidence for PS localization
Functions
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ERC2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ERC2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 56.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 44.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 44.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 44.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 44.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0050808 | synapse organization | 40.0000 | 5 | yes |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 36.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 32.0000 | 4 | no |
| GO:0006996 | organelle organization | 28.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 24.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 24.0000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0000 | 6 | no |
| GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.0000 | 6 | no |
| GO:0036211 | protein modification process | 24.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 24.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.0000 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
| GO:0050807 | regulation of synapse organization | 24.0000 | 5 | no |
| GO:0050890 | cognition | 24.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 16.0000 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 16.0000 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 16.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 16.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 16.0000 | 5 | yes |
| GO:1990709 | presynaptic active zone organization | 16.0000 | 4 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 12.0000 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 12.0000 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 12.0000 | 4 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 8.0000 | 5 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 8.0000 | 8 | yes |
| GO:0034331 | cell junction maintenance | 8.0000 | 5 | yes |
| GO:0043954 | cellular component maintenance | 8.0000 | 4 | yes |
| GO:0048790 | maintenance of presynaptic active zone structure | 8.0000 | 5 | yes |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 8.0000 | 6 | yes |
| GO:0055074 | calcium ion homeostasis | 8.0000 | 4 | yes |
| GO:0099558 | maintenance of synapse structure | 8.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UN13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LSP1_HUMAN | [view interactions] | Low throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |