Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIPA1_HUMAN

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI001596 LIG_PDZ_Class_2 LIG 1197 1202 -
ELMI001596 LIG_PDZ_Class_2 LIG 1197 1202 -

Molecular function

Term Name % Distance from the top of the tree Annotated in LIPA1_HUMAN
GO:0000166 nucleotide binding 29.1139 4 no
GO:0017076 purine nucleotide binding 29.1139 5 no
GO:0032555 purine ribonucleotide binding 29.1139 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.1139 4 no
GO:0043168 anion binding 29.1139 4 no
GO:0019900 kinase binding 21.5190 4 no
GO:0019901 protein kinase binding 20.2532 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LIPA1_HUMAN
GO:0048522 positive regulation of cellular process 55.6962 4 no
GO:0051128 regulation of cellular component organization 54.4304 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.6329 4 no
GO:0048523 negative regulation of cellular process 50.6329 4 yes
GO:0031323 regulation of cellular metabolic process 46.8354 4 no
GO:0080090 regulation of primary metabolic process 43.0380 4 no
GO:0010646 regulation of cell communication 43.0380 4 no
GO:0008104 protein localization 40.5063 4 no
GO:0006996 organelle organization 39.2405 4 no
GO:0009889 regulation of biosynthetic process 37.9747 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.9747 5 no
GO:0031326 regulation of cellular biosynthetic process 37.9747 5 no
GO:0010468 regulation of gene expression 36.7089 6 no
GO:0009966 regulation of signal transduction 34.1772 4 no
GO:0022607 cellular component assembly 34.1772 4 no
GO:0009892 negative regulation of metabolic process 32.9114 4 no
GO:0009893 positive regulation of metabolic process 32.9114 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.6456 5 no
GO:0010605 negative regulation of macromolecule metabolic process 31.6456 5 no
GO:0048584 positive regulation of response to stimulus 30.3797 4 no
GO:0071702 organic substance transport 30.3797 4 no
GO:0051246 regulation of protein metabolic process 29.1139 5 no
GO:0071705 nitrogen compound transport 29.1139 4 no
GO:1902531 regulation of intracellular signal transduction 29.1139 5 no
GO:0051049 regulation of transport 29.1139 4 no
GO:0033043 regulation of organelle organization 29.1139 5 yes
GO:0044087 regulation of cellular component biogenesis 29.1139 4 yes
GO:0031324 negative regulation of cellular metabolic process 27.8481 5 no
GO:0031325 positive regulation of cellular metabolic process 27.8481 5 no
GO:0031399 regulation of protein modification process 26.5823 6 no
GO:0051174 regulation of phosphorus metabolic process 25.3165 5 no
GO:0031344 regulation of cell projection organization 25.3165 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.3165 5 no
GO:0019220 regulation of phosphate metabolic process 25.3165 6 no
GO:0045595 regulation of cell differentiation 24.0506 4 no
GO:0050804 modulation of chemical synaptic transmission 24.0506 5 no
GO:0099177 regulation of trans-synaptic signaling 24.0506 4 no
GO:0060341 regulation of cellular localization 24.0506 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.0506 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.7848 4 no
GO:0051130 positive regulation of cellular component organization 22.7848 5 no
GO:0032880 regulation of protein localization 22.7848 5 yes
GO:0036211 protein modification process 22.7848 4 no
GO:0043412 macromolecule modification 22.7848 4 no
GO:0010647 positive regulation of cell communication 22.7848 5 no
GO:0015031 protein transport 22.7848 4 no
GO:0023056 positive regulation of signaling 22.7848 4 no
GO:0042981 regulation of apoptotic process 21.5190 5 no
GO:0043067 regulation of programmed cell death 21.5190 4 no
GO:0051252 regulation of RNA metabolic process 21.5190 5 no
GO:0051493 regulation of cytoskeleton organization 21.5190 6 yes
GO:0007010 cytoskeleton organization 21.5190 5 no
GO:0009967 positive regulation of signal transduction 21.5190 5 no
GO:0051247 positive regulation of protein metabolic process 20.2532 6 no
GO:2001141 regulation of RNA biosynthetic process 20.2532 6 no
GO:0051094 positive regulation of developmental process 20.2532 4 no
GO:0006796 phosphate-containing compound metabolic process 20.2532 4 no
GO:0001932 regulation of protein phosphorylation 20.2532 7 no
GO:0006355 regulation of DNA-templated transcription 20.2532 7 no
GO:0042325 regulation of phosphorylation 20.2532 7 no
GO:0051129 negative regulation of cellular component organization 18.9873 5 yes
GO:0032956 regulation of actin cytoskeleton organization 17.7215 5 yes
GO:0032970 regulation of actin filament-based process 17.7215 4 yes
GO:0034330 cell junction organization 16.4557 4 yes
GO:1902903 regulation of supramolecular fiber organization 15.1899 5 yes
GO:0110053 regulation of actin filament organization 13.9241 6 yes
GO:1905475 regulation of protein localization to membrane 11.3924 6 yes
GO:0050808 synapse organization 10.1266 5 yes
GO:1904375 regulation of protein localization to cell periphery 10.1266 6 yes
GO:0010639 negative regulation of organelle organization 8.8608 6 yes
GO:0032231 regulation of actin filament bundle assembly 8.8608 5 yes
GO:1903076 regulation of protein localization to plasma membrane 8.8608 7 yes
GO:1903828 negative regulation of protein localization 8.8608 5 yes
GO:0051492 regulation of stress fiber assembly 7.5949 6 yes
GO:0051494 negative regulation of cytoskeleton organization 7.5949 7 yes
GO:0110020 regulation of actomyosin structure organization 7.5949 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 7.5949 6 yes
GO:0007160 cell-matrix adhesion 6.3291 4 yes
GO:0032232 negative regulation of actin filament bundle assembly 3.7975 6 yes
GO:1903077 negative regulation of protein localization to plasma membrane 3.7975 7 yes
GO:1904376 negative regulation of protein localization to cell periphery 3.7975 6 yes
GO:1905476 negative regulation of protein localization to membrane 3.7975 6 yes
GO:0051497 negative regulation of stress fiber assembly 2.5316 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERC2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRS_HUMAN [view entry] [view interactions] Low throughput yes no
GRIP2_HUMAN [view entry] [view interactions] Low throughput yes no
NCOA2_HUMAN [view interactions] Low throughput no no
LNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA2_HUMAN [view entry] [view interactions] Low throughput yes no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ING4_HUMAN [view interactions] Low throughput no no
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
ELOA1_HUMAN [view interactions] High throughput no yes
TNNT1_HUMAN [view interactions] High throughput no no
CUL2_HUMAN [view interactions] High throughput no yes
ADA1D_HUMAN [view interactions] High throughput no no
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
CTNL1_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
CTDP1_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
LATS2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
LTK_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
LIPA3_HUMAN [view entry] [view interactions] High throughput yes yes
LIPB1_HUMAN [view interactions] High throughput no yes
LIPB2_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
CAGE1_HUMAN [view interactions] High throughput no no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
RNC_HUMAN [view entry] [view interactions] High throughput yes no
AURKB_HUMAN [view interactions] High throughput no yes
CDN1A_HUMAN [view interactions] High throughput no no
GPS2_HUMAN [view interactions] High throughput no yes
PHAF1_HUMAN [view interactions] High throughput no yes
CP4X1_HUMAN [view interactions] High throughput no yes
XRCC1_HUMAN [view entry] [view interactions] High throughput yes yes
GBA2_HUMAN [view interactions] High throughput no yes
KIF4A_HUMAN [view interactions] High throughput no yes
KIF4B_HUMAN [view interactions] High throughput no no
RFIP1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
I17RE_HUMAN [view interactions] High throughput no no
L2GL2_HUMAN [view interactions] High throughput no yes
PAI2_HUMAN [view interactions] High throughput no no
STX11_HUMAN [view interactions] High throughput no yes
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
TTC9B_HUMAN [view interactions] High throughput no yes
CC120_HUMAN [view interactions] High throughput no no
P85A_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TF3B_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
CC14A_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
BRPF3_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
KRT37_HUMAN [view interactions] High throughput no no
PP4C_HUMAN [view interactions] High throughput no yes
CART_HUMAN [view interactions] High throughput no yes
MAGA9_HUMAN [view interactions] High throughput no no
TPGS1_HUMAN [view interactions] High throughput no no
BRK1_HUMAN [view interactions] High throughput no no
BTNL9_HUMAN [view interactions] High throughput no no
E41L5_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
P63_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
CNKR1_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
PRS6B_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PSD13_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
OSBP1_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
HAT1_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RINI_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
PRI1_HUMAN [view interactions] High throughput no no
F10A1_HUMAN [view interactions] High throughput no yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
DPOA2_HUMAN [view interactions] High throughput no yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
TBC9B_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
PI42C_HUMAN [view interactions] High throughput no yes
IPO9_HUMAN [view interactions] High throughput no no
RPAP3_HUMAN [view interactions] High throughput no yes
SMYD2_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
VP33B_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
ARL4C_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
ARL14_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
CBPC1_HUMAN [view interactions] High throughput no yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AB_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
2A5D_HUMAN [view entry] [view interactions] High throughput yes yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTRB_HUMAN [view interactions] High throughput no yes
MBIP1_HUMAN [view interactions] High throughput no yes
CEP70_HUMAN [view interactions] High throughput no yes
DTNB_HUMAN [view entry] [view interactions] High throughput yes no
TXLNA_HUMAN [view interactions] High throughput no yes
CCNH_HUMAN [view interactions] High throughput no yes
F161A_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
2A5A_HUMAN [view interactions] High throughput no yes
DRC4_HUMAN [view interactions] High throughput no yes