RAF1_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at Ser-75. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 256 | Arg | Ser | Noonansyndrome5(NS5) | - |
| 257 | Ser | Leu | LEOPARDsyndrome2(LPRD2) | - |
| 257 | Ser | Leu | Noonansyndrome5(NS5) | - |
| 259 | Ser | Phe | Noonansyndrome5(NS5) | - |
| 260 | Thr | Arg | Noonansyndrome5(NS5) | - |
| 261 | Pro | Ala | Noonansyndrome5(NS5) | - |
| 261 | Pro | Leu | Noonansyndrome5(NS5) | - |
| 261 | Pro | Ser | Noonansyndrome5(NS5) | - |
| 263 | Val | Ala | Noonansyndrome5(NS5) | - |
| 486 | Asp | Gly | Noonansyndrome5(NS5) | - |
| 486 | Asp | Asn | Noonansyndrome5(NS5) | - |
| 491 | Thr | Ile | Noonansyndrome5(NS5) | - |
| 491 | Thr | Arg | Noonansyndrome5(NS5) | - |
| 612 | Ser | Thr | Noonansyndrome5(NS5) | - |
| 613 | Leu | Val | LEOPARDsyndrome2(LPRD2) | - |
| 613 | Leu | Val | Noonansyndrome5(NS5) | - |
| 237 | Ala | Thr | Cardiomyopathy,dilated1NN(CMD1NN) | - |
| 310 | Thr | Ala | Cardiomyopathy,dilated1NN(CMD1NN) | - |
| 332 | Pro | Ala | Cardiomyopathy,dilated1NN(CMD1NN) | - |
| 603 | Leu | Pro | Cardiomyopathy,dilated1NN(CMD1NN) | - |
| 626 | His | Arg | Cardiomyopathy,dilated1NN(CMD1NN) | - |
| 641 | Thr | Met | Cardiomyopathy,dilated1NN(CMD1NN) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003010 | LIG_14-3-3_CanoR_1 | LIG | 231 | 235 | - |
| ELMI003008 | LIG_14-3-3_CanoR_1 | LIG | 254 | 263 | - |
| ELMI003009 | LIG_14-3-3_CanoR_1 | LIG | 618 | 623 | - |
| ELMI002553 | MOD_PKB_1 | MOD | 254 | 262 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAF1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 47.4576 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 46.8927 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.3277 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 37.8531 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 37.2881 | 5 | yes |
| GO:0005524 | ATP binding | 36.7232 | 5 | yes |
| GO:0019900 | kinase binding | 24.2938 | 4 | no |
| GO:0019901 | protein kinase binding | 23.7288 | 5 | no |
| GO:0003723 | RNA binding | 23.1638 | 4 | no |
| GO:0046872 | metal ion binding | 22.5989 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 22.0339 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.0339 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.0339 | 6 | no |
| GO:0016301 | kinase activity | 19.2090 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 19.2090 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 18.6441 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 15.2542 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 15.2542 | 4 | yes |
| GO:0004709 | MAP kinase kinase kinase activity | 1.1299 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.1469 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.1469 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 61.0169 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 59.3220 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.7571 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.2373 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.4124 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.1525 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.5876 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.3277 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 46.3277 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.7627 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 44.0678 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 42.9379 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 42.3729 | 5 | yes |
| GO:0010468 | regulation of gene expression | 41.2429 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 38.9831 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.9831 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.4181 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.8531 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 37.8531 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 37.2881 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 36.7232 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 35.5932 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 35.5932 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.0282 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 35.0282 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.8983 | 4 | yes |
| GO:0006996 | organelle organization | 33.3333 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.7684 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 32.2034 | 7 | yes |
| GO:0043412 | macromolecule modification | 31.6384 | 4 | yes |
| GO:0051049 | regulation of transport | 31.6384 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.0734 | 5 | yes |
| GO:0036211 | protein modification process | 31.0734 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 30.5085 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 29.9435 | 4 | yes |
| GO:0010941 | regulation of cell death | 29.9435 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 29.9435 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.3785 | 7 | yes |
| GO:0031401 | positive regulation of protein modification process | 28.8136 | 7 | yes |
| GO:0042981 | regulation of apoptotic process | 28.8136 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 28.8136 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 28.8136 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.2486 | 5 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 27.6836 | 6 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 27.6836 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 27.6836 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.1186 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.5537 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 26.5537 | 8 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.5537 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.5537 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.5537 | 6 | yes |
| GO:0008104 | protein localization | 25.4237 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.4237 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.4237 | 6 | yes |
| GO:0043408 | regulation of MAPK cascade | 25.4237 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.4237 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 25.4237 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.4237 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.8588 | 8 | yes |
| GO:0051336 | regulation of hydrolase activity | 24.8588 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 24.2938 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 24.2938 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 24.2938 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.7288 | 6 | yes |
| GO:0071702 | organic substance transport | 23.7288 | 4 | yes |
| GO:0022607 | cellular component assembly | 23.1638 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 23.1638 | 4 | yes |
| GO:0032880 | regulation of protein localization | 23.1638 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5989 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 22.5989 | 6 | yes |
| GO:0080134 | regulation of response to stress | 22.5989 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.0339 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 22.0339 | 4 | no |
| GO:0060548 | negative regulation of cell death | 21.4689 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 20.9040 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 20.9040 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 20.3390 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 20.3390 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 20.3390 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.3390 | 4 | no |
| GO:0016310 | phosphorylation | 19.7740 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 19.2090 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 19.2090 | 4 | yes |
| GO:0006468 | protein phosphorylation | 18.6441 | 5 | yes |
| GO:0015031 | protein transport | 18.6441 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 16.9492 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 16.9492 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 16.3842 | 6 | yes |
| GO:0006915 | apoptotic process | 15.8192 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 15.2542 | 7 | yes |
| GO:0007010 | cytoskeleton organization | 15.2542 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 15.2542 | 5 | yes |
| GO:2000145 | regulation of cell motility | 15.2542 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 14.6893 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 14.6893 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 14.6893 | 8 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 14.1243 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.1243 | 5 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 12.9944 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 12.9944 | 4 | yes |
| GO:0052547 | regulation of peptidase activity | 12.9944 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 12.9944 | 6 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 12.4294 | 5 | yes |
| GO:0000165 | MAPK cascade | 11.8644 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 11.8644 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 11.2994 | 5 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 11.2994 | 7 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 10.1695 | 8 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.6045 | 8 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 7.9096 | 5 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 7.3446 | 6 | yes |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 7.3446 | 6 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 6.2147 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 6.2147 | 9 | yes |
| GO:0045861 | negative regulation of proteolysis | 6.2147 | 7 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 6.2147 | 6 | yes |
| GO:0048732 | gland development | 5.6497 | 4 | yes |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 5.6497 | 7 | yes |
| GO:0010466 | negative regulation of peptidase activity | 5.0847 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 5.0847 | 7 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5.0847 | 8 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 5.0847 | 7 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 5.0847 | 8 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 4.5198 | 6 | yes |
| GO:0048534 | hematopoietic or lymphoid organ development | 4.5198 | 4 | yes |
| GO:0031279 | regulation of cyclase activity | 3.3898 | 4 | yes |
| GO:0042060 | wound healing | 3.3898 | 4 | yes |
| GO:0046903 | secretion | 3.3898 | 4 | yes |
| GO:0048538 | thymus development | 3.3898 | 5 | yes |
| GO:0023061 | signal release | 2.8249 | 4 | yes |
| GO:0030878 | thyroid gland development | 2.8249 | 5 | yes |
| GO:0031281 | positive regulation of cyclase activity | 2.8249 | 5 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 2.8249 | 8 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 2.8249 | 5 | yes |
| GO:0051339 | regulation of lyase activity | 2.8249 | 4 | yes |
| GO:0035994 | response to muscle stretch | 2.2599 | 4 | yes |
| GO:0038179 | neurotrophin signaling pathway | 2.2599 | 4 | yes |
| GO:0045762 | positive regulation of adenylate cyclase activity | 2.2599 | 6 | yes |
| GO:0051349 | positive regulation of lyase activity | 2.2599 | 5 | yes |
| GO:0007190 | activation of adenylate cyclase activity | 1.6949 | 7 | yes |
| GO:0009914 | hormone transport | 1.6949 | 4 | yes |
| GO:0046879 | hormone secretion | 1.6949 | 5 | yes |
| GO:0048011 | neurotrophin TRK receptor signaling pathway | 1.6949 | 5 | yes |
| GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.6949 | 7 | yes |
| GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.6949 | 8 | yes |
| GO:0002790 | peptide secretion | 1.1299 | 5 | yes |
| GO:0009306 | protein secretion | 1.1299 | 4 | yes |
| GO:0015833 | peptide transport | 1.1299 | 5 | yes |
| GO:0030072 | peptide hormone secretion | 1.1299 | 6 | yes |
| GO:0030073 | insulin secretion | 1.1299 | 5 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 1.1299 | 4 | yes |
| GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 1.1299 | 4 | yes |
| GO:0042886 | amide transport | 1.1299 | 5 | yes |
| GO:0071550 | death-inducing signaling complex assembly | 1.1299 | 6 | yes |
| GO:0071692 | protein localization to extracellular region | 1.1299 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RAF1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 3.3898 | 4 | yes |
| DOID:0060036 | intrinsic cardiomyopathy | 3.3898 | 5 | yes |
| DOID:114 | heart disease | 3.3898 | 3 | yes |
| DOID:12930 | dilated cardiomyopathy | 1.6949 | 6 | yes |
| DOID:2843 | long QT syndrome | 1.6949 | 6 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 1.6949 | 6 | no |
| DOID:440 | neuromuscular disease | 1.6949 | 5 | no |
| DOID:574 | peripheral nervous system disease | 1.6949 | 3 | no |
| DOID:870 | neuropathy | 1.6949 | 4 | no |
| DOID:0050686 | organ system cancer | 1.6949 | 3 | no |
| DOID:0060583 | Noonan syndrome 5 | 1.1299 | 4 | yes |
| DOID:0080549 | Noonan syndrome with multiple lentigines 2 | 1.1299 | 4 | yes |
| DOID:0110432 | dilated cardiomyopathy 1NN | 1.1299 | 7 | yes |
| DOID:14291 | Noonan syndrome with multiple lentigines | 1.1299 | 3 | yes |
| DOID:3490 | Noonan syndrome | 1.1299 | 3 | yes |
| DOID:1289 | neurodegenerative disease | 1.1299 | 4 | no |
| DOID:331 | central nervous system disease | 1.1299 | 3 | no |
| DOID:0060038 | specific developmental disorder | 1.1299 | 3 | no |
| DOID:1059 | intellectual disability | 1.1299 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 1.1299 | 7 | no |
| DOID:2978 | carbohydrate metabolic disorder | 1.1299 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RMD3_HUMAN | [view interactions] | Low throughput | no | yes |
| MAEA_HUMAN | [view interactions] | Low throughput | no | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| RASM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | Low throughput | no | no |
| K1C18_HUMAN | [view interactions] | Low throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
| MPIP1_HUMAN | [view interactions] | Low throughput | no | no |
| ROCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB_HUMAN | [view interactions] | Low throughput | no | yes |
| NFAC3_HUMAN | [view interactions] | Low throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| T22D3_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PAR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | Low throughput | no | no |
| RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAK4_HUMAN | [view interactions] | Low throughput | no | yes |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| CNKR1_HUMAN | [view interactions] | Low throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| APOA1_HUMAN | [view interactions] | Low throughput | no | no |
| STK26_HUMAN | [view interactions] | Low throughput | no | no |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBL2_HUMAN | [view interactions] | Low throughput | no | yes |
| RRAS_HUMAN | [view interactions] | Low throughput | no | yes |
| PRP6_HUMAN | [view interactions] | Low throughput | no | yes |
| RFXK_HUMAN | [view interactions] | Low throughput | no | yes |
| MK_HUMAN | [view interactions] | Low throughput | no | no |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASE_HUMAN | [view interactions] | Low throughput | no | no |
| SPY4_HUMAN | [view interactions] | Low throughput | no | yes |
| SPY2_HUMAN | [view interactions] | Low throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAV_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KGP1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| MK07_HUMAN | [view interactions] | Low throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STK3_HUMAN | [view interactions] | Low throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LTK_HUMAN | [view interactions] | Low throughput | no | no |
| BAG1_HUMAN | [view interactions] | Low throughput | no | yes |
| JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEK10_HUMAN | [view interactions] | Low throughput | no | no |
| AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR83_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LATS1_HUMAN | [view interactions] | Low throughput | no | yes |
| RRAS2_HUMAN | [view interactions] | Low throughput | no | yes |
| VINEX_HUMAN | [view interactions] | Low throughput | no | no |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BIRC7_HUMAN | [view interactions] | Low throughput | no | no |
| PEBP4_HUMAN | [view interactions] | Low throughput | no | no |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| BRAF_HUMAN | [view interactions] | Low throughput | no | yes |
| KNDC1_HUMAN | [view interactions] | Low throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2A5G_HUMAN | [view interactions] | Low throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LYOX_HUMAN | [view interactions] | Low throughput | no | no |
| CDC37_HUMAN | [view interactions] | Low throughput | no | yes |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MABP1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HERC1_HUMAN | [view interactions] | Low throughput | no | no |
| LZTR1_HUMAN | [view interactions] | Low throughput | no | no |
| QKI_HUMAN | [view interactions] | Low throughput | no | no |
| TIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| NANOG_HUMAN | [view interactions] | Low throughput | no | no |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| CRBN_HUMAN | [view interactions] | Low throughput | no | yes |
| PAQR3_HUMAN | [view interactions] | Low throughput | no | no |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCNNB_HUMAN | [view interactions] | Low throughput | no | yes |
| NED4L_HUMAN | [view interactions] | Low throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHES_HUMAN | [view interactions] | Low throughput | no | yes |
| GBG4_HUMAN | [view interactions] | Low throughput | no | no |
| JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIRC2_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | Low throughput | no | no |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| AAKB1_HUMAN | [view interactions] | Low throughput | no | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MP2K7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| GLIS2_HUMAN | [view interactions] | High throughput | no | no |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMO_HUMAN | [view interactions] | High throughput | no | no |
| HGF_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CD44_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| AL1A3_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMED1_HUMAN | [view interactions] | High throughput | no | yes |
| TERT_HUMAN | [view interactions] | High throughput | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPDE4_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| PSB9_HUMAN | [view interactions] | High throughput | no | no |
| SLAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| MON2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKE_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| MK08_HUMAN | [view interactions] | High throughput | no | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| CASZ1_HUMAN | [view interactions] | High throughput | no | no |
| MRC2_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI2_HUMAN | [view interactions] | High throughput | no | no |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RAB38_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| AMER1_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| LAS1L_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU133_HUMAN | [view interactions] | High throughput | no | yes |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| NU160_HUMAN | [view interactions] | High throughput | no | no |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| KPB2_HUMAN | [view interactions] | High throughput | no | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| MYPC1_HUMAN | [view interactions] | High throughput | no | no |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT10_HUMAN | [view interactions] | High throughput | no | yes |
| CPSM_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRAP_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| NUD14_HUMAN | [view interactions] | High throughput | no | yes |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| CDK20_HUMAN | [view interactions] | High throughput | no | yes |
| HIPK4_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| PCDH7_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| S18L2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| PHAX_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM38_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| MGST1_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| S61A2_HUMAN | [view interactions] | High throughput | no | no |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| H90B2_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| TEAD2_HUMAN | [view interactions] | High throughput | no | no |
| T161A_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| DIC_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB5_HUMAN | [view interactions] | High throughput | no | no |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| TRAK1_HUMAN | [view interactions] | Computational | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2ABA_HUMAN | [view interactions] | Computational | no | yes |
| PAK5_HUMAN | [view interactions] | Computational | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KDM7A_HUMAN | [view interactions] | Computational | no | yes |
| SCNNG_HUMAN | [view interactions] | Computational | no | no |
| TIF1A_HUMAN | [view interactions] | Computational | no | yes |
| FA83A_HUMAN | [view interactions] | Computational | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCG_HUMAN | [view interactions] | Computational | no | no |
| 2A5A_HUMAN | [view interactions] | Computational | no | yes |
| CCL4_HUMAN | [view interactions] | Computational | no | no |
| PAK3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| B2L11_HUMAN | [view interactions] | Computational | no | yes |
| FCG2B_HUMAN | [view interactions] | Computational | no | no |
| AKAP9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANGT_HUMAN | [view interactions] | Computational | no | no |
| ATRAP_HUMAN | [view interactions] | Computational | no | yes |
| P85B_HUMAN | [view interactions] | Computational | no | yes |
| RASA1_HUMAN | [view interactions] | Computational | no | yes |
| FCERB_HUMAN | [view interactions] | Computational | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ESRP1_HUMAN | [view interactions] | Computational | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLK3_HUMAN | [view interactions] | Computational | no | no |
| CLCN6_HUMAN | [view interactions] | Computational | no | yes |
| ZCCHV_HUMAN | [view interactions] | Computational | no | yes |
| F131B_HUMAN | [view interactions] | Computational | no | no |
| PK3CD_HUMAN | [view interactions] | Computational | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFKB1_HUMAN | [view interactions] | Computational | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AGGF1_HUMAN | [view interactions] | Computational | no | no |
| SCNND_HUMAN | [view interactions] | Computational | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SND1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P55G_HUMAN | [view interactions] | Computational | no | yes |
| K1549_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| M3K11_HUMAN | [view interactions] | Computational | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 2AAB_HUMAN | [view interactions] | Computational | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DOK1_HUMAN | [view interactions] | Computational | no | yes |
| 2A5B_HUMAN | [view interactions] | Computational | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LSP1_HUMAN | [view interactions] | Computational | no | no |
| KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| F1142_HUMAN | [view interactions] | Computational | no | yes |
| THRB_HUMAN | [view interactions] | Computational | no | no |
| TXND9_HUMAN | [view interactions] | Computational | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHIP1_HUMAN | [view interactions] | Computational | no | no |
| LTOR3_HUMAN | [view interactions] | Computational | no | yes |
| IGF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 2A5E_HUMAN | [view interactions] | Computational | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATG7_HUMAN | [view interactions] | Computational | no | yes |
| FCERG_HUMAN | [view interactions] | Computational | no | no |
| PAPS1_HUMAN | [view interactions] | Computational | no | yes |
| KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AKT3_HUMAN | [view interactions] | Computational | no | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCNNA_HUMAN | [view interactions] | Computational | no | yes |
| FCERA_HUMAN | [view interactions] | Computational | no | yes |
| PK3CB_HUMAN | [view interactions] | Computational | no | yes |
| CCL11_HUMAN | [view interactions] | Computational | no | no |
| NDRG3_HUMAN | [view interactions] | Computational | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |