MYO1D_HUMAN
Evidence for PS localization
Functions
Unconventional myosin that functions as actin-based motor protein with ATPase activity . Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes . Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO1D_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 32.6923 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 32.6923 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.6923 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6923 | 4 | yes |
| GO:0043168 | anion binding | 32.6923 | 4 | yes |
| GO:0019900 | kinase binding | 26.9231 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0005524 | ATP binding | 23.0769 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | yes |
| GO:0003779 | actin binding | 13.4615 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO1D_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.1538 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 59.6154 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 59.6154 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.8462 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.1538 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 44.2308 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.2308 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.3077 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.3077 | 5 | no |
| GO:0010468 | regulation of gene expression | 40.3846 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.3846 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 40.3846 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.3846 | 5 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.5385 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.5385 | 5 | no |
| GO:0023056 | positive regulation of signaling | 36.5385 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.5385 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.5385 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6154 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 34.6154 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.6154 | 5 | no |
| GO:0031399 | regulation of protein modification process | 34.6154 | 6 | no |
| GO:0008104 | protein localization | 32.6923 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.6923 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.6923 | 5 | no |
| GO:0071702 | organic substance transport | 30.7692 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 30.7692 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 30.7692 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.7692 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.8462 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 28.8462 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.8462 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.9231 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 26.9231 | 7 | no |
| GO:0071310 | cellular response to organic substance | 26.9231 | 4 | no |
| GO:0007010 | cytoskeleton organization | 26.9231 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.9231 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0015031 | protein transport | 23.0769 | 4 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 23.0769 | 5 | no |
| GO:0051049 | regulation of transport | 23.0769 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.0769 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0769 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.1538 | 6 | no |
| GO:0030030 | cell projection organization | 21.1538 | 4 | no |
| GO:0036211 | protein modification process | 21.1538 | 4 | no |
| GO:0043412 | macromolecule modification | 21.1538 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.1538 | 7 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.1538 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.1538 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.1538 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 19.2308 | 4 | yes |
| GO:0007015 | actin filament organization | 15.3846 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 9.6154 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 3.8462 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CEMIP_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL9_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| BBS7_HUMAN | [view interactions] | High throughput | no | no |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| FBX40_HUMAN | [view interactions] | High throughput | no | no |
| BTD_HUMAN | [view interactions] | High throughput | no | no |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC3_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| PELO_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSH2_HUMAN | [view interactions] | High throughput | no | no |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| PNM8A_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| HIPL1_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |