Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

E41L2_HUMAN

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in E41L2_HUMAN
GO:0017076 purine nucleotide binding 31.2500 4 no
GO:0032555 purine ribonucleotide binding 31.2500 4 no
GO:0019900 kinase binding 29.6875 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.6875 4 no
GO:0019901 protein kinase binding 28.1250 5 no
GO:0003779 actin binding 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in E41L2_HUMAN
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0048523 negative regulation of cellular process 62.5000 4 no
GO:0048522 positive regulation of cellular process 60.9375 4 yes
GO:0031323 regulation of cellular metabolic process 57.8125 4 no
GO:0051171 regulation of nitrogen compound metabolic process 56.2500 4 no
GO:0080090 regulation of primary metabolic process 56.2500 4 no
GO:0010646 regulation of cell communication 54.6875 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0009893 positive regulation of metabolic process 46.8750 4 no
GO:0006996 organelle organization 45.3125 4 yes
GO:0010468 regulation of gene expression 43.7500 5 no
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0051128 regulation of cellular component organization 42.1875 4 no
GO:0008104 protein localization 42.1875 4 no
GO:0051246 regulation of protein metabolic process 42.1875 5 no
GO:0009892 negative regulation of metabolic process 40.6250 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.6250 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 35.9375 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.9375 5 no
GO:0071702 organic substance transport 35.9375 4 no
GO:0071705 nitrogen compound transport 35.9375 4 no
GO:1902531 regulation of intracellular signal transduction 35.9375 5 no
GO:0031324 negative regulation of cellular metabolic process 34.3750 5 no
GO:0031325 positive regulation of cellular metabolic process 34.3750 5 no
GO:0051049 regulation of transport 32.8125 4 no
GO:0022607 cellular component assembly 32.8125 4 no
GO:0019220 regulation of phosphate metabolic process 32.8125 6 no
GO:0051174 regulation of phosphorus metabolic process 32.8125 5 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0009889 regulation of biosynthetic process 31.2500 4 no
GO:0031326 regulation of cellular biosynthetic process 31.2500 5 no
GO:0007010 cytoskeleton organization 29.6875 5 yes
GO:0016192 vesicle-mediated transport 29.6875 4 no
GO:0048584 positive regulation of response to stimulus 28.1250 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.1250 5 no
GO:0015031 protein transport 26.5625 4 no
GO:0051248 negative regulation of protein metabolic process 26.5625 6 no
GO:0031401 positive regulation of protein modification process 26.5625 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.5625 5 no
GO:0010941 regulation of cell death 26.5625 4 no
GO:0042981 regulation of apoptotic process 26.5625 6 no
GO:0043067 regulation of programmed cell death 26.5625 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0036211 protein modification process 23.4375 4 no
GO:0043412 macromolecule modification 23.4375 4 no
GO:0051094 positive regulation of developmental process 23.4375 4 no
GO:0051240 positive regulation of multicellular organismal process 23.4375 4 no
GO:0010647 positive regulation of cell communication 23.4375 5 no
GO:0023056 positive regulation of signaling 23.4375 4 no
GO:0051050 positive regulation of transport 23.4375 4 no
GO:0071310 cellular response to organic substance 23.4375 4 no
GO:0051338 regulation of transferase activity 23.4375 4 no
GO:0010648 negative regulation of cell communication 23.4375 5 no
GO:0023057 negative regulation of signaling 23.4375 4 no
GO:0006796 phosphate-containing compound metabolic process 21.8750 4 no
GO:0042127 regulation of cell population proliferation 21.8750 4 no
GO:0033043 regulation of organelle organization 21.8750 5 no
GO:0044087 regulation of cellular component biogenesis 21.8750 4 no
GO:0043549 regulation of kinase activity 21.8750 5 no
GO:0045859 regulation of protein kinase activity 21.8750 6 no
GO:0006355 regulation of DNA-templated transcription 21.8750 6 no
GO:1903506 regulation of nucleic acid-templated transcription 21.8750 7 no
GO:2001141 regulation of RNA biosynthetic process 21.8750 6 no
GO:0030030 cell projection organization 21.8750 4 no
GO:0048585 negative regulation of response to stimulus 21.8750 4 no
GO:0009967 positive regulation of signal transduction 20.3125 5 no
GO:0050804 modulation of chemical synaptic transmission 20.3125 5 no
GO:0099177 regulation of trans-synaptic signaling 20.3125 4 no
GO:0060548 negative regulation of cell death 20.3125 5 no
GO:0080134 regulation of response to stress 20.3125 4 no
GO:0060341 regulation of cellular localization 17.1875 4 yes
GO:0032880 regulation of protein localization 15.6250 5 yes
GO:1903829 positive regulation of protein localization 14.0625 5 yes
GO:0030865 cortical cytoskeleton organization 10.9375 6 yes
GO:1904375 regulation of protein localization to cell periphery 10.9375 6 yes
GO:0031032 actomyosin structure organization 9.3750 4 yes
GO:0030866 cortical actin cytoskeleton organization 7.8125 4 yes
GO:1904377 positive regulation of protein localization to cell periphery 7.8125 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in E41L2_HUMAN
DOID:0050700 cardiomyopathy 3.1250 4 no
DOID:0060036 intrinsic cardiomyopathy 3.1250 5 no
DOID:114 heart disease 3.1250 3 no
DOID:2843 long QT syndrome 3.1250 6 no
DOID:1289 neurodegenerative disease 3.1250 4 no
DOID:331 central nervous system disease 3.1250 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NUMA1_HUMAN [view interactions] Low throughput no yes
FCGR1_HUMAN [view interactions] Low throughput no no
PALS2_HUMAN [view interactions] Low throughput no yes
FKBP2_HUMAN [view interactions] Low throughput no yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTH1R_HUMAN [view interactions] Low throughput no no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
DDAH1_HUMAN [view entry] [view interactions] High throughput yes no
SPF27_HUMAN [view interactions] High throughput no yes
SRS10_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
FA83G_HUMAN [view interactions] High throughput no no
KLH15_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
BRD9_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SRP09_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CSN4_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF8_HUMAN [view interactions] High throughput no yes
MEP50_HUMAN [view interactions] High throughput no yes
CADM1_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
CSN6_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DPY30_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
CSN2_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
CSN8_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
SCOC_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSN7A_HUMAN [view interactions] High throughput no yes
GCYB1_HUMAN [view interactions] High throughput no yes
NUP35_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
DCA15_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
RHDF2_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
PLCG2_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
KIBRA_HUMAN [view interactions] High throughput no yes
LIN7A_HUMAN [view entry] [view interactions] High throughput yes yes
KLC4_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
PAX6_HUMAN [view interactions] High throughput no no
FAN_HUMAN [view interactions] High throughput no yes
WASH1_HUMAN [view interactions] High throughput no yes
WRP73_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
ACINU_HUMAN [view interactions] High throughput no yes
GPTC8_HUMAN [view interactions] High throughput no yes
CWC22_HUMAN [view interactions] High throughput no yes
PININ_HUMAN [view interactions] High throughput no yes
NKAP_HUMAN [view interactions] High throughput no yes
PPIG_HUMAN [view interactions] High throughput no yes
ENL_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ICLN_HUMAN [view interactions] High throughput no yes
AF9_HUMAN [view interactions] High throughput no yes
POTEI_HUMAN [view interactions] High throughput no no
SET1A_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
DDAH2_HUMAN [view interactions] High throughput no yes
WDR59_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
SNR40_HUMAN [view interactions] High throughput no yes
ARI5B_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
ZN736_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
PIM3_HUMAN [view interactions] High throughput no no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
TBCK_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
M3K2_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RD3_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
WNK1_HUMAN [view entry] [view interactions] High throughput yes no
CSN5_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CCNT1_HUMAN [view interactions] High throughput no yes
CCD61_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ATX1L_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
SIR7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
RNPS1_HUMAN [view interactions] High throughput no yes
ZRAB2_HUMAN [view interactions] High throughput no yes
CLK2_HUMAN [view interactions] High throughput no yes
SRP68_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
DOC11_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
DTX3L_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX56_HUMAN [view interactions] High throughput no yes
MFAP1_HUMAN [view interactions] High throughput no yes
RB15B_HUMAN [view interactions] High throughput no yes
DCA13_HUMAN [view interactions] High throughput no yes
POP1_HUMAN [view interactions] High throughput no no
NSRP1_HUMAN [view interactions] High throughput no yes
HXA5_HUMAN [view interactions] High throughput no no
MEPCE_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2L_HUMAN [view interactions] High throughput no no
AMRP_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
MMTA2_HUMAN [view interactions] High throughput no yes
PP1RA_HUMAN [view interactions] High throughput no yes
TOX4_HUMAN [view interactions] High throughput no yes
DDX42_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
NUFP2_HUMAN [view interactions] High throughput no no
FA76B_HUMAN [view interactions] High throughput no no
RBM25_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
SNIP1_HUMAN [view interactions] High throughput no no
CBX4_HUMAN [view interactions] High throughput no yes
CPSF7_HUMAN [view interactions] High throughput no yes
TAF2_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
JMJD6_HUMAN [view interactions] High throughput no yes
KT222_HUMAN [view interactions] High throughput no no
SPTN4_HUMAN [view entry] [view interactions] Computational yes no
SPTB2_HUMAN [view entry] [view interactions] Computational yes yes
SPTN1_HUMAN [view entry] [view interactions] Computational yes yes