PBIP1_HUMAN
Evidence for PS localization
Functions
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PBIP1_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 30.3030 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.3030 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 30.3030 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.3030 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.3030 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.3030 | 4 | no |
| GO:0003723 | RNA binding | 21.2121 | 4 | no |
| GO:0140297 | DNA-binding transcription factor binding | 15.1515 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PBIP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.4848 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | yes |
| GO:0071702 | organic substance transport | 42.4242 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.3939 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.3939 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.3939 | 4 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | yes |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.3030 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.3030 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.3030 | 5 | no |
| GO:0071705 | nitrogen compound transport | 30.3030 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | yes |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | yes |
| GO:0008104 | protein localization | 27.2727 | 4 | no |
| GO:0051049 | regulation of transport | 24.2424 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 24.2424 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.2424 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.2424 | 4 | yes |
| GO:0015031 | protein transport | 24.2424 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.2121 | 4 | no |
| GO:0010941 | regulation of cell death | 21.2121 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0080134 | regulation of response to stress | 21.2121 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.2121 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.2121 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.2121 | 5 | no |
| GO:0022607 | cellular component assembly | 21.2121 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2121 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 21.2121 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 18.1818 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 18.1818 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 18.1818 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 18.1818 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 18.1818 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 18.1818 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 18.1818 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 18.1818 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 15.1515 | 6 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 15.1515 | 5 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 12.1212 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 12.1212 | 6 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 12.1212 | 7 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 12.1212 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 12.1212 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 12.1212 | 4 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 12.1212 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 12.1212 | 8 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 9.0909 | 5 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 9.0909 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 9.0909 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PBIP1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 9.0909 | 3 | no |
| DOID:936 | brain disease | 6.0606 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANK_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| TAB3_HUMAN | [view interactions] | Low throughput | no | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN2_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| KR106_HUMAN | [view interactions] | High throughput | no | no |
| GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5L_HUMAN | [view interactions] | High throughput | no | no |
| CAMLG_HUMAN | [view interactions] | High throughput | no | yes |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| MED30_HUMAN | [view interactions] | High throughput | no | no |
| BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZZZ3_HUMAN | [view interactions] | High throughput | no | yes |
| PHS2_HUMAN | [view interactions] | High throughput | no | yes |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA2_HUMAN | [view interactions] | High throughput | no | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12A_HUMAN | [view interactions] | High throughput | no | no |
| BRNP1_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAE_HUMAN | [view interactions] | High throughput | no | no |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| MPPE1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX5_HUMAN | [view interactions] | High throughput | no | no |
| ACM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGT4C_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| PGES2_HUMAN | [view interactions] | High throughput | no | yes |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| B3GT6_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC127_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGW_HUMAN | [view interactions] | High throughput | no | no |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| XPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOG_HUMAN | [view interactions] | High throughput | no | yes |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK19_HUMAN | [view interactions] | High throughput | no | yes |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATR_HUMAN | [view interactions] | High throughput | no | no |
| XYLK_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| TAPT1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| NBN_HUMAN | [view interactions] | High throughput | no | yes |
| AT132_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| ATP23_HUMAN | [view interactions] | High throughput | no | yes |
| SELN_HUMAN | [view interactions] | High throughput | no | yes |
| D19L1_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| BAP29_HUMAN | [view interactions] | High throughput | no | yes |
| KDIS_HUMAN | [view interactions] | High throughput | no | yes |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRAM4_HUMAN | [view interactions] | High throughput | no | no |
| TARB1_HUMAN | [view interactions] | High throughput | no | no |
| RDH14_HUMAN | [view interactions] | High throughput | no | yes |
| D19L3_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
| PM34_HUMAN | [view interactions] | High throughput | no | yes |
| TM38B_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK8_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| XYLT2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4F_HUMAN | [view interactions] | High throughput | no | no |
| MUL1_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CC138_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| UD17_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| CFC1_HUMAN | [view interactions] | High throughput | no | no |
| SIA8C_HUMAN | [view interactions] | High throughput | no | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| CTU1_HUMAN | [view interactions] | High throughput | no | no |
| PI15_HUMAN | [view interactions] | High throughput | no | no |
| LEUK_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| MACOI_HUMAN | [view interactions] | High throughput | no | no |
| DUOX1_HUMAN | [view interactions] | High throughput | no | no |
| NCTR3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2C_HUMAN | [view interactions] | High throughput | no | no |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| CMS1_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
| HTSF1_HUMAN | [view interactions] | High throughput | no | yes |
| HKDC1_HUMAN | [view interactions] | High throughput | no | no |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CTU2_HUMAN | [view interactions] | High throughput | no | yes |
| TLC3A_HUMAN | [view interactions] | High throughput | no | no |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| EPHX4_HUMAN | [view interactions] | High throughput | no | yes |
| TNF14_HUMAN | [view interactions] | High throughput | no | yes |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| VEGFD_HUMAN | [view interactions] | High throughput | no | no |
| S27A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD1A_HUMAN | [view interactions] | High throughput | no | no |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| KCNN4_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDN1B_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| PKCB1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| DEFI6_HUMAN | [view interactions] | High throughput | no | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |