PK3CA_HUMAN
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed, PubMed, PubMed). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed, PubMed). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed, PubMed). Plays a role in the positive regulation of phagocytosis and pinocytosis . [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PK3CA_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 40.6504 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 40.6504 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 40.6504 | 4 | yes |
GO:0019900 | kinase binding | 34.9593 | 4 | no |
GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
GO:0005524 | ATP binding | 26.8293 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 26.8293 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 26.8293 | 5 | yes |
GO:0046872 | metal ion binding | 26.8293 | 4 | no |
GO:0016301 | kinase activity | 24.3902 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 23.5772 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 21.1382 | 4 | yes |
GO:0004674 | protein serine/threonine kinase activity | 12.1951 | 4 | yes |
GO:0106310 | protein serine kinase activity | 12.1951 | 4 | yes |
GO:0019887 | protein kinase regulator activity | 8.9431 | 4 | yes |
GO:0019209 | kinase activator activity | 7.3171 | 4 | yes |
GO:0030295 | protein kinase activator activity | 7.3171 | 5 | yes |
GO:0016307 | phosphatidylinositol phosphate kinase activity | 3.2520 | 5 | yes |
GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity | 2.4390 | 6 | yes |
GO:0052813 | phosphatidylinositol bisphosphate kinase activity | 2.4390 | 5 | yes |
GO:0016303 | 1-phosphatidylinositol-3-kinase activity | 1.6260 | 6 | yes |
GO:0035004 | phosphatidylinositol 3-kinase activity | 1.6260 | 5 | yes |
GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity | 1.6260 | 6 | yes |
GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 1.6260 | 6 | yes |
GO:0052742 | phosphatidylinositol kinase activity | 1.6260 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PK3CA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 75.6098 | 4 | yes |
GO:0010646 | regulation of cell communication | 69.9187 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 68.2927 | 4 | yes |
GO:0009966 | regulation of signal transduction | 65.8537 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 61.7886 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 60.1626 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 59.3496 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 56.9106 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 56.0976 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 52.0325 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 50.4065 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 50.4065 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 49.5935 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.7154 | 5 | yes |
GO:0051049 | regulation of transport | 43.9024 | 4 | no |
GO:0010468 | regulation of gene expression | 43.9024 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 43.9024 | 5 | yes |
GO:0071310 | cellular response to organic substance | 43.0894 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 43.0894 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 43.0894 | 7 | yes |
GO:0048584 | positive regulation of response to stimulus | 43.0894 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 43.0894 | 5 | yes |
GO:0022607 | cellular component assembly | 40.6504 | 4 | no |
GO:0010941 | regulation of cell death | 40.6504 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 39.8374 | 4 | no |
GO:0010647 | positive regulation of cell communication | 39.8374 | 5 | yes |
GO:0023056 | positive regulation of signaling | 39.8374 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 39.0244 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 39.0244 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 39.0244 | 4 | yes |
GO:0043067 | regulation of programmed cell death | 39.0244 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 38.2114 | 5 | no |
GO:0042981 | regulation of apoptotic process | 38.2114 | 6 | yes |
GO:0006996 | organelle organization | 37.3984 | 4 | yes |
GO:0031399 | regulation of protein modification process | 37.3984 | 6 | yes |
GO:0051247 | positive regulation of protein metabolic process | 37.3984 | 6 | yes |
GO:0009892 | negative regulation of metabolic process | 36.5854 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.7724 | 5 | no |
GO:0045595 | regulation of cell differentiation | 34.9593 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 34.9593 | 7 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 34.9593 | 6 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.9593 | 5 | yes |
GO:0042327 | positive regulation of phosphorylation | 34.9593 | 8 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 34.9593 | 7 | yes |
GO:0051338 | regulation of transferase activity | 34.1463 | 4 | no |
GO:0060341 | regulation of cellular localization | 34.1463 | 4 | no |
GO:0043549 | regulation of kinase activity | 33.3333 | 5 | no |
GO:0032880 | regulation of protein localization | 32.5203 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 32.5203 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 31.7073 | 5 | no |
GO:2000145 | regulation of cell motility | 31.7073 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 31.7073 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 31.7073 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 31.7073 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 31.7073 | 7 | yes |
GO:0033043 | regulation of organelle organization | 31.7073 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 30.8943 | 4 | yes |
GO:0008284 | positive regulation of cell population proliferation | 30.8943 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 30.8943 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 30.0813 | 6 | yes |
GO:0048585 | negative regulation of response to stimulus | 30.0813 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 30.0813 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 30.0813 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 30.0813 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.0813 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 29.2683 | 6 | no |
GO:0030334 | regulation of cell migration | 29.2683 | 5 | no |
GO:0051050 | positive regulation of transport | 29.2683 | 4 | no |
GO:0051094 | positive regulation of developmental process | 29.2683 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 29.2683 | 8 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 29.2683 | 4 | no |
GO:0030155 | regulation of cell adhesion | 29.2683 | 4 | yes |
GO:0010648 | negative regulation of cell communication | 28.4553 | 5 | no |
GO:0023057 | negative regulation of signaling | 28.4553 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 28.4553 | 5 | no |
GO:0008104 | protein localization | 28.4553 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 28.4553 | 4 | no |
GO:0007010 | cytoskeleton organization | 28.4553 | 5 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 28.4553 | 4 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.6423 | 5 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 27.6423 | 5 | yes |
GO:0033674 | positive regulation of kinase activity | 26.8293 | 6 | no |
GO:0045859 | regulation of protein kinase activity | 26.8293 | 6 | no |
GO:2000026 | regulation of multicellular organismal development | 26.8293 | 4 | no |
GO:0036211 | protein modification process | 26.8293 | 4 | no |
GO:0043412 | macromolecule modification | 26.8293 | 4 | no |
GO:0060548 | negative regulation of cell death | 26.8293 | 5 | yes |
GO:0030030 | cell projection organization | 26.0163 | 4 | no |
GO:0016310 | phosphorylation | 26.0163 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 25.2033 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 25.2033 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.2033 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 25.2033 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 25.2033 | 6 | yes |
GO:0080134 | regulation of response to stress | 24.3902 | 4 | no |
GO:0034330 | cell junction organization | 24.3902 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 24.3902 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5772 | 6 | yes |
GO:0043408 | regulation of MAPK cascade | 23.5772 | 6 | no |
GO:0002684 | positive regulation of immune system process | 23.5772 | 4 | yes |
GO:0031344 | regulation of cell projection organization | 23.5772 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.7642 | 6 | no |
GO:0010628 | positive regulation of gene expression | 22.7642 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.7642 | 6 | no |
GO:0051345 | positive regulation of hydrolase activity | 22.7642 | 5 | no |
GO:0006468 | protein phosphorylation | 22.7642 | 5 | no |
GO:0009894 | regulation of catabolic process | 22.7642 | 4 | yes |
GO:0034329 | cell junction assembly | 21.9512 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 21.9512 | 5 | yes |
GO:0051493 | regulation of cytoskeleton organization | 21.9512 | 6 | yes |
GO:0030335 | positive regulation of cell migration | 21.1382 | 6 | no |
GO:0034762 | regulation of transmembrane transport | 21.1382 | 4 | no |
GO:0040017 | positive regulation of locomotion | 21.1382 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.1382 | 6 | no |
GO:0051726 | regulation of cell cycle | 21.1382 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 21.1382 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 21.1382 | 4 | no |
GO:2000147 | positive regulation of cell motility | 21.1382 | 5 | no |
GO:0050776 | regulation of immune response | 21.1382 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 20.3252 | 5 | no |
GO:0045860 | positive regulation of protein kinase activity | 20.3252 | 7 | no |
GO:1901652 | response to peptide | 20.3252 | 4 | no |
GO:1903829 | positive regulation of protein localization | 20.3252 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 20.3252 | 5 | yes |
GO:0050865 | regulation of cell activation | 20.3252 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 20.3252 | 5 | yes |
GO:0002694 | regulation of leukocyte activation | 18.6992 | 4 | yes |
GO:0014070 | response to organic cyclic compound | 18.6992 | 4 | yes |
GO:0032970 | regulation of actin filament-based process | 18.6992 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 17.8862 | 4 | yes |
GO:0022407 | regulation of cell-cell adhesion | 17.8862 | 5 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 17.8862 | 5 | yes |
GO:0033993 | response to lipid | 17.8862 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 16.2602 | 5 | yes |
GO:0031329 | regulation of cellular catabolic process | 16.2602 | 5 | yes |
GO:0051249 | regulation of lymphocyte activation | 16.2602 | 5 | yes |
GO:0006915 | apoptotic process | 15.4472 | 4 | yes |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 14.6341 | 6 | yes |
GO:0050778 | positive regulation of immune response | 14.6341 | 5 | yes |
GO:0050863 | regulation of T cell activation | 14.6341 | 6 | yes |
GO:0110053 | regulation of actin filament organization | 13.8211 | 6 | yes |
GO:0002696 | positive regulation of leukocyte activation | 13.8211 | 5 | yes |
GO:0031346 | positive regulation of cell projection organization | 13.8211 | 6 | yes |
GO:0032535 | regulation of cellular component size | 13.8211 | 4 | yes |
GO:0050867 | positive regulation of cell activation | 13.8211 | 5 | yes |
GO:0051251 | positive regulation of lymphocyte activation | 13.8211 | 6 | yes |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 13.0081 | 7 | yes |
GO:0022409 | positive regulation of cell-cell adhesion | 13.0081 | 6 | yes |
GO:0050870 | positive regulation of T cell activation | 12.1951 | 7 | yes |
GO:0010629 | negative regulation of gene expression | 11.3821 | 6 | yes |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 10.5691 | 4 | yes |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 10.5691 | 4 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 10.5691 | 6 | yes |
GO:0030832 | regulation of actin filament length | 10.5691 | 5 | yes |
GO:0060491 | regulation of cell projection assembly | 10.5691 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 9.7561 | 6 | yes |
GO:1901214 | regulation of neuron death | 9.7561 | 5 | yes |
GO:0001667 | ameboidal-type cell migration | 9.7561 | 4 | yes |
GO:0048732 | gland development | 9.7561 | 4 | yes |
GO:1901654 | response to ketone | 8.9431 | 4 | yes |
GO:0010506 | regulation of autophagy | 8.9431 | 6 | yes |
GO:0010639 | negative regulation of organelle organization | 8.9431 | 6 | yes |
GO:0038127 | ERBB signaling pathway | 8.9431 | 6 | yes |
GO:0048660 | regulation of smooth muscle cell proliferation | 8.9431 | 5 | yes |
GO:0007173 | epidermal growth factor receptor signaling pathway | 8.1301 | 7 | yes |
GO:0008286 | insulin receptor signaling pathway | 8.1301 | 6 | yes |
GO:0009895 | negative regulation of catabolic process | 8.1301 | 5 | yes |
GO:0043467 | regulation of generation of precursor metabolites and energy | 8.1301 | 5 | yes |
GO:0048638 | regulation of developmental growth | 8.1301 | 4 | yes |
GO:0048878 | chemical homeostasis | 8.1301 | 4 | yes |
GO:0051896 | regulation of protein kinase B signaling | 8.1301 | 6 | yes |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 7.3171 | 6 | yes |
GO:1901215 | negative regulation of neuron death | 7.3171 | 6 | yes |
GO:0016241 | regulation of macroautophagy | 7.3171 | 7 | yes |
GO:0031960 | response to corticosteroid | 7.3171 | 5 | yes |
GO:0043523 | regulation of neuron apoptotic process | 7.3171 | 6 | yes |
GO:0048015 | phosphatidylinositol-mediated signaling | 7.3171 | 5 | yes |
GO:0048017 | inositol lipid-mediated signaling | 7.3171 | 4 | yes |
GO:0048545 | response to steroid hormone | 7.3171 | 4 | yes |
GO:0050851 | antigen receptor-mediated signaling pathway | 7.3171 | 5 | yes |
GO:0051052 | regulation of DNA metabolic process | 7.3171 | 5 | yes |
GO:1902904 | negative regulation of supramolecular fiber organization | 6.5041 | 6 | yes |
GO:0010631 | epithelial cell migration | 6.5041 | 5 | yes |
GO:0035994 | response to muscle stretch | 6.5041 | 4 | yes |
GO:0046486 | glycerolipid metabolic process | 6.5041 | 4 | yes |
GO:0048661 | positive regulation of smooth muscle cell proliferation | 6.5041 | 6 | yes |
GO:0051384 | response to glucocorticoid | 6.5041 | 6 | yes |
GO:0051494 | negative regulation of cytoskeleton organization | 6.5041 | 7 | yes |
GO:0062197 | cellular response to chemical stress | 6.5041 | 4 | yes |
GO:1901879 | regulation of protein depolymerization | 5.6911 | 6 | yes |
GO:0006644 | phospholipid metabolic process | 5.6911 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 5.6911 | 5 | yes |
GO:0006936 | muscle contraction | 5.6911 | 4 | yes |
GO:0008610 | lipid biosynthetic process | 5.6911 | 4 | yes |
GO:0014065 | phosphatidylinositol 3-kinase signaling | 5.6911 | 6 | yes |
GO:0033500 | carbohydrate homeostasis | 5.6911 | 5 | yes |
GO:0042593 | glucose homeostasis | 5.6911 | 6 | yes |
GO:0043200 | response to amino acid | 5.6911 | 4 | yes |
GO:0043244 | regulation of protein-containing complex disassembly | 5.6911 | 5 | yes |
GO:0043542 | endothelial cell migration | 5.6911 | 6 | yes |
GO:0050852 | T cell receptor signaling pathway | 5.6911 | 6 | yes |
GO:0051897 | positive regulation of protein kinase B signaling | 5.6911 | 7 | yes |
GO:0090407 | organophosphate biosynthetic process | 4.8780 | 4 | yes |
GO:1901880 | negative regulation of protein depolymerization | 4.8780 | 7 | yes |
GO:1902743 | regulation of lamellipodium organization | 4.8780 | 7 | yes |
GO:1902745 | positive regulation of lamellipodium organization | 4.8780 | 7 | yes |
GO:0006909 | phagocytosis | 4.8780 | 5 | yes |
GO:0008654 | phospholipid biosynthetic process | 4.8780 | 4 | yes |
GO:0030834 | regulation of actin filament depolymerization | 4.8780 | 7 | yes |
GO:0031330 | negative regulation of cellular catabolic process | 4.8780 | 6 | yes |
GO:0033135 | regulation of peptidyl-serine phosphorylation | 4.8780 | 8 | yes |
GO:0043242 | negative regulation of protein-containing complex disassembly | 4.8780 | 6 | yes |
GO:0043491 | protein kinase B signaling | 4.8780 | 4 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 4.8780 | 7 | yes |
GO:0045017 | glycerolipid biosynthetic process | 4.8780 | 4 | yes |
GO:0046474 | glycerophospholipid biosynthetic process | 4.8780 | 5 | yes |
GO:0046488 | phosphatidylinositol metabolic process | 4.8780 | 6 | yes |
GO:0071548 | response to dexamethasone | 4.0650 | 5 | yes |
GO:2000209 | regulation of anoikis | 4.0650 | 7 | yes |
GO:2000811 | negative regulation of anoikis | 4.0650 | 8 | yes |
GO:0006661 | phosphatidylinositol biosynthetic process | 4.0650 | 6 | yes |
GO:0009743 | response to carbohydrate | 4.0650 | 4 | yes |
GO:0010507 | negative regulation of autophagy | 4.0650 | 7 | yes |
GO:0010591 | regulation of lamellipodium assembly | 4.0650 | 7 | yes |
GO:0010592 | positive regulation of lamellipodium assembly | 4.0650 | 7 | yes |
GO:0030835 | negative regulation of actin filament depolymerization | 4.0650 | 7 | yes |
GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 4.0650 | 9 | yes |
GO:0070542 | response to fatty acid | 3.2520 | 4 | yes |
GO:0071229 | cellular response to acid chemical | 3.2520 | 4 | yes |
GO:0001889 | liver development | 3.2520 | 5 | yes |
GO:0006006 | glucose metabolic process | 3.2520 | 5 | yes |
GO:0006941 | striated muscle contraction | 3.2520 | 5 | yes |
GO:0009746 | response to hexose | 3.2520 | 6 | yes |
GO:0009749 | response to glucose | 3.2520 | 7 | yes |
GO:0016242 | negative regulation of macroautophagy | 3.2520 | 8 | yes |
GO:0019318 | hexose metabolic process | 3.2520 | 4 | yes |
GO:0034284 | response to monosaccharide | 3.2520 | 5 | yes |
GO:0040014 | regulation of multicellular organism growth | 3.2520 | 4 | yes |
GO:0043201 | response to leucine | 3.2520 | 5 | yes |
GO:0043276 | anoikis | 3.2520 | 5 | yes |
GO:0070252 | actin-mediated cell contraction | 2.4390 | 4 | yes |
GO:0086003 | cardiac muscle cell contraction | 2.4390 | 5 | yes |
GO:0090075 | relaxation of muscle | 2.4390 | 4 | yes |
GO:0001678 | cellular glucose homeostasis | 2.4390 | 4 | yes |
GO:0043457 | regulation of cellular respiration | 2.4390 | 6 | yes |
GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 2.4390 | 7 | yes |
GO:0055119 | relaxation of cardiac muscle | 2.4390 | 5 | yes |
GO:0060048 | cardiac muscle contraction | 2.4390 | 6 | yes |
GO:0071322 | cellular response to carbohydrate stimulus | 1.6260 | 5 | yes |
GO:0071326 | cellular response to monosaccharide stimulus | 1.6260 | 6 | yes |
GO:0071331 | cellular response to hexose stimulus | 1.6260 | 7 | yes |
GO:0071333 | cellular response to glucose stimulus | 1.6260 | 5 | yes |
GO:0071462 | cellular response to water stimulus | 1.6260 | 4 | yes |
GO:0071464 | cellular response to hydrostatic pressure | 1.6260 | 4 | yes |
GO:0120261 | regulation of heterochromatin organization | 1.6260 | 6 | yes |
GO:1902275 | regulation of chromatin organization | 1.6260 | 5 | yes |
GO:1903544 | response to butyrate | 1.6260 | 5 | yes |
GO:2000269 | regulation of fibroblast apoptotic process | 1.6260 | 7 | yes |
GO:2000270 | negative regulation of fibroblast apoptotic process | 1.6260 | 8 | yes |
GO:2000653 | regulation of genetic imprinting | 1.6260 | 7 | yes |
GO:0001944 | vasculature development | 1.6260 | 4 | yes |
GO:0031445 | regulation of heterochromatin formation | 1.6260 | 6 | yes |
GO:0032006 | regulation of TOR signaling | 1.6260 | 6 | yes |
GO:0032008 | positive regulation of TOR signaling | 1.6260 | 7 | yes |
GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process | 1.6260 | 8 | yes |
GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase | 1.6260 | 7 | yes |
GO:0038084 | vascular endothelial growth factor signaling pathway | 1.6260 | 6 | yes |
GO:0044028 | DNA hypomethylation | 1.6260 | 7 | yes |
GO:0044029 | hypomethylation of CpG island | 1.6260 | 8 | yes |
GO:0044030 | regulation of DNA methylation | 1.6260 | 6 | yes |
GO:0060612 | adipose tissue development | 1.6260 | 5 | yes |
GO:0061448 | connective tissue development | 1.6260 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PK3CA_HUMAN |
---|---|---|---|---|
DOID:0050686 | organ system cancer | 4.8780 | 3 | no |
DOID:0050700 | cardiomyopathy | 3.2520 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.2520 | 5 | no |
DOID:114 | heart disease | 3.2520 | 3 | no |
DOID:612 | primary immunodeficiency disease | 2.4390 | 3 | no |
DOID:193 | reproductive organ cancer | 2.4390 | 4 | no |
DOID:2843 | long QT syndrome | 1.6260 | 6 | no |
DOID:12930 | dilated cardiomyopathy | 1.6260 | 6 | no |
DOID:10534 | stomach cancer | 1.6260 | 5 | no |
DOID:120 | female reproductive organ cancer | 1.6260 | 5 | no |
DOID:3119 | gastrointestinal system cancer | 1.6260 | 4 | no |
DOID:6457 | Cowden syndrome | 1.6260 | 3 | no |
DOID:0081062 | diabetes | 1.6260 | 5 | no |
DOID:2978 | carbohydrate metabolic disorder | 1.6260 | 3 | no |
DOID:4194 | glucose metabolism disease | 1.6260 | 4 | no |
DOID:9351 | diabetes mellitus | 1.6260 | 6 | no |
DOID:9352 | type 2 diabetes mellitus | 1.6260 | 7 | no |
DOID:10283 | prostate cancer | 1.6260 | 6 | no |
DOID:3856 | male reproductive organ cancer | 1.6260 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
P53_HUMAN | [view interactions] | Low throughput | no | no |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSK_HUMAN | [view interactions] | Low throughput | no | yes |
CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IL3RB_HUMAN | [view interactions] | Low throughput | no | no |
HLAA_HUMAN | [view interactions] | Low throughput | no | no |
CSF1R_HUMAN | [view interactions] | Low throughput | no | yes |
LCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARHG1_HUMAN | [view interactions] | Low throughput | no | no |
GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GELS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IRS4_HUMAN | [view interactions] | Low throughput | no | no |
UBF1_HUMAN | [view interactions] | Low throughput | no | yes |
WDR5_HUMAN | [view interactions] | Low throughput | no | no |
CD28_HUMAN | [view interactions] | Low throughput | no | no |
IRS2_HUMAN | [view interactions] | Low throughput | no | yes |
TNR5_HUMAN | [view interactions] | Low throughput | no | no |
MED21_HUMAN | [view interactions] | Low throughput | no | yes |
TPOR_HUMAN | [view interactions] | Low throughput | no | no |
KIT_HUMAN | [view interactions] | Low throughput | no | no |
ESR1_HUMAN | [view interactions] | Low throughput | no | no |
AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PGFRA_HUMAN | [view interactions] | Low throughput | no | no |
PTTG1_HUMAN | [view interactions] | Low throughput | no | no |
DERL1_HUMAN | [view interactions] | Low throughput | no | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
RPGF5_HUMAN | [view interactions] | Low throughput | no | yes |
TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
RHES_HUMAN | [view interactions] | Low throughput | no | yes |
ADAP1_HUMAN | [view interactions] | Low throughput | no | yes |
SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
SNX9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRP3_HUMAN | [view interactions] | Low throughput | no | no |
STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NED4L_HUMAN | [view interactions] | Low throughput | no | yes |
PDK1_HUMAN | [view interactions] | Low throughput | no | yes |
CYH3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P85A_HUMAN | [view interactions] | Low throughput | no | yes |
P55G_HUMAN | [view interactions] | Low throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P85B_HUMAN | [view interactions] | Low throughput | no | yes |
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
RASE_HUMAN | [view interactions] | High throughput | no | no |
RRAS_HUMAN | [view interactions] | High throughput | no | yes |
DDR1_HUMAN | [view interactions] | High throughput | no | yes |
PTPRC_HUMAN | [view interactions] | High throughput | no | no |
RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FANCC_HUMAN | [view interactions] | High throughput | no | yes |
GLT12_HUMAN | [view interactions] | High throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFRP4_HUMAN | [view interactions] | High throughput | no | no |
F16P2_HUMAN | [view interactions] | High throughput | no | no |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNF13_HUMAN | [view interactions] | High throughput | no | yes |
UMPS_HUMAN | [view interactions] | High throughput | no | no |
BEX1_HUMAN | [view interactions] | High throughput | no | yes |
BEX2_HUMAN | [view interactions] | High throughput | no | yes |
I13R2_HUMAN | [view interactions] | High throughput | no | no |
IL24_HUMAN | [view interactions] | High throughput | no | no |
HOP2_HUMAN | [view interactions] | High throughput | no | no |
THRSP_HUMAN | [view interactions] | High throughput | no | no |
FOS_HUMAN | [view interactions] | High throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FBX32_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
TSN14_HUMAN | [view interactions] | High throughput | no | no |
BUB1_HUMAN | [view interactions] | High throughput | no | no |
TM52B_HUMAN | [view interactions] | High throughput | no | no |
NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MATN2_HUMAN | [view interactions] | High throughput | no | no |
CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
ZDH23_HUMAN | [view interactions] | High throughput | no | no |
TXNIP_HUMAN | [view interactions] | High throughput | no | no |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
BT3A1_HUMAN | [view interactions] | High throughput | no | yes |
TMM74_HUMAN | [view interactions] | High throughput | no | no |
V1BR_HUMAN | [view interactions] | High throughput | no | no |
ABCB9_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
GP150_HUMAN | [view interactions] | High throughput | no | no |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
CHK1_HUMAN | [view interactions] | High throughput | no | no |
RIR2_HUMAN | [view interactions] | High throughput | no | no |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
BRAF_HUMAN | [view interactions] | High throughput | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC1G_HUMAN | [view interactions] | High throughput | no | no |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACY1_HUMAN | [view interactions] | High throughput | no | no |
CD22_HUMAN | [view interactions] | High throughput | no | no |
CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F4_HUMAN | [view interactions] | High throughput | no | no |
I10R2_HUMAN | [view interactions] | High throughput | no | no |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARAF_HUMAN | [view interactions] | High throughput | no | yes |
CCND2_HUMAN | [view interactions] | High throughput | no | yes |
GLIS2_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
STK11_HUMAN | [view interactions] | High throughput | no | yes |
ATR_HUMAN | [view interactions] | High throughput | no | no |
TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
NHRF1_HUMAN | [view interactions] | High throughput | no | no |
NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
APC7_HUMAN | [view interactions] | High throughput | no | yes |
E2AK1_HUMAN | [view interactions] | High throughput | no | yes |
AMBP_HUMAN | [view interactions] | High throughput | no | no |
ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
SYVM_HUMAN | [view interactions] | High throughput | no | yes |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
ITIH1_HUMAN | [view interactions] | High throughput | no | no |
CASL_HUMAN | [view interactions] | High throughput | no | yes |
RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
UFD1_HUMAN | [view interactions] | High throughput | no | no |
HDAC1_HUMAN | [view interactions] | High throughput | no | no |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
SUN2_HUMAN | [view interactions] | High throughput | no | yes |
HAVR2_HUMAN | [view interactions] | High throughput | no | no |
FLRT1_HUMAN | [view interactions] | High throughput | no | no |
EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEF5_HUMAN | [view interactions] | High throughput | no | no |
I20RA_HUMAN | [view interactions] | High throughput | no | no |
RN19B_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC1_HUMAN | [view interactions] | High throughput | no | no |
PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGKC_HUMAN | [view interactions] | High throughput | no | no |
PIP_HUMAN | [view interactions] | High throughput | no | no |
IGHG1_HUMAN | [view interactions] | High throughput | no | no |
APOA1_HUMAN | [view interactions] | High throughput | no | no |
IGHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BPIA1_HUMAN | [view interactions] | High throughput | no | no |
PROL4_HUMAN | [view interactions] | High throughput | no | no |
MUC5B_HUMAN | [view interactions] | High throughput | no | no |
BPIB1_HUMAN | [view interactions] | High throughput | no | no |
ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRFL_HUMAN | [view interactions] | High throughput | no | no |
ZG16B_HUMAN | [view interactions] | High throughput | no | no |
PIGR_HUMAN | [view interactions] | High throughput | no | no |
SG2A1_HUMAN | [view interactions] | High throughput | no | no |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DSC1_HUMAN | [view interactions] | High throughput | no | no |
RASM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IL2RB_HUMAN | [view interactions] | Computational | no | no |
EFNB1_HUMAN | [view interactions] | Computational | no | yes |
CREB1_HUMAN | [view interactions] | Computational | no | yes |
IL4RA_HUMAN | [view interactions] | Computational | no | no |
SHIP2_HUMAN | [view interactions] | Computational | no | yes |
NRG2_HUMAN | [view interactions] | Computational | no | yes |
CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CXCR4_HUMAN | [view interactions] | Computational | no | no |
NPHN_HUMAN | [view interactions] | Computational | no | no |
THA_HUMAN | [view interactions] | Computational | no | yes |
VEGFC_HUMAN | [view interactions] | Computational | no | no |
PK3CD_HUMAN | [view interactions] | Computational | no | no |
ASM_HUMAN | [view interactions] | Computational | no | no |
IL1AP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NTF3_HUMAN | [view interactions] | Computational | no | no |
EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDN2A_HUMAN | [view interactions] | Computational | no | yes |
CD3E_HUMAN | [view interactions] | Computational | no | no |
KIRR1_HUMAN | [view interactions] | Computational | no | no |
THB_HUMAN | [view interactions] | Computational | no | no |
DRA_HUMAN | [view interactions] | Computational | no | no |
VGFR3_HUMAN | [view interactions] | Computational | no | yes |
BECN1_HUMAN | [view interactions] | Computational | no | yes |
IL2_HUMAN | [view interactions] | Computational | no | no |
VAV_HUMAN | [view interactions] | Computational | no | no |
SDC2_HUMAN | [view interactions] | Computational | no | yes |
LAMA1_HUMAN | [view interactions] | Computational | no | no |
OGT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PREX1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FCERB_HUMAN | [view interactions] | Computational | no | no |
GFRA1_HUMAN | [view interactions] | Computational | no | no |
FLT3_HUMAN | [view interactions] | Computational | no | no |
GTR14_HUMAN | [view interactions] | Computational | no | no |
CD79A_HUMAN | [view interactions] | Computational | no | no |
TNR16_HUMAN | [view entry] [view interactions] | Computational | yes | no |
HGF_HUMAN | [view interactions] | Computational | no | yes |
PDPK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PRGR_HUMAN | [view interactions] | Computational | no | no |
KS6B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHB1_HUMAN | [view interactions] | Computational | no | no |
IL5_HUMAN | [view interactions] | Computational | no | no |
ANGT_HUMAN | [view interactions] | Computational | no | no |
E41L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LAT_HUMAN | [view interactions] | Computational | no | no |
ITK_HUMAN | [view interactions] | Computational | no | no |
SOMA_HUMAN | [view interactions] | Computational | no | no |
I12R1_HUMAN | [view interactions] | Computational | no | no |
CAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD4_HUMAN | [view interactions] | Computational | no | no |
VLDLR_HUMAN | [view interactions] | Computational | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VGFR1_HUMAN | [view interactions] | Computational | no | no |
NRG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ICOS_HUMAN | [view interactions] | Computational | no | no |
NET1_HUMAN | [view interactions] | Computational | no | no |
JAK1_HUMAN | [view interactions] | Computational | no | yes |
A1BG_HUMAN | [view interactions] | Computational | no | no |
CD2_HUMAN | [view interactions] | Computational | no | no |
ANGP1_HUMAN | [view interactions] | Computational | no | no |
CD8B_HUMAN | [view interactions] | Computational | no | no |
INS_HUMAN | [view interactions] | Computational | no | no |
IL3_HUMAN | [view interactions] | Computational | no | no |
GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SDF1_HUMAN | [view interactions] | Computational | no | no |
CD3D_HUMAN | [view interactions] | Computational | no | no |
INSR_HUMAN | [view interactions] | Computational | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ANGP2_HUMAN | [view interactions] | Computational | no | no |
CD8A_HUMAN | [view interactions] | Computational | no | no |
LAMB1_HUMAN | [view interactions] | Computational | no | yes |
PI51A_HUMAN | [view interactions] | Computational | no | yes |
DRB1_HUMAN | [view interactions] | Computational | no | no |
TNF10_HUMAN | [view interactions] | Computational | no | no |
ITA1_HUMAN | [view interactions] | Computational | no | yes |
GCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL2RG_HUMAN | [view interactions] | Computational | no | no |
PDGFA_HUMAN | [view interactions] | Computational | no | yes |
TENS1_HUMAN | [view interactions] | Computational | no | no |
PAXI_HUMAN | [view interactions] | Computational | no | yes |
CD79B_HUMAN | [view interactions] | Computational | no | no |
PI3R5_HUMAN | [view interactions] | Computational | no | no |
ITB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AFAD_HUMAN | [view interactions] | Computational | no | yes |
STAT3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FES_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LCP2_HUMAN | [view interactions] | Computational | no | yes |
CD80_HUMAN | [view interactions] | Computational | no | no |
AKT2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EMAL4_HUMAN | [view interactions] | Computational | no | yes |
IL1R1_HUMAN | [view interactions] | Computational | no | no |
TRAF2_HUMAN | [view interactions] | Computational | no | yes |
LAMC2_HUMAN | [view interactions] | Computational | no | no |
PI3R4_HUMAN | [view interactions] | Computational | no | yes |
RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TLR4_HUMAN | [view interactions] | Computational | no | yes |
IFNG_HUMAN | [view interactions] | Computational | no | no |
HCST_HUMAN | [view interactions] | Computational | no | no |
GRB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RELN_HUMAN | [view interactions] | Computational | no | no |
CD40L_HUMAN | [view interactions] | Computational | no | no |
ACTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL3RA_HUMAN | [view interactions] | Computational | no | yes |
JAM1_HUMAN | [view interactions] | Computational | no | yes |
SP1_HUMAN | [view interactions] | Computational | no | yes |
IL1B_HUMAN | [view interactions] | Computational | no | no |
EPHA2_HUMAN | [view interactions] | Computational | no | no |
BCAR1_HUMAN | [view interactions] | Computational | no | yes |
KPCT_HUMAN | [view interactions] | Computational | no | no |
VEGFD_HUMAN | [view interactions] | Computational | no | no |
DAB1_HUMAN | [view interactions] | Computational | no | yes |
INGR1_HUMAN | [view interactions] | Computational | no | no |
GAB1_HUMAN | [view interactions] | Computational | no | yes |
FCERA_HUMAN | [view interactions] | Computational | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLGF_HUMAN | [view interactions] | Computational | no | no |
CD86_HUMAN | [view interactions] | Computational | no | yes |
PK3CB_HUMAN | [view interactions] | Computational | no | yes |
MET_HUMAN | [view interactions] | Computational | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ITB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PTN1_HUMAN | [view interactions] | Computational | no | yes |
ARI1A_HUMAN | [view interactions] | Computational | no | yes |
AKT3_HUMAN | [view interactions] | Computational | no | yes |
IL5RA_HUMAN | [view interactions] | Computational | no | no |
UNC5B_HUMAN | [view interactions] | Computational | no | yes |
IL23A_HUMAN | [view interactions] | Computational | no | no |
ITA2B_HUMAN | [view interactions] | Computational | no | no |
SHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RET_HUMAN | [view interactions] | Computational | no | yes |
EPS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FCERG_HUMAN | [view interactions] | Computational | no | no |
S1PR1_HUMAN | [view interactions] | Computational | no | no |
KSYK_HUMAN | [view interactions] | Computational | no | no |
IKBA_HUMAN | [view interactions] | Computational | no | yes |
PI5L1_HUMAN | [view interactions] | Computational | no | no |
EFNA1_HUMAN | [view interactions] | Computational | no | no |
MP2K2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PODO_HUMAN | [view interactions] | Computational | no | no |
P3C2B_HUMAN | [view interactions] | Computational | no | no |
CD19_HUMAN | [view interactions] | Computational | no | no |
ACTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD2AP_HUMAN | [view interactions] | Computational | no | no |
EPHB4_HUMAN | [view interactions] | Computational | no | yes |
BTK_HUMAN | [view interactions] | Computational | no | no |
IGF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
BDNF_HUMAN | [view interactions] | Computational | no | yes |
VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IL23R_HUMAN | [view interactions] | Computational | no | yes |
CSF2_HUMAN | [view interactions] | Computational | no | no |
SHIP1_HUMAN | [view interactions] | Computational | no | no |
CD3Z_HUMAN | [view interactions] | Computational | no | no |
BCL6_HUMAN | [view interactions] | Computational | no | no |
UFO_HUMAN | [view interactions] | Computational | no | no |
PI3R6_HUMAN | [view interactions] | Computational | no | yes |
NGF_HUMAN | [view interactions] | Computational | no | no |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
ITA6_HUMAN | [view interactions] | Computational | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD3G_HUMAN | [view interactions] | Computational | no | no |
PTN6_HUMAN | [view interactions] | Computational | no | no |
VGFR2_HUMAN | [view interactions] | Computational | no | no |
AGTR2_HUMAN | [view interactions] | Computational | no | no |
KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PI42B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRAP2_HUMAN | [view interactions] | Computational | no | no |
CEGT_HUMAN | [view interactions] | Computational | no | yes |
HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PI51B_HUMAN | [view interactions] | Computational | no | yes |
SMS1_HUMAN | [view interactions] | Computational | no | yes |
BCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ITAV_HUMAN | [view interactions] | Computational | no | yes |
ANDR_HUMAN | [view interactions] | Computational | no | no |
CSF2R_HUMAN | [view interactions] | Computational | no | no |
NECT3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TYK2_HUMAN | [view interactions] | Computational | no | no |
DAPP1_HUMAN | [view interactions] | Computational | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PK3CG_HUMAN | [view interactions] | Computational | no | yes |
JAK3_HUMAN | [view interactions] | Computational | no | no |
EGF_HUMAN | [view interactions] | Computational | no | no |
IL12B_HUMAN | [view interactions] | Computational | no | yes |
TIE2_HUMAN | [view interactions] | Computational | no | no |
ACTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KPCZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ALK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BCAP_HUMAN | [view interactions] | Computational | no | no |
ZYX_HUMAN | [view interactions] | Computational | no | no |
PGFRB_HUMAN | [view interactions] | Computational | no | yes |
IL4_HUMAN | [view interactions] | Computational | no | no |
RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CADH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GDNF_HUMAN | [view interactions] | Computational | no | yes |
HBEGF_HUMAN | [view interactions] | Computational | no | no |
GBG1_HUMAN | [view interactions] | Computational | no | no |
FGFR3_HUMAN | [view interactions] | Computational | no | yes |
CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACTS_HUMAN | [view interactions] | Computational | no | no |
PDGFB_HUMAN | [view interactions] | Computational | no | yes |
FRS2_HUMAN | [view interactions] | Computational | no | no |
TLN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KISSR_HUMAN | [view interactions] | Computational | no | yes |
ILK_HUMAN | [view interactions] | Computational | no | no |
GAB2_HUMAN | [view interactions] | Computational | no | yes |
IL2RA_HUMAN | [view interactions] | Computational | no | no |
ZAP70_HUMAN | [view interactions] | Computational | no | no |
FGFR2_HUMAN | [view interactions] | Computational | no | yes |