ACHA9_HUMAN
Evidence for PS localization
Functions
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed, PubMed). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed, PubMed). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA9_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 21.4286 | 4 | no |
| GO:0043168 | anion binding | 21.4286 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.4286 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 21.4286 | 5 | yes |
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 14.2857 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 14.2857 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 14.2857 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 14.2857 | 5 | yes |
| GO:0005262 | calcium channel activity | 14.2857 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 14.2857 | 6 | yes |
| GO:0015267 | channel activity | 14.2857 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 14.2857 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 14.2857 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 14.2857 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 14.2857 | 4 | yes |
| GO:0022836 | gated channel activity | 14.2857 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 14.2857 | 7 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 14.2857 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 14.2857 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 14.2857 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 14.2857 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA9_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 35.7143 | 4 | no |
| GO:0008104 | protein localization | 35.7143 | 4 | no |
| GO:0022411 | cellular component disassembly | 28.5714 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 28.5714 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.4286 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 21.4286 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 21.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.4286 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.4286 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0015031 | protein transport | 21.4286 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | no |
| GO:0071702 | organic substance transport | 21.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | no |
| GO:0035418 | protein localization to synapse | 21.4286 | 6 | no |
| GO:1902414 | protein localization to cell junction | 21.4286 | 5 | no |
| GO:0010996 | response to auditory stimulus | 14.2857 | 4 | yes |
| GO:0042472 | inner ear morphogenesis | 14.2857 | 4 | yes |
| GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound | 14.2857 | 4 | yes |
| GO:0050974 | detection of mechanical stimulus involved in sensory perception | 14.2857 | 4 | yes |
| GO:0050982 | detection of mechanical stimulus | 14.2857 | 4 | yes |
| GO:0051899 | membrane depolarization | 14.2857 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST1_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE3B_HUMAN | [view interactions] | High throughput | no | no |
| PR15B_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT7_HUMAN | [view interactions] | High throughput | no | no |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A2_HUMAN | [view interactions] | High throughput | no | no |
| NGBR_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METL9_HUMAN | [view interactions] | High throughput | no | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC9_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPC7L_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGK_HUMAN | [view interactions] | High throughput | no | yes |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| S12A9_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CELR1_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| RNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GHDC_HUMAN | [view interactions] | High throughput | no | yes |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| HYEP_HUMAN | [view interactions] | High throughput | no | no |
| HMOX1_HUMAN | [view interactions] | High throughput | no | no |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| HMDH_HUMAN | [view interactions] | High throughput | no | yes |
| MACOI_HUMAN | [view interactions] | High throughput | no | no |
| ZNT6_HUMAN | [view interactions] | High throughput | no | yes |
| AT11C_HUMAN | [view interactions] | High throughput | no | no |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| SNX14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| EREP3_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| LCLT1_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| TM268_HUMAN | [view interactions] | High throughput | no | yes |
| ANR10_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC2_HUMAN | [view interactions] | High throughput | no | no |