Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RASM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RASM_HUMAN
GO:0000166 nucleotide binding 55.5556 4 yes
GO:0017076 purine nucleotide binding 55.5556 5 yes
GO:0032555 purine ribonucleotide binding 55.5556 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 yes
GO:0043168 anion binding 55.5556 4 yes
GO:0043169 cation binding 55.5556 4 no
GO:0046872 metal ion binding 55.5556 5 no
GO:0005524 ATP binding 44.4444 5 no
GO:0016301 kinase activity 44.4444 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 44.4444 4 no
GO:0030554 adenyl nucleotide binding 44.4444 6 no
GO:0032559 adenyl ribonucleotide binding 44.4444 5 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0004709 MAP kinase kinase kinase activity 22.2222 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0004722 protein serine/threonine phosphatase activity 22.2222 4 no
GO:0008157 protein phosphatase 1 binding 22.2222 6 no
GO:0016791 phosphatase activity 22.2222 5 no
GO:0017018 myosin phosphatase activity 22.2222 5 no
GO:0019902 phosphatase binding 22.2222 4 no
GO:0019903 protein phosphatase binding 22.2222 5 no
GO:0042578 phosphoric ester hydrolase activity 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RASM_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 no
GO:0006796 phosphate-containing compound metabolic process 66.6667 4 no
GO:0009889 regulation of biosynthetic process 66.6667 4 no
GO:0010468 regulation of gene expression 66.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 66.6667 5 no
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 66.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0023056 positive regulation of signaling 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0048584 positive regulation of response to stimulus 55.5556 4 no
GO:0141124 intracellular signaling cassette 55.5556 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0009967 positive regulation of signal transduction 55.5556 5 no
GO:0010646 regulation of cell communication 55.5556 4 no
GO:0010647 positive regulation of cell communication 55.5556 5 no
GO:0022607 cellular component assembly 44.4444 4 no
GO:0030155 regulation of cell adhesion 44.4444 4 no
GO:0042127 regulation of cell population proliferation 44.4444 4 no
GO:0045595 regulation of cell differentiation 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:1902533 positive regulation of intracellular signal transduction 44.4444 6 no
GO:2000145 regulation of cell motility 44.4444 4 no
GO:0016310 phosphorylation 44.4444 5 no
GO:0036211 protein modification process 44.4444 4 no
GO:0042981 regulation of apoptotic process 44.4444 5 no
GO:0043067 regulation of programmed cell death 44.4444 4 no
GO:0043412 macromolecule modification 44.4444 4 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0043933 protein-containing complex organization 44.4444 4 no
GO:0006996 organelle organization 44.4444 4 yes
GO:0007010 cytoskeleton organization 44.4444 5 yes
GO:0010720 positive regulation of cell development 33.3333 6 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031346 positive regulation of cell projection organization 33.3333 6 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0050767 regulation of neurogenesis 33.3333 6 no
GO:0050769 positive regulation of neurogenesis 33.3333 6 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0051960 regulation of nervous system development 33.3333 5 no
GO:0051962 positive regulation of nervous system development 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:2000026 regulation of multicellular organismal development 33.3333 4 no
GO:0000165 MAPK cascade 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006915 apoptotic process 33.3333 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0009416 response to light stimulus 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0014070 response to organic cyclic compound 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0038127 ERBB signaling pathway 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043066 negative regulation of apoptotic process 33.3333 6 no
GO:0043069 negative regulation of programmed cell death 33.3333 5 no
GO:0043434 response to peptide hormone 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0045785 positive regulation of cell adhesion 33.3333 5 no
GO:0048732 gland development 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0034329 cell junction assembly 22.2222 5 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0035023 regulation of Rho protein signal transduction 22.2222 7 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0050770 regulation of axonogenesis 22.2222 5 no
GO:0050772 positive regulation of axonogenesis 22.2222 6 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 22.2222 6 no
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 22.2222 4 no
GO:0002684 positive regulation of immune system process 22.2222 4 no
GO:0002694 regulation of leukocyte activation 22.2222 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 22.2222 4 no
GO:0006468 protein phosphorylation 22.2222 5 no
GO:0007173 epidermal growth factor receptor signaling pathway 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0014074 response to purine-containing compound 22.2222 5 no
GO:0023061 signal release 22.2222 4 no
GO:0030336 negative regulation of cell migration 22.2222 6 no
GO:0030878 thyroid gland development 22.2222 5 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0033135 regulation of peptidyl-serine phosphorylation 22.2222 8 no
GO:0033138 positive regulation of peptidyl-serine phosphorylation 22.2222 9 no
GO:0040013 negative regulation of locomotion 22.2222 4 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0046683 response to organophosphorus 22.2222 4 no
GO:0046903 secretion 22.2222 4 no
GO:0048534 hematopoietic or lymphoid organ development 22.2222 4 no
GO:0048538 thymus development 22.2222 5 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0050778 positive regulation of immune response 22.2222 5 no
GO:0050851 antigen receptor-mediated signaling pathway 22.2222 5 no
GO:0050852 T cell receptor signaling pathway 22.2222 6 no
GO:0050863 regulation of T cell activation 22.2222 6 no
GO:0050865 regulation of cell activation 22.2222 4 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051249 regulation of lymphocyte activation 22.2222 5 no
GO:0051591 response to cAMP 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0090150 establishment of protein localization to membrane 22.2222 4 no
GO:0110053 regulation of actin filament organization 22.2222 6 no
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 no
GO:2000146 negative regulation of cell motility 22.2222 5 no
GO:0008286 insulin receptor signaling pathway 22.2222 6 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0035994 response to muscle stretch 22.2222 4 no
GO:0048009 insulin-like growth factor receptor signaling pathway 22.2222 6 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 22.2222 6 no
GO:0005976 polysaccharide metabolic process 22.2222 4 no
GO:0005977 glycogen metabolic process 22.2222 6 no
GO:0006112 energy reserve metabolic process 22.2222 5 no
GO:0006470 protein dephosphorylation 22.2222 5 no
GO:0009648 photoperiodism 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0015980 energy derivation by oxidation of organic compounds 22.2222 4 no
GO:0016311 dephosphorylation 22.2222 5 no
GO:0032535 regulation of cellular component size 22.2222 4 no
GO:0043153 entrainment of circadian clock by photoperiod 22.2222 4 no
GO:0043467 regulation of generation of precursor metabolites and energy 22.2222 5 no
GO:0044042 glucan metabolic process 22.2222 5 no
GO:0009743 response to carbohydrate 22.2222 4 no
GO:0009746 response to hexose 22.2222 6 no
GO:0009749 response to glucose 22.2222 7 no
GO:0032868 response to insulin 22.2222 5 no
GO:0032869 cellular response to insulin stimulus 22.2222 6 no
GO:0032870 cellular response to hormone stimulus 22.2222 4 no
GO:0034284 response to monosaccharide 22.2222 5 no
GO:0071375 cellular response to peptide hormone stimulus 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0022407 regulation of cell-cell adhesion 22.2222 5 no
GO:0022409 positive regulation of cell-cell adhesion 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
RASF5_HUMAN [view interactions] Low throughput no yes
PLXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
GNDS_HUMAN [view interactions] Low throughput no yes
BRAF_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF5_HUMAN [view interactions] Low throughput no yes
SHOC2_HUMAN [view interactions] Low throughput no yes
HUWE1_HUMAN [view interactions] Low throughput no yes
PRS8_HUMAN [view interactions] Low throughput no yes
LZTR1_HUMAN [view interactions] Low throughput no no
RPGF6_HUMAN [view interactions] Low throughput no yes
PP1G_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
ELOC_HUMAN [view interactions] High throughput no no
KPYR_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no