GRIP1_HUMAN
Evidence for PS localization
Functions
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIP1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 20.5882 | 4 | no |
| GO:0016922 | nuclear receptor binding | 5.8824 | 6 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 5.8824 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 5.8824 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 4.4118 | 4 | yes |
| GO:0035259 | nuclear glucocorticoid receptor binding | 4.4118 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIP1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 54.4118 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | yes |
| GO:0010646 | regulation of cell communication | 44.1176 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.6471 | 4 | yes |
| GO:0008104 | protein localization | 39.7059 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.7059 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.7059 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.7647 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.7647 | 4 | no |
| GO:0071702 | organic substance transport | 32.3529 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 32.3529 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 30.8824 | 4 | yes |
| GO:0051049 | regulation of transport | 30.8824 | 4 | no |
| GO:0015031 | protein transport | 29.4118 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.9412 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.9412 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.9412 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.9412 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.9412 | 4 | no |
| GO:0022607 | cellular component assembly | 26.4706 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 26.4706 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.4706 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.4706 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 23.5294 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 23.5294 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0030030 | cell projection organization | 22.0588 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 22.0588 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.0588 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.0588 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.0588 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0006996 | organelle organization | 20.5882 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0010468 | regulation of gene expression | 20.5882 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 19.1176 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 17.6471 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 17.6471 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 17.6471 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 16.1765 | 4 | yes |
| GO:0072657 | protein localization to membrane | 16.1765 | 4 | yes |
| GO:0031175 | neuron projection development | 13.2353 | 6 | yes |
| GO:1990778 | protein localization to cell periphery | 13.2353 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 10.2941 | 5 | yes |
| GO:0016197 | endosomal transport | 8.8235 | 4 | yes |
| GO:0035418 | protein localization to synapse | 8.8235 | 6 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 8.8235 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 8.8235 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 7.3529 | 6 | yes |
| GO:0061951 | establishment of protein localization to plasma membrane | 7.3529 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 7.3529 | 7 | yes |
| GO:0090150 | establishment of protein localization to membrane | 7.3529 | 4 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 7.3529 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 5.8824 | 5 | yes |
| GO:0032456 | endocytic recycling | 5.8824 | 5 | yes |
| GO:0098877 | neurotransmitter receptor transport to plasma membrane | 5.8824 | 4 | yes |
| GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane | 5.8824 | 5 | yes |
| GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 5.8824 | 4 | yes |
| GO:0099638 | endosome to plasma membrane protein transport | 5.8824 | 5 | yes |
| GO:0099639 | neurotransmitter receptor transport, endosome to plasma membrane | 5.8824 | 5 | yes |
| GO:1903540 | establishment of protein localization to postsynaptic membrane | 5.8824 | 5 | yes |
| GO:0150011 | regulation of neuron projection arborization | 4.4118 | 6 | yes |
| GO:0150012 | positive regulation of neuron projection arborization | 4.4118 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GRIP1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 2.9412 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.9412 | 5 | no |
| DOID:114 | heart disease | 2.9412 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 2.9412 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EFNB1_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIPA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSPG4_HUMAN | [view interactions] | Low throughput | no | yes |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| PSB9_HUMAN | [view interactions] | Low throughput | no | no |
| NCOA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| VDR_HUMAN | [view interactions] | Low throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRLHR_HUMAN | [view interactions] | Low throughput | no | no |
| LRRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIPA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLI1_HUMAN | [view interactions] | Low throughput | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NCOA3_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| NUMBL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| CARM1_HUMAN | [view interactions] | Low throughput | no | yes |
| THA_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| FRAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| GPR37_HUMAN | [view interactions] | Low throughput | no | no |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| RXRA_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| EHMT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| NRIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANM1_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNA5_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOA6_HUMAN | [view interactions] | Low throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL1_HUMAN | [view interactions] | Low throughput | no | yes |
| NSG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
| MYH6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PKP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZDHC8_HUMAN | [view interactions] | Low throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM4_HUMAN | [view interactions] | High throughput | no | no |
| GRM6_HUMAN | [view interactions] | High throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| B9D2_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| SDC2_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| EEPD1_HUMAN | [view interactions] | High throughput | no | no |
| HUS1_HUMAN | [view interactions] | High throughput | no | yes |
| XDH_HUMAN | [view interactions] | High throughput | no | no |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| SYF2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PHF1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA7_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TF2AA_HUMAN | [view interactions] | Computational | no | yes |
| TF3A_HUMAN | [view interactions] | Computational | no | yes |
| T2FA_HUMAN | [view interactions] | Computational | no | yes |
| GCC2_HUMAN | [view interactions] | Computational | no | yes |
| MEF2D_HUMAN | [view interactions] | Computational | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| T2EA_HUMAN | [view interactions] | Computational | no | yes |
| MEF2A_HUMAN | [view interactions] | Computational | no | yes |
| TSN7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RGPD8_HUMAN | [view interactions] | Computational | no | no |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYOD1_HUMAN | [view interactions] | Computational | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MEF2C_HUMAN | [view interactions] | Computational | no | yes |