GRIP2_HUMAN
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GRIP2_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 28.5714 | 4 | no |
GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
GO:0001784 | phosphotyrosine residue binding | 21.4286 | 5 | no |
GO:0017124 | SH3 domain binding | 21.4286 | 4 | no |
GO:0045309 | protein phosphorylated amino acid binding | 21.4286 | 4 | no |
GO:0046875 | ephrin receptor binding | 21.4286 | 4 | no |
GO:0003723 | RNA binding | 21.4286 | 4 | no |
GO:0030695 | GTPase regulator activity | 21.4286 | 4 | no |
GO:0035254 | glutamate receptor binding | 14.2857 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GRIP2_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 71.4286 | 4 | no |
GO:0010646 | regulation of cell communication | 64.2857 | 4 | no |
GO:0048522 | positive regulation of cellular process | 64.2857 | 4 | no |
GO:0048523 | negative regulation of cellular process | 64.2857 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
GO:0010468 | regulation of gene expression | 42.8571 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | no |
GO:0033043 | regulation of organelle organization | 42.8571 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 42.8571 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 42.8571 | 6 | no |
GO:0050804 | modulation of chemical synaptic transmission | 42.8571 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 42.8571 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 42.8571 | 4 | no |
GO:0007010 | cytoskeleton organization | 35.7143 | 5 | no |
GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | no |
GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
GO:0023056 | positive regulation of signaling | 35.7143 | 4 | no |
GO:0031344 | regulation of cell projection organization | 35.7143 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 35.7143 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 35.7143 | 6 | no |
GO:0080134 | regulation of response to stress | 35.7143 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.7143 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 35.7143 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 35.7143 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 35.7143 | 8 | no |
GO:0009892 | negative regulation of metabolic process | 35.7143 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 35.7143 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.7143 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 35.7143 | 5 | no |
GO:0031399 | regulation of protein modification process | 35.7143 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 35.7143 | 7 | no |
GO:0042325 | regulation of phosphorylation | 35.7143 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 35.7143 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 35.7143 | 7 | no |
GO:0051049 | regulation of transport | 35.7143 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 35.7143 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 35.7143 | 6 | no |
GO:0060627 | regulation of vesicle-mediated transport | 35.7143 | 4 | no |
GO:0008104 | protein localization | 35.7143 | 4 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 28.5714 | 4 | no |
GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 28.5714 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
GO:0031347 | regulation of defense response | 28.5714 | 5 | no |
GO:0032101 | regulation of response to external stimulus | 28.5714 | 4 | no |
GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 28.5714 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 28.5714 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
GO:0050776 | regulation of immune response | 28.5714 | 4 | no |
GO:0051056 | regulation of small GTPase mediated signal transduction | 28.5714 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
GO:1905475 | regulation of protein localization to membrane | 28.5714 | 6 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 28.5714 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
GO:1902903 | regulation of supramolecular fiber organization | 28.5714 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 28.5714 | 5 | no |
GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
GO:0010628 | positive regulation of gene expression | 28.5714 | 7 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
GO:0071702 | organic substance transport | 28.5714 | 4 | yes |
GO:0072657 | protein localization to membrane | 28.5714 | 4 | yes |
GO:1990778 | protein localization to cell periphery | 21.4286 | 5 | yes |
GO:0010975 | regulation of neuron projection development | 21.4286 | 7 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.4286 | 4 | no |
GO:0030334 | regulation of cell migration | 21.4286 | 5 | no |
GO:0031348 | negative regulation of defense response | 21.4286 | 5 | no |
GO:0032102 | negative regulation of response to external stimulus | 21.4286 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 21.4286 | 6 | no |
GO:0070925 | organelle assembly | 21.4286 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 21.4286 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.4286 | 6 | no |
GO:2000145 | regulation of cell motility | 21.4286 | 4 | no |
GO:0002684 | positive regulation of immune system process | 21.4286 | 4 | no |
GO:0006974 | DNA damage response | 21.4286 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 21.4286 | 6 | no |
GO:0032271 | regulation of protein polymerization | 21.4286 | 6 | no |
GO:0043254 | regulation of protein-containing complex assembly | 21.4286 | 5 | no |
GO:0050778 | positive regulation of immune response | 21.4286 | 5 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 21.4286 | 7 | no |
GO:0110053 | regulation of actin filament organization | 21.4286 | 6 | no |
GO:0141124 | intracellular signaling cassette | 21.4286 | 4 | no |
GO:1902905 | positive regulation of supramolecular fiber organization | 21.4286 | 6 | no |
GO:0001817 | regulation of cytokine production | 21.4286 | 4 | no |
GO:0006915 | apoptotic process | 21.4286 | 4 | no |
GO:0007612 | learning | 21.4286 | 4 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 21.4286 | 6 | no |
GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 21.4286 | 7 | no |
GO:0050807 | regulation of synapse organization | 21.4286 | 5 | no |
GO:0050890 | cognition | 21.4286 | 4 | no |
GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
GO:0060284 | regulation of cell development | 21.4286 | 5 | no |
GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 21.4286 | 4 | no |
GO:0034330 | cell junction organization | 21.4286 | 4 | no |
GO:0050808 | synapse organization | 21.4286 | 5 | no |
GO:1903076 | regulation of protein localization to plasma membrane | 21.4286 | 7 | no |
GO:1904375 | regulation of protein localization to cell periphery | 21.4286 | 6 | no |
GO:0009890 | negative regulation of biosynthetic process | 21.4286 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
GO:0010629 | negative regulation of gene expression | 21.4286 | 7 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 21.4286 | 6 | no |
GO:0071705 | nitrogen compound transport | 21.4286 | 4 | yes |
GO:0072659 | protein localization to plasma membrane | 21.4286 | 5 | yes |
GO:1903539 | protein localization to postsynaptic membrane | 14.2857 | 5 | yes |
GO:1903540 | establishment of protein localization to postsynaptic membrane | 14.2857 | 5 | yes |
GO:0003018 | vascular process in circulatory system | 14.2857 | 4 | yes |
GO:0006886 | intracellular protein transport | 14.2857 | 4 | yes |
GO:0015031 | protein transport | 14.2857 | 4 | yes |
GO:0032456 | endocytic recycling | 14.2857 | 4 | yes |
GO:0035150 | regulation of tube size | 14.2857 | 4 | yes |
GO:0035296 | regulation of tube diameter | 14.2857 | 5 | yes |
GO:0035418 | protein localization to synapse | 14.2857 | 6 | yes |
GO:0061951 | establishment of protein localization to plasma membrane | 14.2857 | 5 | yes |
GO:0062237 | protein localization to postsynapse | 14.2857 | 7 | yes |
GO:0090150 | establishment of protein localization to membrane | 14.2857 | 4 | yes |
GO:0097746 | blood vessel diameter maintenance | 14.2857 | 5 | yes |
GO:0098877 | neurotransmitter receptor transport to plasma membrane | 14.2857 | 4 | yes |
GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 14.2857 | 5 | yes |
GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 14.2857 | 4 | yes |
GO:0099638 | endosome to plasma membrane protein transport | 14.2857 | 5 | yes |
GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 14.2857 | 5 | yes |
GO:1902414 | protein localization to cell junction | 14.2857 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSPG4_HUMAN | [view interactions] | Low throughput | no | yes |
NECT1_HUMAN | [view interactions] | Low throughput | no | yes |
GRAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRLHR_HUMAN | [view interactions] | Low throughput | no | no |
LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EFNB1_HUMAN | [view interactions] | Low throughput | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GFI1B_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |