LIPA3_HUMAN
Evidence for PS localization
Functions
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIPA3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.8065 | 4 | no |
| GO:0019900 | kinase binding | 22.5806 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIPA3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 61.2903 | 4 | no |
| GO:0010646 | regulation of cell communication | 61.2903 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.8387 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.6129 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.3871 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 41.9355 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 41.9355 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.9355 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.9355 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.9355 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.7097 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.4839 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.4839 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.4839 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.4839 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.4839 | 5 | no |
| GO:0008104 | protein localization | 35.4839 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.2581 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.2581 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 32.2581 | 4 | no |
| GO:0051049 | regulation of transport | 32.2581 | 4 | no |
| GO:0071702 | organic substance transport | 32.2581 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.2581 | 4 | no |
| GO:0046903 | secretion | 29.0323 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.0323 | 5 | no |
| GO:0036211 | protein modification process | 29.0323 | 4 | no |
| GO:0043412 | macromolecule modification | 29.0323 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.0323 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 29.0323 | 5 | no |
| GO:0015031 | protein transport | 29.0323 | 4 | no |
| GO:0023061 | signal release | 25.8065 | 4 | yes |
| GO:0099643 | signal release from synapse | 25.8065 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.8065 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.8065 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.8065 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.8065 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.8065 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.8065 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.8065 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.8065 | 4 | no |
| GO:0022607 | cellular component assembly | 25.8065 | 4 | no |
| GO:0051046 | regulation of secretion | 25.8065 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 25.8065 | 4 | no |
| GO:0034330 | cell junction organization | 22.5806 | 4 | yes |
| GO:0050808 | synapse organization | 22.5806 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.5806 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 22.5806 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.5806 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 22.5806 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.5806 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.5806 | 6 | no |
| GO:0042326 | negative regulation of phosphorylation | 22.5806 | 8 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 22.5806 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.5806 | 5 | no |
| GO:0051726 | regulation of cell cycle | 22.5806 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 22.5806 | 7 | no |
| GO:0050807 | regulation of synapse organization | 22.5806 | 5 | no |
| GO:0043269 | regulation of ion transport | 22.5806 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.5806 | 4 | no |
| GO:0006887 | exocytosis | 22.5806 | 4 | no |
| GO:0072657 | protein localization to membrane | 22.5806 | 4 | no |
| GO:0006836 | neurotransmitter transport | 22.5806 | 4 | yes |
| GO:0007269 | neurotransmitter secretion | 19.3548 | 4 | yes |
| GO:0048278 | vesicle docking | 12.9032 | 4 | yes |
| GO:0016081 | synaptic vesicle docking | 9.6774 | 4 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 9.6774 | 4 | yes |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 9.6774 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LIPA3_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.4516 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.4516 | 5 | no |
| DOID:114 | heart disease | 6.4516 | 3 | no |
| DOID:2843 | long QT syndrome | 6.4516 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| S10AA_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| R3GEF_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| CC113_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| CNKR1_HUMAN | [view interactions] | High throughput | no | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ICAL_HUMAN | [view interactions] | High throughput | no | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5G_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| LIPB2_HUMAN | [view interactions] | Computational | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KIF1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |