LIPA1_HUMAN
Evidence for PS localization
Functions
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001596 | LIG_PDZ_Class_2 | LIG | 1197 | 1202 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIPA1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.8182 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.8182 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.8182 | 4 | no |
| GO:0019900 | kinase binding | 24.2424 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.2424 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.2424 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.2424 | 6 | no |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | no |
| GO:0003924 | GTPase activity | 22.7273 | 7 | no |
| GO:0005525 | GTP binding | 22.7273 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.7273 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.7273 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIPA1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 51.5152 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.9394 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.9394 | 4 | no |
| GO:0008104 | protein localization | 42.4242 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0071702 | organic substance transport | 39.3939 | 4 | no |
| GO:0071705 | nitrogen compound transport | 39.3939 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 31.8182 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.7879 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.7879 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.2727 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 27.2727 | 5 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.7576 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.7576 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.7576 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.7576 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.7576 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.7576 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 25.7576 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.7576 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.7576 | 6 | no |
| GO:0030030 | cell projection organization | 25.7576 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.2424 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.2424 | 5 | no |
| GO:0036211 | protein modification process | 24.2424 | 4 | no |
| GO:0043412 | macromolecule modification | 24.2424 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.2424 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.7273 | 6 | yes |
| GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
| GO:0006886 | intracellular protein transport | 22.7273 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 21.2121 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 21.2121 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 21.2121 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2121 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2121 | 5 | no |
| GO:0032880 | regulation of protein localization | 18.1818 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.1818 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 18.1818 | 4 | yes |
| GO:0034330 | cell junction organization | 16.6667 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 15.1515 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 13.6364 | 6 | yes |
| GO:0050808 | synapse organization | 12.1212 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 10.6061 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 10.6061 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 9.0909 | 6 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 9.0909 | 7 | yes |
| GO:0007160 | cell-matrix adhesion | 7.5758 | 4 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 7.5758 | 5 | yes |
| GO:0051492 | regulation of stress fiber assembly | 7.5758 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 7.5758 | 7 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 7.5758 | 6 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 7.5758 | 6 | yes |
| GO:1903828 | negative regulation of protein localization | 6.0606 | 5 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 3.0303 | 6 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 3.0303 | 7 | yes |
| GO:1903077 | negative regulation of protein localization to plasma membrane | 3.0303 | 7 | yes |
| GO:1904376 | negative regulation of protein localization to cell periphery | 3.0303 | 6 | yes |
| GO:1905476 | negative regulation of protein localization to membrane | 3.0303 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LIPA1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.0606 | 3 | no |
| DOID:0060038 | specific developmental disorder | 3.0303 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 3.0303 | 5 | no |
| DOID:1059 | intellectual disability | 3.0303 | 4 | no |
| DOID:1289 | neurodegenerative disease | 3.0303 | 4 | no |
| DOID:936 | brain disease | 3.0303 | 4 | no |
| DOID:0111962 | combined immunodeficiency | 3.0303 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 3.0303 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| LNX1_HUMAN | [view interactions] | Low throughput | no | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ING4_HUMAN | [view interactions] | Low throughput | no | no |
| CCNH_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| TNNT1_HUMAN | [view interactions] | High throughput | no | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNL1_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPB2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAGE1_HUMAN | [view interactions] | High throughput | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| PHAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CP4X1_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBA2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| RFIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| I17RE_HUMAN | [view interactions] | High throughput | no | no |
| L2GL2_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9B_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CC14A_HUMAN | [view interactions] | High throughput | no | yes |
| MTM1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR1_HUMAN | [view interactions] | High throughput | no | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| CBPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP70_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| RB6I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LTO1_HUMAN | [view interactions] | Computational | no | no |