E41L2_HUMAN
Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in E41L2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 31.2500 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 31.2500 | 4 | no |
GO:0019900 | kinase binding | 29.6875 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.6875 | 4 | no |
GO:0019901 | protein kinase binding | 28.1250 | 5 | no |
GO:0003779 | actin binding | 18.7500 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in E41L2_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 62.5000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 62.5000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 60.9375 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 57.8125 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 56.2500 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 56.2500 | 4 | no |
GO:0010646 | regulation of cell communication | 54.6875 | 4 | no |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 46.8750 | 4 | no |
GO:0006996 | organelle organization | 45.3125 | 4 | yes |
GO:0010468 | regulation of gene expression | 43.7500 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 43.7500 | 5 | no |
GO:0051128 | regulation of cellular component organization | 42.1875 | 4 | no |
GO:0008104 | protein localization | 42.1875 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 42.1875 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 40.6250 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 40.6250 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.5000 | 5 | no |
GO:0031399 | regulation of protein modification process | 35.9375 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.9375 | 5 | no |
GO:0071702 | organic substance transport | 35.9375 | 4 | no |
GO:0071705 | nitrogen compound transport | 35.9375 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 35.9375 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 34.3750 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.3750 | 5 | no |
GO:0051049 | regulation of transport | 32.8125 | 4 | no |
GO:0022607 | cellular component assembly | 32.8125 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 32.8125 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 32.8125 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 31.2500 | 7 | no |
GO:0042325 | regulation of phosphorylation | 31.2500 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 31.2500 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 31.2500 | 5 | no |
GO:0007010 | cytoskeleton organization | 29.6875 | 5 | yes |
GO:0016192 | vesicle-mediated transport | 29.6875 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 28.1250 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 28.1250 | 5 | no |
GO:0015031 | protein transport | 26.5625 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 26.5625 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 26.5625 | 7 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.5625 | 5 | no |
GO:0010941 | regulation of cell death | 26.5625 | 4 | no |
GO:0042981 | regulation of apoptotic process | 26.5625 | 6 | no |
GO:0043067 | regulation of programmed cell death | 26.5625 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
GO:0036211 | protein modification process | 23.4375 | 4 | no |
GO:0043412 | macromolecule modification | 23.4375 | 4 | no |
GO:0051094 | positive regulation of developmental process | 23.4375 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 23.4375 | 4 | no |
GO:0010647 | positive regulation of cell communication | 23.4375 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.4375 | 4 | no |
GO:0051050 | positive regulation of transport | 23.4375 | 4 | no |
GO:0071310 | cellular response to organic substance | 23.4375 | 4 | no |
GO:0051338 | regulation of transferase activity | 23.4375 | 4 | no |
GO:0010648 | negative regulation of cell communication | 23.4375 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.4375 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 21.8750 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 21.8750 | 4 | no |
GO:0033043 | regulation of organelle organization | 21.8750 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.8750 | 4 | no |
GO:0043549 | regulation of kinase activity | 21.8750 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 21.8750 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 21.8750 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 21.8750 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.8750 | 6 | no |
GO:0030030 | cell projection organization | 21.8750 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 21.8750 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 20.3125 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 20.3125 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 20.3125 | 4 | no |
GO:0060548 | negative regulation of cell death | 20.3125 | 5 | no |
GO:0080134 | regulation of response to stress | 20.3125 | 4 | no |
GO:0060341 | regulation of cellular localization | 17.1875 | 4 | yes |
GO:0032880 | regulation of protein localization | 15.6250 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 14.0625 | 5 | yes |
GO:0030865 | cortical cytoskeleton organization | 10.9375 | 6 | yes |
GO:1904375 | regulation of protein localization to cell periphery | 10.9375 | 6 | yes |
GO:0031032 | actomyosin structure organization | 9.3750 | 4 | yes |
GO:0030866 | cortical actin cytoskeleton organization | 7.8125 | 4 | yes |
GO:1904377 | positive regulation of protein localization to cell periphery | 7.8125 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in E41L2_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 3.1250 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.1250 | 5 | no |
DOID:114 | heart disease | 3.1250 | 3 | no |
DOID:2843 | long QT syndrome | 3.1250 | 6 | no |
DOID:1289 | neurodegenerative disease | 3.1250 | 4 | no |
DOID:331 | central nervous system disease | 3.1250 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NUMA1_HUMAN | [view interactions] | Low throughput | no | yes |
FCGR1_HUMAN | [view interactions] | Low throughput | no | no |
PALS2_HUMAN | [view interactions] | Low throughput | no | yes |
FKBP2_HUMAN | [view interactions] | Low throughput | no | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTH1R_HUMAN | [view interactions] | Low throughput | no | no |
GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPF27_HUMAN | [view interactions] | High throughput | no | yes |
SRS10_HUMAN | [view interactions] | High throughput | no | yes |
ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
FA83G_HUMAN | [view interactions] | High throughput | no | no |
KLH15_HUMAN | [view interactions] | High throughput | no | yes |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
BRD9_HUMAN | [view interactions] | High throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN4_HUMAN | [view interactions] | High throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
MEP50_HUMAN | [view interactions] | High throughput | no | yes |
CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN6_HUMAN | [view interactions] | High throughput | no | yes |
DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
PI42C_HUMAN | [view interactions] | High throughput | no | yes |
AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN2_HUMAN | [view interactions] | High throughput | no | yes |
CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN8_HUMAN | [view interactions] | High throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCOC_HUMAN | [view interactions] | High throughput | no | yes |
TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
NUP35_HUMAN | [view interactions] | High throughput | no | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UFO_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
PLCG2_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLC4_HUMAN | [view interactions] | High throughput | no | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAX6_HUMAN | [view interactions] | High throughput | no | no |
FAN_HUMAN | [view interactions] | High throughput | no | yes |
WASH1_HUMAN | [view interactions] | High throughput | no | yes |
WRP73_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
CXB7_HUMAN | [view interactions] | High throughput | no | no |
SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
ACINU_HUMAN | [view interactions] | High throughput | no | yes |
GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
CWC22_HUMAN | [view interactions] | High throughput | no | yes |
PININ_HUMAN | [view interactions] | High throughput | no | yes |
NKAP_HUMAN | [view interactions] | High throughput | no | yes |
PPIG_HUMAN | [view interactions] | High throughput | no | yes |
ENL_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
AF9_HUMAN | [view interactions] | High throughput | no | yes |
POTEI_HUMAN | [view interactions] | High throughput | no | no |
SET1A_HUMAN | [view interactions] | High throughput | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
WDR59_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNR40_HUMAN | [view interactions] | High throughput | no | yes |
ARI5B_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
ZN736_HUMAN | [view interactions] | High throughput | no | no |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
PIM3_HUMAN | [view interactions] | High throughput | no | no |
CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
M3K2_HUMAN | [view interactions] | High throughput | no | yes |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD3_HUMAN | [view interactions] | High throughput | no | no |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
CCD61_HUMAN | [view interactions] | High throughput | no | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATX1L_HUMAN | [view interactions] | High throughput | no | no |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
CLK2_HUMAN | [view interactions] | High throughput | no | yes |
SRP68_HUMAN | [view interactions] | High throughput | no | yes |
CP2S1_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
WDR76_HUMAN | [view interactions] | High throughput | no | no |
H4_HUMAN | [view interactions] | High throughput | no | yes |
H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
DOC11_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
CIC_HUMAN | [view interactions] | High throughput | no | yes |
DTX3L_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DDX56_HUMAN | [view interactions] | High throughput | no | yes |
MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
RB15B_HUMAN | [view interactions] | High throughput | no | yes |
DCA13_HUMAN | [view interactions] | High throughput | no | yes |
POP1_HUMAN | [view interactions] | High throughput | no | no |
NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
HXA5_HUMAN | [view interactions] | High throughput | no | no |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
PR40A_HUMAN | [view interactions] | High throughput | no | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATX2L_HUMAN | [view interactions] | High throughput | no | no |
AMRP_HUMAN | [view interactions] | High throughput | no | yes |
RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
PP1RA_HUMAN | [view interactions] | High throughput | no | yes |
TOX4_HUMAN | [view interactions] | High throughput | no | yes |
DDX42_HUMAN | [view interactions] | High throughput | no | yes |
MECP2_HUMAN | [view interactions] | High throughput | no | yes |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
FA76B_HUMAN | [view interactions] | High throughput | no | no |
RBM25_HUMAN | [view interactions] | High throughput | no | yes |
KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNIP1_HUMAN | [view interactions] | High throughput | no | no |
CBX4_HUMAN | [view interactions] | High throughput | no | yes |
CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
TAF2_HUMAN | [view interactions] | High throughput | no | no |
APR_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
KT222_HUMAN | [view interactions] | High throughput | no | no |
SPTN4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SPTB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SPTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |