ACHA9_HUMAN
Evidence for PS localization
Functions
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed, PubMed). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed, PubMed). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA9_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 45.0000 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 45.0000 | 4 | yes |
| GO:0005216 | ion channel activity | 40.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 40.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 40.0000 | 7 | yes |
| GO:0005261 | cation channel activity | 40.0000 | 5 | yes |
| GO:0015267 | channel activity | 40.0000 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 40.0000 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 40.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 40.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 40.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 40.0000 | 5 | yes |
| GO:0022848 | acetylcholine-gated cation-selective channel activity | 40.0000 | 7 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 40.0000 | 4 | yes |
| GO:0099094 | ligand-gated cation channel activity | 40.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 40.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 40.0000 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 30.0000 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 20.0000 | 5 | yes |
| GO:0005262 | calcium channel activity | 15.0000 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 15.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA9_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | yes |
| GO:0006811 | ion transport | 45.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 45.0000 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 45.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 45.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | yes |
| GO:0051899 | membrane depolarization | 40.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 35.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 30.0000 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 30.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 20.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 20.0000 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.0000 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 15.0000 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 15.0000 | 4 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 15.0000 | 7 | yes |
| GO:0080164 | regulation of nitric oxide metabolic process | 15.0000 | 5 | yes |
| GO:0010996 | response to auditory stimulus | 10.0000 | 4 | yes |
| GO:0042472 | inner ear morphogenesis | 10.0000 | 4 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 10.0000 | 7 | yes |
| GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound | 10.0000 | 4 | yes |
| GO:0050974 | detection of mechanical stimulus involved in sensory perception | 10.0000 | 4 | yes |
| GO:0050982 | detection of mechanical stimulus | 10.0000 | 4 | yes |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 10.0000 | 8 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 10.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| NGBR_HUMAN | [view interactions] | High throughput | no | no |
| BT2A2_HUMAN | [view interactions] | High throughput | no | no |
| ZNT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC9_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| METL9_HUMAN | [view interactions] | High throughput | no | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT7_HUMAN | [view interactions] | High throughput | no | no |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| PR15B_HUMAN | [view interactions] | High throughput | no | no |
| PDE3B_HUMAN | [view interactions] | High throughput | no | no |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H6ST1_HUMAN | [view interactions] | High throughput | no | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| RPC7L_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| S12A9_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CELR1_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| RNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GHDC_HUMAN | [view interactions] | High throughput | no | yes |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| HYEP_HUMAN | [view interactions] | High throughput | no | no |
| HMOX1_HUMAN | [view interactions] | High throughput | no | no |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| HMDH_HUMAN | [view interactions] | High throughput | no | yes |
| MACOI_HUMAN | [view interactions] | High throughput | no | no |
| ZNT6_HUMAN | [view interactions] | High throughput | no | yes |
| AT11C_HUMAN | [view interactions] | High throughput | no | no |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| SNX14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| F189B_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| LCLT1_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| TM268_HUMAN | [view interactions] | High throughput | no | yes |
| ANR10_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC2_HUMAN | [view interactions] | High throughput | no | no |
| ACHB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHB4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHA2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACHA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |