GRIP1_HUMAN
Evidence for PS localization
Functions
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIP1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 20.5882 | 4 | no |
| GO:0046872 | metal ion binding | 20.5882 | 5 | no |
| GO:0030159 | signaling receptor complex adaptor activity | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIP1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 58.8235 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.3529 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.4118 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.5294 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.5882 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.1176 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.7059 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 38.2353 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 38.2353 | 4 | no |
| GO:0008104 | protein localization | 36.7647 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.2941 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.8235 | 5 | no |
| GO:0009966 | regulation of signal transduction | 33.8235 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.3529 | 5 | no |
| GO:0099536 | synaptic signaling | 32.3529 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 32.3529 | 5 | no |
| GO:0022607 | cellular component assembly | 32.3529 | 4 | no |
| GO:0023056 | positive regulation of signaling | 30.8824 | 4 | no |
| GO:0051049 | regulation of transport | 30.8824 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 29.4118 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 29.4118 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 29.4118 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 29.4118 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.9412 | 6 | no |
| GO:0006996 | organelle organization | 26.4706 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.5294 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0071702 | organic substance transport | 22.0588 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 22.0588 | 4 | no |
| GO:0034330 | cell junction organization | 22.0588 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.0588 | 5 | no |
| GO:0030030 | cell projection organization | 22.0588 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0588 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.0588 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.0588 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.0588 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 20.5882 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 20.5882 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 20.5882 | 5 | no |
| GO:0043412 | macromolecule modification | 20.5882 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.5882 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 19.1176 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 17.6471 | 4 | yes |
| GO:0015031 | protein transport | 16.1765 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 16.1765 | 4 | yes |
| GO:0072657 | protein localization to membrane | 16.1765 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 13.2353 | 5 | yes |
| GO:0006886 | intracellular protein transport | 11.7647 | 4 | yes |
| GO:0035418 | protein localization to synapse | 10.2941 | 6 | yes |
| GO:0072659 | protein localization to plasma membrane | 10.2941 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 10.2941 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 8.8235 | 7 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 8.8235 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 7.3529 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 5.8824 | 5 | yes |
| GO:0032456 | endocytic recycling | 5.8824 | 4 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 5.8824 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 5.8824 | 4 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 5.8824 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 5.8824 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 5.8824 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 5.8824 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 5.8824 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 5.8824 | 5 | yes |
| GO:0150011 | regulation of neuron projection arborization | 4.4118 | 6 | yes |
| GO:0150012 | positive regulation of neuron projection arborization | 4.4118 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| EHMT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| NRIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNA5_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOA6_HUMAN | [view interactions] | Low throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL1_HUMAN | [view interactions] | Low throughput | no | yes |
| NSG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
| MYH6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PKP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZDHC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EFNB1_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSPG4_HUMAN | [view interactions] | Low throughput | no | yes |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| PSB9_HUMAN | [view interactions] | Low throughput | no | no |
| NCOA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| VDR_HUMAN | [view interactions] | Low throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRLHR_HUMAN | [view interactions] | Low throughput | no | no |
| LRRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLI1_HUMAN | [view interactions] | Low throughput | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCOA3_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| NUMBL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| CARM1_HUMAN | [view interactions] | Low throughput | no | yes |
| THA_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| GPR37_HUMAN | [view interactions] | Low throughput | no | no |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| RXRA_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUS1_HUMAN | [view interactions] | High throughput | no | yes |
| XDH_HUMAN | [view interactions] | High throughput | no | no |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| SYF2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PHF1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA7_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM4_HUMAN | [view interactions] | High throughput | no | no |
| GRM6_HUMAN | [view interactions] | High throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| B9D2_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| EEPD1_HUMAN | [view interactions] | High throughput | no | no |