MYO1D_HUMAN
Evidence for PS localization
Functions
Unconventional myosin that functions as actin-based motor protein with ATPase activity . Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes . Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYO1D_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0019900 | kinase binding | 31.2500 | 4 | no |
| GO:0019901 | protein kinase binding | 29.1667 | 5 | no |
| GO:0005524 | ATP binding | 22.9167 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.9167 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.9167 | 5 | yes |
| GO:0003779 | actin binding | 14.5833 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYO1D_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.8333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.9167 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.8333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 43.7500 | 5 | no |
| GO:0009966 | regulation of signal transduction | 41.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0006996 | organelle organization | 39.5833 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.5833 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.4167 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0008104 | protein localization | 31.2500 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 31.2500 | 4 | yes |
| GO:0010468 | regulation of gene expression | 31.2500 | 5 | no |
| GO:0036211 | protein modification process | 31.2500 | 4 | no |
| GO:0043412 | macromolecule modification | 31.2500 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.2500 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.2500 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.2500 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.2500 | 6 | no |
| GO:0071310 | cellular response to organic substance | 31.2500 | 4 | no |
| GO:0071702 | organic substance transport | 29.1667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 29.1667 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 29.1667 | 5 | no |
| GO:0010941 | regulation of cell death | 29.1667 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.1667 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 29.1667 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.1667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.1667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.1667 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.0833 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 27.0833 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.0833 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 27.0833 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 27.0833 | 7 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.9167 | 5 | no |
| GO:0015031 | protein transport | 20.8333 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.8333 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8333 | 6 | no |
| GO:0010942 | positive regulation of cell death | 20.8333 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.8333 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8333 | 7 | no |
| GO:0051336 | regulation of hydrolase activity | 20.8333 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.8333 | 4 | no |
| GO:0030030 | cell projection organization | 20.8333 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 20.8333 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.8333 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 16.6667 | 4 | yes |
| GO:0007015 | actin filament organization | 14.5833 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 8.3333 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 4.1667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYO1D_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 6.2500 | 3 | no |
| DOID:0050700 | cardiomyopathy | 4.1667 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.1667 | 5 | no |
| DOID:2843 | long QT syndrome | 4.1667 | 6 | no |
| DOID:612 | primary immunodeficiency disease | 4.1667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSH2_HUMAN | [view interactions] | High throughput | no | no |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| PNM8A_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| GAGE5_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| ABRA_HUMAN | [view interactions] | High throughput | no | no |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OIT3_HUMAN | [view interactions] | High throughput | no | no |
| HIPL1_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| ERLEC_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL9_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| BBS7_HUMAN | [view interactions] | High throughput | no | no |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| BTD_HUMAN | [view interactions] | High throughput | no | no |
| FBX40_HUMAN | [view interactions] | High throughput | no | no |
| EID1_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC3_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| PP4C_HUMAN | [view interactions] | High throughput | no | yes |
| PELO_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |