Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PK3CA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed, PubMed, PubMed). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed, PubMed). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed, PubMed). Plays a role in the positive regulation of phagocytosis and pinocytosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PK3CA_HUMAN
GO:0043168 anion binding 34.4828 4 yes
GO:0000166 nucleotide binding 30.1724 4 yes
GO:0017076 purine nucleotide binding 30.1724 5 yes
GO:0032555 purine ribonucleotide binding 30.1724 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.1724 4 yes
GO:0019900 kinase binding 28.4483 4 no
GO:0003779 actin binding 26.7241 4 no
GO:0019901 protein kinase binding 24.1379 5 no
GO:0005524 ATP binding 21.5517 5 yes
GO:0030554 adenyl nucleotide binding 21.5517 6 yes
GO:0032559 adenyl ribonucleotide binding 21.5517 5 yes
GO:0045296 cadherin binding 20.6897 4 no
GO:0016301 kinase activity 13.7931 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 12.9310 4 yes
GO:0019887 protein kinase regulator activity 7.7586 4 yes
GO:0004674 protein serine/threonine kinase activity 6.8966 4 yes
GO:0106310 protein serine kinase activity 6.8966 4 yes
GO:0019209 kinase activator activity 5.1724 4 yes
GO:0030295 protein kinase activator activity 5.1724 5 yes
GO:0001727 lipid kinase activity 3.4483 5 yes
GO:0052742 phosphatidylinositol kinase activity 2.5862 5 yes
GO:0016303 1-phosphatidylinositol-3-kinase activity 1.7241 6 yes
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity 1.7241 6 yes
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.7241 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PK3CA_HUMAN
GO:0048522 positive regulation of cellular process 63.7931 4 yes
GO:0048523 negative regulation of cellular process 55.1724 4 yes
GO:0031323 regulation of cellular metabolic process 51.7241 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0051128 regulation of cellular component organization 49.1379 4 yes
GO:0080090 regulation of primary metabolic process 46.5517 4 yes
GO:0009966 regulation of signal transduction 44.8276 4 yes
GO:0009893 positive regulation of metabolic process 39.6552 4 no
GO:0006996 organelle organization 39.6552 4 yes
GO:0031326 regulation of cellular biosynthetic process 37.9310 5 yes
GO:0009889 regulation of biosynthetic process 37.9310 4 yes
GO:1902531 regulation of intracellular signal transduction 36.2069 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.2069 5 no
GO:0010556 regulation of macromolecule biosynthetic process 36.2069 5 yes
GO:0031325 positive regulation of cellular metabolic process 35.3448 5 no
GO:0022607 cellular component assembly 35.3448 4 no
GO:0048584 positive regulation of response to stimulus 34.4828 4 yes
GO:0051246 regulation of protein metabolic process 33.6207 5 yes
GO:0010468 regulation of gene expression 33.6207 6 yes
GO:0007010 cytoskeleton organization 32.7586 5 yes
GO:0033043 regulation of organelle organization 30.1724 5 yes
GO:0051049 regulation of transport 30.1724 4 no
GO:0010647 positive regulation of cell communication 29.3103 5 yes
GO:0023056 positive regulation of signaling 29.3103 4 yes
GO:0044087 regulation of cellular component biogenesis 29.3103 4 yes
GO:0051240 positive regulation of multicellular organismal process 29.3103 4 yes
GO:0009892 negative regulation of metabolic process 29.3103 4 yes
GO:0009967 positive regulation of signal transduction 29.3103 5 yes
GO:0008104 protein localization 28.4483 4 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 yes
GO:0051130 positive regulation of cellular component organization 27.5862 5 yes
GO:0031399 regulation of protein modification process 26.7241 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.7241 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.7241 5 yes
GO:0060341 regulation of cellular localization 25.8621 4 yes
GO:0009891 positive regulation of biosynthetic process 25.8621 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.8621 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.8621 6 no
GO:0045595 regulation of cell differentiation 25.8621 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 24.1379 6 yes
GO:0042325 regulation of phosphorylation 24.1379 7 yes
GO:0051174 regulation of phosphorus metabolic process 24.1379 5 yes
GO:0071310 cellular response to organic substance 24.1379 4 yes
GO:0051247 positive regulation of protein metabolic process 24.1379 6 no
GO:0032880 regulation of protein localization 23.2759 5 yes
GO:0042127 regulation of cell population proliferation 23.2759 4 yes
GO:0042981 regulation of apoptotic process 23.2759 5 yes
GO:0043067 regulation of programmed cell death 23.2759 4 yes
GO:0001932 regulation of protein phosphorylation 23.2759 7 yes
GO:0051094 positive regulation of developmental process 22.4138 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.4138 4 yes
GO:0030155 regulation of cell adhesion 21.5517 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 21.5517 6 yes
GO:0051493 regulation of cytoskeleton organization 21.5517 6 yes
GO:0010628 positive regulation of gene expression 21.5517 7 no
GO:2000026 regulation of multicellular organismal development 21.5517 4 no
GO:0097435 supramolecular fiber organization 21.5517 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.5517 5 yes
GO:0009890 negative regulation of biosynthetic process 21.5517 5 yes
GO:0007015 actin filament organization 20.6897 5 no
GO:0002684 positive regulation of immune system process 20.6897 4 yes
GO:0031344 regulation of cell projection organization 19.8276 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.8276 6 yes
GO:0008284 positive regulation of cell population proliferation 19.8276 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 19.8276 6 yes
GO:0050776 regulation of immune response 18.9655 4 yes
GO:0032970 regulation of actin filament-based process 18.1034 4 yes
GO:0043933 protein-containing complex organization 18.1034 4 yes
GO:0045785 positive regulation of cell adhesion 18.1034 5 yes
GO:0051129 negative regulation of cellular component organization 18.1034 5 yes
GO:0032956 regulation of actin cytoskeleton organization 17.2414 5 yes
GO:0044089 positive regulation of cellular component biogenesis 17.2414 5 yes
GO:1901701 cellular response to oxygen-containing compound 17.2414 4 yes
GO:0010243 response to organonitrogen compound 17.2414 4 yes
GO:0043066 negative regulation of apoptotic process 16.3793 6 yes
GO:0043069 negative regulation of programmed cell death 16.3793 5 yes
GO:1902903 regulation of supramolecular fiber organization 16.3793 5 yes
GO:0022407 regulation of cell-cell adhesion 15.5172 5 yes
GO:0050865 regulation of cell activation 15.5172 4 yes
GO:0006796 phosphate-containing compound metabolic process 15.5172 4 yes
GO:0050778 positive regulation of immune response 14.6552 5 yes
GO:1901699 cellular response to nitrogen compound 14.6552 4 yes
GO:1903829 positive regulation of protein localization 14.6552 5 yes
GO:0010629 negative regulation of gene expression 13.7931 7 yes
GO:0071417 cellular response to organonitrogen compound 13.7931 4 yes
GO:0110053 regulation of actin filament organization 13.7931 6 yes
GO:1905475 regulation of protein localization to membrane 13.7931 6 yes
GO:0002694 regulation of leukocyte activation 13.7931 4 yes
GO:0009894 regulation of catabolic process 13.7931 4 yes
GO:0032535 regulation of cellular component size 12.9310 4 yes
GO:0050863 regulation of T cell activation 12.9310 6 yes
GO:0051249 regulation of lymphocyte activation 12.9310 5 yes
GO:0016310 phosphorylation 12.0690 5 yes
GO:0031346 positive regulation of cell projection organization 12.0690 6 yes
GO:0032870 cellular response to hormone stimulus 12.0690 4 yes
GO:0043434 response to peptide hormone 12.0690 4 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 12.0690 6 yes
GO:0010639 negative regulation of organelle organization 11.2069 6 yes
GO:0014070 response to organic cyclic compound 11.2069 4 yes
GO:0022409 positive regulation of cell-cell adhesion 11.2069 6 yes
GO:0030832 regulation of actin filament length 11.2069 5 yes
GO:0033993 response to lipid 11.2069 4 yes
GO:0098657 import into cell 11.2069 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 11.2069 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 11.2069 4 yes
GO:0006915 apoptotic process 11.2069 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 11.2069 6 yes
GO:0038127 ERBB signaling pathway 10.3448 6 yes
GO:0043244 regulation of protein-containing complex disassembly 10.3448 5 yes
GO:1901879 regulation of protein depolymerization 10.3448 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 10.3448 7 yes
GO:1905477 positive regulation of protein localization to membrane 10.3448 6 yes
GO:0050867 positive regulation of cell activation 9.4828 5 yes
GO:0050870 positive regulation of T cell activation 9.4828 7 yes
GO:0051251 positive regulation of lymphocyte activation 9.4828 6 yes
GO:0051494 negative regulation of cytoskeleton organization 9.4828 7 yes
GO:0071375 cellular response to peptide hormone stimulus 9.4828 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 9.4828 6 yes
GO:0002696 positive regulation of leukocyte activation 9.4828 5 yes
GO:0030834 regulation of actin filament depolymerization 8.6207 7 yes
GO:0043242 negative regulation of protein-containing complex disassembly 8.6207 6 yes
GO:0048732 gland development 8.6207 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 8.6207 5 yes
GO:0060491 regulation of cell projection assembly 8.6207 5 yes
GO:1901880 negative regulation of protein depolymerization 8.6207 7 yes
GO:0007173 epidermal growth factor receptor signaling pathway 8.6207 7 yes
GO:0031329 regulation of cellular catabolic process 7.7586 5 yes
GO:0032868 response to insulin 7.7586 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 7.7586 6 yes
GO:0001667 ameboidal-type cell migration 7.7586 4 yes
GO:0030835 negative regulation of actin filament depolymerization 6.8966 7 yes
GO:0032869 cellular response to insulin stimulus 6.8966 6 yes
GO:0043523 regulation of neuron apoptotic process 6.8966 6 yes
GO:0050852 T cell receptor signaling pathway 6.8966 6 yes
GO:0062197 cellular response to chemical stress 6.8966 4 yes
GO:0008286 insulin receptor signaling pathway 6.8966 6 yes
GO:0010631 epithelial cell migration 6.0345 5 yes
GO:0043524 negative regulation of neuron apoptotic process 6.0345 7 yes
GO:0048638 regulation of developmental growth 6.0345 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 6.0345 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 6.0345 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 6.0345 6 yes
GO:1901654 response to ketone 6.0345 4 yes
GO:0010506 regulation of autophagy 6.0345 6 yes
GO:0016241 regulation of macroautophagy 5.1724 7 yes
GO:0035994 response to muscle stretch 5.1724 4 yes
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 5.1724 5 yes
GO:0043542 endothelial cell migration 5.1724 6 yes
GO:0046486 glycerolipid metabolic process 5.1724 4 yes
GO:0048009 insulin-like growth factor receptor signaling pathway 5.1724 6 yes
GO:0048545 response to steroid hormone 5.1724 4 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 5.1724 6 yes
GO:1902743 regulation of lamellipodium organization 5.1724 7 yes
GO:1902745 positive regulation of lamellipodium organization 5.1724 7 yes
GO:0006936 muscle contraction 5.1724 4 yes
GO:0032006 regulation of TOR signaling 4.3103 6 yes
GO:0042593 glucose homeostasis 4.3103 4 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 4.3103 7 yes
GO:2000209 regulation of anoikis 4.3103 6 yes
GO:2000811 negative regulation of anoikis 4.3103 7 yes
GO:0006644 phospholipid metabolic process 4.3103 4 yes
GO:0006650 glycerophospholipid metabolic process 4.3103 5 yes
GO:0006909 phagocytosis 4.3103 4 yes
GO:0008610 lipid biosynthetic process 4.3103 4 yes
GO:0009895 negative regulation of catabolic process 4.3103 5 yes
GO:0031960 response to corticosteroid 3.4483 5 yes
GO:0032008 positive regulation of TOR signaling 3.4483 7 yes
GO:0038084 vascular endothelial growth factor signaling pathway 3.4483 6 yes
GO:0043200 response to amino acid 3.4483 4 yes
GO:0043467 regulation of generation of precursor metabolites and energy 3.4483 5 yes
GO:0045017 glycerolipid biosynthetic process 3.4483 4 yes
GO:0046474 glycerophospholipid biosynthetic process 3.4483 5 yes
GO:0046488 phosphatidylinositol metabolic process 3.4483 6 yes
GO:0070542 response to fatty acid 3.4483 4 yes
GO:0071824 protein-DNA complex organization 3.4483 5 yes
GO:0090407 organophosphate biosynthetic process 3.4483 4 yes
GO:0001889 liver development 3.4483 5 yes
GO:0006325 chromatin organization 3.4483 6 yes
GO:0008654 phospholipid biosynthetic process 3.4483 5 yes
GO:0010591 regulation of lamellipodium assembly 3.4483 7 yes
GO:0010592 positive regulation of lamellipodium assembly 3.4483 7 yes
GO:0016242 negative regulation of macroautophagy 2.5862 8 yes
GO:0019318 hexose metabolic process 2.5862 4 yes
GO:0031330 negative regulation of cellular catabolic process 2.5862 6 yes
GO:0043276 anoikis 2.5862 5 yes
GO:0046854 phosphatidylinositol phosphate biosynthetic process 2.5862 7 yes
GO:0048015 phosphatidylinositol-mediated signaling 2.5862 4 yes
GO:0051384 response to glucocorticoid 2.5862 6 yes
GO:0055119 relaxation of cardiac muscle 2.5862 5 yes
GO:0060612 adipose tissue development 2.5862 5 yes
GO:0061448 connective tissue development 2.5862 4 yes
GO:0070252 actin-mediated cell contraction 2.5862 4 yes
GO:0071229 cellular response to acid chemical 2.5862 4 yes
GO:0071462 cellular response to water stimulus 2.5862 4 yes
GO:0071464 cellular response to hydrostatic pressure 2.5862 4 yes
GO:0086003 cardiac muscle cell contraction 2.5862 5 yes
GO:0090075 relaxation of muscle 2.5862 4 yes
GO:0006006 glucose metabolic process 2.5862 5 yes
GO:0006338 chromatin remodeling 2.5862 7 yes
GO:0006661 phosphatidylinositol biosynthetic process 2.5862 6 yes
GO:0006941 striated muscle contraction 2.5862 5 yes
GO:0009743 response to carbohydrate 2.5862 4 yes
GO:0010507 negative regulation of autophagy 2.5862 7 yes
GO:0034284 response to monosaccharide 1.7241 5 yes
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 1.7241 8 yes
GO:0040014 regulation of multicellular organism growth 1.7241 4 yes
GO:0040029 epigenetic regulation of gene expression 1.7241 7 yes
GO:0043045 epigenetic programming of gene expression 1.7241 8 yes
GO:0043201 response to L-leucine 1.7241 4 yes
GO:0043457 regulation of cellular respiration 1.7241 6 yes
GO:0060048 cardiac muscle contraction 1.7241 6 yes
GO:0071322 cellular response to carbohydrate stimulus 1.7241 5 yes
GO:0071326 cellular response to monosaccharide stimulus 1.7241 6 yes
GO:0071331 cellular response to hexose stimulus 1.7241 7 yes
GO:0071333 cellular response to glucose stimulus 1.7241 5 yes
GO:0071514 genomic imprinting 1.7241 9 yes
GO:0071548 response to dexamethasone 1.7241 5 yes
GO:0141068 autosome genomic imprinting 1.7241 10 yes
GO:1903544 response to butyrate 1.7241 5 yes
GO:2000269 regulation of fibroblast apoptotic process 1.7241 6 yes
GO:2000270 negative regulation of fibroblast apoptotic process 1.7241 7 yes
GO:0001678 intracellular glucose homeostasis 1.7241 4 yes
GO:0001944 vasculature development 1.7241 4 yes
GO:0009746 response to hexose 1.7241 6 yes
GO:0009749 response to glucose 1.7241 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ERBB3_HUMAN [view interactions] Low throughput no yes
CCND1_HUMAN [view interactions] Low throughput no yes
IRS2_HUMAN [view interactions] Low throughput no yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
RASN_HUMAN [view entry] [view interactions] Low throughput yes no
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
P53_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK_HUMAN [view interactions] Low throughput no yes
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
IL3RB_HUMAN [view interactions] Low throughput no no
CSF1R_HUMAN [view interactions] Low throughput no yes
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG1_HUMAN [view interactions] Low throughput no no
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GELS_HUMAN [view entry] [view interactions] Low throughput yes no
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
IRS4_HUMAN [view interactions] Low throughput no no
UBF1_HUMAN [view interactions] Low throughput no yes
WDR5_HUMAN [view interactions] Low throughput no no
CD28_HUMAN [view interactions] Low throughput no no
TNR5_HUMAN [view interactions] Low throughput no no
MED21_HUMAN [view interactions] Low throughput no yes
TPOR_HUMAN [view interactions] Low throughput no no
KIT_HUMAN [view interactions] Low throughput no no
ESR1_HUMAN [view interactions] Low throughput no no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
PGFRA_HUMAN [view interactions] Low throughput no no
PTTG1_HUMAN [view interactions] Low throughput no no
DERL1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
RPGF5_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PAQR3_HUMAN [view interactions] Low throughput no no
NED4L_HUMAN [view entry] [view interactions] Low throughput yes yes
P55G_HUMAN [view interactions] Low throughput no yes
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
P85B_HUMAN [view interactions] Low throughput no yes
RHES_HUMAN [view interactions] Low throughput no yes
ADAP1_HUMAN [view interactions] Low throughput no yes
SGK1_HUMAN [view interactions] Low throughput no yes
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
SNX9_HUMAN [view entry] [view interactions] Low throughput yes yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
GRP3_HUMAN [view interactions] Low throughput no no
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
BPIA1_HUMAN [view interactions] Low throughput no no
PDK1_HUMAN [view interactions] Low throughput no yes
CYH3_HUMAN [view entry] [view interactions] Low throughput yes yes
CYH2_HUMAN [view entry] [view interactions] Low throughput yes yes
B2MG_HUMAN [view interactions] Low throughput no yes
HLAA_HUMAN [view interactions] Low throughput no no
COHA1_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
CING_HUMAN [view interactions] High throughput no no
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
CRBG1_HUMAN [view interactions] High throughput no no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
LAD1_HUMAN [view interactions] High throughput no no
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
CD109_HUMAN [view interactions] High throughput no no
COR2A_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRZ_HUMAN [view entry] [view interactions] High throughput yes yes
TRFM_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
KC1A_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
SC16A_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
THOC5_HUMAN [view interactions] High throughput no no
PI51C_HUMAN [view entry] [view interactions] High throughput yes yes
CCNT1_HUMAN [view interactions] High throughput no yes
TYY1_HUMAN [view interactions] High throughput no yes
PP1RA_HUMAN [view interactions] High throughput no yes
FUT8_HUMAN [view interactions] High throughput no yes
COIL_HUMAN [view interactions] High throughput no yes
RPB7_HUMAN [view interactions] High throughput no yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
SON_HUMAN [view interactions] High throughput no yes
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
ELMO1_HUMAN [view entry] [view interactions] High throughput yes no
IRF7_HUMAN [view interactions] High throughput no yes
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
COG4_HUMAN [view interactions] High throughput no no
UTP11_HUMAN [view interactions] High throughput no yes
2AAB_HUMAN [view interactions] High throughput no yes
YIPF3_HUMAN [view interactions] High throughput no yes
IL1AP_HUMAN [view entry] [view interactions] High throughput yes yes
CDC23_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
DAP1_HUMAN [view interactions] High throughput no yes
ZN326_HUMAN [view interactions] High throughput no yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
GAB1_HUMAN [view interactions] High throughput no yes
AF1L2_HUMAN [view interactions] High throughput no no
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
FA10_HUMAN [view interactions] High throughput no no
PP6R1_HUMAN [view interactions] High throughput no no
MAGD1_HUMAN [view interactions] High throughput no no
RPAP3_HUMAN [view interactions] High throughput no yes
UROK_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
DJB14_HUMAN [view interactions] High throughput no yes
IPRI_HUMAN [view interactions] High throughput no no
SEPT6_HUMAN [view interactions] High throughput no yes
UNC50_HUMAN [view interactions] High throughput no yes
AR6P4_HUMAN [view interactions] High throughput no yes
SLTM_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
SHLB1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
HCLS1_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
EXT2_HUMAN [view entry] [view interactions] High throughput yes no
RM38_HUMAN [view interactions] High throughput no yes
CAP2_HUMAN [view entry] [view interactions] High throughput yes yes
UB2G2_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
RRAS2_HUMAN [view interactions] High throughput no yes
RASM_HUMAN [view entry] [view interactions] High throughput yes yes
RRAS_HUMAN [view interactions] High throughput no yes
RASE_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
PTPRC_HUMAN [view interactions] High throughput no no
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
FANCC_HUMAN [view interactions] High throughput no yes
GLT12_HUMAN [view interactions] High throughput no yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
SFRP4_HUMAN [view interactions] High throughput no no
F16P2_HUMAN [view interactions] High throughput no no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
UMPS_HUMAN [view interactions] High throughput no no
TNF13_HUMAN [view interactions] High throughput no yes
BEX1_HUMAN [view interactions] High throughput no yes
BEX2_HUMAN [view interactions] High throughput no yes
I13R2_HUMAN [view interactions] High throughput no no
IL24_HUMAN [view interactions] High throughput no no
HOP2_HUMAN [view interactions] High throughput no no
THRSP_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
TNR1A_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
FBX32_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
TSN14_HUMAN [view interactions] High throughput no no
BUB1_HUMAN [view interactions] High throughput no no
TM52B_HUMAN [view interactions] High throughput no no
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
MATN2_HUMAN [view interactions] High throughput no no
CNOT3_HUMAN [view interactions] High throughput no yes
RS27_HUMAN [view entry] [view interactions] High throughput yes no
VIR_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
TXNIP_HUMAN [view interactions] High throughput no no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
BT3A1_HUMAN [view interactions] High throughput no yes
TMM74_HUMAN [view interactions] High throughput no no
V1BR_HUMAN [view interactions] High throughput no no
ABCB9_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
GP150_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOH_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
APC7_HUMAN [view interactions] High throughput no yes
E2AK1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
AMBP_HUMAN [view interactions] High throughput no no
EIPR1_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
SYVM_HUMAN [view interactions] High throughput no yes
RIR2_HUMAN [view interactions] High throughput no no
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
FRIL_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view entry] [view interactions] High throughput yes yes
ITIH1_HUMAN [view interactions] High throughput no no
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
CASL_HUMAN [view interactions] High throughput no yes
KCC1G_HUMAN [view interactions] High throughput no no
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
SQSTM_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
UFD1_HUMAN [view interactions] High throughput no no
ACY1_HUMAN [view interactions] High throughput no no
CD22_HUMAN [view interactions] High throughput no no
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
HDAC1_HUMAN [view interactions] High throughput no no
I10R2_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
MANS1_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SUN2_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
HAVR2_HUMAN [view interactions] High throughput no no
FLRT1_HUMAN [view interactions] High throughput no no
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
DEF5_HUMAN [view interactions] High throughput no no
I20RA_HUMAN [view interactions] High throughput no no
RN19B_HUMAN [view interactions] High throughput no yes
ZDHC1_HUMAN [view interactions] High throughput no no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SG2A1_HUMAN [view interactions] High throughput no no
PIGR_HUMAN [view interactions] High throughput no no
ARAF_HUMAN [view interactions] High throughput no yes
PAUF_HUMAN [view interactions] High throughput no no
CCND2_HUMAN [view interactions] High throughput no yes
TRFL_HUMAN [view interactions] High throughput no no
GLIS2_HUMAN [view interactions] High throughput no no
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
BPIB1_HUMAN [view interactions] High throughput no no
STK11_HUMAN [view interactions] High throughput no yes
MUC5B_HUMAN [view interactions] High throughput no no
ATR_HUMAN [view entry] [view interactions] High throughput yes no
PROL4_HUMAN [view interactions] High throughput no no
TNFL6_HUMAN [view interactions] High throughput no yes
IGHA1_HUMAN [view entry] [view interactions] High throughput yes yes
APOA1_HUMAN [view interactions] High throughput no no
IGHG1_HUMAN [view interactions] High throughput no no
NHRF1_HUMAN [view interactions] High throughput no no
PIP_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view interactions] High throughput no no
IGKC_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
DSC1_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
FA83B_HUMAN [view interactions] High throughput no no
PKHG3_HUMAN [view interactions] High throughput no yes
K1671_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
FA83H_HUMAN [view interactions] High throughput no yes
CYTSA_HUMAN [view interactions] High throughput no yes
MISP_HUMAN [view interactions] High throughput no no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes