TMUB1_HUMAN
Evidence for PS localization
Functions
May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation . May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TMUB1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.4348 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.7391 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.7391 | 4 | no |
| GO:0042803 | protein homodimerization activity | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TMUB1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 39.1304 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.1304 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.7826 | 4 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | no |
| GO:0071702 | organic substance transport | 34.7826 | 4 | no |
| GO:0071705 | nitrogen compound transport | 34.7826 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.7826 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.7826 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.4348 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0015031 | protein transport | 30.4348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.4348 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.4348 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.4348 | 5 | no |
| GO:0006508 | proteolysis | 26.0870 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 26.0870 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.0870 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 26.0870 | 4 | no |
| GO:0009894 | regulation of catabolic process | 26.0870 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.0870 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0023057 | negative regulation of signaling | 26.0870 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 21.7391 | 6 | yes |
| GO:0030163 | protein catabolic process | 21.7391 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 21.7391 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 21.7391 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 21.7391 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 21.7391 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.7391 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.7391 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 7 | no |
| GO:0006897 | endocytosis | 21.7391 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.7391 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.7391 | 6 | no |
| GO:0043408 | regulation of MAPK cascade | 21.7391 | 6 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.7391 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.7391 | 6 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 21.7391 | 8 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.7391 | 6 | no |
| GO:1901652 | response to peptide | 21.7391 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.7391 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.7391 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.7391 | 8 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.7391 | 6 | no |
| GO:0006886 | intracellular protein transport | 21.7391 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.7391 | 6 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 17.3913 | 7 | yes |
| GO:0010498 | proteasomal protein catabolic process | 17.3913 | 5 | yes |
| GO:0030433 | ubiquitin-dependent ERAD pathway | 17.3913 | 6 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 17.3913 | 4 | yes |
| GO:0036503 | ERAD pathway | 17.3913 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 17.3913 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAMLG_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | Low throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| RN139_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| BI1_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| KISSR_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIC3_HUMAN | [view interactions] | High throughput | no | yes |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| CGAT1_HUMAN | [view interactions] | High throughput | no | no |
| KCNKG_HUMAN | [view interactions] | High throughput | no | no |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKN2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBRL_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| NRM_HUMAN | [view interactions] | High throughput | no | no |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| KCJ10_HUMAN | [view interactions] | High throughput | no | no |
| ERLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |