Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIP2_HUMAN
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0001784 phosphotyrosine residue binding 21.4286 5 no
GO:0017124 SH3 domain binding 21.4286 4 no
GO:0045309 protein phosphorylated amino acid binding 21.4286 4 no
GO:0046875 ephrin receptor binding 21.4286 4 no
GO:0003723 RNA binding 21.4286 4 no
GO:0030159 signaling receptor complex adaptor activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRIP2_HUMAN
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010468 regulation of gene expression 42.8571 5 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0019220 regulation of phosphate metabolic process 42.8571 6 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0042325 regulation of phosphorylation 42.8571 7 no
GO:0051174 regulation of phosphorus metabolic process 42.8571 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0048584 positive regulation of response to stimulus 35.7143 4 no
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 no
GO:0051493 regulation of cytoskeleton organization 35.7143 6 no
GO:0080134 regulation of response to stress 35.7143 4 no
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 no
GO:0016192 vesicle-mediated transport 35.7143 4 yes
GO:0051049 regulation of transport 35.7143 4 no
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0001934 positive regulation of protein phosphorylation 35.7143 8 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0010562 positive regulation of phosphorus metabolic process 35.7143 6 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0031344 regulation of cell projection organization 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0042327 positive regulation of phosphorylation 35.7143 8 no
GO:0045937 positive regulation of phosphate metabolic process 35.7143 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0051247 positive regulation of protein metabolic process 35.7143 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010628 positive regulation of gene expression 28.5714 6 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0032956 regulation of actin cytoskeleton organization 28.5714 5 no
GO:0032970 regulation of actin filament-based process 28.5714 4 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1902903 regulation of supramolecular fiber organization 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 28.5714 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 28.5714 5 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010638 positive regulation of organelle organization 21.4286 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0031329 regulation of cellular catabolic process 21.4286 5 no
GO:0032271 regulation of protein polymerization 21.4286 6 no
GO:0043254 regulation of protein-containing complex assembly 21.4286 5 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0046578 regulation of Ras protein signal transduction 21.4286 7 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 21.4286 6 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0051495 positive regulation of cytoskeleton organization 21.4286 7 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0080135 regulation of cellular response to stress 21.4286 4 no
GO:0110053 regulation of actin filament organization 21.4286 6 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902905 positive regulation of supramolecular fiber organization 21.4286 6 no
GO:2001020 regulation of response to DNA damage stimulus 21.4286 5 no
GO:0010629 negative regulation of gene expression 21.4286 6 no
GO:0034330 cell junction organization 21.4286 4 no
GO:0050808 synapse organization 21.4286 5 no
GO:0008104 protein localization 21.4286 4 yes
GO:0071702 organic substance transport 21.4286 4 yes
GO:0071705 nitrogen compound transport 21.4286 4 yes
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:1903076 regulation of protein localization to plasma membrane 21.4286 7 no
GO:1904375 regulation of protein localization to cell periphery 21.4286 6 no
GO:1905475 regulation of protein localization to membrane 21.4286 6 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0051046 regulation of secretion 21.4286 5 no
GO:1903530 regulation of secretion by cell 21.4286 4 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0006974 cellular response to DNA damage stimulus 21.4286 4 no
GO:0007612 learning 21.4286 4 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0003018 vascular process in circulatory system 14.2857 4 yes
GO:0006886 intracellular protein transport 14.2857 4 yes
GO:0015031 protein transport 14.2857 4 yes
GO:0016197 endosomal transport 14.2857 4 yes
GO:0032456 endocytic recycling 14.2857 5 yes
GO:0035150 regulation of tube size 14.2857 4 yes
GO:0035296 regulation of tube diameter 14.2857 5 yes
GO:0035418 protein localization to synapse 14.2857 6 yes
GO:0061951 establishment of protein localization to plasma membrane 14.2857 5 yes
GO:0062237 protein localization to postsynapse 14.2857 7 yes
GO:0072657 protein localization to membrane 14.2857 4 yes
GO:0072659 protein localization to plasma membrane 14.2857 5 yes
GO:0090150 establishment of protein localization to membrane 14.2857 4 yes
GO:0097746 blood vessel diameter maintenance 14.2857 5 yes
GO:0098876 vesicle-mediated transport to the plasma membrane 14.2857 4 yes
GO:0098877 neurotransmitter receptor transport to plasma membrane 14.2857 4 yes
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane 14.2857 5 yes
GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 14.2857 4 yes
GO:0099638 endosome to plasma membrane protein transport 14.2857 5 yes
GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 14.2857 5 yes
GO:1902414 protein localization to cell junction 14.2857 5 yes
GO:1903539 protein localization to postsynaptic membrane 14.2857 5 yes
GO:1903540 establishment of protein localization to postsynaptic membrane 14.2857 5 yes
GO:1990778 protein localization to cell periphery 14.2857 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LIPA4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSPG4_HUMAN [view interactions] Low throughput no yes
NECT1_HUMAN [view interactions] Low throughput no yes
GRAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRLHR_HUMAN [view interactions] Low throughput no no
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB1_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
GFI1B_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes