ERC2_HUMAN
Evidence for PS localization
Functions
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ERC2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 31.8182 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ERC2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 45.4545 | 4 | yes |
| GO:0034330 | cell junction organization | 45.4545 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 45.4545 | 5 | yes |
| GO:0050808 | synapse organization | 45.4545 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 45.4545 | 4 | yes |
| GO:0008104 | protein localization | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.3636 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:0051049 | regulation of transport | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.8182 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 31.8182 | 4 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.2727 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.2727 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.2727 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 27.2727 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.7273 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.7273 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 22.7273 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.7273 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 22.7273 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 22.7273 | 7 | no |
| GO:0050890 | cognition | 22.7273 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.7273 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0015031 | protein transport | 22.7273 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 22.7273 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 22.7273 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.7273 | 6 | no |
| GO:0046903 | secretion | 22.7273 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 18.1818 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 18.1818 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 18.1818 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 18.1818 | 4 | yes |
| GO:1990709 | presynaptic active zone organization | 18.1818 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 13.6364 | 5 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 9.0909 | 7 | yes |
| GO:0034331 | cell junction maintenance | 9.0909 | 5 | yes |
| GO:0043954 | cellular component maintenance | 9.0909 | 4 | yes |
| GO:0048790 | maintenance of presynaptic active zone structure | 9.0909 | 5 | yes |
| GO:0099558 | maintenance of synapse structure | 9.0909 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UN13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LSP1_HUMAN | [view interactions] | Low throughput | no | no |
| LNX1_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP2_HUMAN | [view interactions] | Computational | no | yes |